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| 1 | Metabonomic phenotype and identification of “heart blood stasis obstruction pattern” and “qi and yin deficiency pattern” of myocardial ischemia rat models显示文摘The traditional Chinese medicine concepts of 'Xinxueyuzuzheng (heart blood stasis obstruction pattern)' and 'Qiyinliangxuzheng (qi and yin deficiency pattern)' for myocardial ischemia rat models were constructed in the present study. Endogenous metabolites in rat plasma were analyzed using the GC/TOF-MS-based metabonomic method. Significant metabolic differences were observed between the control and two model groups, and the three groups were distinguished clearly by pattern recognition. Compared with those of the control, the levels of hydroxyproline, threonic acid, glutamine and citric acid were strikingly up or down-regulated in model rats. The metabolites contributing most to the classification between the two 'pattern' rats were identified, such as valine, serine, threonine, ornithine, hydroxyproline, lysine, 2-hydroxybutanoic acid, 3-hydroxybutanoic acid, galactofuranose and inositol. These compounds were indicated as the potential biomarkers. The results suggested that the two 'patterns' are involved in dysfunction in oxidative stress, energy metabolism and amino acid metabolism. These findings also provided the substantial foundation for exploring the scientific connotation of these two 'Zhengxing (pattern types)' of myocardial ischemia, and 'Bianzheng (pattern identification)'. | YAN Bei1, A JiYe1, HAO HaiPing1, WANG GuangJi1, ZHU XuanXuan2, 3, ZHA WeiBin1, LIU LinSheng1, GUAN EnZe3, ZHANG Ying1, GU ShengHua1, HUANG Qing1 & ZHENG YuanTing1 1Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China 2Pharmacological Laboratory of Clinical Research Institute, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing 210029, China 3College of Pharmacy, Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China | 2009 | Science China(Life Sciences)2009，52，11： | 19 |
| 2 | Influence of IFNα-2b and BCG on the release of TNF and IL-1 by Kupffer cells in rats with hepatoma显示文摘INTRODUCTIONKupffer cells are residential macrophages in the liver ,which play a critical role in the maintenance of normal liver function and in immunal surveilance of hepatocellular carcinoma (HCC) and other cancers[1].The biological immune modulants have cancers[2].In our previous studies ,the combined use of biological immune modulants showed better dffects . | Xian Yong Bai~1 Xiu Hong Jia~2 Ling Zhong Cheng~3 Yun Di Gu~3 ~1Department of Histology and Embryology,Binzhou Medical College,Binzhou 256603,Shandong Province,China ~2Departrnent of Pediatrics,Binzhou Medical College,Binzhou 256603,Shandong Province,China ~3Department of Histology and Embryology,Shanghai Medical University,Shanghai 200032,ChinaDr.Xian Yong Bai graduated from the Shanghai Medical University as a postgraduate in 1995,Professor of Histology and Embryology,specialized in hepatic tumor immunology,having 36 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 7 |
| 3 | Trogocytosis of CD80 and CD86 by induced regulatory 7 cells显示文摘 | Peng Gu Julia Fang Gao Cheryl A D'Souza Aleksandra Kowalczyk Kuang-Yen Chou Li Zhang | 2012 | Cellular & Molecular Immunology2012，9，2： | 7 |
| 4 | Effects of grazing intensity on seed production of Caragana stenophylla along a climatic aridity gradient in the Inner Mongolia Steppe,China显示文摘As the increases of climatic aridity and grazing intensity,shrubs play an increasingly important role in grassland ecosystem in arid and semi-arid regions,and its abundance also generally increases.However,the effects of climatic aridity and grazing intensity on sexual reproduction of shrubs in grassland remain largely unclear.In order to understand the effects of grazing intensity and climatic drought stress,and their interaction on seed production of shrub species,we examined the seed number,seed weight and seed yield of Caragana stenophylla under three grazing intensities(fenced,mild grazing and severe grazing) across a climatic aridity gradient(semi-arid,arid,very arid and intensively arid zones) in the Inner Mongolia Steppe,northern China during 2012–2013.The seed number,seed weight and seed yield gradually increased from the semi-arid to the very arid zones,but decreased from the very arid to the intensively arid zones in fenced plots.The seed number and seed yield decreased from the semi-arid to the intensively arid zones in mild and severe grazing treatment plots,therefore,grazing enhanced the suppression effect of climatic aridity on seed production of C.stenophylla.The seed number and seed yield gradually decreased as grazing intensity increased.The seed weight was highest in severe grazing plots,followed by the mild grazing plots and then the fenced plots.Precipitation varied interannually during the study period.We observed that the seed number,seed weight and seed yield were lower in the low precipitation year(2013) than in the high precipitation year(2012).As climatic drought stress increased,the negative effects of grazing on seed production of C.stenophylla also gradually increased.Our results indicated that climatic drought stress may contribute to the encroachment of C.stenophylla shrub in arid zones by promoting its seed production.However,grazing had negative effects on sexual reproduction of C.stenophylla,and the combined effects of drought stress and grazing seriously suppressed sexual reproduction of C.stenophylla in the intensively arid zone. | XIE Lina CHEN Weizhong Christopher A GABLER HAN Lei GUO Hongyu CHEN Qing MA Chengcang GU Song | 2016 | Journal of Arid Land2016，8，6： | 5 |
| 5 | Confucian Human Rights Ideas and Their Influence on Modern Human Rights Thought显示文摘The world in which we are now living is becoming economically globalized, politically multi-polarized and culturally diversified. In such a global trend, the discussion on oriental culture and human rights development aims at stimulating Chinese and international human rights development, promoting China’s human rights exchanges and cooperation with the theme of peace and development. This is of theoretical and practical importance. | GU CHUNDE The author is a professor with Renmin University of China. | 2004 | The Journal of Human Rights2004，3，1： | 3 |
| 6 | Enzymatic hydrolysis of proteins from yellowfin tuna ( Thunnus albacares ) wastes using Alcalase显示文摘 | F Guérard L Dufossé D De La Broise A Binet | 2001 | Journal of Molecular Catalysis B Enzymatic2001，，4： | 3 |
| 7 | 环境铅暴露与血压的关系:2003-2010美国健康和营养调查显示文摘在铅暴露逐渐降低的环境下,该文通过分析2003-2010美国健康和营养调查资料,旨在研究血铅与血压、高血压的关系。纳入研究对象12 725人,其中非洲裔21.1%,西语裔20.5%,白人58.4%,女性48.7%。与非非洲裔比较,非洲裔的血压[126.5/71.9比123.9/69.6mm Hg(1mm Hg=0. | Hara A Thijs L Asayama K Gu YM Jacobs L Zhang ZY Liu YP Nawrot TS Staessen JA 刘莉 叶鹏 | 2014 | 中华高血压杂志2014，22，10： | 3 |
| 8 | Identification of cryll-type genes from Bacillus thuringiensis strains and characterization of novel cryll-type gene显示文摘 | Song F Zhang J Gu A | 2003 | Appl Environ Microbiol2003，69，9： | 1 |
| 9 | Delamination buckling and postbuekling of composite cylindrical shells 显示文摘 | Chattopadhyay A Gu H | 1996 | AIAA Journal1996，34，6： | 1 |
| 10 | Fabrication of high -- quality opal films with controllable thickness 显示文摘 | Gu Z Z Fujishima A Sato S | 2002 | Chem Mater2002，14，2： | 1 |
| 11 | Ethanol increases carotenoid production in Phaffia rhodozyma 显示文摘 | Gu W L An G H Johnson E A | 1997 | Journal of Industrial Microbiology & Biotechnology1997，19，： | 1 |
| 12 | Wave propagation in periodic stiffened shells: Spectral finite element modeling and experiments 显示文摘 | SOLAROLI G GU Z BAZ A RUZZENE M | 2003 | Journal of Vibration and Control2003，9，9： | 1 |
| 13 | Environmental risk as- sessment: A critical approach of the European TGD in an in situ application 显示文摘 | Gu e rit 1 Boequen e G James A | 2008 | Ecotoxicology and Environmental Safety2008，71，9： | 1 |
| 14 | Human MutY homolog,a DNA glycosylase involved in base excision repair,physically and functionally interacts with mismatch repair proteins human MutS homolog 2/human MutS homolog 6显示文摘 | Gu Y Parker A Wilson TM | 2002 | J Biol Chem2002，277，11： | 1 |
| 15 | Response of human mammary epithelial cells to DNA damage induced by BPDE:involvement of novel regulatory pathways显示文摘 | WANG A GU J JUDSON-KREMER K | 2003 | Carcinog2003，24，2： | 1 |
| 16 | Pulse generators for pulsed electric field exposure of biological cells and tissues显示文摘 | Behrend M Kuthi A Gu X | 2003 | Dielectrics and Electrical Insulation IEEE Transactions2003，10，： | 1 |
| 17 | Influence of pH and carrageenan type on properties of fl-lactoglobulin stabilized oil-in- water emulsions显示文摘 | GU S Y DECKER E A MCCLEMENTS D J | 2005 | Food Hydrocolloids2005，19，1： | 1 |
| 18 | On the design of two-dimensional cellular metals for combined heat dissipation and structural load capacity显示文摘 | Gu S Lu T Evans A | | 0，，： | 1 |
| 19 | Comparison of buccal and nasal dexmedetomidine premeditation for pe- diatric patients显示文摘 | Cimen ZS Hanci A Sivrikaya GU | 2013 | Paediatr Anaesth2013，23，2： | 1 |
| 20 | Glutathione monoethyl ester improves functional recovery,enhances neuron survival,and stabilizes spinal cord blood flow after spinal cord injury in rats显示文摘 | Guízar-Sahagún G Ibar ra A Espitia A | 2005 | Neuroscience2005，130，3： | 1 |
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