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| 1 | Upregulation of CD81 in trophoblasts induces an imbalance of Treg/Th17 cells by promoting IL-6 expression in preeclampsia显示文摘The disturbance of maternal immune tolerance to a semiallogeneic fetus is recognized as one of the key pathologies of preeclampsia(PE),in which an imbalance between the inflammation-limiting regulatory T cells(Tregs)and the inflammationmediating Th17 cells plays an essential role.Previously,we reported that the abnormal upregulation of tetraspannin CD81 in trophoblast cells(fetal component)participated in the pathogenesis of PE.However,as one of the potential immune regulatory molecules,whether CD81 induces PE by interfering with the balance of the maternal immune system has not yet been clarified.Thus,we investigated the relationship between the upregulation of CD81 in trophoblast cells and the imbalance of Treg and Th17 cells in mothers.Here,we demonstrated that upregulation of CD81 in trophoblast cells was accompanied by a decrease in Treg cells and an increase in Th17 cells in both the basal plate(placental maternal side)and peripheral blood of patients with PE.In vitro culture of naïve T cells with medium from the CD81-overexpressing trophoblast cell line HTR-8 resulted in enhanced differentiation of T cells into Th17 cells and decreased the formation of Tregs,which was dependent on the paracrine signaling of IL-6 in trophocytes,induced by CD81.In a CD81-induced PE rat model,we found a significant shift of T cell differentiation towards Th17 cells,and administration of IL-6 antibody mitigated the PE phenotype and the imbalance of the Treg/Th17 cells.These results define a vital regulatory cascade involving trophocyte-derived CD81,IL-6,and maternal Treg/Th17 cells in the pathogenesis of PE and suggests new therapeutic approaches based on CD81 and IL-6 downregulation to prevent human PE. | Hailin Ding Yimin Dai Yi Lei Zhiyin Wang Dan Liu Ruotian Li Li Shen Ning Gu Mingming Zheng Xiangyu Zhu Guangfeng Zhao Yali Hu | 2019 | Cellular & Molecular Immunology2019，16，3： | 15 |
| 2 | 浅析海上平台生产废水含油在线监测技术显示文摘海上平台生产过程产生的含油污水量日益增长,正确处理采出水确保回注水的质量,实现水中石油类物质在线监测,对加强海洋石油勘探开发工作有重要意义。本文总结了水中石油类污染的检测方法,介绍了石油类在线监测系统,指出了紫外荧光法在线监测水中石油类污染存在并需克服的问题。 | 王妮 刘铭辉 石文婷 刘涛 闫肃 Cao Xingtao Gu Guangfeng | 2019 | 石化技术2019，26，8： | 6 |
| 3 | Study on digital image watermark algorithm based on chaos mapping and DWT显示文摘 | Gu Zhifeng Li Guangfeng Yang Zongxiao | | 0，，： | 1 |
| 4 | Silver oxide nanowalls grown on Cu substrate as an enzymeless glucose sensor显示文摘 | Bin Fang Aixia Gu Guangfeng Wang | 2009 | ACS Appl Mater Interfaces2009，1，12： | 1 |
| 5 | CuS nanotubes for uhrasensitive nonenzymatie glucose sensors 显示文摘 | ZHANG Xiaojun WANG Guangfeng GU Aixia | 2008 | Chemistry Communications2008，45，： | 1 |
| 6 | Selective hydrodechlorination of 1,2-dichloroethane to ethylene over Pd-Ag/Al2O3catalysts prepared by surface reduction显示文摘 | Han Yuiang Gu Guangfeng Sun Jingya | 2015 | Applied Surface Science2015，355，： | 1 |
| 7 | Topological effect on fluorescence emission of tetraphenylethylene-based metallacages显示文摘Herein,we describe the selective formation of a barrel-shaped or a ball-shaped fluorescent metallacage by controlling the shape and stoichiometry of the building blocks.Specifically,the tetraphenylethylene-based donor and two acceptors with different numbers of Pt(Ⅱ)centers were combined via coordination-driven self-assembly.Owing to the differences in the shapes of the assemblies,the resultant ball-shaped metallacage displayed stronger and blue-shifted fluorescence compared to the barrel-shaped one in dilute solutions,while a reversal of fluorescence intensities was observed in the aggregation process.Overall,this work demonstrates that the photophysical properties of supramolecular coordination complexes can be affected by subtle geometrical factors,which can be controlled precisely at the molecular level. | Yuhang Liu Zhewen Guo Yuchen Gu Guangfeng Li Shengbing Yang Xuzhou Yan Yi Shen Jinbing Wang | 2023 | Chinese Chemical Letters2023，34，12： | 0 |
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