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| 1 | Sinomenine reduces iNOS expressionvia inhibiting the T-bet IFN-γ pathway in experimental autoimmune encephalomyelitis in rats显示文摘Sinomenine is a bioactive alkaloid isolated from the Chinese medicinal plant Sinomenium acutum.It is widely used as an immunosuppressive drug for treating rheumatic and arthritic diseases.In our previous studies,we found that sinomenine reduced cellular infiltration within the spinal cord and alleviated experimental autoimmune encephalomyelitis(EAE) in rats.In this study,we further investigated the mechanisms of sinomenine treatment in EAE rats.In EAE rats,treatment with sinomenine exerted an anti-inducible NO synthase(anti-iNOS) effect,which is related to the reductions of Th1 cytokine interferon-γ(IFN-γ) and its transcription factor,T-bet,in spinal cords.Moreover,sinomenine treatment of splenocytes stimulated with anti-CD3 antibody and recombinant rat interleukin 12 reduced the expression of T-bet and IFN-γ in vitro and also reduced the capability of supernatants of splenocyte culture to induce iNOS expression by primary astrocytes.However,sinomenine had no direct inhibitory effect on iNOS produced by astrocytes cultured with IFN-γ and tumor necrosis factor α in vitro.In conclusion,the anti-iNOS effect of sinomenine on EAE is mediated via the suppression of T-bet /IFN-γ pathway. | Bingjie Gu Yanying Zeng Cheng Yin Huijiuan Wang Xiaofan Yang Song Wang Xiaohui Ji | 2012 | The Journal of Biomedical Research2012，26，6： | 11 |
| 2 | A survey of indoor positioning systems for wireless personal networks显示文摘 | Gu Yanying Anthony Lo Ignas Niemegeers | 2009 | Communications Surveys&Tutorials IEEE2009，11，1： | 1 |
| 3 | A Survey of Indoor Positioning Systems for Wireless Personal Networks 显示文摘 | Yanying Gu Anthony Lo Ignas Niemegeers | 2009 | IEEE Communications Surveys and Tutorials2009，11，1： | 1 |
| 4 | A survey of indoor positioning systems for wireless personal networks 显示文摘 | GU Yanying LO A NIEMEGEERS 1 | 2009 | IF EE commun surveys & tutorials2009，11，1： | 1 |
| 5 | A Survey of Indoor Posi-tioning Systems for Wireless Personal Networks显示文摘 | GU Yanying LO A NIEMEGEERS I | 2009 | IEEE Com-munications Surveysand Tutorials2009，11，1： | 1 |
| 6 | A survey of indoor positioning systems for wireless personal networks显示文摘 | Gu Yanying Lo A Niemegeers I | 2009 | Communications Surveys&Tutorials IEEE2009，11，1： | 1 |
| 7 | A survey of indoor positioning systems for wireless personal networks显示文摘 | Gu Yanying | 2009 | IEEE Communication Surveys&Tutorials2009，11，1： | 1 |
| 8 | A survey of indoor positioning systems for wireless personal networks显示文摘 | Gu Yanying Lo A Niemegeers I | 2009 | IEEE Communications Surveys & Tutorials2009，11，1： | 1 |
| 9 | A survey of indoor positioning systems for wireless personal networks 显示文摘 | Yanying Gu Anthony C C Lo Ignas G Niemegeers | 2009 | IEEE Communications Surveys and Tutorials2009，11，1： | 1 |
| 10 | La_(0.7)Ca_(0.3)MnO_(3-δ):Ag nanocomposite thin films with large temperature coefficient of resistance(TCR)显示文摘In this work, oxygen vacancy-regulated La_(0.7)Ca_(0.3)MnO_(3-δ):Ag (LCMO:A) nanocomposite thin films onLaAlO_(3) (001) substrates were investigated to obtain films with large temperature coefficient of resistance(TCR) values. LCMO:A nanocomposite thin films were synthesized using pulsed laser deposition, andoxygen pressures during film deposition and annealing steps were optimized. As oxygen pressuresincreased, lattice parameter increased from 70 Pa to 100 Pa, Tp increased monotonically from 168 K to282 K, and average Mn^(4+) concentration in the film increased as indicated by X-ray photoemissionspectroscopy data. Record high TCR value of ~37% K^(-1) was achieved in LCMO:A nanocomposite thin filmprepared with optimal oxygen pressures, making this film promising candidate for applications inbolometers. | Fei Jin Duojie Wu Yani Lu Zizhao Pan Meng Gu Hong Wang | 2022 | Journal of Materiomics2022，8，4： | 0 |
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