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| 1 | (-)-Epigallocatechin-3-gallate inhibits growth of gastric cancer by reducing VEGF production and angiogenesis显示文摘AIM: To investigate the effect of (-)-epigallocatechin- 3-gallate (EGCG) on growth of gastric cancer and its possible mechanism. METHODS: Heterotopic tumors were induced by subcutaneously injection of SGC-7901 cells in nude mice. Tumor growth was measured by calipers in two dimensions. Tumor angiogenesis was determined with tumor microvessel density (MVD) by immunohistology. Vascular endothelial growth factor (VEGF) protein level and activation of signal transducer and activator of transcription 3 (Stat3) were examined by Western blotting. VEGF mRNA expression was determined by RT-PCR and VEGF release in tumor culture medium by ELISA. VEGF-induced cell proliferation was studied by MTT assay, cell migration by gelatin modified Boyden chamber (Transwell) and in vitro angiogenesis by endothelial tube formation in Matrigel. RESULTS: Intraperitoneal injection of EGCG inhibited the growth of gastric cancer by 60.4%. MVD in tumor tissues treated with EGCG was markedly reduced. EGCG treatment reduced VEGF protein level in vitro and in vivo. Secretion and mRNA expression of VEGF in tumor cells were also suppressed by EGCG in a dose-dependent manner. This inhibitory effect was associated with reduced activation of Stat3, but EGCG treatment did not change the total Stat3 expression. EGCG also inhibited VEGF-induced endothelial cell proliferation, migration and tube formation. CONCLUSION: EGCG inhibits the growth of gastriccancer by reducing VEGF production and angiogenesis, and is a promising candidate for anti-angiogenic treatment of gastric cancer. | Bao-He Zhu, Wen-Hua Zhan, Zheng-Rong Li, Zhao Wang, Yu-Long He, Jun-Sheng Peng, Shi-Rong Cai, Jin-Ping Ma, Chang-Hua Zhang, Department of Gastrointestinal & Pancreatic Surgery, First Affiliated Hospital, Sun Yat-Sen University Gastric Center of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China | 2007 | World Journal of Gastroenterology2007，13，8： | 30 |
| 2 | The prognostic value of preoperative serum levels of CEA,CA19-9 and CA72-4 in patients with colorectal cancer显示文摘INTRODUCTIONCarcinoembryonic antigen ( CEA) , originally described by Gold and Freedman [1] in 1965, is now an acknowledged member of immunoglobulin superfamily[2],with a role as an intracellular adhesion molecule[3].Carbohydrate antigen 19-9(CA19-9), obtained with a monoclonal antibody produced by immunizing a monoclonal antibody produced by immunizing a mouse with a colonic cancer cell line in 1979[4],is a ligand for E-selectin that plays an important role in the addhesion of cancer cells to endothelial cells [5,6]. | Chao Xu Zheng~1 Wen Hua Zhan~1 Ji Zong Zhao~2 Dong Zheng~3 Dong Ping Wang~1 Yu Long He~1 Zhang Qing Zheng~1 ~1Department of General Surgery,~2Laboratory of Surgery,~3Department of Medicine,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,Guangzhou 510080,Guangdong Province,ChinaDr.Chao Xu Zheng now working as a surgeon and lecturer in the Department of General Surgery,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,who is a Ph.D.student,having 7 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 25 |
| 3 | Nitrogen Deposition and Its Spatial Pattern in Main Forest Ecosystems along North-South Transect of Eastern China显示文摘A continuous three-year observation(from May 2008 to April 2011)was conducted to characterize the spatial variation of dissolved inorganic nitrogen(DIN)deposition at eight main forest ecosystems along the north-south transect of eastern China(NSTEC).The results show that both throughfall DIN deposition and bulk DIN deposition increase from north to south along the NSTEC.Throughfall DIN deposition varies greatly from 2.7 kg N/(ha·yr)to 33.0 kg N/(ha·yr),with an average of 10.6 kg N/(ha·yr),and bulk DIN deposition ranges from 4.1 kg N/(ha·yr)to 25.4 kg N/(ha·yr),with an average of 9.8 kg N/(ha·yr).NH4+-N is the dominant form of DIN deposition at most sampling sites.Additionally,the spatial variation of DIN deposition is controlled mainly by precipitation.Moreover,in the northern part of the NSTEC,bulk DIN deposition is 17%higher than throughfall DIN deposition,whereas the trend is opposite in the southern part of the NSTEC.The results demonstrate that DIN deposition would likely threaten the forest ecosystems along the NSTEC,compared with the critical loads(CL)of N deposition,and DIN deposition in this region is mostly controlled by agricultural activities rather than industrial activities or transportation. | ZHAN Xiaoyun YU Guirui HE Nianpeng FANG Huajun JIA Bingrui ZHOU Mei WANG Chuankuan ZHANG Junhui ZHAO Guangdong WANG Silong LIU Yunfen YAN Junhua | 2014 | Chinese Geographical Science2014，24，2： | 10 |
| 4 | Deep Desulphurization and DeNO_X in Circulating Fluidized Bed Boiler显示文摘With the revision of emission standards, deep desulphurization and DeNO X is needed in circulating fluidized bed (CFB) boilers. The operation of the first set of 300-MW CFB boiler plus limestone/gypsum wet flue gas desulphurization (FGD) system in the world shows that deep desulphurization and DeNO X of CFB boilers has higher SO2 removal efficiency at a lower Ca/S ratio compared with traditional inner desulphurization mode. It can meet the increasingly rigid emission standards, and is suitable for more fuels. Deep desulphurization and DeNO X can also achieve a highly-efficient high-temperature CFB boiler that can not only achieve inner desulphurization and low NO X emission, but benefits low-grade, high sulfur content fuels as well. Research of deep desulphurization and DeNO X will be a developing direction for CFB boilers. | Zeng Tinghua, Zhan Zhigang Electric Power Research Institute of Guangdong Power Grid Corp. | 2011 | Electricity2011，22，5： | 1 |
| 5 | A GEOMETRIC FEATURE FOR FINITE ELEMENT SCHEMES显示文摘In this note we characterize the geometric facture of a (μ, r, k) - FES. Namely, for a C~μ triangular in-terpolation schcme with C^r vertex data, any angle of the macrotriangle must be divided into at least(μ + 1)/ (r + 1 - μ) parts. | Zhan Yinwei Beijing Normal University, China Permanent address: Dr. Zhan Yinwei Institute of Mathematics Shantou University, Shantou 515063 Guangdong, China | 1994 | Analysis in Theory and Applications1994，10，2： | 1 |
| 6 | The Fall of an Americanized Mensch:A Men’s Study of Swede Levov in Philip Roth’s American Pastoral显示文摘本文研究美国当代犹太作家菲利普·罗斯的小说《美国牧歌》中的男主人公瑞典老·列沃夫的身份政治问题。本文主要运用康奈尔的男性研究理论,探讨了在瑞典老生命的不同阶段中,他的种族身份和男性气质身份之间的相互关系。本文认为,瑞典老由一个犹太人转变为盎格鲁萨克森新教美国白人,这主要得益于他把自身的犹太男性气质改造为美国男性气质,而改造的主要途径是通过培养自身杰出的体育技能以及在男性主导的职业中做出突出表现。但是他的美国男性气质身份却时常被他所坚持的犹太绅士气质,即传统犹太社会中许多有成就的犹太男性奉行的理想男性气质所削弱。瑞典老的女儿玛丽·列沃夫策划的爆炸案及其连锁反应迫使瑞典老直面自己的种族和男性气质身份中的矛盾。最后,瑞典老选择放弃犹太绅士气质,在走向彻底美国化的同时,走向他悲剧性的堕落。 | Zhan Junfeng Guangdong University of Foreign Studies | 2008 | Comparative Literature:East & West2008，，1： | 0 |
| 7 | Auto-CSC:A Transfer Learning Based Automatic Cell Segmentation and Count Framework显示文摘Cell segmentation and counting play a very important role in the medical field.The diagnosis of many diseases relies heavily on the kind and number of cells in the blood.convolution neural network achieves encouraging results on image segmentation.However,this data-driven method requires a large number of annotations and can be a time-consuming and expensive process,prone to human error.In this paper,we present a novel frame to segment and count cells without too many manually annotated cell images.Before training.we generated the cell image labels on single-kind cell images using traditional algorithms.These images were then used to form the train set with the label.Different train sets composed of different kinds of cell images are presented to the segmentation model to update its parameters.Finally,the pretrained U-Net model is transferred to segment the mixed cell images using a small dataset of manually labeled mixed cell images.To better evaluate the efectiveness of the proposed method,we design and train a new automatic cell segmentation and count framework.The test results and analyses show that the segmentation and count performance of the framework trained by the proposed method equal the model trained by large amounts of annotated mixed cell images. | Guangdong Zhan Wentong Wang Hongyan Sun Yaxin Hou Lin Feng | 2022 | Cyborg and Bionic Systems2022，，1： | 0 |
| 8 | ON TRIANGULAR C^1 SCHEMES: A NOVEL CONSTRUCTION显示文摘In this paper we present a C^1 interpolation scheme on a triangle. The interpolant assumes given values and one order derivatives at the venices of the triangle. It is made up of partial interpolants blended with corresponding weight functions. Any partial interpolant is a piecewise cubics defined on a split of the triangle, while the weight function is just the respective baryceatric coordinate. Hence the interpolant can be regarded as a piecewise quartic. We device a simple algorithm for the evaluation of the interpolate. It’s easy to represent the interpolant With B-net method. We also depict the Franke’s function and its interpolant, the illustration of which shows good visual effect of the scheme. | Yin-wei Zhan (Key Lab of Digital Image Processing Techniques of Guangdong Province Science Center Shantou University, Shantou, 515063, China) | 2000 | Journal of Computational Mathematics2000，18，4： | 0 |
| 9 | Mapping and ablation of atrial arrhythmia after valve surgery plus mini-maze procedure显示文摘Background Recurrent atrial arrhythmia is very common in patients after mitral valve surgery plus mini-maze procedure.Investigation about the mechanism for these patients may have important implication to improve the surgery strategy.Methods Mini-maze procedure was defined as follow: Pulmonary vein encircling incision and roof line connecting the two circles lesion,left atrial isthmus lesion,and the right atrial isthmus lesion.There were 517 patients with rheumatic valvular disease and pre-operative atrial fibrillation (AF) undergoing valve surgery plus mini-maze procedure in our hospital in the last 3 years,and 93 patients(18%) had recurrent atrial arrhythmia.Twelve patients(6 males and 6 females,mean age 53.8±7.8 ys) underwent electrophysiological study using 3-D mapping system(10 pts) or conventional mapping method(2 pts).Results The first recurrent time from surgery was 4.4±2.2 months.The mean follow-up time after catheter ablation was(12.0±6.0) months.One patient with sinus bradycardia had recurrent incessant atrial tachycardia (AT),but the AT was terminated by catheter position and never could be induced any more.She underwent a repeat procedure but failed just as the course in the first time, and was treated with DDDR pacemaker plus amiodarone.Six patients had 10 kinds of stable AT,including 5 at right atrial isthmus,2 at roof line,1 related to right atrial incision, 1 at anterior wall of left atrial,and 1 related to left superior pulmonary vene.All the stable AT were eliminated and remained sinus rhythm.Three patients had ATs with variable cycle length and the 3-D mapping suggested macro-reentry AT around mitral annulus.We tried to ablate at routine mitral isthmus and also in coronary sinus,but could not reach bi-directional conduction blocking.The other 2 patients were AF with reconnection at all previous ablation sites.Ablation strategy for AF included lesion at re-conduction sites and complex fractionated atrial electrogram.The patients with AF and mitral isthmus related AT were administrated with DC cardioversion and then took amiodarone.One AT and one AF recurred. Conclusions The recurrent atrial arrhythmia after mini-maze mostly related to reconnection at previous lesion sites and catheter ablation for AT could have a high success rate.It would be very hard to block mitral isthmus after valve replacement,so transmural lesion during surgery procedure is the most important strategy for preventing postoperative atrial arrhythmia. | XUE Yu-mei,ZHAN Xian-zhang,YANG Ping-zhen,LIAO Hong-tao,FANG Xian-hong,WEI Wei,WU Shu-lin (Guangdong Institute of Cardiology,Guangdong General Hospital, Guangdong Academy of Medical Sciences,Guangzhou 510100) | 2011 | 岭南心血管病杂志2011，17，S1： | 0 |
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