|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know显示文摘Granulocyte 巨噬细胞刺激殖民地的因素(GM-CSF ) 是一个重要造血的生长因素和有免疫力的调节的人。GM-CSF 也在各种各样的传播白血球的功能的活动有深刻效果。它被许多房间类型在收到有免疫力的刺激之上包括 T 房间,巨噬细胞, endothelial 房间和成纤维细胞生产。尽管 GM-CSF 局部地被生产,它能以一种 paracrine 方式行动到在主人防卫提高他们的功能的成员传播 neutrophils,单核白血球和淋巴细胞。最近的集中的调查为它增加树枝状的房间(DC ) 成熟和功能以及巨噬细胞活动的能力作为一个有免疫力的助手在 GM-CSF 的应用程序上被集中。在经历化疗的癌症病人对待嗜中性白血球减少症临床上被使用,在在治疗期间的爱滋病病人,并且在在骨髓移植以后的病人。有趣地, GM-CSF-deficient 老鼠的造血的系统看起来正常;最重要的变化在一些特定的 T 房间回答。尽管 GM-CSF 的分子的克隆用 T 房间的 cDNA 图书馆被执行, T 房间在激活以后生产 GM-CSF,是众所周知的,在 T 房间功能上有在由 T 房间和它的效果的生产的这 cytokine 的系统的调查的缺乏。在这篇文章,我们将在 T 房间主要集中于 GM-CSF 的免疫生物学。 | Yufang Shi Catherine H Liu Arthur I Roberts Jyoti Das Guangwu Xu Guangwen Ren Yingyu Zhang Liying Zhang Zeng Rong Yuan Hung Sheng William Tan Gobardhan Das Satish Devadas | 2006 | Cell Research2006，16，2： | 22 |
| 2 | Apoptosis signaling pathways and lymphocyte homeostasis显示文摘自从术语起,现在是几乎三十年“ apoptosis ”首先被制造描述包含的房间死亡的一种唯一的形式有序,基因依赖者细胞 disintegration.It 现在很好被接受那 apoptosis 是为后生动物的动物的一个必要生活过程并且为纸巾和器官的形成和功能是批评的。在成年哺乳动物的身体, apoptosis 为免疫系统的合适的工作是特别重要的。在最近的年里,与分子、细胞的生物学的快速的前进一起,大进步在理解导致 apoptosis 的机制被取得了。有 apoptotic 房间死亡正式就职的二条主要小径,这通常被接受:通过导致导致死亡的发信号的形成的死亡受体的外来的发信号建筑群(圆盘) ,并且主要通过导致 apoptosome 的形成的线粒体的内在的发信号。分别地,磁盘 orapoptosome 的形成激活开始者和执行 theapoptosis 过程的普通受动器 caspases。在免疫系统,两条小径操作;然而,他们是否是足够的维持淋巴细胞动态平衡,不被知道。最近, includingcaspase 独立的小径和开始 granzyme 的小径被显示出在淋巴细胞存在的新 apoptotic 机制。这评论将总结我们控制各种各样的淋巴细胞人口的动态平衡的机制的理解。 | Guangwu Xu Yufang Shi | 2007 | Cell Research2007，17，9： | 13 |
| 3 | Deformed coal types and pore characteristics in Hancheng coalmines in Eastern Weibei coalfields显示文摘Based on SEM observance,the methods of low-temperature nitrogen and isothermal adsorption were used to test and analyze the coal samples of Hancheng,and pore structure characteristics of tectonic coals were discussed.The results indicate that in the same coal rank,stratification and crack are well developed in cataclastic coal,which is mostly filled by mineral substance in the geohydrologic element abundance,results in pore connectivity variation.Granulated and mylonitic coal being of these characteristics,as develop microstructures and exogenous fractures as well as large quantity of pores resulted from gas generation and strong impermeability,stimulate the recovery of seepage coal,improve coal connectivity and enhance reservoir permeability.Absorption pore(micro-pore) is dominant in coal pore for different coal body structure,the percentage of which pore aperture is from 1 to 100 nm is 71.44% to 88.15%,including large of micro-pore with the 74.56%-94.70%;with the deformation becoming more intense in the same coal rank,mesopore enlarge further,open-end pores become thin-neck-bottle-shaped pores step by step,specific surface area of micro-pore for cataclastic coal is 0.0027 m 2 /g,while mylonitic coal increases to 7.479 m 2 /g,micro-pore gradually play a dominant role in effecting pore structural parameters. | xue Guangwu Liu Hongfu Li Wei | 2012 | International Journal of Mining Science and Technology2012，22，5： | 9 |
| 4 | Effect of Train Carbody's Parameters on Vertical Bending Stiffness Performance显示文摘Finite element analysis(FEA) and modal test are main methods to give the first-order vertical bending vibration frequency of train carbody at present, but they are inefficiency and waste plenty of time. Based on Timoshenko beam theory, the bending deformation,moment of inertia and shear deformation are considered. Carbody is divided into some parts with the same length, and it's stiffness is calculated with series principle, it's cross section area, moment of inertia and shear shape coefficient is equivalent by segment length,and the fimal corrected first-order vertical bending vibration frequency analytical formula is deduced. There are 6 simple carbodies and1 real carbody as examples to test the formula, all analysis frequencies are very close to their FEA frequencies, and especially for the real carbody, the error between analysis and experiment frequency is 0.75%. Based on the analytic formula, sensitivity analysis of the real carbody's design parameters is done, and some main parameters are found. The series principle of carbody stiffness is introduced into Timoshenko beam theory to deduce a formula, which can estimate the first-order vertical bending vibration frequency of carbody quickly without traditional FEA method and provide a reference to design engineers. | YANG Guangwu WANG Changke XIANG Futeng XIAO Shoune | 2016 | Chinese Journal of Mechanical Engineering2016，29，6： | 7 |
| 5 | The geometric factor of high energy protons detector on FY-3 satellite显示文摘Geometric factor is the key parameter for inversion of particle spectrum in space particle detection. Traditional geometric factor is obtained through the method of numerical calculation with the actual structure of the detector as the input condition. The degree of accuracy for data inversion is reduced since traditional geometric factor fails to take into account the physical process of interaction between the particle and substance as well as the influence of factors such as the particle interference between different energy channels on the measurement result. Here we propose an improved geometrical factor calculation method, the concept of which is to conduct actual structural modelling of the detector in the GEANT4 program, consider the process of interaction between the particle and substance, obtain the response function of the detector to particles of different energy channels through the method of Monte Carlo simulation, calculate the influence of contaminated particle on the geometrical factor, and finally get the geometrical factors for different energy channels of the detector. The imrpoved geometrical factor obtained through the method has carried out inversion for the data of high energy protons detector on China's FY-3 satellite, the energy spectrum after which is more in line with the power law distribution recognized by space physics. The comparison with the measured result of POES satellite indicates that the FY-3 satellite data are in good accordance with the satellite data, which shows the method may effectively improve the quality of data inversion. | ZHANG ShenYi ZHANG XianGuo WANG ChuiQin SHEN GuoHong JIN Tao ZHANG BinQuan SUN YueQiang ZHU GuangWu LIANG JinBao ZHANG XiaoXin LI JiaWei HUANG Cong HAN Ying | 2014 | Science China Earth Sciences2014，57，10： | 6 |
| 6 | Effect of boron doping on waterproof and dielectric properties of polyborosiloxane coating on SiO2f/SiO2 composites显示文摘A hydrophobic coating of the silica fiber reinforced silica composites(SiO2f/SiO2) was synthesized by sol-gel method using methyltriethoxy-silane(MTES) and boric acid(B(OH)3) as raw materials. The relationship among boron doping, chemical structure of precursors and durability of hydrophobic coatings was discussed. The Si-O-B and methyl groups were successfully introduced in the gel precursors according to the FT-IR and XPS results. The resins were filled in the internal and surface holes of the SiO2f/SiO2 composites partially or completely, which is beneficial to reduce the physical adsorption of the moisture. In addition, hydroxyl groups of the SiO2f/SiO2 composites reacted with the resins and hydrophobic methyl groups were introduced, leading to the reduction of the chemical adsorption of water. Also, the boron doping was beneficial to enhancing the physical cross-linking between the coating and the SiO2f/SiO2 composites, and improved the adhesion of the coating to the substrate. The results show that the optimal hydrophobic coating with contact angle 130.33°, moisture absorption 0.33% and adhesion level 1 is obtained when the molar ratio of MTES to B(OH)3 is 10:4. The real permittivity of M10B4 is constant in the range of 2.32–2.51 and the dielectric tangent loss is constant in the range of 5.5 × 10-4–8.7 × 10-3. The hydrophobic coating has excellent dielectric properties. | Long XIA Siru LU Bo ZHONG Longnan HUANG Hua YANG Tao ZHANG Haibo HAN Pan WANG Li XIONG Guangwu WEN | 2019 | Chinese Journal of Aeronautics2019，32，8： | 5 |
| 7 | Synthesis and Ceramic Conversion of Polysiloxazane to Silicon Oxynitride显示文摘Amorphous silicon oxynitride powders have been obtained by pyrolysis of polysiloxazane in a stream of anhydrous NH3 at the temperature up to 1000℃. The polysiloxazane is fabricated from ammonolysis of chloropolysiloxane that is produced by the hydrolysis of silicon tetrachloride. The conversion of polysiloxazane to silicon oxynitride and the structural features of the final powders have also been studied by infrared spectra, elemental composition and X-ray diffraction analysis and SEM observation. | Junbao ZHANG Tingquan LEI Guangwu WEN and Yu ZHOU School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China | 2001 | Journal of Materials Science & Technology2001，17，1： | 4 |
| 8 | The study on the mechanical properties of PU/MF double shell self-healing microcapsules显示文摘The self-healing microcapsules can be buried in the coating to improve the anticorrosive ability.In this paper,self-healing microcapsules of polyurea(PU)/melamine resin(MF)double shell were prepared by in-situ polymerization and interfacial polymerization with isocyanate as the core material.Scanning electron microscope was used to observe the microcapsule morphology.The structures of microcapsules prepared with different chain extenders were characterized by Fourier transform infrared spectroscopy.The micromanipulation system was used to loading–holding,loading–unloading and loading to rupture individual microcapsules,so as to explore the mechanical properties of microcapsules.The Young’s modulus corresponding to microcapsules was calculated by mathematical model fitting.The self-healing properties of microcapsule coating were characterized by optical microscope.The experimental results showed that the microcapsule shell prepared under optimized conditions had a complete morphology and good mechanical properties.The microcapsule was in the elastic deformation stage under small deformation,and the plastic deformation stage under large deformation.The Young’s modulus range of microcapsules was 9.29–14.51 MPa,and the corresponding Young’s modulus could be prepared by adjusting the process.The surface crack of the coating containing microcapsule could heal itself after48 h in a humid environment. | Guohao Du Jianfeng Hu Jianhui Zhou Guangwu Wang Shengli Guan Hailing Liu Man Geng Chuang Lv Yaoqiang Ming Jinqing Qu | 2020 | Chinese Journal of Chemical Engineering2020，28，5： | 4 |
| 9 | Cross-calibration of high energetic particles data——A case study between FY-3B and NOAA-17显示文摘Cross-calibration of high energetic particle data is a primary requirement for the availability of multi-instrument,multi-spacecraft data.It also can provide a method to verify relative reliability of data from single satellite measurement.This paper presents a case study of energetic particles data cross-calibration between FY-3B and NOAA-17.A generally good agreement is acquired in the flux values and distribution trend of 2.5–6.9 MeV protons and 0.3–1.1 MeV electrons between FY-3B and NOAA-17 satellites.It suggests that the data observed by FY-3B is properly cross-calibrated.We can also confirm that energetic particles data observed by FY-3B satellite is available. | WANG ChunQin ZHANG XianGuo LI JiaWei HUANG Cong ZHANG XiaoXin JING Tao SHEN GuoHong ZHANG ShenYi CAO GuangWei SUN YueQiang LIANG JinBao ZHU GuangWu HAN Ying | 2013 | Science China(Technological Sciences)2013，56，11： | 4 |
| 10 | Super solar particle event around AD775 was found显示文摘A rapid radiocarbon14C increase of 120/00in AD774–775 has been reported in cedar and oak tree rings.So far,the origin of the14C increase is still uncertain and the possible origin is either supernova or solar particle event.The most possible origin of14C increase is strong solar flares and Coronal Mass Ejections(CMEs)with strong particles emission.Comprehensive approaches to identify the strong historical solar particle events based on the rapid14C/10Be increase in tree/coral rings and ice cores,long duration strong auroras and geomagnetic storms are introduced.Evidence of the super auroras in AD775 was first found in a Chinese Chronicles Jiutangshu and it supports the views that the rapid14C increase and strong auroras around AD775 are most possibly caused by strong solar storms with intense particles emission.It was identified that the solar event around AD775 would be the strongest solar particle event in the past 11400 years.The discovery is significant for the research on the history of solar activities,space weather and forecast,radiation of solar energetic particles and protection. | Dazhuang Zhou Chi Wang Binquan Zhang Shenyi Zhang Ping Zhou Yueqiang Sun Jinbao Liang Guangwu Zhu Ji Wu | 2014 | Chinese Science Bulletin2014，59，22： | 4 |
| 11 | Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric Oxide显示文摘 | Guangwen Ren Liying Zhang Xin Zhao Guangwu Xu Yingyu Zhang Arthur I. Roberts Robert Chunhua Zhao Yufang Shi | 2008 | Cell Stem Cell2008，，2： | 3 |
| 12 | Large-scale Multi-modal Pre-trained Models: A Comprehensive Survey显示文摘With the urgent demand for generalized deep models,many pre-trained big models are proposed,such as bidirectional encoder representations(BERT),vision transformer(ViT),generative pre-trained transformers(GPT),etc.Inspired by the success of these models in single domains(like computer vision and natural language processing),the multi-modal pre-trained big models have also drawn more and more attention in recent years.In this work,we give a comprehensive survey of these models and hope this paper could provide new insights and helps fresh researchers to track the most cutting-edge works.Specifically,we firstly introduce the background of multi-modal pre-training by reviewing the conventional deep learning,pre-training works in natural language process,computer vision,and speech.Then,we introduce the task definition,key challenges,and advantages of multi-modal pre-training models(MM-PTMs),and discuss the MM-PTMs with a focus on data,objectives,network architectures,and knowledge enhanced pre-training.After that,we introduce the downstream tasks used for the validation of large-scale MM-PTMs,including generative,classification,and regression tasks.We also give visualization and analysis of the model parameters and results on representative downstream tasks.Finally,we point out possible research directions for this topic that may benefit future works.In addition,we maintain a continuously updated paper list for large-scale pre-trained multi-modal big models:http://gffzz188fe103f8f1460asnofpvqpbu9up69ux.ffgz.tsg.suse.edu.cn/wangxiao5791509/MultiModal_BigModels_Survey. | Xiao Wang Guangyao Chen Guangwu Qian Pengcheng Gao Xiao-Yong Wei Yaowei Wang Yonghong Tian Wen Gao | 2023 | Machine Intelligence Research2023，20，4： | 3 |
| 13 | On an attack on RSA with small CRT-exponents显示文摘This paper concerns the RSA system with private CRT-exponents. Since Chinese remainder representation provides efficiency in computation, such system is of some practical significance. In this paper, an existing attack to small private CRT-exponents is analyzed. It is indicated that this attack makes nice use of lattice in RSA analysis, but some argument does not hold in general. Several counterexamples are constructed. Refinements and more precise statements of the attack are given. | HAN LiDong 1,2 , WANG XiaoYun 3 & XU GuangWu 3,4 1 Key Laboratory of Cryptologic Technology and Information Security, Ministry of Education, Shandong University, Jinan 250100, China 2 School of Mathematics, Shandong University, Jinan 250100, China 3 Institute for Advanced Study, Tsinghua University, Beijing 100084, China 4 Department of Electrical Engineering and Computer Science, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA | 2010 | Science China(Information Sciences)2010，53，8： | 3 |
| 14 | Cytochrome b5 reductase 2 suppresses tumor formation in nasopharyngeal carcinoma by attenuating angiogenesis显示文摘Background:Cytochrome b5 reductase 2(CYB5R2) is a potential tumor suppressor that inhibits cell proliferation and motility in nasopharyngeal carcinoma(NPC).Inactivation of CYB5R2 is associated with lymph node metastasis in NPC.This study aimed to explore the mechanisms contributing to the anti-neoplastic effects of CYB5R2.Methods:Polymerase chain reaction(PCR) assays were used to analyze the transcription of 84 genes known to be involved in representative cancer pathways in the NPC cell line HONE1.NPC cell lines CNE2 and HONE1 were transiently transfected with CYB5R2,and data was validated by real-time PCR.A chick chorioallantoic membrane(CAM)embryo model was implanted with CYB5R2-expressing CNE2 and HONE1 cells to evaluate the effect of CYB5R2 on angiogenesis.An immunohistochemical assay of the CAM model was used to analyze the protein expression of vascular endothelial growth factor(VEGF).Results:In CYB5R2-transfected NPC cells,PCR assays revealed up-regulated mRNA levels of Fas cell surface death receptor(FAS),FBJ murine osteosarcoma viral oncogene homolog(FOS),phosphoinositide-3-kinase regulatory subunit 1(PIK3R1),integrin beta 3(ITGB3),metastasis suppressor 1(MTSSl),interferon beta 1(IFNB1),and cyclin-dependent kinase inhibitor 2A(CDKN2A) and down-regulated levels of integrin beta 5(ITGB5),insulin-like growth factor 1(IGF1),TEK tyrosine kinase(TEK),transforming growth factor beta receptor 1(TGFBRl),and VEGF.The angiogenesis in the CAM model implanted with CYB5R2-transfected NPC cells was inhibited.Down-regulation of VEGF by CYB5R2 in NPC cells was confirmed by immunohistochemical staining in the CAM model.Conclusion:CYB5R2 up-regulates the expression of genes that negatively modulate angiogenesis in NPC cells and down-regulates the expression of VEGF to reduce angiogenesis,thereby suppressing tumor formation. | Huixin Ming Ying Lan Feng He Xue Xiao Xiaoying Zhou Zhe Zhang Ping Li Guangwu Huang | 2015 | Chinese Journal of Cancer2015，34，10： | 3 |
| 15 | Detection of Variants of B.1.617 Lineage from Five Returning Chinese Nationals at a Guangxi-Vietnam Border Port——Guangxi Zhuang Autonomous Region,China,April 2021显示文摘A 47-year-old male(Patient A)passenger from Vietnam whose nucleic acid results for coronavirus disease 2019(COVID-19),also known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),were positive at Pingxiang Customs on April 29,2021,and subsequently confirmed by Guangxi CDC laboratories on April 30. | Ning Kang Yinpin Liu Fuyin Bi Jing Wang Huafeng Chen Jing Wang Zhenli Liang Min Chen Guangwu Wei Aiming Li Yonghong Li Bao Lu Zhenling Jiang Yi Tan Ge Zhong Mei Lin Yu Ju | 2021 | China CDC weekly2021，3，30： | 3 |
| 16 | Recovery of the scale-ε2pattern by lattice BGK model显示文摘 | Yan Guangwu Yuan Li | 2001 | Communication in Nonlinear Science & Numerical Simulation2001，1，： | 2 |
| 17 | Electrolyte-mediated dense integration of graphene-MXene films for high volumetric capacitance flexible supercapacitors显示文摘High conductivity two-dimensional(2D)materials have been proved to be potential electrode materials for flexible supercapacitors because of its outstanding chemical and physical properties.However,electrodes based on 2D materials always suffer from limited electrolyte-accessible surface due to the restacking of the 2D sheets,hindering the full utilization of their surface area.In this regard,an electrolyte-mediated method is used to integrate dense structure reduced graphene oxide/MXene(RGM)-electrolyte composite films.In such composite films,reduced graphene oxide(RGO)and MXene sheets are controllable assembly in compact layered structure with electrolyte filled between the layers.The electrolyte layer between RGO and MXene sheets forms continuous ion transport channels in the composite films.Therefore,the RGM-electrolyte composite films can be used directly as self-supporting electrodes for supercapacitors without additional conductive agents and binders.As a result,the composite films demonstrate enhanced volumetric specific capacity,improved volumetric energy density and higher power density compared with both pure RGO electrode and porous composite electrode prepared by traditional methods.Specifically,when the mass ratio of MXene is 30%,the electrode delivers a volumetric specific capacity of 454.9 F·cm^(−3) with a high energy density of 39.4 Wh·L^(−1).More importantly,supercapacitors based on the composite films exhibit good flexibility electrochemical performance.The investigation provides a new approach to synthesize dense structure films based on 2D materials for application in high volumetric capacitance flexible supercapacitors. | Min Zhang Jun Cao Yi Wang Jia Song Tianci Jiang Yanyu Zhang Weimeng Si Xiaowei Li Bo Meng Guangwu Wen | 2021 | Nano Research2021，14，3： | 2 |
| 18 | On the l_(1)-Norm Invariant Convex k-Sparse Decomposition of Signals显示文摘Inspired by an interesting idea of Cai and Zhang,we formulate and prove the convex k-sparse decomposition of vectors that is invariant with respect to the l_(1) norm.This result fits well in discussing compressed sensing problems under the Restricted Isometry property,but we believe it also has independent interest.As an application,a simple derivation of the RIP recovery conditionδk+θk,k<1 is presented. | Guangwu Xu Zhiqiang Xu | 2013 | Journal of the Operations Research Society of China2013，1，4： | 2 |
| 19 | Genetic diversity analysis of Sinojackia microcarpa, a rare tree species endemic in China, based on simple sequence repeat markers显示文摘Although most Sinojackia species are endangered, they contribute greatly to the biodiversity of local ecosystems. Sinojackia microcarpa, an endangered species, is distributed only in three provinces of eastern China. Determining the genetic diversity of S. microcarpa provides key information for germplasm evaluation and species conservation. Here we used simple sequence repeat (SSR) markers to investigate the genetic diversity of eight natural populations of S. microcarpa. Leaf samples were collected from 144 individuals in 8 wild populations. The 156 bands were generated from 14 pairs of informative SSR primers, with an average percentage of polymorphic bands of 45.67%. The average values of Nei’s genetic diversity (He) and Shannon’s diversity index (I) were 0.1007 and 0.1658, respectively. The total genetic variation of S. microcarpa existed mainly within the eight populations, rather than among populations, and reached 86.41%. A cluster analysis showed that the eight wild populations of S. microcarpa could be classified into four groups, at a threshold of 4.0, based on an analysis of the SSR genotypes. Furthermore, there was a significant association between the phylogenetic relationships and the geographic locations of the S. microcarpa populations. In particular, populations from Fuyang, Jiande, and Lin’an in Zhejiang Province had close phylogenetic relationships and geographic distances. In addition, these three populations had the highest genetic diversity and the most individuals, suggesting that these three locations may be the S.microcarpa distribution center. This study serves as a model for studying the genetic diversity of endangered plant species. | Tailin Zhong Guangwu Zhao Yongfeng Lou Xinchun Lin Xiaomin Guo | 2019 | Journal of Forestry Research2019，30，3： | 2 |
| 20 | The space environment monitor aboard FY-2 satellite显示文摘The space environment monitor (SEM) aboard FY-2 satellite consists of the high energy particle detector (HEPD) and the solar X-ray flux detector (SXFD). The SEM can provide real-time monitoring of flare and solar proton event for its operation at geostationary orbit and is also the first Chinese space system for monitoring and alerting solar proton event. During the 23rd solar maximum cycle, almost all the solar proton events that took place in this period are monitored and some of them are predicted successfully by analyzing the characteristics of X-ray flare monitored by the SEM. Some basic variation characteristics of particle at geostationary orbit are found such as day-night periodic variation of particle flux, the electron flux with energy >1.4 MeV in the scope from 10 to 200/cm2.s-sr and the proton flux with energy >1.1 MeV in the scope from 600 to 8000/cm2-s.sr during the time with no magnetic storm and solar eruption. | ZHU Guangwu LI Baoquan WANG Shijin LIN Hua'an LIANG Jinbao SUN Yueqiang WU Weiqi | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，1： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员