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| 1 | Long-term outcomes of hepatocellular carcinoma that underwent chemoembolization for bridging or downstaging显示文摘BACKGROUND Prospective study of 200 patients with hepatocellular carcinoma(HCC)that underwent liver transplant(LT)after drug-eluting beads transarterial chemoembolization(DEB-TACE)for downstaging versus bridging.Overall survival and tumor recurrence rates were calculated,eligibility for LT,time on the waiting list and radiological response were compared.After TACE,only patients within Milan Criteria(MC)were transplanted.More patients underwent LT in bridging group.Five-year post-transplant overall survival,recurrence-free survival has no difference between the groups.Complete response was observed more frequently in bridging group.Patients in DS group can achieve posttransplant survival and HCC recurrence-free probability,at five years,just like patients within MC in patients undergoing DEB-TACE.AIM To determine long-term outcomes of patients with HCC that underwent LT after DEB-TACE for downstaging vs bridging.METHODS Prospective cohort study of 200 patients included from April 2011 through June 2014.Bridging group included patients within MC.Downstaging group(out of MC)was divided in 5 subgroups(G1 to G5).Total tumor diameter was≤8 cm for G1,2,3,4(n=42)and was>8 cm for G5(n=22).Downstaging(n=64)and bridging(n=136)populations were not significantly different.Overall survival and tumor recurrence rates were calculated by the Kaplan-Meier method.Additionally,eligibility for LT,time on the waiting list until LT and radiological response were compared.RESULTS After TACE,only patients within MC were transplanted.More patients underwent LT in bridging group 65.9%(P=0.001).Downstaging population presented:higher number of nodules 2.81(P=0.001);larger total tumor diameter 8.09(P=0.001);multifocal HCC 78%(P=0.001);more post-transplantation recurrence 25%(P=0.02).Patients with maximal tumor diameter up to 7.05 cm were more likely to receive LT(P=0.005).Median time on the waiting list was significantly longer in downstaging group 10.6 mo(P=0.028).Five-year posttransplant overall survival was 73.5%in downstaging and 72.3%bridging groups(P=0.31),and recurrence-free survival was 62.1%in downstaging and 74.8%bridging groups(P=0.93).Radiological response:complete response was observed more frequently in bridging group(P=0.004).CONCLUSION Tumors initially exceeding the MC down-staged after DEB-TACE,can achieve post-transplant survival and HCC recurrence-free probability,at five years,just like patients within MC in patients undergoing DEB-TACE. | Breno Boueri Affonso Francisco Leonardo Galastri Joaquim Mauricio da Motta Leal Filho Felipe Nasser Priscila Mina Falsarella Rafael Noronha Cavalcante Marcio Dias de Almeida Guilherme Eduardo Goncalves Felga Leonardo Guedes Moreira Valle Nelson Wolosker | 2019 | World Journal of Gastroenterology2019，25，37： | 21 |
| 2 | 四川新津宝墩遗址的植硅体分析显示文摘农业是文明产生的深厚基础。成都平原是长江上游地区文明起源的中心,探讨其史前农业的经济形态一直是学术界关心的热点问题。本文拟对新津宝墩遗址的文化层剖面及两处灰坑的样品进行植硅体分析,并结合浮选结果,以期探讨宝墩遗址农业经济状况。研究结果表明,宝墩文化层中,存在大量具有驯化特征的产于水稻叶秆的扇型和横排双裂片型(哑铃型)植硅体以及产于水稻稃壳的双峰型植硅体,同时还存在少量黍稃壳植硅体碎片。水稻扇型植硅体多呈典型的驯化形态,总体尺寸较大,其测量数据符合粳稻植硅体特征。这表明宝墩先民的经济结构是以稻作农业为主,兼有粟作农业。 | 陈涛 江章华 何锟宇 杨洋 Jade d’Alpoim GUEDES 蒋洪恩 胡耀武 王昌燧 吴妍 | 2015 | 人类学学报2015，34，2： | 11 |
| 3 | Computation of Ship Hydrodynamic Interaction Forces in Restricted Waters using Potential Theory显示文摘计算机代码基于双身体潜力流动模型和经典来源,面板方法被开发了包括海床学习和稳固的边界的在轮船和另外的对象之间的水动力学相互作用的各种各样的问题。建议实现的一个怪癖是为模仿大延期的稳定的边界的所谓的动人补丁的方法的应用程序。方法基于在任何时刻,就谎言关门到交往的轮船的边界(动人的补丁) 的部分为近地的相互作用是重要的一个假设。为扁平的底部的一个特定的盒子,比较计算被执行基于在可接受的精确性和合理效率之间的交易决定补丁并且组成的面板的最佳的尺寸。方法被使用在越过一条挖出的隧道倾斜地移动的轮船壳上估计摇摆力量。当坦克数据是可得到的时,方法为 ship-to-ship 相互作用的一个盒子被验证。这研究也包含对为与精炼的各种各样的度创造轮船壳的一致 discretizations 必要的一个最新发达的花键近似算法的描述。 | Xueqian Zhou Serge Sutulo C. Guedes Soares | 2012 | Journal of Marine Science and Application2012，11，3： | 8 |
| 4 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 5 | 在面内压力作用下点腐蚀低碳钢板的非线性有限元分析(英文)显示文摘无论是军船还是民船,船体及主要结构构件表面的点腐蚀对于船舶结构强度和安全性都有较大的破坏作用。文中采用系列非线性有限元计算研究了点腐蚀对于低碳钢板极限抗压强度的影响,模型中计及板初始缺陷的影响,详细讨论了板和点腐蚀物理、几何特性的变化对于板极限承载能力的作用。研究发现在众多影响因素中(例如点腐蚀的直径和深度、板的柔度系数等),点腐蚀密集度指标DOP对于板的极限承载能力有主要和直接的影响。此外,在腐蚀环境恶劣的情况下,厚低碳钢板的使用不一定如预期的那样能延长其使用期限。 | 江晓俐 C. GUEDES SOARES | 2009 | 船舶力学2009，13，3： | 7 |
| 6 | Selecting suitable solid organ transplant donors: Reducing the risk of donor-transmitted infections显示文摘Selection of the appropriate donor is essential to a successful allograft recipient outcome for solid organ transplantation. Multiple infectious diseases have been transmitted from the donor to the recipient via transplantation. Donor-transmitted infections cause increased morbidity and mortality to the recipient. In recent years, a series of high-profile transmissions of infections have occurred in organ recipients prompt-ing increased attention on the process of improving the selection of an appropriate donor that balances the shortage of needed allografts with an approach that mitigates the risk of donor-transmitted infection to the recipient. Important advances focused on improving donor screening diagnostics, using previously excluded high-risk donors, and individualizing the selection of allografts to recipients based on their prior infection history are serving to increase the donor pool and improve outcomes after transplant. This article serves to review the relevant literature surrounding this topic and to provide a suggested approach to the selection of an appropriate solid organ transplant donor. | Christopher S Kovacs Jr Christine E Koval David van Duin Amanda Guedes de Morais Blanca E Gonzalez Robin K Avery Steven D Mawhorter Kyle D Brizendine Eric D Cober Cyndee Miranda Rabin K Shrestha Lucileia Teixeira Sherif B Mossad | 2014 | World Journal of Transplantation2014，4，2： | 7 |
| 7 | Fault-tree Models of Accident Scenarios of RoPax Vessels显示文摘为货物和旅客(RoPax ) 的 Ro-Ro 容器是证明了在地中海区域流行并且在北欧洲正在变得更普遍的一个相对新的概念。由于它的设计特征和旅客的数量,尽管不到一架常规旅客班机,有 RoPax 容器的事故远让两个都到达后果为节俭并且为人的生活。这篇论文的目的是识别与 RoPax 容器的伤亡有关的危险。选择的终端伤亡事件为这类容器与事故和事件统计有关。这篇论文集中于能导致一个事故和表演要求的基本事件的鉴定。危险鉴定作为一个正式安全评价(FSA ) 的第一步被执行,在相关事件之间的关系的建模用差错树分析(FTA ) 被做。这研究的结论是到 FSA 而非为决策(步 5 FSA ) 的以后的步的建议。这些建议将集中于差错树在整个切割集合在分析期间识别的可能的设计缺点。另外,人的因素有的角色通过他们的影响为起始的概率的增加导致几乎 90% 事故出现的变化的扎根和碰撞是更高的,这被显示出的敏感分析被分析。关键词轮船事故 - 差错树 - 人的因素 Pedro 蚂蚁 ? o 从在 1998 设计葡萄牙首都(Instituto 优异 T 茅 c nico ) 的技术大学的教师毕业了。他从租地继承税瓦特大学收到了他的 M.Sc 度,在 2000 的苏格兰。一会儿他在葡萄牙首都的技术大学是在海洋的技术和工程的单位的一个研究助手。他的研究兴趣在他们的出现包括海上的事故和人的因素的影响。卡洛斯·盖德斯·索雷斯在 1976 从麻省理工学院收到了他的 M.Sc 学位,来自在 1984 的 Trondheim 和来自在 1991 的葡萄牙首都的技术大学的科学的一位医生的大学的一个博士学位。一会儿他是在葡萄牙首都(Instituto 优异 T 茅 c nico ) 的技术大学的设计学院的一个教授。他的研究兴趣为风险和可靠性分析包括概率的建模。 | Pedro Antao C. Guedes Soares | 2006 | International Journal of Automation and computing2006，3，2： | 4 |
| 8 | System Reliability Analysis of an Offshore Jacket Platform显示文摘This study investigates strategies for solving the system reliability of large three-dimensional jacket structures.These structural systems normally fail as a result of a series of different components failures.The failure characteristics are investigated under various environmental conditions and direction combinations.Theβ-unzipping technique is adopted to determine critical failure components,and the entire system is simplified as a series-parallel system to approximately evaluate the structural system reliability.However,this approach needs excessive computational effort for searching failure components and failure paths.Based on a trained artificial neural network(ANN),which can be used to approximate the implicit limit-state function of a complicated structure,a new alternative procedure is proposed to improve the efficiency of the system reliability analysis method.The failure probability is calculated through Monte Carlo simulation(MCS)with Latin hypercube sampling(LHS).The features and applicability of the above procedure are discussed and compared using an example jacket platform located in Chengdao Oilfield,Bohai Sea,China.This study provides a reference for the evaluation of the system reliability of jacket structures. | ZHAO Yuliang DONG Sheng JIANG Fengyuan GUEDES SOARES Carlos | 2020 | Journal of Ocean University of China2020，19，1： | 3 |
| 9 | Differences in viral kinetics between genotypes 1 and 3 of hepatitis C virus and between cirrhotic and non-cirrhotic patients during antiviral therapy显示文摘AIM: To evaluate the impact of hepatitis C virus (HCV) infection with genotype 1 or 3 and the presence or absence of liver cirrhosis (LC) in the early viral kinetics response to treatment. METHODS: Naive patients (n = 46) treated with interferon-α (IFN-α) and ribavirin and followed up with frequent early HCV-RNA determinations were analysed. Patients were infected with genotype 1 (n = 28, 7 with LC) or 3 (n = 18, 5 with LC). RESULTS: The fi rst phase decline was larger in geno- type 3 patients than in genotype 1 patients (1.72 vs 0.95 log IU/mL, P < 0.001). The second phase slope decline was also larger in genotype 3 patients than in genotype 1 patients (0.87 vs 0.15 log/wk, P < 0.001). Differences were found in both cirrhotic and non-cirrhotic patients. Genotype 1 cirrhotic patients had a slower 2nd phase slope than non-cirrhotic patients (0.06 vs 0.18 log/wk, P < 0.02). None of genotype 1 cirrhotic patients had a 1st phase decline larger than 1 log (non-cirrhotic patients: 55%, P < 0.02). A similar trend toward a slower 2nd phase slope was observed in genotype 3 cirrhotic pa- tients but the 1st phase slope decline was not different. Sustained viral response was higher in genotype 3 pa- tients than in genotype 1 patients (72% vs 14%, P < 0.001) and in genotype 1 non-cirrhotic patients than in genotype 1 cirrhotic patients (19% vs 0%). A secondphase decline slower than 0.3 log/wk was predictive of non-response in all groups. CONCLUSION: Genotype 3 has faster early viral decline than genotype 1. Cirrhosis correlates with a slower 2nd phase decline and possibly with a lower 1st phase slope decline in genotype 1 patients. | José Eymard Medeiros-Filho Isabel Maria Vicente Guedes de Carvalho Mello Joo Renato Rebello Pinho Avidan U Neumann Fernanda de Mello Malta Luiz Caetano da Silva Flair José Carrilho | 2006 | World Journal of Gastroenterology2006，12，45： | 3 |
| 10 | Glycine max (L.) Merr., Vigna radiata L. and Medicago sativa L. sprouts: A natural source of bioactive compounds显示文摘 | Luís R. Silva Maria J. Pereira Jessica Azevedo Rui F. Gon?alves Patrícia Valent?o Paula Guedes de Pinho Paula B. Andrade | 2013 | Food Research International2013，，1： | 2 |
| 11 | Imaging response predictors following drug eluting beads chemoembolization in the neoadjuvant liver transplant treatment of hepatocellular carcinoma显示文摘BACKGROUND Drug-eluting bead transarterial chemoembolization(DEB-TACE)is an endovascular treatment to release chemotherapeutic agents within a target lesion,minimizing systemic exposure and adverse effects to chemotherapeutics.Therefore,identifying which patient characteristics may predict imaging response to DEB-TACE can improve treatment results while selecting the best candidates.Predictors of the response after DEB-TACE still have not been fully elucidated.This is the first prospective study performed with standardized DEBTACE technique that aim to identify predictors of radiological response,assessing patients clinical and laboratory characteristics,diagnostic imaging and intraprocedure data of the hepatocellular carcinoma treated in the neoadjuvant context for liver transplantation.AIM To identify pre-and intraoperative clinical and imaging predictors of the radiological response of drug-eluting bead transarterial chemoembolization(DEB-TACE)for the neoadjuvant treatment of hepatocellular carcinoma(HCC).METHODS This is prospective,cohort study,performed in a single transplant center,from 2011 to 2014.Consecutive patients with HCC considered for liver transplant who underwent DEB-TACE in the first session for downstaging or bridging purposes were recruited.Pre and post-chemoembolization imaging studies were performed by computed tomography or magnetic resonance.The radiological response of each individual HCC was evaluated by objective response using mRECIST and the percentage of necrosis.RESULTS Two hundred patients with 380 HCCs were examined.Analysis of the objective response(nodule-based analysis)demonstrated that HCC with pseudocapsules had a 2.01 times greater chance of being responders than those without pseudocapsules(P=0.01),and the addition of every 1mg of chemoembolic agent increased the chance of therapeutic response in 4%(P<0.001).Analysis of the percentage of necrosis through multiple linear regression revealed that the addition of each 1mg of the chemoembolic agent caused an average increase of 0.65%(P<0.001)in necrosis in the treated lesion,whereas the hepatocellular carcinoma with pseudocapsules presented 18.27%(P<0.001)increased necrosis compared to those without pseudocapsules.CONCLUSION The presence of a pseudocapsule and the addition of the amount of chemoembolic agent increases the chance of an objective response in hepatocellular carcinoma and increases the percentage of tumor necrosis following drug-eluting bead chemoembolization in the neoadjuvant treatment,prior to liver transplantation. | Francisco Leonardo Galastri Felipe Nasser Breno Boueri Affonso Leonardo Guedes Moreira Valle Bruno Calazans Odísio Joaquim Mauricio Motta-Leal Filho Paolo Rogério Salvalaggio Rodrigo Gobbo Garcia Márcio Dias de Almeida Ronaldo Hueb Baroni Nelson Wolosker | 2020 | World Journal of Hepatology2020，12，1： | 2 |
| 12 | Reliability of maintained,corrosion protected plates subjected to non-liner corrosion and compressive loads显示文摘 | Guedes Soares C Garbatov Y | 1999 | Marine Structures1999，12，6： | 2 |
| 13 | Optimization of Fenton's oxidation of chemical laboratory wastewaters using the response surface methodology 显示文摘 | Benatti C T Tavares C R G Guedes T A | 2006 | Journal of Environmental Management2006，80，： | 1 |
| 14 | Reliability of maintained ship hulls subjected to corrosion 显示文摘 | Guedes Soares C Garbatov Y | 1996 | Journalof Ship Research1996，40，3： | 1 |
| 15 | Effects of a Saccharomyces cerevisiae yeast on ruminal fermentation and fibre degradation of maize silages in cows显示文摘 | Guedes C M Gon alves D Rodrigues M A M | 2008 | Anim Feed Sci Tech2008，145，1： | 1 |
| 16 | Inhibitory action of aqueous coffee ground extracts on the corrosion of carbon steel in HCl solution显示文摘 | Vanessa Vasconcelos Torres Roberto Salgado Amado Camila Faia de Sá Tatiana Lopez Fernandez Carlos Alberto da Silva Riehl Alexandre Guedes Torres Eliane D’Elia | 2011 | Corrosion Science2011，，7： | 1 |
| 17 | Validation of an immunoperoxidase monolayer assay for total anti-Vac- cinia virus antibody titration 显示文摘 | Gerber P F Matos A C Guedes M I | 2012 | J Vet Diagn Invest2012，24，2： | 1 |
| 18 | SRY gene increases the risk of developing gonadoblastoma and/or nontumoral gonadal lesions in Turner syndrome显示文摘 | Bianco 13 Lipay M Guedes A | 2009 | lnt J Gynecol Pathol2009，28，： | 1 |
| 19 | Steepness and asymmetry of the largest waves in stormy sea states 显示文摘 | Guedes S C Cherneva Z Antao E M | 2004 | Ocean Engineering2004，，31： | 1 |
| 20 | Preprocessing and postprocessing for materials based on the homogenization method with adaptive finite element method显示文摘 | GUEDES J M KIKUCHI N | 1990 | Computer Methods in Applied Mechanics and Engineering1990，83，： | 1 |
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