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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Time do main modeling of the transient asymmetric flooding of Ro-Ro ship显示文摘 | T A Santos L E Winkle C Guedes Soares | 2002 | Ocean Engineering2002，，： | 1 |
| 3 | The coverage problem in video-basedwireless sensor networks:A survey显示文摘 | Costa D G Guedes L A | 2010 | Sensors2010，10，9： | 1 |
| 4 | Reliability and availability evaluation of wireless sensor networks for industrial applications 显示文摘 | Silva I Guedes L A Portugal P | 2012 | Sensors2012，12，1： | 1 |
| 5 | ELISA for early diagnosis of histoplasmosis显示文摘 | Guimaraes A J Pizzini C V Guedes H L | 2004 | J Med Microbiol2004，53，6： | 1 |
| 6 | A Survey on Multimedia-based Cross-layer Optimization in Visual Sensor Net-works显示文摘 | Costa D G Guedes L A | 2011 | Sensors2011，11，5： | 1 |
| 7 | Fenton oxidation of cork cooking wastewater-overall kinetic analysis显示文摘 | GUEDES A M F M MADEIRA L M P BOAVENTURA R A R | 2003 | Water Res2003，37，13： | 1 |
| 8 | Reliability and availa- bility evaluation of wireless sensor networks for industrial appli- cations 显示文摘 | Silva I Guedes L A Portugal P | 2012 | Sensors2012，12，1： | 1 |
| 9 | Fenton Oxidation of Cork Cooking Wastewateroverall Kinetic Analysis 显示文摘 | Guedes A M F M Madeira L M P Boaventura R A R | 2003 | Water Research2003，，37： | 1 |
| 10 | Saddle-node Index as Bounding Value for Hopf Bifurcation Detection显示文摘 | de Souza A C Z Lima Lops B I Guedes R B L | 2005 | IEE Pro-Gener Transm and Distrib2005，152，5： | 1 |
| 11 | Fenton oxidation of cork cooking wastewater-overall kinetic analysis 显示文摘 | Guedes A M F M Madeira L M P Boaventura R A R | 2003 | Water Research2003，37，13： | 1 |
| 12 | Life cycle varia- tions of mesoscale convective systems over the Americas显示文摘 | Machado W B Rossow R L Guedes A W W | 1998 | Mon Wea Rev1998，126，： | 1 |
| 13 | Reliability and Availability Evaluation of Wireless Sensor Networks for Industrial Applications显示文摘 | Silva I Guedes L A Portugal P | 2012 | Sensors2012，12，1： | 1 |
| 14 | Phospine resistance in Brazilian populations of Sitophilus zeamais Motschulsky ( Coleoptera: Curculionidae ) 显示文摘 | Pimentel M A G Faroni L R D'A Guedes R N C | 2009 | Journal of Stored Products Research2009，45，： | 1 |
| 15 | Acute effects of CPAP vs BiPAP low or high intensity in patients with severe congestive heart failure显示文摘 | Nogueira A D N C Guedes I T T Marinho L S | 2014 | Eur Res J2014，44，58： | 1 |
| 16 | Life cycle variation of mesoscale convective systems over the American显示文摘 | MACHADO L A ROSSOW T W B GUEDES R L | 1998 | Mon Wea Rev1998，126，： | 1 |
| 17 | Fenton oxidation of cork cooking wastewater-overall kinetic analysis 显示文摘 | Guedes A M F M Madeira L M P Boaventura R A R | 2003 | Water Res2003，37，： | 1 |
| 18 | Changes in lipid class and fatty acid composition of cultures of Pavlova lutheri, in response to light intensity 显示文摘 | Guedes A C Meireles L A Amaro H M | 2010 | Journal of the American Oil Chemists'' Society2010，87，7： | 1 |
| 19 | Multianalytical approaches to the characterisation of minerals associated with coals and the diagnosis of their potential risk by using combined instrumental microspectroscopic techniques and thermodynamic speciation显示文摘 | Silva L F O Sampaio C H Guedes A | 2012 | Fuel2012，，94： | 1 |
| 20 | A Multiobjective Heuristic for Reconfiguration of the Electrical Radial Network 显示文摘 | GUEDES L S M LISBOA A C VIEIRA D A G | 2013 | IEEE Transactions on Power Delivery2013，28，1： | 1 |
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