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| 1 | Recent advances in cytokines:Therapeutic implications for inflammatory bowel diseases显示文摘Inflammatory bowel diseases(IBDs) are complex and chronic disabling conditions resulting from a dysregulated dialogue between intestinal microbiota and components of both the innate and adaptive immune systems.Cytokines are essential mediators between activated immune and non-immune cells,including epithelial and mesenchymal cells.They are immunomodulatory peptides released by numerous cells and these have significant effects on immune function leading to the differentiation and survival of T cells.The physiology of IBD is becoming a very attractive field of research for development of new therapeutic agents.These include cytokines involved in intestinal immune inflammation.This review will focus on mechanisms of action of cytokines involved in IBD and new therapeutic opportunities for these diseases. | Guillaume Bouguen Jean-Baptiste Chevaux Laurent Peyrin-Biroulet | 2011 | World Journal of Gastroenterology2011，17，5： | 27 |
| 2 | Albumin liver dialysis as pregnancy-saving procedure in cholestatic liver disease and intractable pruritus显示文摘Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a rare cholestatic liver disease. Such liver disease can get worse by female hormone disorder. Albumin dialysis or Molecular Adsorbent Recirculating System (MARS) has been reported to reverse severe cholestasis-linked pruritus. Here, we report the first use of MARS during a spontaneous pregnancy and its successful outcome in a patient with PFIC3 and intractable pruritus. Albumin dialysis could be considered as a pregnancy-saving procedure in pregnant women with severe cholestasis and refractory pruritus. | Maud Lemoine Aurélie Revaux Claire Francoz Guillaume Ducarme Sabine Brechignac Emmanuel Jacquemin Michèle Uzan Nathalie Ganne-Carrié | 2008 | World Journal of Gastroenterology2008，14，42： | 14 |
| 3 | Machine-learning-assisted discovery of polymers with high thermal conductivity using a molecular design algorithm显示文摘The use of machine learning in computational molecular design has great potential to accelerate the discovery of innovative materials.However,its practical benefits still remain unproven in real-world applications,particularly in polymer science.We demonstrate the successful discovery of new polymers with high thermal conductivity,inspired by machine-learning-assisted polymer chemistry.This discovery was made by the interplay between machine intelligence trained on a substantially limited amount of polymeric properties data,expertise from laboratory synthesis and advanced technologies for thermophysical property measurements.Using a molecular design algorithm trained to recognize quantitative structure—property relationships with respect to thermal conductivity and other targeted polymeric properties,we identified thousands of promising hypothetical polymers.From these candidates,three were selected for monomer synthesis and polymerization because of their synthetic accessibility and their potential for ease of processing in further applications.The synthesized polymers reached thermal conductivities of 0.18–0.41 W/mK,which are comparable to those of state-of-the-art polymers in non-composite thermo-plastics. | Stephen Wu Yukiko Kondo Masa-aki Kakimoto Bin Yang Hironao Yamada Isao Kuwajima Guillaume Lambard Kenta Hongo Yibin Xu Junichiro Shiomi Christoph Schick Junko Morikawa Ryo Yoshida | 2019 | npj Computational Materials2019，，1： | 14 |
| 4 | Management of early gastrointestinal neuroendocrine neoplasms显示文摘Neuroendocrine neoplasms (NENs) of the stomach, duo- denum, appendix or rectum that are small (≤ 1 cm) and well differentiated can be considered 'early' tumors, since they generally have a (very) good prognosis. In the new WHO classification of 2010, these neoplasms are called neuroendocrine tumors/ carcinoids (NETs), grade (G) 1 or 2, and distinguished from poorly differentiated neuroendocrine carcinomas (NECs), G3. NETs are increasing, with a rise in the age-adjusted incidence in the U.S.A. by about 700 % in the last 35 years. Improved early detection seems to be the main reason for these epidemiological changes. Both the better generalavailability of endoscopy, and imaging techniques, have led to a shift in the discovery of smaller-sized (≤ 10-20 mm) intestinal NETs/carcinoids and earlier tumor stages at diagnosis. Endoscopic screening is therefore effective in the early diagnosis, not only of colorectal adenocarcinomas, but also of NETs/carcinoids. Endoscopic removal, followed up with endoscopic surveillance is the treatment of choice in NETs/carcinoids of the stomach, duodenum and rectum that are ≤ 10 mm in size, have a low proliferative activity (G1), do not infiltrate the muscular layer and show no angioinvasion. In all the other intestinal NENs, optimal treatment generally needs surgery and/or medical therapy depending on type, biology and stage of the tumor, as well as the individual situation of the patient. | Hans Scherübl Robert T Jensen Guillaume Cadiot Ulrich Stlzel Günter Klppel | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，7： | 13 |
| 5 | Amino Acid Export in Plants: A Missing Link in Nitrogen Cycling显示文摘到他们被要求的身体的部分的从来源机关的营养素的出口(例如水池机关) 是一个基本生物过程。氨基酸的出口,在植物的最丰富的氮种类之一长途的运输纸巾(即木部和韧皮部) ,是为在植物的氮的合适的分发的一个必要过程。生理的研究在植物房间膜检测了多重氨基酸出口系统的存在。然而,令人惊讶地,很少对氨基酸出口商的分子的身份被知道,部分由于技术困难妨碍出口商蛋白质的鉴定。在这短评论,我们将在植物关于氨基酸出口系统总结我们的当前的知识。几研究描述了能够的植物氨基酸 transporters 双向, facilitative 运输,更早生理的研究识别的活动暗示。而且,在可得到的氨基酸 transporter 序列的数字的最近的扩大表明了在从有很多 uncharacterized 的另外的有机体的氨基酸出口商之间的进化关系种蛋白质,其中一些可能也作为氨基酸出口商工作。另外,可以调整氨基酸的出口的基因被发现了。这些通常认为的 transporter 和管理者蛋白质的研究可以在理解帮助逃犯在植物的氨基酸出口的分子的机制。 | Sakiko Okumoto Guillaume Pilot | 2011 | Molecular Plant2011，4，3： | 13 |
| 6 | 中国碳排放态势与绿色经济展望显示文摘中国从2007年开始已成为世界温室气体排放第一大国,减排的国际压力越来越大。本文采用国际能源署公布的国别时间系列数据(1990-2007),系统分析了中国碳排放的现状、特点及历史变化;从经济发展、能源消费、经济全球化、社会转型等多方面解析了中国未来碳排放总量将会继续增长的基本态势。同时,从绿色技术、可再生能源的发展、生态城市建设等方面论述了中国未来必然成为世界绿色经济大国的可能性。最后,为了实现中国从排放大国走向绿色经济大国,提出了理论上需要深入研究的几个问题,即:碳排放速度与不同空间尺度问题,经济转型与反转型,碳排放的责任与国界。 | 刘慧 樊杰 Guillaume Giroir | 2011 | 中国人口·资源与环境2011，21，S1： | 10 |
| 7 | Technical and conceptual considerations forusing animated stimuli in studies of animalbehavior显示文摘Rapid technical advances in the field of computeropened new avenues in animal behavior research.animation (CA) and virtual reality (VR) haveAnimated stimuli are powerful tools as theyoffer standardization, repeatability, and complete control over the stimulus presented, thereby"reducing" and "replacing" the animals used, and "refining" the experimental design in line withthe 3Rs. However, appropriate use of these technologies raises conceptual and technical questions.In this review, we offer guidelines for common technical and conceptual considerations related tothe use of animated stimuli in animal behavior research. Following the steps required to create ananimated stimulus, we discuss (I) the creation, (11) the presentation, and (111) the validation of CAsand VRs. Although our review is geared toward computer-graphically designed stimuli, consider-ations on presentation and validation also apply to video playbacks. CA and VR allow both new be-havioral questions to be addressed and existing questions to be addressed in new ways, thus weexpect a rich future for these methods in both ultimate and proximate studies of animal behavior. | Laura CHOUINARD-THULY Stefanie GIERSZEWSKI Gil G. ROSENTHAL Simon M. READER Guillaume RIEUCAU Kevin L. Woo Robert GERLAI Cynthia TEDORE Spencer J. INGLEY John R. STOWERS Joachim G.FROMMENI Francine L. DOLINS Klaudia WITTE | 2017 | Current Zoology2017，63，1： | 10 |
| 8 | H2O2-Activated Up-Regulation of Glutathione in Arabidopsis Involves Induction of Genes Encoding Enzymes Involved in Cysteine Synthesis in the Chloroplast显示文摘谷胱甘肽在对 H2O2 的反应是在细胞的氧化还原作用动态平衡并且,因此的一个关键播放器,但是调整激活氧化的谷胱甘肽合成的因素仍然是不清楚的。我们在有条件的 Arabidopsis 过氧化氢酶缺乏的异种(cat2 ) 调查了导致 H2O2 的谷胱甘肽合成。植物为 5 在提高的 CO2 从种子被种 ? 星期,然后处于短天或长天的条件转了到空气。处于任何条件在提高的 CO2 或野类型的植物比作 cat2,到在两个光周期的空气的 cat2 的转移在小时以内引起了叶谷胱甘肽水池的可测量的氧化。氧化在随后的天继续并且被谷胱甘肽的累积伴随。这效果在在短天内转移到空气的 cat2 是更强壮的,并且没被连接到可引出的活动或涉及谷胱甘肽合成的承诺的小径的抄本编码酶的可估计的增加。相反,它被丝氨酸, O-acetylserine,和半胱氨酸的增加伴随。在代谢物的这些变化被编码腺苷 phosphosulfate reductase (4 月) 的基因的正式就职伴随,特别地, APR3,以及编码 chloroplastic 的特定的丝氨酸 acetyltransferase 基因(SAT2.1 ) 坐了。标记这些基因的正式就职仅仅在处于短天的条件转移到空气的 cat2 被观察,在半胱氨酸和谷胱甘肽累积是很戏剧的的地方。不同于另外的容纳的基因,它在 cat2 显示出可以忽略的正式就职,相对许多 4 月和 SAT2.1 抄本密切为 H2O2 发信号与标记抄本被相关。一起,数据在谷胱甘肽合成的导致氧化剂的起来规定加重半胱氨酸合成的重要性并且建议叶绿体在这些情形下面做重要贡献到半胱氨酸生产。 | Guillaume Queval Dorothée Thominet Hélène Vanacker Myroslawa Miginiac-Maslow Bertrand Gakière Graham Noctor | 2009 | Molecular Plant2009，2，2： | 10 |
| 9 | Neuroendocrine tumors of the small bowels are on the rise:Early aspects and management显示文摘Neuroendocrine tumors of the small bowel are on the rise. In the US they have increased by 300%-500% in the last 35 years. At the same time their prognosis is much improved. Today,most neuroendocrine tumors (NETs) of the duodenum are detected 'incidentally' and therefore recognized at an early stage. Duodenal NETs which are well differentiated,not larger than 10 mm and limited to the mucosa/submucosa can be endoscopically resected. The management of duodenal NETs ranging between 10 and 20 mm needs an interdisciplinary discussion. Endoscopic ultrasound is the method of choice to determine tumor size and depth of infiltration. Surgery is recommended for well-differentiated duodenal NET tumors greater than 20 mm,for localized sporadic gastrinomas (of any size) and for localized poorly differentiated NE cancers. Surgery is recommended for any ileal NET. Advanced ileal NETs with a carcinoid syndrome are treated with longacting somatostatin analogs. This treatment significantly improves (progression-free) survival in patients with metastatic NETs of the ileum. For optimal NET management,tumor biology,type,localization and stage of the neoplasm,as well as the patient's individual circumstances have to be taken into account. | Hans Scherbl Robert T Jensen Guillaume Cadiot Ulrich Stlzel Gnter Klppel | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，10： | 10 |
| 10 | Optimization and design of an aircraft's morphing wing-tip demonstrator for drag reduction at low speeds, Part II- Experimental validation using Infra-Red transition measurement from Wind Tunnel tests显示文摘In the present paper, an ‘in-house' genetic algorithm was numerically and experimentally validated. The genetic algorithm was applied to an optimization problem for improving the aerodynamic performances of an aircraft wing tip through upper surface morphing. The optimization was performed for 16 flight cases expressed in terms of various combinations of speeds, angles of attack and aileron deflections. The displacements resulted from the optimization were used during the wind tunnel tests of the wing tip demonstrator for the actuators control to change the upper surface shape of the wing. The results of the optimization of the flow behavior for the airfoil morphing upper-surface problem were validated with wind tunnel experimental transition results obtained with infra-red Thermography on the wing-tip demonstrator. The validation proved that the 2D numerical optimization using the ‘in-house' genetic algorithm was an appropriate tool in improving various aspects of a wing's aerodynamic performances. | Andreea Koreanschi Oliviu Sugar Gabor Joran Acotto Guillaume Brianchon Gregoire Portier Ruxandra Mihaela Botez Mahmoud Mamou Youssef Mebarki | 2017 | Chinese Journal of Aeronautics2017，30，1： | 10 |
| 11 | Targeting natural killer cells in solid tumors显示文摘Natural killer(NK)cells are innate lymphoid cells endowed with cytolytic activity and a capacity to secrete cytokines and chemokines.Several lines of evidence suggest that NK cells play an important role in anti-tumor immunity.Some therapies against hematological malignacies make use of the immune properties of NK cells,such as their ability to kill residual leukemic blasts efficiently after conditioning during haploidentical hematopoietic stem cell transplantation.However,knowledge on NK cell infiltration and the status of NK cell responsiveness in solid tumors is limited so far.The pro-angiogenic role of the recently described NK cell-like type 1 innate lymphoid cells(ILC1s)and their phenotypic resemblance to NK cells are confounding factors that add a level of complexity,at least in mice.Here,we review the current knowledge on the presence and function of NK cells in solid tumors as well as the immunotherapeutic approaches designed to harness NK cell functions in these conditions,including those that aim to reinforce conventional anti-tumor therapies to increase the chances of successful treatment. | Guillaume Habif Adeline Crinier Pascale Andre Eric Vivier Emilie Narni-Mancinelli | 2019 | Cellular & Molecular Immunology2019，16，5： | 9 |
| 12 | Gender influence on defecographic abnormalities in patients with posterior pelvic floor disorders显示文摘AIM:To compare defecographic abnormalities in symptomatic men and women and to analyze differences between men and age-and symptom-matched women.METHODS:Sixty-six men(mean age:55.4 years,range:20-81 years) who complained of constipation and/or fecal incontinence and/or pelvic pain underwent defecography after intake of a barium meal.Radiographs were analyzed for the diagnosis of rectocele,enterocele,intussusception and perineal descent.They were compared with age-and symptom-matched women(n = 198) who underwent defecography during the same period.RESULTS:Normal defecography was observed in 22.7% of men vs 5.5% of women(P < 0.001).Defecography in men compared with women showed 4.5%vs 44.4%(P < 0.001) rectocele,and 10.6% vs 29.8%(P < 0.001) enterocele,respectively.No difference was observed for the diagnosis of intussusception(57.6% vs 44.9%).Perineal descent at rest was more frequent in women(P < 0.005).CONCLUSION:For the same complaint,diagnosis of defecographic abnormalities was different in men than in women:rectocele,enterocele and perineal descent at rest were observed less frequently in men than in women. | Céline Savoye-Collet Guillaume Savoye Edith Koning Anne-Marie Leroi Jean-Nicolas Dacher | 2010 | World Journal of Gastroenterology2010，16，4： | 8 |
| 13 | Optimization and design of an aircraft's morphing wing-tip demonstrator for drag reduction at low speed, Part Ⅰ–Aerodynamic optimization using genetic, bee colony and gradient descent algorithms显示文摘In this paper, an ‘in-house' genetic algorithm is described and applied to an optimization problem for improving the aerodynamic performances of an aircraft wing tip through upper surface morphing. The algorithm's performances were studied from the convergence point of view, in accordance with design conditions. The algorithm was compared to two other optimization methods,namely the artificial bee colony and a gradient method, for two optimization objectives, and the results of the optimizations with each of the three methods were plotted on response surfaces obtained with the Monte Carlo method, to show that they were situated in the global optimum region. The optimization results for 16 wind tunnel test cases and 2 objective functions were presented. The 16 cases used for the optimizations were included in the experimental test plan for the morphing wing-tip demonstrator, and the results obtained using the displacements given by the optimizations were evaluated. | Andreea Koreanschi Oliviu Sugar Gabor Joran Acotto Guillaume Brianchon Gregoire Portier Ruxandra Mihaela Botez Mahmoud Mamou Youssef Mebarki | 2017 | Chinese Journal of Aeronautics2017，30，1： | 8 |
| 14 | Color retargeting:Interactive time-varying color image composition from time-lapse sequences显示文摘In this paper,we present an interactive static image composition approach,namely color retargeting,to flexibly represent time-varying color editing effect based on time-lapse video sequences.Instead of performing precise image matting or blending techniques,our approach treats the color composition as a pixel-level resampling problem. In order to both satisfy the user's editing requirements and avoid visual artifacts,we construct a globally optimized interpolation field. This field defines from which input video frames the output pixels should be resampled.Our proposed resampling solution ensures that(i) the global color transition in the output image is as smooth as possible,(ii) the desired colors/objects specified by the user from different video frames are well preserved,and(iii) additional local color transition directions in the image space assigned by the user are also satisfied.Various examples have been shown to demonstrate that our efficient solution enables the user to easily create time-varying color image composition results. | Shao-Ping Lu Guillaume Dauphin Gauthier Lafruit Adrian Munteanu | 2015 | Computational Visual Media2015，1，4： | 7 |
| 15 | Ductal adenocarcinoma of the pancreatic head:A focus on current diagnostic and surgical concepts显示文摘Complete surgical resection still remains the only possibility of curing pancreatic cancer,however,only 10% of patients undergo curative surgery.Pancreatic resection currently remains the only method of curing patients,and has a 5-year overall survival rate between 7%-34% compared to a median survival of 3-11 mo for unresected cancer.Pancreatic surgery is a technically demanding procedure requiring highly standardized surgical techniques.Nevertheless,even in experienced hands,perioperative morbidity rates(delayed gastric emptying,pancreatic fistula etc.) are as high as 50%.Different strategies to reduce postoperative morbidity,such as different techniques of gastroenteric reconstruction(pancreatico-jejunostomy vs pancreatico-gastrostomy),intraoperative placement of a pancreatic main duct stent or temporary sealing of the main pancreatic duct with fibrin glue have not led to a significant improvement in clinical outcome.The perioperative application of somatostatin or its analogues may decrease the incidence of pancreatic fistulas in cases with soft pancreatic tissue and a small main pancreatic duct(< 3 mm).The positive effects of external pancreatic main duct drainage and antecolic gastrointestinal reconstruction have been observed to decrease the rate of pancreatic fistulas and delayed gastric emptying,respectively.Currently,the concept of extended radical lymphadenectomy has been found to be associated with higher perioperative morbidity,but without any positive impact on overall survival.However,there is growing evidence that portal vein resections can be performed with acceptable low perioperative morbidity and mortality but does not achieve a cure. | Mehdi Ouassi Urs Giger Guillaume Louis Igor Sielezneff Bernard Sastre Olivier Farges | 2012 | World Journal of Gastroenterology2012，18，24： | 7 |
| 16 | Usefulness of staging systems and prognostic scores for hepatocellular carcinoma treatments显示文摘Therapeutic management of hepatocellular carcinoma(HCC) is quite complex owing to the underlying cirrhosis and portal vein hypertension. Different scores or classification systems based on liver function and tumoral stages have been published in the recent years. If none of them is currently 'universally' recognized, the Barcelona Clinic Liver Cancer(BCLC) staging system has become the reference classification system in Western countries. Based on a robust treatment algorithm associated with stage stratification, it relies on a high level of evidence. However, BCLC stage B and C HCC include a broad spectrum of tumors but are only matched with a single therapeutic option. Some experts have thus suggested to extend the indications for surgery or for transarterial chemoembolization. In clinical practice, many patients are already treated beyond the scope of recommendations. Additional alternative prognostic scores that could be applied to any therapeutic modality have been recently proposed. They could represent complementary tools to the BCLC staging system and improve the stratification of HCC patients enrolled in clinical trials, as illustrated by the NIACE score. Prospective studies are needed to compare these scores and refine their role in the decision making process. | Xavier Adhoute Guillaume Penaranda Jean Luc Raoul Patrice Le Treut Emilie Bollon Jean Hardwigsen Paul Castellani Hervé Perrier Marc Bourlière | 2016 | World Journal of Hepatology2016，8，17： | 7 |
| 17 | Recommendations for the use of chemoembolization in patients with hepatocellular carcinoma: Usefulness of scoring system?显示文摘Several hepatocellular carcinoma(HCC) staging systems have been established, and a variety of countryspecific treatment strategies are also proposed. The barcelona- clinic liver cancer(BCLC) system is the most widely used in Europe. The Hong Kong liverCancer is a new prognostic staging system; it might become the reference system in Asia. Transarterial chemoembolization(TACE) is the most widely used treatment for HCC worldwide; but it showed a benefit only for intermediate stage HCC(BCLC B), and there is still no consensus concerning treatment methods and treatment strategies. In view of the highly diverse nature of HCC and practices, a scoring system designed to assist with decision making before the first TACE is performed or prior to repeating the procedure would be highly useful. | Xavier Adhoute Guillaume Penaranda Paul Castellani Herve Perrier Marc Bourliere | 2015 | World Journal of Hepatology2015，7，3： | 6 |
| 18 | New approaches for evaluation of soil health, sensitivity and resistance to degradation显示文摘Assessment of soil health requires complexevaluation of properties and functions responsible for abroad range of ecosystem services. Numerous soil qualityindices (SQI) have been suggested for the evaluation ofspecific groups of soil functions, but comparison of variousSQI is impossible because they are based on a combinationof specific soil properties. To avoid this problem, wesuggest an SQI-area approach based on the comparison ofthe areas on a radar diagram of a combination of chemical,biological and physical properties. The new approach isindependent of the SQI principle and allows rapid andsimple comparison of parameter groups and soils. Anotherapproach analyzing the resistance and sensitivity ofproperties to degradation is suggested for a detailedevaluation of soil health. The resistance and sensitivityof soil properties are determined through comparison withthe decrease of soil organic carbon (SOC) as a universalparameter responsible for many functions. The SQI-areaand resistance/sensitivity approaches were tested based on quences after the ab and on ment of agricultural soils. Both the SQI-area and the resistance/sensitivity approaches areuseful for basic and applied research, and for decisionmakersto evaluate land-use practices and measure thedegree of soil degradation. | Yakov KUZYAKOV Anna GUNINA Kazem ZAMANIAN Jing TIAN Yu LUO Xingliang XU Anna YUDINA Humberto APONTE Hattan ALHARBI Lilit OVSEPYAN Irina KURGANOVA Tida GE Thomas GUILLAUME | 2020 | Frontiers of Agricultural Science and Engineering2020，7，3： | 6 |
| 19 | Archaea and the human gut:New beginning of an old story显示文摘Methanogenic archaea are known as human gut inhabitants since more than 30 years ago through the detection of methane in the breath and isolation of two methanogenic species belonging to the order Methanobacteriales,Methanobrevibacter smithii and Methanosphaera stadtmanae.During the last decade,diversity of archaea encountered in the human gastrointestinal tract(GIT)has been extended by sequence identification and culturing of new strains.Here we provide an updated census of the archaeal diversity associatedwith the human GIT and their possible role in the gut physiology and health.We particularly focus on the still poorly characterized 7th order of methanogens,the Methanomassiliicoccales,associated to aged population.While also largely distributed in non-GIT environments,our actual knowledge on this novel order of methanogens has been mainly revealed through GIT inhabitants.They enlarge the number of final electron acceptors of the gut metabolites to mono-di-and trimethylamine.Trimethylamine is exclusively a microbiota-derived product of nutrients(lecithin,choline,TMAO,L-carnitine)from normal diet,from which seems originate two diseases,trimethylaminuria(or Fish-Odor Syndrome)and cardiovascular disease through the proatherogenic property of its oxidized liver-derived form.This therefore supports interest on these methanogenic species and its use as archaebiotics,a term coined from the notion of archaea-derived probiotics. | Nadia Gaci Guillaume Borrel William Tottey Paul William O’Toole Jean-Fran?ois Brugère | 2014 | World Journal of Gastroenterology2014，20，43： | 5 |
| 20 | Surgery in Esophageal and Gastric Cancer Patients: What is the Role for Nutrition Support in your Daily Practice?显示文摘 | Christophe Mariette Marie-Laure Botton Guillaume Piessen | 2012 | Annals of Surgical Oncology2012，，7： | 5 |
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