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| 1 | Opposite Interplay Between the Canonical WNT/β-Catenin Pathway and PPAR Gamma: A Potential Therapeutic Target in Gliomas显示文摘In gliomas, the canonical Wingless/Int(WNT)/b-catenin pathway is increased while peroxisome proliferator-activated receptor gamma(PPAR-c) is downregulated.The two systems act in an opposite manner. This review focuses on the interplay between WNT/b-catenin signaling and PPAR-c and their metabolic implications as potential therapeutic target in gliomas. Activation of the WNT/bcatenin pathway stimulates the transcription of genes involved in proliferation, invasion, nucleotide synthesis,tumor growth, and angiogenesis. Activation of PPAR-c agonists inhibits various signaling pathways such as the JAK/STAT, WNT/b-catenin, and PI3 K/Akt pathways,which reduces tumor growth, cell proliferation, cell invasiveness, and angiogenesis. Nonsteroidal anti-inflammatory drugs, curcumin, antipsychotic drugs, adiponectin,and sulforaphane downregulate the WNT/b-catenin pathway through the upregulation of PPAR-c and thus appear to provide an interesting therapeutic approach for gliomas.Temozolomide(TMZ) is an antiangiogenic agent. The downstream action of this opposite interplay may explain the TMZ-resistance often reported in gliomas. | AlexANDre Vallée Yves Lecarpentier Rémy Guillevin Jean-Noёl Vallée | 2018 | Neuroscience Bulletin2018，34，3： | 7 |
| 2 | Tolerance and efficacy ofrituximab and changes in serum B cell biomarkers in patientswith systemic complications of primary Sjagren's syndrome 显示文摘 | Seror R Sordet C Guillevin L | 2007 | Ann Rheum Dis2007，66，3： | 1 |
| 3 | Vasculitis associated with viral infection- s显示文摘 | Cohen P Guillevin L | 2004 | Presse Med2004，33，192： | 1 |
| 4 | Tumor necrosis factor-alpha blockade and the risk of vasculitis显示文摘 | Guillevin L Mouthon L | 2004 | J Rheumatol2004，31，10： | 1 |
| 5 | EULAR recommendations for the management of large vessel vasculitis显示文摘 | Mukhtyar C Guillevin L Cid MC | 2009 | Ann Rheum Dis2009，68，3： | 1 |
| 6 | Low grade marginal zone B cell lymphoma of the breast associated with localized amyloidosis and corpora amylacea in a woman with long standing primary Sjogren's syndrome显示文摘 | Kambouchner M Godmer P Guillevin L | 2003 | J Clin Pathol2003，56，： | 1 |
| 7 | Comparison of cell-ELISA, flow eytometry and Western blotting for the detection of antiendothelial cell antibodies 显示文摘 | Revelen R D'Arbonneau F Guillevin L | 2002 | Clin Exp Rheumatol2002，20，1： | 1 |
| 8 | Small solitary littoral cell angioma associated with splenic marginal zone lymphoma and villous lymphocyte leukaemia in a patient with hepatitis C infection显示文摘 | Chatelain D Bonte H Guillevin L | 2002 | Histopathology2002，41，5： | 1 |
| 9 | Churg-Strauss syndrome 显示文摘 | Pagnoux C Guilpain P Guillevin L | 2007 | Curr Opin Rheumatol2007，19，1： | 1 |
| 10 | Early detection of pulmonary arterial hypertension in systemic sclerosis: A French nation-wide prospective multicenter study显示文摘 | Hachulla E Gressin V Guillevin L | 2005 | ArthritisRheum2005，210，52： | 1 |
| 11 | Diagnostic and prognostic rel- evance of neuromuscular biopsy in primary Sjogren' s syndrome-relat- ed neuropathy显示文摘 | Terrier B Lacroix C Guillevin L | 2007 | Arthritis Rheum2007，57，： | 1 |
| 12 | Granulomatosis with polyangiitis (Wegener's): an ahernative name for Wegener's granulomatosis 显示文摘 | Falk RJ Gross WL Guillevin L | 2011 | Arthritis Rheum2011，63，4： | 1 |
| 13 | Vasculitis: mechanisms involved andclinical manifestations 显示文摘 | Guillevin L Dorner T | 2007 | Arthritis Res Ther2007，9，2： | 1 |
| 14 | The Five- Factor Score revisited: assessment of prognoses of systemic necrotizing vasculitides based on the French Vasculitis Study Group (FVSG) cohort 显示文摘 | Guillevin L Pagnoux C Seror R | 2011 | Medicine ( Baltimore)2011，90，： | 1 |
| 15 | Treatment of polyarteritis nodosa and microscopic polyangiitis with poor prognosis factors: a prospective trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in sixty-five patients 显示文摘 | Guillevin L Cohen P Mahr A | 2003 | Arthritis Rheum2003，49，1： | 1 |
| 16 | Diagnostic and prognos- tic relevance of neuromuscular biopsy in primary Sjtigren's syn- drome-related neuropathy 显示文摘 | Terrier B Lacroix C Guillevin L | 2007 | Arthritis Rheum2007，57，： | 1 |
| 17 | Churg-Strauss syndrome 显示文摘 | Pagnoux C Guilpain P Guillevin L | 2007 | Curt Opin Rheumatol2007，19，1： | 1 |
| 18 | Granulomatosis with polyangiitis (Wegener's):an alternative name for Wegener's granulomatosis显示文摘 | Falk RJ Gross WL Guillevin L | | 0，，04： | 1 |
| 19 | Treatment of granulomatosis with polyangiitis (Wegener's) 显示文摘 | Pagnoux C Guillevin L | 2015 | Expert Rev Clin Immunol2015，11，： | 1 |
| 20 | Churg Strauss syndrome显示文摘 | Pagnoux C Guilpain P Guillevin L | 2007 | CurrOpin Rheumatol2007，19，1： | 1 |
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