3篇
您的检索式：作者名="Gulcin Demirci"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | IL-2 and IL-15 Exhibit Opposing Effects on Fas Mediated Apoptosis显示文摘It has been shown that IL-2 and IL-15 can have opposing effects on life and death of T cells. However, the role of IL-2 and IL-15 in regulating the fate of other cell types is less clear. In the present study, we examined the impact of IL-2 and IL-15 on life and death of pre-B cells using the BAF-B03 line. We showed that BAF-B03 cells constitutively expressed the private IL-2Rα chain and IL-15Rα chain, and the shared IL-2Rβ chain and γc chain. Stimulation of BAF-B03 cells in vitro with IL-2 and IL-15 induced vigorous cell proliferation in a dose-dependent fashion. Titration of IL-2 and IL-15 in the assay showed that the mitotic effects of IL-2 and IL-15 were remarkably similar, Howerer, the sensitivities of BAF-B03 cells to Fas mediated apoptosis after IL-2 and IL-15 stimulation were strikingly different. Cells cultured in IL-2 readily underwent apoptotic cell deathupon cross-linking of the Fas receptor whereas cells cultured in IL-15 were extremely resistant to Fas triggered cell death. The anti-apoptotic effect of IL-15 in this model was associated with increased expression of Bcl-xL. FLIP expression, however, was comparable between IL-2 and IL-15 stimulated cells. We conclude that IL-2 and IL-15 have diametrically opposite effect on the fate of BAF-B03 cells, although both cytokines share similar receptor structure and exhibitsimilarmitoticactivities. | Gulcin Demirci | 2004 | Cellular & Molecular Immunology2004，1，2： | 4 |
| 2 | Inhibitory Receptors of the Immune System:Functions and Therapeutic Implications显示文摘The immune system has a remarkable ability to respond to seemingly endless antigens.In essence,a productive immune response takes place along a well defined but treacherous line,that is to effectively eradicate pathogens,and at the same time avoid causing damage to self organs.This type of response is fine-tuned,at least in part,by a complex array of pathways that either promote or inhibit the activation of innate and adaptive immune cells.Much effort has been focused on pathways that can support immune activation.In this article,we review specifically pathways that can inhibit immune responses and maintain immune homeostasis,highlighting our recent understanding on the role of inhibitory receptors that selectively engage the self MHC class I molecules and the B7 superfamily members,we also discuss the inhibitory Fc receptors and inhibitory cytokines and how such pathways,either individually or collectively,regulate innate and adaptive immune responses.Finally,we summarize new emerging approaches on how such negative pathways can be therapeutically modulated in various disease settings. | Jian Zhang Xiang Xiao Wentao Liu Gulcin Demirci Xian C.Li | 2009 | Cellular & Molecular Immunology2009，6，6： | 2 |
| 3 | Stimulating PD-1 negative signals concttrrent with blocking CD154 costimulation induces long term islet allograft survival 显示文摘 | Wenda Gao Gulcin Demirci Terry B | 2003 | Transplantation2003，76，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员