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| 1 | Angiogenesis and liver fibrosis显示文摘Recent data indicate that hepatic angiogenesis, regardless of the etiology, takes place in chronic liver diseases(CLDs) that are characterized by inflammat ion and progre s s ive f ibros is. B e c aus e ant iangiogenic therapy has been found to be efficient in the prevention of fibrosis in experimental models of CLDs, it is suggested that blocking angiogenesis could be a promising therapeutic option in patients with advanced fibrosis. Consequently, efforts are being directed to revealing the mechanisms involved in angiogenesis during the progression of liver fibrosis. Literature evidences indicate that hepatic angiogenesis and fibrosis are closely related in both clinical andexperimental conditions. Hypoxia is a major inducer of angiogenesis together with inflammation and hepatic stellate cells. These profibrogenic cells stand at the intersection between inflammation, angiogenesis and fibrosis and play also a pivotal role in angiogenesis. This review mainly focuses to give a clear view on the relevant features that communicate angiogenesis with progression of fibrosis in CLDs towards the-end point of cirrhosis that may be translated into future therapies. The pathogenesis of hepatic angiogenesis associated with portal hypertension, viral hepatitis, non-alcoholic fatty liver disease and alcoholic liver disease are also discussed to emphasize the various mechanisms involved in angiogenesis during liver fibrogenesis. | Gulsum Ozlem Elpek | 2015 | World Journal of Hepatology2015，7，3： | 24 |
| 2 | Expression of Notch pathway components (Numb, Itch, and Siah-1) in colorectal tumors: A clinicopathological study显示文摘BACKGROUND The role of the Notch pathway in carcinogenesis and tumor progression has been demonstrated in many organs,including the colon.Accordingly,studies aimed at developing therapies targeting this pathway in various cancers require the identification of several factors that may play a role in regulating Notch-1 expression.Although Numb,Itch,and seven in absentia homolog-1(Siah-1)have been shown to contribute to the regulation of Notch signaling,their role in colorectal carcinogenesis and tumor progression has not been fully elucidated to date.AIM To evaluate Numb,Itch,and Siah-1 expression in colorectal tumors to clarify their relationship with Notch-1 expression and their role in carcinogenesis and tumor behavior.METHODS Expression of Notch-1,Numb,Itch,and Siah-1 was investigated in 50 colorectal carcinomas,30 adenomas,and 20 healthy colonic tissues by immunohistochemistry and quantitative real-time polymerase chain reaction(PCR)analyses.RESULTS In contrast to Notch-1,which is expressed at higher levels in tumor tissues and adenomas,expression of Numb,Itch,and Siah-1 was stronger and more frequent in normal mucosa(P<0.01).There was a positive correlation between Notch-1 expression and high histological grade,the presence of lymph node metastasis,and advanced-stage tumors,whereas expression of Numb,Itch,and Siah-1 was absent or reduced in tumors with these clinicopathological parameters(P<0.05).In survival analysis,expression of Notch was related to poor prognosis but that of Numb,Itch,and Siah-1 correlated with improved survival(P<0.05).Multivariate analysis revealed Notch-1 expression and loss of Numb expression to be independent prognostic parameters together with lymph node metastasis(P<0.05).CONCLUSION Our findings support the role of Notch-1 in colorectal carcinoma and indicate that loss of Numb,Itch,and Siah-1 expression is associated with carcinogenesis.Our data also suggest that these three proteins might be involved in the Notch-1 pathway during colorectal carcinoma(CRC)progression and might play an essential role in approaches targeting Notch as novel molecular therapies for CRC. | Sinem Cil Gonulcu Betul Unal Ibrahim Cumhur Bassorgun Mualla Ozcan Hasan Senol Coskun Gulsum Ozlem Elpek | 2020 | World Journal of Gastroenterology2020，26，26： | 5 |
| 3 | Mixed neuroendocrine–nonneuroendocrine neoplasms of the gastrointestinal system:An update显示文摘Mixed neuroendocrine-nonneuroendocrine neoplasms(Mi NENs)of the digestive tract are a rare heterogeneous group of tumors that present many challenges in terms of diagnosis and treatment.Over the years,the diagnostic criteria,classification,and clinical behavior of these tumors have been the subjects of ongoing debate,and the various changes in their nomenclature have strengthened the challenges associated with Mi NENs.This review is performed to provide an understanding of the key factors involved in the evolution of the designation of these tumors as Mi NEN,highlight the current diagnostic criteria,summarize the latest data on pathogenesis and provide information on available treatments.Moreover,this work seeks to increase the awareness about these rare neoplasms by presenting the clinicopathological features and prognostic factors that play important roles in their behavior and discussing their different regions of origin in the gastrointestinal system(GIS).Currently,the Mi NEN category also includes tumors in the GIS with a nonneuroendocrine component and epithelial tumors other than adenocarcinoma,depending on the organ of origin.Diagnosis is based on the presence of both morphological components in more than 30%of the tumor.However,this value needs to be reconfirmed with further studies and may be a limiting factor in the diagnosis of Mi NEN by biopsy.Furthermore,available clinicopathological data suggest that the inclusion of amphicrine tumors in the definition of Mi NEN is not supportive and warrants further investigation.The diagnosis of these tumors is not solely based on immunohistochemical findings.They are not hybrid tumors and both components can act independently;thus,careful grading of each component separately is required.In addition to parameters such as the metastatic state of the tumor at the time of diagnosis and the feasibility of surgical resection,the aggressive potential of both components has paramount importance in the choice of treatment.Regardless of the organ of origin within the GIS,almost Mi NENs are tumors with poor prognosis and are frequently encountered in the elderly and men.They are most frequently reported in the colorectum,where data from molecular studies indicate a monoclonal origin;however,further studies are required to provide additional support for this origin. | Gulsum Ozlem Elpek | 2022 | World Journal of Gastroenterology2022，28，8： | 2 |
| 4 | Neuropilins and liver显示文摘Neuropilins(NRPs) are highly conserved transmembrane glycoproteins that possess pleiotropic functions. Neuropilin-1(NRP1) and its homologue neuropilin-2 interact as coreceptors with both class 3 semaphorins and vascular endothelial growth factor and are involved in neuronal guidance and angiogenesis, respectively. The contribution of NRPs to tumor angiogenesis has been highlighted in previous studies, leading to the development of NRP antagonists as novel anti-angiogenesis therapies. However, more recent studies have demonstrated that NRPs have a much broader spectrum of activity in the integration of different pathways in physiological and pathological conditions. A few studies investigated the role of NRPs in both malignant and non-neoplastic liver diseases. In normal liver, NRP1 is expressed in hepatic stellate cells and liver sinusoidal endothelial cells. NRP1 expression in hepatocytes has been associated with malignant transformation and may play an important role in tumor behavior. A contribution of NRPs in sinusoidal remodeling during liver regeneration has been also noted. Studies in chronic liver diseases have indicated that, besides its influence on angiogenesis, NRP1 might contribute to the progression of liver fibrosis owing to its effects on other growth factors, including transforming growth factor β1. As a result, NRP1 has been identified as a promising therapeutic target for future antifibrotic therapies based on the simultaneous blockade of multiple growth factor signaling pathways. In this review, the structure of NRPs and their interactions with various ligands and associated cell surface receptors are described briefly. The current understanding of the roles of the NRPs in liver diseases including tumors, regeneration and fibrogenesis, are also summarized. | Gulsum Ozlem Elpek | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 5 | 无压熔渗AlN-Si-Al复合材料的热性能(英文)显示文摘采用无压熔渗法将Al/Al合金渗透到多孔α-Si3N4中,并对AlN-Si-Al复合材料在50~300°C的热性能进行研究。SEM和TEM结果表明,AlN的晶粒尺寸小于1μm,另外,AlN-Si-Al复合材料还表现出较高的热导率55~107W/(m·K)。采用热导率为107W/(m·K)的商用Al得到的AlN-Si-Al复合材料的热膨胀系数为6.5×10-6K-1。Al的热膨胀系数高达23.6×10-6K-1,而AlN-Si-Al复合材料却具有低的热膨胀系数,其原因是在渗透过程中形成了Si和AlN。 | Ayse KALEMTAS Gulsum TOPATES OzlemBAHADIR Pinar KAYAISCI Hasan MANDAL | 2013 | Transactions of Nonferrous Metals Society of China2013，23，5： | 2 |
| 6 | Successful medical treatment of cesarean scar ectopic pregnancies with systemic multidose methotrexate: Single‐center experience显示文摘 | Mehmet Serdar Kutuk Gulsum Uysal Mehmet Dolanbay Mahmut Tuncay Ozgun | 2014 | J Obstet Gynaecol Res2014，，6： | 1 |
| 7 | Preparation of ion-exchange beads based on poly(methacrylic acid) brush grafted chitosan beads for isolation oflysozyme 显示文摘 | GULAY B GULSUM E NECATI B | 2007 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2007，310，123： | 1 |
| 8 | The effect of neighborhood structures on tabu search algorithm in solving course timetabling problem 显示文摘 | Cagdas H A Gulsum H Murat A B | 2009 | Expert Systems with Applications2009，36，12： | 1 |
| 9 | Povidone-iodine for persistent air leak in an extremely low birth weight infant显示文摘 | Sema Arayici Gulsum Kadioglu Simsek Mehmet Yekta Oncel Yavuz Yilmaz Fuat Emre Canpolat Ugur Dilmen | 2013 | Journal of Pediatric Surgery2013，，5： | 1 |
| 10 | Ther- apeutic hotline: Treatment of prurigo nodularis and lichen simplex chronicus with gabapentin显示文摘 | Gulsum Gencoglan Isil Inanir Kamer Gunduz | 2010 | Dermato- logic Therapy2010，23，2： | 1 |
| 11 | Anticarcino- genic effect and carcinogenic potential of the dietary phenolic acid (9) :1269 acid 显示文摘 | Alaattin Sen Pelin Atmaca Gulsum Terzioglu | 2013 | Natural product communications2013，8，： | 1 |
| 12 | Evaluation of abiotic stress tolerance and physiological characteristics of potato ( Solanum tuberosum L. cv. Kennebec) that heterologously expresses the rice Osmyb4 gene显示文摘 | Gulsum Aydin Meral Yucel Ming-Tsair Chan Huseyin Avni Oktem | 2014 | Plant Biotechnology Reports2014，，3： | 1 |
| 13 | Effects of serum uric acid levels on coronary collateral circulation in patients with non-ST elevation acute coronary syndrome显示文摘 | Haci Ahmet Kasapkara Ramazan Topsakal Mikail Yarlioglues Gulsum Yarlioglues Orhan Dogdu Idris Ardic Mahmut Akpek Mehmet Gungor Kaya | 2012 | Coronary Artery Disease2012，，7： | 1 |
| 14 | Clinical and genetic characteristics of retinoblastoma patients in a single center with four novel RB1 variants显示文摘AIM:To assess the clinical and genetic characteristics of children diagnosed with retinoblastoma(RB)at Gazi University Faculty of Medicine’s Department of Pediatric Oncology.METHODS:All cases diagnosed with RB and received treatment and follow-up in the Ophthalmology and Pediatric Oncology Department,October 2016 to May 2021 were evaluated retrospectively.The RB1 gene was analyzed by next-generation sequencing(NGS)technique in DNAs obtained from peripheral blood samples of the patients.RESULTS:This study included 53 cases with 67 RBaffected eyes during the study period.The mean age was 24.6(median:18.5,range:3–151)mo.There were 15(22.3%)Group D eyes and 39(58.2%)Group E eyes.The RB1 gene was sequenced by the NGS method in 19 patients.Heterozygous RB1:NM_000321.3:c.54_76del(p.Glu19AlafsTer4)variant was detected in a 15-month-old female with bilateral RB.Heterozygous RB1:NM_000321.3:c.1814+3A>T variant was detected in a 5.5-month-old male with bilateral RB.The intronic RB1:NM_000321.3:c.1332+4A>G variant was detected in patient 14,a 13-month-old male with unilateral RB.The RB1:NM_000321.3:c.575_576del(p.Lys192SerfsTer10)variant was found in an 18-month-old female with an allele frequency of 37%.These variants have not been reported in the literature and mutation databases.CONCLUSION:Four novel variants are described and one of them is found in two different patients.This data is crucial for assessing prognosis.It serves as a guide for estimating the long-term risk of secondary malignancy as well as the short-term risk of developing additional malignancies in the same eye and the other eye. | Özge Vural Hatice Tuba Atalay Gulsum Kayhan Bercin Tarlan Merve Oral Arzu Okur Faruk GüçlüPınarlı Ceyda Karadeniz | 2023 | International Journal of Ophthalmology(English edition)2023，16，8： | 1 |
| 15 | Chemical and biological treatment technologies for leather tannery chemicals and wastewaters:a review显示文摘 | LOFRANO G MERIC S GULSUM E Z | 2013 | Science of the Total Environment2013，，： | 1 |
| 16 | Effect of aspartate and glutamate on the fate of enhanced biological phosphorus removal process and microbial community structure 显示文摘 | Gulsum Emel Z Nazik A Derin O | 2011 | Bioresource Technology2011，102，2： | 1 |
| 17 | Molecular pathways in viral hepatitis-associated liver carcinogenesis: An update显示文摘Hepatocellular carcinoma(HCC)is the most common type of cancer among primary malignant tumors of the liver and is a consequential cause of cancerrelated deaths worldwide.In recent years,uncovering the molecular mechanisms involved in the development and behavior of this tumor has led to the identification of multiple potential treatment targets.Despite the vast amount of data on this topic,HCC remains a challenging tumor to treat due to its aggressive behavior and complex molecular profile.Therefore,the number of studies aiming to elucidate the mechanisms involved in both carcinogenesis and tumor progression in HCC continues to increase.In this context,the close association of HCC with viral hepatitis has led to numerous studies focusing on the direct or indirect involvement of viruses in the mechanisms contributing to tumor development and behavior.In line with these efforts,this review was undertaken to highlight the current understanding of the molecular mechanisms by which hepatitis B virus(HBV)and hepatitis C virus(HCV)participate in oncogenesis and tumor progression in HCC and summarize new findings.Cumulative evidence indicates that HBV DNA integration promotes genomic instability,resulting in the overexpression of genes related to cancer development,metastasis,and angiogenesis or inactivation of tumor suppressor genes.In addition,genetic variations in HBV itself,especially preS2 deletions,may play a role in malignant transformation.Epigenetic dysregulation caused by both viruses might also contribute to tumor formation and metastasis by modifying the methylation of DNA and histones or altering the expression of microRNAs.Similarly,viral proteins of both HBV and HCV can affect pathways that are important anticancer targets.The effects of these two viruses on the Hippo-Yap-Taz pathway in HCC development and behavior need to be investigated.Additional,comprehensive studies are also needed to determine these viruses'interaction with integrins,farnesoid X,and the apelin system in malignant transformation and tumor progression.Although the relationship of persistent inflammation caused by HBV and HCV hepatitis with carcinogenesis is well defined,further studies are warranted to decipher the relationship among inflam masomes and viruses in carcinogenesis and elucidate the role of virus-microbiota interactions in HCC development and progression. | Gulsum Ozlem Elpek | 2021 | World Journal of Clinical Cases2021，9，19： | 1 |
| 18 | Depression, anxiety and influencing factors in pregnancy: A study in a Turkish population显示文摘 | Zekiye K Gulsum A | 2009 | Midwifery2009，25，4： | 1 |
| 19 | A sequencing batch reactor system for high-level biological nitrogen and phosphorus removal from abattoir wastewater显示文摘 | Romain Lemaire Zhiguo Yuan Nicolas Bernet Marcelino Marcos Gulsum Yilmaz Jürg Keller | 2009 | Biodegradation2009，，3： | 1 |
| 20 | Childhood chronic gastritis and duodenitis: Role of altered sensory neuromediators显示文摘AIM To investigate the roles of the neuropeptides vasoactive intestinal peptide(VIP), substance P(SP), and calcitonin gene-related peptide(CGRP) in chronic gastritis and duodenitis in children.METHODS Biopsy samples from the gastric and duodenal mucosa of 52 patients and 30 control subjects were obtained. Samples were taken for pathological examination, immunohistochemical staining, enzyme activity measurements and quantitative measurements of tissue peptide levels.RESULTS We observed differential effects of the disease on peptide levels, which were somewhat different from previously reported changes in chronic gastritis in adults. Specifically, SP was increased and CGRP and VIP were decreased in patients with gastritis. The changes were more prominent at sites where gastritis was severe, but significant changes were also observedin neighboring areas where gastritis was less severe. Furthermore, the degree of changes was correlated with the pathological grade of the disease. The expression of CD10, the enzyme primarily involved in SP hydrolysis, was also decreased in patients with duodenitis.CONCLUSION Based on these findings, we propose that decreased levels of VIP and CGRP and increased levels of SP contribute to pathological changes in gastric mucosa. Hence, new treatments targeting these molecules may have therapeutic and preventive effects. | Ali Islek Aygen Yilmaz Gulsum Ozlem Elpek Nuray Erin | 2016 | World Journal of Gastroenterology2016，22，37： | 1 |
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