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| 1 | Expression of DNA-dependent protein kinase in human granulocytes显示文摘Human polymorphonuclear leukocytes (PMN) have been reported to completely lack of DNA-dependent protein kinase (DNA-PK) which is composed of Ku protein and the catalytic subunit DNA-PKcs, needed for nonhomologous end-joining (NHEJ) of DNA double-strand breaks. Promyelocytic HL-60 cells express a variant form of Ku resulting in enhanced radiation sensitivity. This raises the question if low efficiency of NHEJ, instrumental for the cellular repair of oxidative damage, is a normal characteristic of myeloid differentiation. Here we confirmed the complete lack of DNAPK in P MN protein extracts, and the expression of the truncated Ku86 variant form in HL-60. However, this degradation of DNA-PK was shown to be due to a DNA-PK-degrading protease in PMN and HL-60. In addition, by using a protease-resistant whole cell assay, both Ku86 and DNA-PKcs could be demonstrated in PMN, suggesting the previously reported absence in PMN of DNA-PK to be an artefact. The levels of Ku86 and DNA-PKcs were much reduced in PMN, as compared with that of the lymphocytes, whereas HL-60 displayed a markedly elevated DNA-PK concentration.In conclusion, our findings provide evidence of reduced, not depleted expression of DNA-PK during the mature stages of myeloid differentiation. | Annahita SALLMYR Anna MILLER Aida GABDOULKHAKOVA Valentina SAFRONOVA Gunnel HENRIKSSON Anders BREDBERG | 2004 | Cell Research2004，14，4： | 3 |
| 2 | Acute phase response predicts erythropoietin resistance in hemodialysis and peritoneal dialysis patients显示文摘 | Gunnell J Yeun J Y Depner T A | 1999 | AmJ Kidney Dis1999，33，1： | 1 |
| 3 | Prevention of suicide: aspiration and evi- dence 显示文摘 | Gunnell D Frankel S | 1994 | BMJ1994，308，6938： | 1 |
| 4 | Comparison of trends in prostatecancer mortality in English and Wales and the USA显示文摘 | Oliver SE Gunnell D Donovan JL | 2000 | Lancet2000，355，： | 1 |
| 5 | Advanced paternalage:How old is too old ?显示文摘 | BrayI Gunnell D Davey S G | 2006 | J Epidemiol Community Health2006，60，10： | 1 |
| 6 | Insulin-like growth factor-I and growth in height,leg length, and trunk length between ages 5 and 10 years显示文摘 | Rogers I Metealfe C Gunnell D | 2006 | J Clin Endoerinol Metab2006，，7： | 1 |
| 7 | Acute-phase response predicts erythropoietin resistance in hemodialysis and peritoneal dialysis patients显示文摘 | Gunnell J Yeun JY Depner TA | 1999 | Am J Kidney Dis1999，33，： | 1 |
| 8 | Denudation history of the continental margin of western penisular India since the early Mesozoic reconciling apatite fission-track data with geomorphology显示文摘 | Gunnell Y Gallagher K Carter A | 2003 | Earth and Planetary Science Letters2003，215，： | 1 |
| 9 | Why suicide rates are high in China 显示文摘 | Eddleston M Gunnell D | 2006 | Science2006，311，： | 1 |
| 10 | Suicide by intentional ingestion of pesticides:a continuting tragedy in developing countries显示文摘 | Gunnell D Eddleston M | | 0，，06： | 1 |
| 11 | Suicide by intentional ingestion of pesticides:a continuing tragedy in developing countries 显示文摘 | Gunnell D Eddleston M | 2003 | Int J Epidemic2003，32，6： | 1 |
| 12 | Investments in combined heat and power plants: influence of fuel price on cost minimised operation显示文摘 | Gunnel Sundberg Dag Henning | 2002 | Energy Conversion and Management2002，，： | 1 |
| 13 | Life course breast cancer risk factors and adult breast density显示文摘 | Jeffreys M Warren R Gunnell D | 2004 | Cancer Causes Contr2004，15，9： | 1 |
| 14 | Selective serotonin reuptake inhibitors(SSRIs)and suicide in adults:meta-analysis of drug company data from placebo controlled,randomised controlled trials submitted to the MHRA's safety review显示文摘 | Gunnell DJ Saperia D Ashby | 2005 | Bmj2005，330，7488： | 1 |
| 15 | Comparison of inhibition assays using nitrogen removing bacteria:Application to industrial wastewater显示文摘 | CAMILLA Grunditz LENA Guamelius GUNNEL Dalhammar | 1998 | Wat Res1998，32，10： | 1 |
| 16 | The global distri- bution of fatal pesticide self- poisoning: systematic review 显示文摘 | Gunnell D Eddleston M Phillips MR | 2007 | BMC Public Health2007，，7： | 1 |
| 17 | Patterns of fetal and childhood growth and the development of psychosis in young males : a cohort study 显示文摘 | Gunnel| D Rasmussen F Fouskakis D eta| | 2003 | Am J Epidemio12003，158，4： | 1 |
| 18 | Taxonomy and morphology of Colletotrichum species pathogenic to strawberry显示文摘 | Gubler W D | 1992 | Mycology1992，，84： | 1 |
| 19 | Infections in the CNS dur- ing childhood and the risk of subsequent psychotic illness: a cohort study of more than one million Swedish subjects 显示文摘 | Dalman C Allebeck P Gunnell D | 2008 | Am J Psychiatry2008，165，1： | 1 |
| 20 | Taxonomy and morphology of Colletotrichum species pathogenic to strawberry显示文摘 | GUNNELL P S GUBLER W D | 1992 | Mycologia1992，84，2： | 1 |
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