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| 1 | Coinfection with influenza A virus enhances SARS-CoV-2 infectivity显示文摘The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health.Through experimental coinfection with influenza A virus(IAV)and either pseudotyped or live SARS-CoV-2 virus,we found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types.Remarkably,in vivo,increased SARS-CoV-2 viral load and more severe lung damage were observed in mice coinfected with IAV.Moreover,such enhancement of SARS-CoV-2 infectivity was not observed with several other respiratory viruses,likely due to a unique feature of IAV to elevate ACE2 expression.This study illustrates that IAV has a unique ability to aggravate SARS-CoV-2 infection,and thus,prevention of IAV infection is of great significance during the COVID-19 pandemic. | Lei Bai Yongliang Zhao Jiazhen Dong Simeng Liang Ming Guo Xinjin Liu Xin Wang Zhixiang Huang Xiaoyi Sun Zhen Zhang Lianghui Dong Qianyun Liu Yucheng Zheng Danping Niu Min Xiang Kun Song Jiajie Ye Wenchao Zheng Zhidong Tang Mingliang Tang Yu Zhou Chao Shen Li Zhou Yu Chen Huan Yan Ke Lan Ke Xu | 2021 | Cell Research2021，31，4： | 16 |
| 2 | DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS-STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis显示文摘Gastrointestinal mucositis is one of the most debilitating side effects of the chemotherapeutic agent irinotecan(CPT-11). Andrographolide, a natural bicyclic diterpenoid lactone, has been reported to possess anti-colitis activity. In this study, andrographolide treatment was found to significantly relieve CPT-11-induced colitis in tumor-bearing mice without decreasing the tumor suppression effect of CPT-11. CPT-11 causes DNA damage and the release of double-stranded DNA(ds DNA) from the intestine, leading to cyclic-GMP-AMP synthase(c GAS)-stimulator of interferon genes(STING)-mediated colitis, which was significantly decreased by andrographolide both in vivo and in vitro. Mechanistic studies revealed that andrographolide could promote homologous recombination(HR) repair and downregulate ds DNA-c GAS-STING signaling and contribute to the improvement of CPT-11-induced gastrointestinal mucositis. These results suggest that andrographolide may be a novel agent to relieve gastrointestinal mucositis caused by CPT-11. | Yuanyuan Wang Bin Wei Danping Wang Jingjing Wu Jianhua Gao Haiqing Zhong Yang Sun Qiang Xu Wen Liu Yanhong Gu Wenjie Guo | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 3 |
| 3 | HWVP: hierarchical wavelet packet descriptors and their applica- tions in scene categorization and semantic concept retrieval显示文摘 | Qian Xueming Guo Danping Hou Xingsong | 2014 | Multimedia Tools and Applications2014，69，3： | 1 |
| 4 | An Approach to the Compact and Efficient Visual Codebook Based on SIFT Descriptor显示文摘 | Zhe Wang Guizhong Liu Xueming Qian Danping Guo | 2010 | Lecture Notes in Computer Science2010，6297，： | 1 |
| 5 | Key technologies for wireless network digital twin towards smart railways显示文摘An emerging railway technology called smart railway promises to deliver higher transportation efficiency,enhanced comfort in services,and greater eco-friendliness.The smart railway is expected to integrate fifth-generation mobile communication(5G),Artificial Intelligence(AI),and other technologies,which poses new problems in the construction,operation and maintenance of railway wireless networks.Wireless Digital Twins(DTs),which have recently emerged as a new paradigm for the design of wireless networks,can address these problems and enable the whole lifecycle management of railway wireless networks.However,there are still many scientific issues and challenges for railway-oriented wireless DT.Relevant key technologies to solve these problems are introduced and described,including characterization of materials'physical-EM properties,autonomous reconstruction of Three-dimensional(3D)environment model,AI-empowered environmental cognition,Ray-Tracing(RT),model-based and AIbased RT acceleration,and generation of multi-spectra sensing data.Moreover,this paper presents our research results for each key technology and describes the wireless network planning and optimization system based on highperformance RT developed by our laboratory.This paper outlines the framework for realizing the wireless DT of smart railways,providing the direction for future research. | Ke Guan Xinghai Guo Danping He Philipp Svoboda Marion Berbineau Stephen Wang Bo Ai Zhangdui Zhong Markus Rupp | 2024 | High-Speed Railway2024，2，1： | 0 |
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