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| 1 | Digoxin Ameliorates Glymphatic Transport and Cognitive Impairment in a Mouse Model of Chronic Cerebral Hypoperfusion显示文摘The glymphatic system plays a pivotal role in maintaining cerebral homeostasis.Chronic cerebral hypoperfusion,arising from small vessel disease or carotid stenosis,results in cerebrometabolic disturbances ultimately manifesting in white matter injury and cognitive dysfunction.However,whether the glymphatic system serves as a potential therapeutic target for white matter injury and cognitive decline during hypoperfusion remains unknown.Here,we established a mouse model of chronic cerebral hypoperfusion via bilateral common carotid artery stenosis.We found that the hypoperfusion model was associated with significant white matter injury and initial cognitive impairment in conjunction with impaired glym・phatic system function.The glymphatic dysfunction was associated with altered cerebral perfusion and loss of aquaporin 4 polarization.Treatment of digoxin rescued changes in glymphatic transport,white matter structure,and cognitive function.Suppression of glymphatic functions by treatment with the AQP4 inhibitor TGN-020 abolished this protective effect of digoxin from hypoperfusion injury.Our research yields new insight into the relationship between hemodynamics,glymphatic transport,white matter injury,and cognitive changes after chronic cerebral hypoperfusion. | Jie Cao Di Yao Rong Li Xuequn Guo Jiahuan Hao Minjie Xie Jia Li Dengji Pan Xiang Luo Zhiyuan Yu Minghuan Wang Wei Wang | 2022 | Neuroscience Bulletin2022，38，2： | 5 |
| 2 | Determination of the angular parameters in the general altitude-azimuth tracking angle formulas for a heliostat with a mirror-pivot offset based on experimental tracking data显示文摘 | Guo Minghuan Wang Zhifeng Zhang Jianhan eta| | 2012 | Solar Energy2012，86，3： | 1 |
| 3 | On the analysis of anelliptical Gaussian flux image and its equivalent circularGaussian flux images 显示文摘 | Guo Minghuan Wang Zhifeng | 2011 | Solar Energy2011，85，5： | 1 |
| 4 | Properties of a general azimuth-elevation tracking angle formula for a heliostat with a mirror-pivot offset and other angular errors 显示文摘 | Guo Minghuan Sun Feihu Wang Zhifeng | 2013 | Solar Energy2013，96，： | 1 |
| 5 | 载能离子辐照316L不锈钢的力学性能及微观结构表征显示文摘The 316L type austenitic stainless steel as main structural materials,are widely used for the fission reactors for more than 30 years.Besides,316L steel has been chosen as primary structural material for future advanced nuclear facility,such as fusion reactor and Accelerator Driven Subcritical(ADS)system[1].In this work,one set of the 316L steel specimens were irradiated with H and Heions to the doses of 1.01017 and 1.01018ioncm��2,at room temperature(RT)and 500℃,respectively.Another set of specimens with and without 100 ppm He pre-implantation were irradiated with Feions to the doses of 10,20 and 50 dpa at 450℃and 600℃,respectively. | Shen Tielong Jin Peng Zhu Yabin Cui Minghuan Wei Kongfang Chai Jianlong Guo Yawei Zhang Tongmin Li Jinyu Wang Zhiguang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 6 | MgAl_(2)O_(4)掺杂对ZTA-MgAl_(2)O_(4)复相陶瓷力学及热学性能影响显示文摘MgAl_(2)O_(4) is a very suitable reinforcing phase owing to the advantageous performance such as high melting point,high strength,high hardness,corrosion resistance and good thermal shock stability.In this paper,the effects of MgAl_(2)O_(4) addition on microstructure and mechanical properties of ZTA-MgAl_(2)O_(4) composite ceramics prepared by Spark Plasma Sintering(SPS)were investigated. | Guo Yawei Chai Jianlong Zhu Yabin Wei Kongfang Li Shufeng Shen Tielong Yao Cunfeng Cui Minghuan Wang Zhiguang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 7 | SiC含量对ZTA和ATZ复相陶瓷力学及热学性能的影响显示文摘Oxide/carbide composite ceramics were prepared by spark plasma sintering(SPS)usingα-Al2O3,ZrO2andβ-SiC powders as raw materials.The effects of SiC doping on the microstructure,mechanical and thermal properties of zirconia toughened alumina(ZTA)and alumina toughened zirconia(ATZ)based composites were investigated.Fig.1 shows the effect of SiC content on the mechanical properties of the complex phase ceramics.With the increase of SiC content,the bending strength of SiC-ATZ80mol%composite phase ceramics decreased from 992 to 761 MPa.The reason is that the thermal expansion mismatch between the SiC and the substrate induces thermal stress,resulting in the different shrinkage between the substrate and the SiC affecting its strength. | Chai Jianlong Guo Yawei Zhu Yabin Li Shufeng Shen Tielong Yao Cunfeng Cui Minghuan Wang Zhiguang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
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