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| 1 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 2 | In situ plasmonic optical fiber detection of the state of charge of supercapacitors for renewable energy storage显示文摘In situ and continuous monitoring of electrochemical activity is key to understanding and evaluating the operation mechanism and efficiency of energy storage devices.However,this task remains challenging.For example,the present methods are not capable of providing the real-time information about the state of charge(SOC)of the energy storage devices while in operation.To address this,a novel approach based on an electrochemical surface plasmon resonance(SPR)optical fiber sensor is proposed here.This approach offers the capability of in situ comprehensive monitoring of the electrochemical activity(the electrode potential and the SOC)of supercapacitors(used as an example).The sensor adopted is a tilted fiber Bragg grating imprinted in a commercial single-mode fiber and coated with a nanoscale gold film for high-efficiency SPR excitation.Unlike conventional“bulk”detection methods for electrode activity,our approach targets the“localized”(sub-μm-scale)charge state of the ions adjacent to the electrode interface of supercapacitors by monitoring the properties of the SPR wave on the fiber sensor surface located adjacent to the electrode.A stable and reproducible correlation between the real-time charge–discharge cycles of the supercapacitors and the optical transmission of the optical fiber has been found.Moreover,the method proposed is inherently immune to temperature cross-talk because of the presence of environmentally insensitive reference features in the optical transmission spectrum of the devices.Finally,this particular application is ideally suited to the fundamental qualities of optical fiber sensors,such as their compact size,flexible shape,and remote operation capability,thereby opening the way for other opportunities for electrochemical monitoring in various hard-to-reach spaces and remote environments. | Jiajie Lao Peng Sun Fu Liu Xuejun Zhang Chuanxi Zhao Wenjie Mai Tuan Guo Gaozhi Xiao Jacques Albert | 2018 | Light(Science & Applications)2018，7，1： | 8 |
| 3 | Narrow bandwidth fiber-optic spectral combs for renewable hydrogen detection显示文摘Hydrogen sensors are of great importance to detect leakage in time because the hydrogen-air mixture is highly flammable.Based on optical fiber-based configurations reported so far,using palladium coating only does not meet stringent performance targets,such as fast response time and limited deactivation caused by poisoning.Here,a palladium-gold alloy-coated optical fiber hydrogen sensor,i.e.,highly tilted fiber Bragg grating(TFBG),was proposed by using its narrow bandwidth cladding modes whose effective refractive index(ERI)extends to 1.0 where the gas measurement is possible,which led to faster specific hydrogen measurement response time(a shorter stabilization time during the association and dissociation phases less than 20s and 30s,respectively)and improved deactivation resistance(higher than 99%per test cycle).Meanwhile,the temperature cross-sensitivity can be eliminated via referencing the'target'spectral combs to the core mode.We are sure that this promising configuration extends research directions for rapid,repeatable and high deactivation-resistance in hydrogen gas detection. | Shunshuo CAI Fu LIU Runlin WANG Yongguang XIAO Kaiwei LI Christophe CAUCHETEUR Tuan GUO | 2020 | Science China(Information Sciences)2020，63，12： | 4 |
| 4 | High-sensitive and temperature-self-calibrated tilted fiber grating biological sensing probe显示文摘High sensitivity biological sample measurement has been achieved by using a 10° tilted fiber Bragg grating sensing probe. Human acute leukemia cells with different intracellular densities were clearly discriminated by identifying their slight refraction index (RI) perturbations in the range from 1.3342 to 1.3344, combining with a temperature self-calibration property. We studied the relationship between the intracellular density of cells (S50 and S60) and their RIs, the experimental results provide a potential way to verify the hypothesis for 'density alteration in non-physiological cells (DANCE)'. | LIU Fu GUO Tuan LIU JianGuo ZHU XiaoYang LIU Yu GUAN BaiOu ALBERT Jacques | 2013 | Chinese Science Bulletin2013，58，21： | 3 |
| 5 | Ultrasensitive detection of endocrine disruptors via superfine plasmonic spectral combs显示文摘The apparent increase in hormone-induced cancers and disorders of the reproductive tract has led to a growing demand for new technologies capable of detecting endocrine disruptors.However,a long-lasting challenge unaddressed is how to achieve ultrahigh sensitive,continuous,and in situ measurement with a portable device for infield and remote environmental monitoring.Here we demonstrate a simple-to-implement plasmonic optical fiber biosensing platform to achieve an improved light–matter interaction and advanced surface chemistry for ultrasensitive detection of endocrine disruptors.Our platform is based on a gold-coated highly tilted fiber Bragg grating that excites high-density narrow cladding mode spectral combs that overlap with the broad absorption of the surface plasmon for high accuracy interrogation,hence enabling the ultrasensitive monitoring of refractive index changes at the fiber surface.Through the use of estrogen receptors as the model,we design an estradiol–streptavidin conjugate with the assistance of molecular dynamics,converting the specific recognition of environmental estrogens(EEs)by estrogen receptor into surface-based affinity bioassay for protein.The ultrasensitive platform with conjugate-induced amplification biosensing approach enables the subsequent detection for EEs down to 1.5×10−3 ng ml−1 estradiol equivalent concentration level,which is one order lower than the defined maximal E2 level in drinking water set by the Japanese government.The capability to detect EEs down to nanogram per liter level is the lowest limit of detection for any estrogen receptor-based detection reported thus far.Its compact size,flexible shape,and remote operation capability open the way for detecting other endocrine disruptors with ultrahigh sensitivity and in various hard-toreach spaces,thereby having the potential to revolutionize environment and health monitoring. | Lanhua Liu Xuejun Zhang Qian Zhu Kaiwei Li Yun Lu Xiaohong Zhou Tuan Guo | 2021 | Light(Science & Applications)2021，10，10： | 2 |
| 6 | Tem-perature-independent tilted fiber grating vibration sensorbased on cladding-core recoupling显示文摘 | GUO Tuan IVANANOV A CHEN Cheng-kun | 2008 | Optics Letters2008，33，9： | 1 |
| 7 | Comparative evaluation of MSCs from bone marrow and adipose tissue seeded in PRP-derived scaffold for cartilage regeneration显示文摘 | Xuetao Xie Yang Wang Cunju Zhao Shangchun Guo Shen Liu Weitao Jia Rocky S. Tuan Changqing Zhang | 2012 | Biomaterials2012，，29： | 1 |
| 8 | Temperature-independent tilted fiber vibration sensor based on cladding-core recoupling显示文摘 | GUO Tuan IVANANOV A CHEN Cheng-kun | | 0，，09： | 1 |
| 9 | Polarization- maintaining fiber-optic-grating vector vibroscope显示文摘 | GUO Tuan SHANG Li-bin LIU Fu | 2013 | Optics Letters2013，38，4： | 1 |
| 10 | Polarimetric multi-mode tilted fiber grating sensors显示文摘 | GUO Tuan LIU Fu 'GUAN Bai-ou | 2014 | Optics Express2014，22，6： | 1 |
| 11 | A ro- bust and compact fiber Bragg grating vibration sensor for seismic measurement显示文摘 | WENG Yin-yan QIAO Xue-guang GUO Tuan | 2011 | IEEE Sensors Journal2011，12，4： | 1 |
| 12 | Temperature insensitive fiber Bragg grating liquid-level sensor based on bending cantilever beam显示文摘 | GUO Tuan ZHAO Qida DOU Qingying | 2005 | IEEE Photonics Technology Letters2005，17，11： | 1 |
| 13 | Beneficial effect of SPM-5185, a cysteine-containing nitric oxide donor, in rat carotid artery intimal injury显示文摘 | Guo JP Milhoan KA Tuan RS | 1994 | Circ Res1994，75，： | 1 |
| 14 | Temperature-calibrated fiber-optic refractometer based on a compact FBG-SMS structure 显示文摘 | Rong Qiangzhou Qiao Xueguang Guo Tuan | 2012 | Chinese Optics Letters2012，10，03： | 1 |
| 15 | Tem- perature-independent tilted fiber grating vibration sensor based on cladding-core recoupling 显示文摘 | GUO Tuan VAMPV A CHEN Cheng-kun | 2008 | Optics Letters2008，38，9： | 1 |
| 16 | Tilted fiber grating accelerometer incorporating an abrupt biconical taper for cladding to core recouping显示文摘 | Tuan Guo Li yang Shao Hwa-Yaw Tam | 2009 | Optics Express2009，17，20： | 1 |
| 17 | Toughening ceramics with both ceramicand metallic inclusious显示文摘 | TUAN W H GUO J K | 2001 | Key Engineering Materials2001，，： | 1 |
| 18 | Temperature-insensitive fiber Bragg grating force sensor via a bandwidth modulation and optical power detection technique显示文摘 | GUO Tuan ZHAO Qi-da ZHANG Hao | 2006 | Journal of Lightwave Tech- nology2006，24，10： | 1 |
| 19 | Mach-Ze-hnder interferometer based on a sandwich fiber structureof refractive index measurement显示文摘 | MA Yue QIAO Xue-guang GUO Tuan | 2012 | IEEE Sensors Jour-nal2012，12，6： | 1 |
| 20 | Clini- cal diagnosis for discogenic low back pain 显示文摘 | ZHANG Yin - gang GUO Tuan - mao XIONG Guo | 2009 | Int J Biol Sci2009，5，7： | 1 |
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