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| 1 | Numerical Study on Heat Transfer and Flow Characteristics for Laminar Flow in a Circular Tube with Swirl Generators显示文摘This study investigated the heat transfer and flow characteristics of one kind of swirlgenerator in a circular heat exchanger tube through a numericalsimulation. The swirlflow induced by this type of swirlgenerator can obtain a high heat transfer rate with minimalpressure drop penalty. The simulations were carried out to understand the physicalbehavior of this kind of mesoscale heat enhancement component. By visualizing the heat transfer and flow characteristics, it is found that the swirlflow is induced by swirlgenerator in the circular tube couples with the impinging jet effect. After passing through the swirlgenerator, the localfriction factor of liquid can quickly return to lower levelmore quickly, while the localNusselt number maintains higher values for a distance; thus, the evaluation criterion of localperformance is improved. Single-factor optimization is used for three geometric parameters, i.e., the angle of swirlgenerator(25o, 45o, and 60o), the length of swirlgenerator(0.005, 0.01, and 0.02 m), and the center rod radius(1, 2, and 3 mm). The optimum parameters of the swirlgenerator for laminar flow of air in a circular tube are obtained, which should be 60o, 0.005 m, and 3 mm, respectively. | Yongli Sun Guobin Wen Xiaoming Xiao Bohua Ren Na Yang Luhong Zhang | 2018 | Transactions of Tianjin University2018，24，3： | 1 |
| 2 | Regulating ethane and ethylene synthesis by proton corridor microenvironment for CO_(2) electrolysis显示文摘Electrocatalytic reduction of carbon dioxide is one of the most effective strategies to achieve carbon neutrality and energy sustainability.Although high-value multi-carbon products have been widely studied,limited electrocatalysts have been reported for the selective conversion of ethane.More importantly,the factors tuning the selectivity between ethane and ethylene have not been clarified.Here,Zn@Cu nanowire arrays(Zn@Cu-NWAs) catalyst is proposed to stimulate the maintenance of efficient CO_(2)-to-C_(2)H_(6) conversion at high current densities.Meanwhile,in order to investigate the factors affecting the interconversion between ethane and ethylene,the counterpart catalyst that facilitates C–C coupling to ethylene was also synthesized.Time-of-flight secondary-ion mass spectroscopy(TOF-SIMS),in-situ Raman spectroscopy,and simulation results show that Zn@Cu-NWAs can provide a localized proton corridor environment for the formation of ethane,accelerating the further proton-coupled CO_(2) reduction reaction(CO_(2)RR)kinetics.Hence,this catalyst delivered an ethane Faraday efficiency of over 65% at-1.14 V vs.RHE with a total current density of 142.3 mA/cm^(2).This work provides a new perspective on regulating the local microenvironment to modify the selectivity of multi-carbon products. | Xiaowen Zhang Bohua Ren Hao Li Shuxuan Liu Haoyang Xiong Silong Dong Yifan Li Dan Luo Yi Cui Guobin Wen Xin Wang | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 3 | Injectable silk sericin scaffolds with programmable shape-memory property and neuro-differentiation-promoting activity for individualized brain repair of severe ischemic stroke显示文摘Severe ischemic stroke damages neuronal tissue,forming irregular-shaped stroke cavities devoid of supporting structure.Implanting biomaterials to provide structural and functional support is thought to favor ingrowth of regenerated neuronal networks.Injectable hydrogels capable of in situ gelation are often utilized for stroke repair,but challenged by incomplete gelation and imprecise control over end-macrostructure.Injectable shape-memory scaffolds might overcome these limitations,but are not explored for stroke repair.Here,we report an injectable,photoluminescent,carbon-nanotubes-doped sericin scaffold(CNTs-SS)with programmable shape-memory property.By adjusting CNTs’concentrations,CNTs-SS′recovery dynamics can be mathematically calculated at the scale of seconds,and its shapes can be pre-designed to precisely match any irregular-shaped cavities.Using a preclinical stroke model,we show that CNTs-SS with the customized shape is successfully injected into the cavity and recovers its pre-designed shape to well fit the cavity.Notably,CNTs-SS’near-infrared photoluminescence enables non-invasive,real-time tracking after in vivo implantation.Moreover,as a cell carrier,CNTs-SS not only deliver bone marrow mesenchymal stem cells(BMSCs)into brain tissues,but also functionally promote their neuronal differentiation.Together,we for the first time demonstrate the feasibility of applying injectable shape-memory scaffolds for stroke repair,paving the way for personalized stroke repair. | Jian Wang Xiaolin Li Yu Song Qiangfei Su Xiakeerzhati Xiaohalati Wen Yang Luming Xu Bo Cai Guobin Wang Zheng Wang Lin Wang | 2021 | Bioactive Materials2021，6，7： | 0 |
| 4 | Proteomic and phosphoproteomic analysis reveal threonine deficiency increases hepatic lipid deposition in Pekin ducks via reducing STAT phosphorylation显示文摘Dietary threonine(Thr)deficiency enhances triglyceride(TG)deposition in the liver of Pekin ducks,which injures hepatic function and impairs growth performance.However,the underlying molecular mechanisms remain unclear.In the present study,we investigated the effects of dietary Thr deficiency on the expressions of proteins and phosphoproteins in liver of Pekin ducks,to identify the underlying molecular changes.A total of 300 one-day-old ducklings were divided into 3 groups with 10 replicates of 10 birds.All ducks were fed corn-wheat-peanut meal diets containing 0.46%,0.71%,and 0.96%Thr,respectively,from 1 to 21 days of age.Growth performance,serum parameters,hepatic TG content,and expression of genes involved in lipid metabolism of Pekin ducks were determined.A Thr deficiency group(Thr-D,0.46%Thr)and a Thr sufficiency group(Thr-S,0.71%Thr)were selected for subsequent proteomic and phosphoproteomic analysis.The results showed that Thr-D reduced the growth performance(P<0.001),and increased the plasma concentrations of cholesterol,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,and hepatic TG(P<0.05).Thr-D increased gene expression related to fatty acid and TG synthesis(P<0.05).A total of 176 proteins and 259 phosphosites(containing 198 phosphoproteins)were observed to be differentially expressed as a result of Thr-D.The upregulated proteins were enriched in the pathway related to amino acid metabolism,peroxisome.The down-regulated proteins were enriched in linolenic and arachidonic acid metabolism,and the Janus kinase-signal transducer and activator of transcription(JAK-STAT)signaling pathway.The upregulated phos-phoproteins were enriched in the pathways related to fatty acid biosynthesis,fructose and mannose metabolism,and glycolysis/gluconeogenesis.Thr-D reduced the phosphorylation of STAT1 at S729 and STAT3 at S728,and expression of STAT5B.In contrast,Thr-D increased non-receptor tyrosine-protein kinase(TYK2)expression and STAT1 phosphorylation at S649.Taken together,dietary Thr-D increased hepatic TG accumulation by upregulating the expression of genes and proteins,and phosphoproteins related to fatty acid and triglyceride synthesis.Furthermore,these processes might be regulated by the JAK-STAT signaling pathway,especially the phosphorylation of STAT1 and STAT3. | Yong Jiang Zhong Zhuang Wenqia Jia Zhiguo Wen Ming Xie Hao Bai Yulin Bi Zhixiu Wang Guobin Chang Shuisheng Hou Guohong Chen | 2023 | Animal Nutrition2023，，2： | 0 |
| 5 | Ratiometric fluorescent Si-FITC nanoprobe for immunoassay of SARS-CoV-2 nucleocapsid protein显示文摘Coronavirus disease 2019(COVID-19)highlights the importance of rapid and reliable diagnostic assays for the management of virus transmission.Here,we developed a one-pot hydrothermal method to prepare Si-FITC nanoparticles(NPs)for the fluorescent immunoassay of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)nucleocapsid protein(N protein).The synthesis of Si-FITC NPs did not need post-modification,which addressed the issue of quantum yield reduction during the coupling reaction.Si-FITC NPs showed two distinct peaks,Si fluorescence atλem=385 nm and FITC fluorescence atλem=490 nm.In the presence of KMnO_(4),Si fluorescence was decreased and FITC fluorescence was enhanced.Briefly,in the presence of N protein,catalase(CAT)-linked secondary antibody/reporter antibody/N protein/capture antibody immunocomplexes were formed on microplates.Subsequently,hydrogen peroxide(H_(2)O_(2))and Si-FITC NPs/KMnO_(4)were injected into the microplate together.The decomposition of H_(2)O_(2)by CAT resulted in remaining of KMnO_(4),which changed the fluorescence intensity ratio of Si-FITC NPs.The fluorescence intensity ratio correlated significantly with the N protein concentration ranging from 0.02 to 50.00 ng/mL,and the detection limit was 0.003 ng/mL,which was more sensitive than the commercial ELISA kit with a detection limit of 0.057 ng/mL.The N protein concentration can be accurately determined in human serum.Furthermore,the COVID-19 and non-COVID-19 patients were distinguishable by this method.Therefore,the ratiometric fluorescent immunoassay can be used for SARS-CoV-2 infection diagnosis with a high sensitivity and selectivity. | Guobin Mao Silu Ye Wen Yin Yang Yang Xinghu Ji Jin He Yingxia Liu Junbiao Dai Zhike He Yingxin Ma | 2023 | Nano Research2023，16，2： | 0 |
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