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| 1 | Current protective strategies in liver surgery显示文摘During liver resection surgery for cancer or liver transplantation,the liver is subject to ischaemia (reduction in blood flow) followed by reperfusion (restoration of blood flow),which results in liver injury [ischemiareperfusion (IR) or IR injury]. Modulation of IR injury can be achieved in various ways. These include hypothermia,ischaemic preconditioning (IPC) (brief cycles of ischaemia followed by reperfusion of the organ before the prolonged period of ischaemia i.e. a conditioning response),ischaemic postconditioning (conditioning after the prolonged period of ischaemia but before the reperfusion),pharmacological agents to decrease IR injury,genetic modulation of IR injury,and machine perfusion (pulsatile perfusion). Hypothermia decreases the metabolic functions and the oxygen consumption of organs. Static cold storage in University of Wisconsin solution reduces IR injury and has prolonged organ storage and improved the function of transplanted grafts. There is currently no evidence for any clinical advantage in the use of alternate solutions for static cold storage. Although experimental data from animal models suggest that IPC,ischaemic postconditioning,various pharma-cological agents,gene therapy,and machine perfusion decrease IR injury,none of these interventions can be recommended in clinical practice. This is because of the lack of randomized controlled trials assessing the safety and efficacy of ischaemic postconditioning,gene therapy,and machine perfusion. Randomized controlled trials and systematic reviews of randomized controlled trials assessing the safety and efficacy of IPC and various pharmacological agents have demonstrated biochemical or histological improvements but this has not translated to clinical benefit. Further well designed randomized controlled trials are necessary to assess the various new protective strategies in liver resection. | Kurinchi S Gurusamy Hector D Gonzalez Brian R Davidson | 2010 | World Journal of Gastroenterology2010，16，48： | 7 |
| 2 | Physical chemical and biological characterization of a new bacteriocin produced by Bacillus cereus NS02显示文摘Objective:To screen the bacteriocinogenic isolate from buffalo milk and to characterize it on physical,chemical and biological aspects for the application in biopreservation.Methods:Bacillus cereus(B.cereus)was isolated and assessed for its baceteriocinogenic activity.Bacteriocin was produced and purified by ammonium sulphate precipitation,dialysis and gel filtration chromatography.Purified bacteriocin was used to clieck its antimicrobial activity against food borne bacteria.Effect and stability of bacteripcin was determined with the respect to temperature,pH,enzymes,organic solvents and chemicals.Bacteriocin was also subjected to SDS PAGE analysis to determine its molecular weight.In addition,functional groups exist in the bacteriocin was determined by FTIR analysis.Results:B.cereus was identified by 16S rRNA sequence analysis.Bacteriocin showed increased activity against all the bacteria used and its activity unit was found to be 51,200 AU/mL.It was stable to high temperature(100℃)and wide range of pH(3-10),sensitive to proteolytic enzymes and resistant to nonprotcolytic enzymes.It was low molecular weight(3.5-6 kDa)protein and FTIR study revealed the presence of amide group and NH stretching,Conclusions:Bacteriocin produced in this study possesses the highest antimicrobial activity against both gram positive and gram negative bacteria thereby it has immense application as biopreservative agent.FTIR proved its peptide nature. | Senbagam D Gurusamy R Senthilkumar B | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，12： | 4 |
| 3 | Routine abdominal drainage versus no abdominal drainage for uncomplicated laparoscopic cholecystectomy显示文摘 | Gurusamy KS Koti R Davidson BR | 2013 | Cochrane Database Syst Rev2013，9，00： | 1 |
| 4 | Incidence of fracture healing complications after femoral neck fractures 显示文摘 | PARKER M J RAGHAVAN R GURUSAMY K | 2007 | Clin Orthop Relat Res2007，，458： | 1 |
| 5 | T-tube drainage versus primary closure after open common bile duct explora- tion 显示文摘 | GURUSAMY K S KOTI R DAVIDSON B R | 2013 | Cochrane Database Syst Rev2013，21，00： | 1 |
| 6 | Abdominal lift forlaparoscopic cholecystectomy 显示文摘 | GURUSAMY KS KOTI R DAVIDSON BR | 2013 | Cochrane Database SystRev2013，31，00： | 1 |
| 7 | Role of14-3-3 protein and oxidative stress in diabetic cardiomyopa-thy显示文摘 | anabe K Thandavarayan R A Gurusamy N | 2009 | Acta Physiol Hung2009，96，3： | 1 |
| 8 | Somatostatin analogues for pancreatic surgery显示文摘 | Gurusamy KS Koti R Fusai G | | 0，，： | 1 |
| 9 | Incidence of fracture- healing complications after femoral neck fractures显示文摘 | Parker M J Raghavan R Gurusamy K | 2007 | Clin Orthop Relat Res2007，458，： | 1 |
| 10 | Incidence of fracturehealing complications after femoral neck fractures显示文摘 | Parker MJ Raghavan R Gurusamy K | | 0，，458： | 1 |
| 11 | Incidence of fracture- healing complications after femoral neck fractures 显示文摘 | Parker MJ Raghavan R Gurusamy K | 2007 | Clin Orthop Relat Res2007，458，： | 1 |
| 12 | Incidence of frac- ture-healing complications after femoral neck fractures 显示文摘 | Parker MJ Raghavan R Gurusamy K | 2007 | Clin Orthop Relat Res2007，，458： | 1 |
| 13 | Harmonic Optimization by Single Phase Improved Power Quality AC-DC Power Factor Corrected Converters显示文摘 | Balamurugan R Gurusamy G | | 0，，05： | 1 |
| 14 | Incidence of fracture-healing complications after femoral neck fractures显示文摘 | Parker M I Raghavan R Gurusamy K | 2007 | Clin Orthop Relat Res2007，458，： | 1 |
| 15 | T-tube drainage versus primary closure after laparoscopic common bile duct exploration显示文摘 | Gurusamy KS Koti R Davidson BR | 2013 | Cochrane Database Syst Rev2013，6，00： | 1 |
| 16 | Methods of preventing bacte- rial sepsis and wound complications for liver transplantation 显示文摘 | Gurusamy K S Kumar Y Davidson B R | 2008 | Co- chrane Database Syst Rev2008，，00： | 1 |
| 17 | Assessment of genetic and functional diversity of phosphate solubilizing fluorescent pseudomonads isolated from rhizospheric soil显示文摘 | Popavath R N Gurusamy R Kannan B N | 2008 | BMC Microbiology2008，8，： | 1 |
| 18 | T-tube drainage versus no T-tube drainage after open common bile duct exploration 显示文摘 | Gurusamy K Koti R Davidson BR | 2013 | 2013，，： | 1 |
| 19 | T-tube drainage versus primary closure after laparoscopic common bile duct exploration显示文摘 | Gurusamy KS Koti R Davidson BR | 2013 | Cochrane Database Syst Rev2013，6，00： | 1 |
| 20 | Postoperative adhesive intestinal obstruction: the role of intestinal setenting显示文摘 | Valkodai RR Gurusami R Duraisami V | 2012 | J Indian Assoc Pediatr Surg2012，17，1： | 1 |
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