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| 1 | Noninvasive assessment of liver damage in chronic hepatitis B显示文摘AIM:To evaluate the efficacy of the aspartate aminotransferase/platelet ratio index(APRI)and neutrophillymphocyte(N/L)ratio to predict liver damage in chronic hepatitis B(CHB).METHODS:We analyzed 89 patients diagnosed with CHB by percutaneous liver biopsy and 43 healthy subjects.Liver biopsy materials were stained with hematoxylin-eosin and Masson’s trichrome.Patients’fibrosis scores and histological activity index(HAI)were calculated according to the Ishak scoring system.Fibrosis score was recognized as follows:F0-1 No/early-stage fibrosis,F2-6 significant fibrosis,F0-4 non-cirrhotic and F5-6 cirrhotic.Significant liver fibrosis was defined as an Ishak score of≥2.APRI and N/L ratio calculation was made by blood test results.RESULTS:The hepatitis B and control group showed no difference in N/L ratios while there was a significant difference in terms of APRI scores(P<0.001).Multiple logistic regression analysis revealed that the only independent predictive factor for liver fibrosis in CHB was platelet count.APRI score was significantly higher in cirrhotic patients than in non-cirrhotic patients.However,this significance was not confirmed by multiple logistic regression analysis.The optimum APRI score cut-off point to identify patients with cirrhosis was 1.01with sensitivity,specificity,positive predictive value and negative predictive value of 62%(36%-86%),74%(62%-83%),29%(13%-49%)and 92%(82%-97%),respectively.In addition,correlation analyses revealed that N/L ratio has a negative and significant relationship with HAI(r=-0.218,P=0.041).CONCLUSION:N/L ratio was negatively correlated with HAI.APRI score may be useful to exclude cirrhosis in CHB patients. | Mehmet Celikbilek Serkan Dogan Sebnem Gursoy Gokmen Zararsιz Alper Yurci Omer Ozbakιr Kadri Guven Mehmet Yucesoy | 2013 | World Journal of Hepatology2013，5，8： | 5 |
| 2 | Genetic determinants of biofilm development of opaque and translucent Vibrio parahaemolyticus显示文摘 | Enos-Berlage J L Guvener Z T Keenan C E | 2005 | Mol Microbiol2005，55，11： | 1 |
| 3 | Thiopentone and etomidate concentrations in maternal and umbilical plasma,and in colostrum显示文摘 | Esener Z Sarihasan B Guven H | 1992 | Br J Anaesth1992，69，： | 1 |
| 4 | Results of intravitreal triameinolone aeetonide in patients with maeular edema secondary to branch retinal vein occlusion 显示文摘 | DEMIR M OBA E GUVEN D ACAR Z CINAR S | 2014 | Int J Clin Pharm2014，36，2： | 1 |
| 5 | When should we per-form prophylactic antibiotics in elective cesarean cases?显示文摘 | Yildirim G Gungorduk K Guven H Z | 2009 | Arch Gy-necol Obstet2009，280，1： | 1 |
| 6 | Thin Film Thickness Determination with Neutron Activation Analysis显示文摘 | C S Ozben F Z Tepehan H H Guven | 2001 | Applied Radiation and Isotopes2001，55，1： | 1 |
| 7 | Genetic determinants of biofilm development of opaque and translucent Vibrio parahaemolyticus 显示文摘 | Enos-Berlage J L Guvener Z T Keenan C E | 2005 | Mol Microbiol2005，55，： | 1 |
| 8 | Conventional chiller performances simulation and field data显示文摘 | Beyene A Guven H Jawdat Z | 1994 | International Journal of Energy Research1994，18，3： | 1 |
| 9 | Protective effects of tadalafil on experimental spinal cord injury in rats 显示文摘 | Serarslan Y YSnden Z 0zgiray E Oktar S Guven E O Sogut S Yilmaz N Yurtseven T | 2010 | Journal of Clinical Neuroseience2010，17，3： | 1 |
| 10 | Health-related quality of life in patients with myofascial pain syndrome显示文摘 | Celiker R Atalay A Guven Z | 2010 | Curr Pain Headache Rep2010，14，5： | 1 |
| 11 | Usefulness of admission red cell distribution width as a predictor of early mortality in patients with acute pulmonary embolism 显示文摘 | All Z Gokhan B Guven FMK | 2012 | Am J Cardiol2012，109，： | 1 |
| 12 | The effects of daily alendronate, daily calcitonin and alendronate every other day on bone mineral density in osteoporotic men 显示文摘 | Guven Z Karadag-Saygi E Unlu-Ozkan F | 2007 | Aging Male2007，10，4： | 1 |
| 13 | The effects of daily alendronate,daily calcitonin and alendronate every other day on bone mineral density in osteoporotic men显示文摘 | Guven Z Karadag-Saygi E Unlu-Ozkan F | 2007 | Aging Male2007，10，： | 1 |
| 14 | Concomitant rotator cuff tear and brachial plexus injury in association with anterior shoulder dislocation:unhappy triad of the shoulder显示文摘 | Akbar Z Yalcin S | 1994 | J Orthop Trauma1994，8，： | 1 |
| 15 | Multiple regulators control capsular polysaccharide production in Vibrio parahaemolyticus显示文摘 | Guvener Z T McCarter L L | 2003 | J Bacteriol2003，185，： | 1 |
| 16 | Multiple regulators control capsu-lar polysaccharide production in Vibrio parahaemolyticus显示文摘 | Guvener Z T McCarter L L | | 0，，18： | 1 |
| 17 | Pulmonary involvement in sea-blue histiocytosis 显示文摘 | Gunay E Firat Guven S Aktas Z | 2012 | Tuberk Toraks2012，60，2： | 1 |
| 18 | Evaluation of Mulli- gan's technique for adhesive capsulitis of the shoulder显示文摘 | Doner G Guven Z Atalay A | 2013 | J Rehabil Med2013，45，1： | 1 |
| 19 | When should we perform prophylactic antibiotics in elective cesarean cases显示文摘 | Yildirim G Gungorduk K Guven H Z | | 0，，1： | 1 |
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