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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Potent antitumor efficacy of an E1B 55kDa-deficient adenovirus carrying murine endostatin in hepatocellular carcinoma显示文摘 | Li G Sham J Yang J Su C Xue H Chua D Sun L Zhang Q Cui Z Wu M Qian Q | 2005 | 第二军医大学学报2005，26，11： | 9 |
| 3 | Pyrrolidine dithiocarbamate reduces ischemia-reperfusion injury of the small intestine显示文摘AIM: To evaluate whether pyrrolidine dithiocarbamate (PDTC), an enhancer of HO production, attenuates intestinal IR injury.METHODS: Eighteen male rats were randomly allocated into three groups: (a) sham; (b) IR, consisting of 30 min of intestinal ischemia, followed by 2-h period of reperfusion; and (c) PDTC treatment before IR. Intestinal microvascular perfusion (IMP) was monitored continuously by laser Doppler fiowmetry. At the end of the reperfusion, serum samples for lactate dehydrogenase (LDH) levels and biopsies of ileum were obtained. HO activity in the ileum was assessed at the end of the reperfusion period.RESULTS: At the end of the reperfusion in the IR group,IMP recovered partially to 42.5% of baseline (P<0.05vs sham), whereas PDTC improved IMP to 67.3% of baseline (P<0.01 vs IR). There was a twofold increase in HO activity in PDTC group (2 062.66±106.11) as compared to IR (842.3±85.12) (P<0.001). LDH was significantly reduced (P<0.001) in PDTC group (585.6±102.4)as compared to IR group (1 973.8±306.5). Histological examination showed that the ileal mucosa was significantly less injured in PDTC group as compared with IR group.CONCLUSION: Our study demonstrates that PDTC improves the IMP and attenuates IR injury of the intestine possibly via HO production. Additional studies are warranted to evaluate the clinical efficacy of PDTC in the prevention of IR injury of the small intestine. | Ismail H Mallick Wen-Xuan Yang Marc C Winslet Alexander M Seifalian | 2005 | World Journal of Gastroenterology2005，11，46： | 8 |
| 4 | Establishment and Applications of Epstein-Barr Virus-based Episomal Vectors in Human Embryonic Stem Cells显示文摘 | Ren C Zhao M Yang X Li D Jiang X Wang L Shan W Yang H Zhou L Zhou W Zhang H | 2006 | 中国生物学文摘2006，20，7： | 4 |
| 5 | Models and algorithms for road network design:A review and some new developments显示文摘 | YANG H BELL M G H | 1998 | Transport Review1998，18，3： | 2 |
| 6 | Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling显示文摘 | Min J H Yang H Ivan M | 2002 | Science2002，296，5574： | 2 |
| 7 | Sliding mode motion control of nonholonomic mobile robots显示文摘 | Yang J M Kim J H | 1999 | IEEE Transactions on Robotics and Automation1999，15，3： | 2 |
| 8 | Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study显示文摘 | Hongjie Yu Joseph T Wu Benjamin J Cowling Qiaohong Liao Vicky J Fang Sheng Zhou Peng Wu Hang Zhou Eric H Y Lau Danhuai Guo Michael Y Ni Zhibin Peng Luzhao Feng Hui Jiang Huiming Luo Qun Li Zijian Feng Yu Wang Weizhong Yang Gabriel M Leung | 2013 | The Lancet2013，，： | 2 |
| 9 | 深部地球条件下铁和氧元素的化学变化显示文摘氧与铁分别为地球上丰度最高的元素与占地球质量最大的元素,它们所形成的化合物遍布我们的星球,具有-2价的氧控制着地球的氧逸度,随着深度的增加氧逸度逐渐降低,与铁所形成的氧化物中铁的价态也逐渐降低,O/Fe逐渐增加,近些年来科学家们发现深部地球条件下铁的一系列氧化物,其中具有高压黄铁矿结构的铁超氧化物FeO2具有最高的O/Fe,并且它还能够携带一定量的H(表示为Py-FeO2H,, x=0-1)。 | 夏群科 Liu J Hu Q Y Bi W L Yang L X Xiao Y M Chow P Meng Y.Prakapenka V B Mao H K Mao W L | 2019 | 矿物岩石地球化学通报2019，38，3： | 2 |
| 10 | Monoallelically expressed gene related to p53 at 1p36,a region frequently deleted in neuroblastoma and other human cancer显示文摘 | Kaghad M Bonnet H Yang A | | 0，，： | 2 |
| 11 | Visual analysis of the flow behavior of core material in a fork portion of plastic sandwich injection molding显示文摘 | W M Yang H Yokoi | 2003 | Polymer Test2003，22，1： | 2 |
| 12 | Electronic structure and optical properties of the Co-doped anatase TiO2 studied from first principles 显示文摘 | Weng H M Yang X P Dong J M | 2004 | Phys Rev2004，69，12： | 1 |
| 13 | Glioma Grading; Sensitivity, Speceficity,and Predictive Values of Perfusion MR Imaging and Proton MR Spectroscopic Imaging Compared with Conventional MR Imaging显示文摘 | Law M Yang S Wang H | 2003 | AJNR2003，24，8： | 1 |
| 14 | An integrated, multi-lot-size production inventory model for deteriorating item 显示文摘 | Yang P C Wee H M | 2003 | Computers and Operations Research2003，30，： | 1 |
| 15 | Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancer显示文摘 | Bonnet H Yang A | 1997 | Cell1997，90，4： | 1 |
| 16 | An integrated multi-lot-size production inventory model for deteriorating item显示文摘 | WEE H M | 2003 | Computer & Operations research2003，30，： | 1 |
| 17 | Inequalities for eigenvalues of a clamped plate problem显示文摘 | Cheng Q M Yang H C | 2006 | Trans Amer Math Soc2006，358，6： | 1 |
| 18 | Airborne hyperspectral imagery and linear spectral unmixing for mapping variation in corp yield显示文摘 | Cheng hai Yang James H Everitt Joe M Bradford | 2007 | Precision Agric2007，8，： | 1 |
| 19 | The Effect of an External Electric Field on the Structure Of Liquid Water Using Molecular Dynamics Simulations 显示文摘 | Jung D H Yang J H Jhon M S | 1999 | Chemical Physics1999，244，23： | 1 |
| 20 | Efficient Agrobactetium tumefaciens-mediated transformation of soybeans using an embryonic tip regeneration system显示文摘 | Liu H K Yang C Wei Z M | 2004 | Planta2004，219，： | 1 |
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