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| 1 | Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors显示文摘 | Jing Liao Zhao Wu Ying Wang Lu Cheng Chun Cui Yuan Gao Taotao Chen Lingjun Rao Siye Chen Nannan Jia Huiming Dai Shunmei Xin Jiuhong Kang Gang Pei Lei Xiao | 2008 | Cell Research2008，18，5： | 61 |
| 2 | A critical role of IFNγ in priming MSC-mediated suppression of T cell proliferation through up-regulation of BT-H1显示文摘 | Huiming Sheng | 2008 | Cell Research2008，18，8： | 55 |
| 3 | U-Pb zircon age of the foliated garnet-bearing granites in western Dabie Mountains,Central China显示文摘U-Pb zircon dating on two foliated garnet-bearing granite samples in the western Dabie ultra-high-pressure (UHP) metamorphic unit yields concordant ages of (234±4) Ma and (227±5) Ma, respectively. These ages, following the UHP peak metamorphism, represent the magma emplacement ages for the foliated garnet-bearing granites. This, for the first time, shows that there are the Triassic granites in the Dabie Mountains. The foliated garnet-bearing granites resemble A-type granite in geochemical characteristics, indicating that they were formed in exten-sional geodynamic setting. The magma formation reflects a reheating event in the Dabie orogenic belt and it enhances the transfer of tectonic regime from collision into extension and promotes the rapid exhumation into lower crust for the UHP metamorphic rocks. | ZHANG Hongfei ZHONG Zengqiu GAO Shan ZHANG Benren LI Huiming | 2001 | Chinese Science Bulletin2001，46，19： | 25 |
| 4 | Amplitudes, rates, periodicities and causes of temperature variations in the past 2485 years and future trends over the central-eastern Tibetan Plateau显示文摘Amplitudes, rates, periodicities, causes and future trends of temperature variations based on tree rings for the past 2485 years on the central-eastern Tibetan Plateau were analyzed. The results showed that extreme climatic events on the Plateau, such as the Medieval Warm Period, Little Ice Age and 20th Century Warming appeared synchronously with those in other places worldwide. The largest amplitude and rate of temperature change occurred during the Eastern Jin Event (343-425 AD), and not in the late 20th century. There were significant cycles of 1324 a, 800 a, 199 a, 110 a and 2-3 a in the 2485-year temperature series. The 1324 a, 800 a, 199 a and 110 a cycles are associated with solar activity, which greatly affects the Earth surface temperature. The long-term trends (>1000 a) of temperature were controlled by the millennium-scale cycle, and amplitudes were dominated by multi-century cycles. Moreover, cold intervals corresponded to sunspot minimums. The prediction indicated that the temperature will decrease in the future until to 2068 AD and then increase again. | LIU YU CAI QiuFang SONG HuiMing AN ZhiSheng Hans W. LINDERHOLM | 2011 | Chinese Science Bulletin2011，56，28： | 23 |
| 5 | Similarity criteria and coal-like material in coal and gas outburst physical simulation显示文摘 | Bo Zhao Guangcai Wen Haitao Sun Dongling Sun Huiming Yang Jie Cao Linchao Dai Bo Wang | 2018 | International Journal of Coal Science & Technology2018，5，2： | 17 |
| 6 | An ACC Oxidase Gene Essential for Cucumber Carpel Development显示文摘在植物的性决心产生便于 outcrossing 并且提高基因差异的单性的花。在黄瓜和甜瓜,乙烯支持心皮开发并且逮捕雄蕊开发。五性决心基因被识别了,包括四个编码在乙烯生合成催化限制率的步骤的 1-aminocyclopropane-1-carboxylate (ACC ) synthase,和抄写因素基因在甜瓜对应于孟德尔的地点 gynoecious 并且是女性的一个否定管理者的 CmWIP1。ACC oxidase (ACO ) 把 ACC 变换成乙烯;然而,它留下逃犯在黄瓜染色体的基因为性决心是它 ACO 并且怎么批评的 CmWIP1 镇压女花的开发。在这研究,我们在 ACO 基因发现了那个变化, CsACO2,在忍受仅仅男的花的黄瓜授与 androecy。变化破坏 CsACO2 的酶的活动,导致从射击尖端的 50% 更少的乙烯排放。CsACO2 在心皮 primordia 被表示,它的表示为性决心在关键阶段在女花与 CsACS11 的重叠了,大概提供为合适的 CsACS2 要求的足够的乙烯表示。CmACO3, CsACO2 的 ortholog,在心皮区域显示出一个类似的表示模式,建议 CsACO2/CmACO3 的保存功能。我们表明了那 CsWIP1, CmWIP1 的 ortholog,能直接绑 CsACO2 的倡导者并且镇压它的表示。一起拿,我们建议由 WIP1 抄写因素和 ACO 组成的一个大概保存的规章的模块在黄瓜和甜瓜控制单性的花开发。 | Huiming Chen Jinjing Sun Shuai Li Qingzhi Cui Huimin Zhang Fengjiao Xin Huaisong Wang Tao Lin Dongli Gao Shenhao Wang Xia Li Donghui Wang Zhonghua Zhang Zhihong Xu Sanwen Huang | 2016 | Molecular Plant2016，9，9： | 16 |
| 7 | Epigenetic regulation in plant abiotic stress responses显示文摘In eukaryotic cells,gene expression is greatly influenced by the dynamic chromatin environment.Epigenetic mechanisms,including covalent modifications to DNA and histone tails and the accessibility of chromatin,create various chromatin states for stress-responsive gene expression that is important for adaptation to harsh environmental conditions.Recent studies have revealed that many epigenetic factors participate in abiotic stress responses,and various chromatin modifications are changed when plants are exposed to stressful environments.In this review,we summarize recent progress on the cross-talk between abiotic stress response pathways and epigenetic regulatory pathways in plants.Our review focuses on epigenetic regulation of plant responses to extreme temperatures,drought,salinity,the stress hormone abscisic acid,nutrient limitations and ultraviolet stress,and on epigenetic mechanisms of stress memory. | Ya-Nan Chang Chen Zhu Jing Jiang Huiming Zhang Jian-Kang Zhu Cheng-Guo Duan | 2020 | Journal of Integrative Plant Biology2020，62，5： | 14 |
| 8 | Progress in the stratigraphy and geochronology of the Shuidonggou site,Ningxia,North China显示文摘In the past years we carried out further stratigraphy division in field and it is found that rich stone artifacts can be found in fluvial-shallow lake-alluvial sediments on the terrace Ⅱ of Biangou River, in Shuidonggou site, Ningxia and they are SDG1, 2 and 7. More luminescence and AMS 14C dating in laboratory show that Paleolithic culture develops during the Upper Paleolithic period with ages of 35―20 ka. The Paleolithic culture of SDG 1 is a little earlier than that of SDG 2 similar to SDG 7. The sandy sediments on terrace Ⅱ of Biangou River deposits in the past 72―18 ka, corresponding to Last Glacial. SDG2 has a stable sedimentary environment, resulting in the continuous stratigraphy, thickest deposits and rich environment and culture information, which can be regarded as the important and classic paleoanthropological section of Late Pleistocene in this region. | LIU DeCheng WANG XuLong GAO Xing XIA ZhengKai PEI ShuWen CHEN FuYou WANG HuiMing | 2009 | Chinese Science Bulletin2009，54，21： | 13 |
| 9 | On-board measurement of particle numbers and their size distribution from a light-duty diesel vehicle:Influences of VSP and altitude显示文摘In this study,the particle size-resolved distribution from a China-3 certificated light-duty diesel vehicle was measured by using a portable emission measurement system(PEMS).In order to examine the influences of vehicle specific power(VSP) and high-altitude operation,measurements were conducted at 8 constant speeds,which ranged from 10 to 80 km/hr at10 km/hr intervals,and two different high altitudes,namely 2200 and 3200 m.The results demonstrated that the numbers of particles in all size ranges decreased significantly as VSP increased when the test vehicle was running at lower speeds(< 20 km/hr),while at a moderate speed(between 30 and 60 km/hr),the particle number was statistically insensitive to increase VSP.Under high-speed cruising conditions,the numbers of ultrafine particles and PM2.5were insensitive to changes in VSP,but the numbers of nanoparticles and PM10 surged considerably.An increase in the operational altitude of the test vehicle resulted in increased particle number emissions at low and high driving speeds;however,particle numbers obtained at moderate speeds decreased as altitude rose.When the test vehicle was running at moderate speeds,particle numbers measured at the two altitudes were very close,except for comparatively higher number concentrations of nanoparticles measured at 2200 m. | Jia Liu Yunshan Ge Xin Wang Lijun Hao Jianwei Tan Zihang Peng Chuanzhen Zhang Huiming Gong Ying Huang | 2017 | Journal of Environmental Sciences2017，29，7： | 12 |
| 10 | 间歇A/O+MBR工艺在猪场沼液处理中的应用显示文摘猪场沼液含有大量有机物、氮、磷等营养元素,可回用与农业生产,排放水体却可造成严重的环境污染。在农业回用无法消纳时,采用间歇A/O+MBR工艺进行处理,一次性投资少,运行管理简单,出水水质稳定,COD、BOD_5、NH_(3^-)N、TP、SS的平均去除率可达到94.07%、94.96%、84.12%、93.20%和98.45%,出水水质优于GB 18596-2001。 | 邱俊 徐晓云 吴志勇 吴志坚 张磊 余峰 Wang Huiming | 2016 | 水处理技术2016，42，5： | 11 |
| 11 | Promoting the methanol oxidation catalytic activity by introducing surface nickel on platinum nanoparticles显示文摘高效甲醇氧化反应(粗腐殖质) 催化剂对吸引人的、直接甲醇燃料房间的表演批评。这里,我们使用表面学习 MOR 机制并且给的模型催化剂推进指导到新高效粗腐殖质催化剂的设计的控制 PtNi 合金 nanoparticles。PtNi 合金的提高的粗腐殖质活动主要被归因于提高哦由于表面 Ni 地点的吸附。这建议 MOR 经历 Langmuir-Hinshelwood 机制,由此吸附了公司,与帮助被移开吸附哦。在 PtNi 催化剂以内,磅提供甲醇吸附地点(在哪个甲醇被变换成吸附的公司) 并且 Ni 提供哦吸附地点。为粗腐殖质的优化 Pt-Ni 比率被发现是 1:1。这建议那 bifunctional 有公司的催化剂并且哦吸附地点能导致高度活跃的粗腐殖质催化剂。 | Siqi Lu Huiming Li Jingyao Sun Zhongbin Zhuang | 2018 | Nano Research2018，11，4： | 11 |
| 12 | Low-threshold topological nanolasers based on the second-order corner state显示文摘Topological lasers are immune to imperfections and disorder.They have been recently demonstrated based on many kinds of robust edge states,which are mostly at the microscale.The realization of 2D on-chip topological nanolasers with a small footprint,a low threshold and high energy efficiency has yet to be explored.Here,we report the first experimental demonstration of a topological nanolaser with high performance in a 2D photonic crystal slab.A topological nanocavity is formed utilizing the Wannier-type 0D corner state.Lasing behaviour with a low threshold of approximately 1μW and a high spontaneous emission coupling factor of 0.25 is observed with quantum dots as the active material.Such performance is much better than that of topological edge lasers and comparable to that of conventional photonic crystal nanolasers.Our experimental demonstration of a low-threshold topological nanolaser will be of great significance to the development of topological nanophotonic circuitry for the manipulation of photons in classical and quantum regimes. | Weixuan Zhang Xin Xie Huiming Hao Jianchen Dang Shan Xiao Shushu Shi Haiqiao Ni Zhichuan Niu Can Wang Kuijuan Jin Xiangdong Zhang Xiulai Xu | 2020 | Light(Science & Applications)2020，9，1： | 10 |
| 13 | Introduction to Wireless Endogenous Security and Safety:Problems, Attributes, Structures and Functions显示文摘The information security and functional safety are fundamental issues of wireless communications sytems.The endogenous security principle based on Dynamic Heterogeneous Redundancy provides a direction for the development of wireless communication security and safety technology.This paper introduces the concept of wireless endogenous security from the following four aspects.First,we sorts out the endogenous security problems faced by the current wireless communications system,and then analyzes the endogenous security and safety attributes of the wireless channel.After that,the endogenous security and safety structure of the wireless communications system is given,and finally the applications of the existing wireless communication endogenous security and safety functions are listed. | Liang Jin Xiaoyan Hu Yangming Lou Zhou Zhong Xiaoli Sun Huiming Wang Jiangxing Wu | 2021 | China Communications2021，18，9： | 10 |
| 14 | Tree-ring-based reconstruction of the April to September mean temperature since 1826 AD for north-central Shaanxi Province,China显示文摘Long-time series of high-resolution temperature record from Chinese Loess Plateau is rare. An April-September mean temperature reconstruction (1826-2004) has been developed for the north-central Shaanxi Province, China, based on tree-ring width analysis. The reconstruction captures 39.3% (p<0.001) of the variance in the instrumental data over the calibration period from 1951 to 2002. The reconstruction shows a high temperature period of 1928-1933, which coincides with the timing of the extreme drought event in 1920s in the entire northern China. The two low temperature periods in reconstruction are 1883-1888 and 1938-1942. With the global warming, the April-September mean temperature in study area has also increased since the 1970s, but has not exceeded the temperature in 1928-1933. Besides the statistical analysis, the reconstruction is also verified by the local dryness/wetness index and other dendroclimatological results. | CAI QiuFang LIU Yu SONG HuiMing SUN JunYan | 2008 | Science China Earth Sciences2008，51，8： | 10 |
| 15 | The High Energy X-ray telescope (HE) onboard the Insight-HXMT astronomy satellite显示文摘The Insight-Hard X-ray Modulation Telescope(Insight-HXMT) is a broadband X-ray and γ-ray(1-3000 ke V) astronomy satellite. One of its three main telescopes is the High Energy X-ray telescope(HE). The main detector plane of HE comprises 18 Na I(Tl)/Cs I(Na) phoswich detectors, where Na I(Tl) is used as the primary detector to measure ~ 20-250 ke V photons incident from the field of view(FOV) defined by collimators, and Cs I(Na) is used as the active shielding detector to Na I(Tl) by pulse shape discrimination. Additionally, Cs I(Na) is used as an omnidirectional γ-ray monitor. The HE collimators have a diverse FOV,i.e. 1.1°×5.7°(15 units), 5.7°×5.7°(2 units), and blocked(1 unit). Therefore, the combined FOV of HE is approximately5.7°×5.7°. Each HE detector has a diameter of 190 mm resulting in a total geometrical area of approximately 5100 cm2, and the energy resolution is ~15% at 60 ke V. For each recorded X-ray event by HE, the timing accuracy is less than 10 μs and the deadtime is less than 10 μs. HE is used for observing spectra and temporal variability of X-ray sources in the 20-250 ke V band either by pointing observations for known sources or scanning observations to unveil new sources. Additionally, HE is used for monitoring the γ-ray burst in 0.2-3 Me V band. This paper not only presents the design and performance of HE instruments but also reports results of the on-ground calibration experiments. | CongZhan Liu YiFei Zhang XuFang Li XueFeng Lu Zhi Chang ZhengWei Li AiMei Zhang YongJie Jin HuiMing Yu Zhao Zhang MinXue Fu YiBao Chen JianFeng Ji YuPeng Xu JingKang Deng RenCheng Shang GuoQing Liu FangJun Lu ShuangNan Zhang YongWei Dong TiPei Li Mei Wu YanGuo Li HuanYu Wang BoBing Wu YongJie Zhang Zhi Zhang ShaoLin Xiong Yuan Liu Shu Zhang HongWei Liu YiJung Yang Fan Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 9 |
| 16 | Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation,angiogenesis,tumor growth and metabolism显示文摘Bone morphogenetic protein 9(BMP9)(or GDF2)was originally identified from fetal mouse liver cDNA libraries.Emerging evidence indicates BMP9 exerts diverse and pleiotropic functions during postnatal development and in maintaining tissue homeostasis.However,the expression landscape of BMP9 signaling during development and/or in adult tissues remains to be analyzed.Here,we conducted a comprehensive analysis of the expression landscape of BMP9 and its signaling mediators in postnatal mice.By analyzing mouse ENCODE transcriptome datasets we found Bmp9 was highly expressed in the liver and detectable in embryonic brain,adult lungs and adult placenta.We next conducted a comprehensive qPCR analysis of RNAs isolated from major mouse tissues/organs at various ages.We found that Bmp9 was highly expressed in the liver and lung tissues of young adult mice,but decreased in older mice.Interestingly,Bmp9 was only expressed at low to modest levels in developing bones.BMP9-associated TGFβ/BMPR type I receptor Alk1 was highly expressed in the adult lungs.Furthermore,the feedback inhibitor Smads Smad6 and Smad7 were widely expressed in mouse postnatal tissues.However,the BMP signaling antagonist noggin was highly expressed in fat and heart in the older age groups,as well as in kidney,liver and lungs in a biphasic fashion.Thus,our findings indicate that the circulating BMP9 produced in liver and lungs may account for its pleiotropic effects on postnatal tissues/organs although possible roles of BMP9 signaling in liver and lungs remain to be fully understood. | Wei Liu Zhongliang Deng Zongyue Zeng Jiaming Fan Yixiao Feng Xi Wang Daigui Cao Bo Zhang Lijuan Yang Bin Liu Mikhail Pakvasa William Wagstaff Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Huiming Ding Yongtao Zhang Changchun Niu Rex C.Haydon Hue H.Luu Jennifer Moriatis Wolf Michael J.Lee Wei Huang Tong-Chuan He Yulong Zou | 2020 | Genes & Diseases2020，7，2： | 9 |
| 17 | Tree-ring-based annual precipitation reconstruction in Kalaqin, Inner Mongolia for the last 238 years显示文摘A tree-ring-width chronology of Pinus tabulaeformis from Kalaqin, Inner Mongolia was developed using modern dendroc hronological techniques. Based on the results of correlation function analysis, the total precipitation from the previous August to current July was reconstructed for 1771-2008 AD with an explained variance of 49.3%. The reconstruction correlated well with the dryness/wetness series derived from historical documents, as well as the precipitation reconstruction of the Chifeng-Weichang region. There were eight intervals with greater precipitation than the average (associated with the strong East Asian summer monsoon) and seven intervals lower than the average (weak monsoon). A power spectrum analysis showed that there were 120 a, 80 a, 8 a and 2 a periodicities. | LIU Yu WANG CaiYong HAO WenJun SONG HuiMing CAI QiuFang TIAN Hua SUN Bo Hans W. LINDERHOLM | 2011 | Chinese Science Bulletin2011，56，28： | 9 |
| 18 | Inositol Pyrophosphate lnsP8 Acts as an Intracellular Phosphate Signal in Arabidopsis显示文摘The maintenance of cellular phosphate(Pi)homeostasis is of great importance in living organisms.The SPX domain-containing protein 1(SPX1)proteins from both Arabidopsis and rice have been proposed to act as sensors of Pi status.The molecular signal indicating the cellular Pi status and regulating Pi homeostasis in plants,however,remains to be identified,as Pi itself does not bind to the SPX domain.Here,we report the identification of the inositol pyrophosphate lnsP8 as a signaling molecule that regulates Pi homeostasis in Arabidopsis.Polyacrylamide gel electrophoresis profiling of InsPs revealed that lnsP8 level positively correlates with cellular Pi concentration.We demonstrated that the homologs of diphosphoinositol pentaki-sphosphate kinase(PPIP5K),VIH1 and VIH2,function redundantly to synthesize lnsP8,and that the vih1 vih2 double mutant overaccumulates Pi.SPX1 directly interacts with PHR1,the central regulator of Pi starvation responses,to inhibit its function under Pi-replete conditions.However,this interaction is compromised in the vih1 vih2 double mutant,resulting in the constitutive induction of Pi starvation-induced genes,indicating that plant cells cannot sense cellular Pi status without lnsP8.Furthermore,we showed that lnsP8 could directly bind to the SPX domain of SPX1 and is essential for the interaction between SPX1 and PHR1.Collectively,our study suggests that lnsP8 is the intracellular Pi signaling molecule serving as the ligand of SPX1 for controlling Pi homeostasis in plants. | Jinsong Dong Guojie Ma Liqian Sui Mengwei Wei Viswanathan Satheesh Ruyue Zhang Shenghong Ge Jinkai Li Tong-En Zhang Christopher Wittwer Henning JJessen Huiming Zhang Guo-Yong An Dai-Yin Chao Dong Liu Mingguang Lei | 2019 | Molecular Plant2019，12，11： | 8 |
| 19 | WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells显示文摘POU 抄写因素 OCT4 不仅在维持 pluripotent 和房间而且幕作为通过基因剂量的一个房间命运决定因素完成的胚胎的茎(ES ) 的自我更新的状态起一个必要作用。然而,控制细胞内部的 OCT4 蛋白质水平的分子的机制留下逃犯。这里,我们报导那人的 WWP2, E3 ubiquitin (Ub ) 蛋白质 ligase,通过它的 WW 领域明确地与 OCT4 交往并且在 vitro 并且在 vivo 提高 OCT4 的 Ub 修正。我们首先证明在人的 ES 房间的内长的 OCT4 能被 Ub post-translationally 修改。而且,我们发现 WWP2 以一种剂量依赖者方式,和 WWP2 的活跃地点半胱氨酸残余通过 26S proteasome 支持了 OCT4 的降级在 OCT4 上为它的酶的活动和解朊的效果被要求。显著地,我们当 WWP2 表示是由特定的 RNA 干扰(RNAi ) 的 downregulated 时,内长的 OCT4 蛋白质水平显著地被提高的数据表演,建议那 WWP2 是为在人的 ES 房间维持合适的 OCT4 蛋白质水平的一个重要管理者。而且,北污点分析证明 WWP2 抄本在多样的人的织物 / 器官是广泛地在场的并且高度在无差别的人的 ES 房间表示了。然而,它的表示水平快速在区分的人的 ES 房间以后被减少,显示 WWP2 表示力量发展地被调整。我们的调查结果证明 WWP2 是在人的 ES 房间的 OCT4 蛋白质水平的一个重要管理者。 | Huiming Xu Weicheng Wang Chunliang Li Hongyao Yu Acong Yang Beibei Wang Ying Jin | 2009 | Cell Research2009，19，5： | 8 |
| 20 | A Constitutive Model of Granite Shear Creep under Moisture显示文摘Previous constitutive models of granite shear creep have two limitations:(1) although moisture greatly affects granite shear creep behavior, currently there are no constitutive models that include this factor;(2) there are also no models that include an acceleration stage. This paper presents an improved Burgers constitutive model with the addition of a damage parameter to characterize the moisture effect and uses a nonlinear relation equation between stress and strain for inclusion as the acceleration stage. The damage parameter is determined from granite creep experiment under four different moisture contents(0%, 0.22%, 0.49%, and 0.79%). The nonlinear relation equation is obtained by fitting a dataset of stain versus time under five different loading stages. To verify the presented model, a creep experiment was conducted on other granite samples and the results show that the model agrees well with the experimental observation data. | Xingang Wang Bin Hu Huiming Tang Xinli Hu Jiading Wang Lei Huang | 2016 | Journal of Earth Science2016，27，4： | 8 |
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