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| 1 | Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis显示文摘指导暗示的裂缝家庭绑在环岛(Robo ) 受体并且调制房间移植。我们这里报导 Slit2 的那宫外的表情和上皮的癌房间招募了的表示 Robo1 colorectal 的 Robo1 或 recombinant Slit2 处理为 E-cadherin (电子恶棍) ubiquitination 和 lysosomal 降级,上皮间充质的转变(EMT ) ,和肿瘤生长和肝转移的 ubiquitin ligase Hakai,它被救由 Hakai 击倒。相反,内长的 Robo1 或对 Robo1 有约束力的 Slit2 的特定的封锁击倒阻止的电子恶棍降级和颠倒的 EMT,导致减少的肿瘤生长和肝转移。Robo1 的宫外的表示也在 Slit2 积极的人的胚胎的肾触发了恶意的转变 293 个房间。重要地, Slit2 和 Robo1 的表示显著地在 colorectal 癌病人与增加的变形风险和更差的全面幸存被联系。我们断定由 Slit2 的 Robo1 的那个约会在 colorectal 期间通过调停 Hakai 的电子恶棍 ubiquitination 和 lysosomal 降级导致恶意的转变上皮的房间 carcinogenesis。 | Wei-Jie Zhou Zhen H Geng Shan Chi Wenli Zhang Xiao-Feng Niu Shu-Jue Lan Li Ma Xuesong Yang Li-Jing Wang Yan-Qing Ding Jian-Guo Geng | 2011 | Cell Research2011，21，4： | 14 |
| 2 | Establishment and Applications of Epstein-Barr Virus-based Episomal Vectors in Human Embryonic Stem Cells显示文摘 | Ren C Zhao M Yang X Li D Jiang X Wang L Shan W Yang H Zhou L Zhou W Zhang H | 2006 | 中国生物学文摘2006，20，7： | 4 |
| 3 | Circadian clock gene expression regulates cancer cell growth through glutaminase显示文摘夫酸安是为恶意的肿瘤房间的必要氨基酸。使夫酸安产生代射变化的 Glutaminase 到达肿瘤立即在最大的增长前评估的最大的 expressionin。肿瘤房间在日子期间以不同的率成长。我们 postulatedthat 在肿瘤房间的 glutaminase 的活动服从于生理节奏的钟基因的规定。我们测量了由在在六 equispaced 时间的肝和 tumorcells 的即时聚合酶链反应的西方的污点分析和生理节奏的钟基因表示削尖的 glutaminaseby 在一张 12/12 h 光 / 黑暗时间表的单个鼠标今日。结果显示出 thatthe 忍受肿瘤的鼠标,在正常下面日报条件,生理节奏地被乘火车,由正常主机 locomotoractivity 节奏和有韵律的肝钟基因表示思考了。在这些老鼠以内的肿瘤生理节奏地也被组织,由生理节奏的钟基因(Bmal1 ) 的 asreflected 表示。是很显著的的,是肾类型 glutaminase 也在一样的模式 withtumor 显示出生理节奏的节奏在肝癌症异种皮移植模型的生理节奏的钟基因表示,有条件地显示那禁止 glutaminaseactivity 可以为癌症提供一个新目标治疗。 | Aixia Huang Bingbo Bao H Rex Gaskins Haijun Liu Xueli Zhang Liwen Lu Shan Gao Yihai Shi Ming Zhang Yuanzhou Shan Jing Feng Guoxiang Yao | 2014 | Acta Biochimica et Biophysica Sinica2014，46，5： | 3 |
| 4 | Effect of a Patient Education Intervention on Asthma Control and Patient-Doctor Relationship显示文摘 | Yu-Qin Zeng David H Au Shan Cai Evan Carey Fen Jiang Yan Chen Zhi-Jun Liu Ping Chen | 2018 | Chinese Medical Journal2018，，9： | 2 |
| 5 | EXPERIMENTAL AND THEORETICAL STUDY OF STATIC-DYNAMIC MIXED MODE BRITTLE FRACTURE OF ROCK显示文摘Variousmode-Ⅰinvestigationsinthetheoryoflinearelasticfracturemechanicsareimportantindeterminingthefractureconstants.Toanalyse... | Li Zhenzi Lin Guoxiang Xu Jicheng Zhang Jingyi Luo Zhang (Department of Architecture Engineering, Central South University of Technology,Changsha 410083,China) Zhou Hongbin Li Huijian (Department of Civil Engineering,Yan shan University,H | 1998 | Journal of Central South University1998，10，2： | 2 |
| 6 | Health risk assessment of abandoned agricultural soils based on heavy metal contents in Hong Kong, the world’s most populated city显示文摘 | Yu Bon Man Xiao Lin Sun Yin Ge Zhao Brenda Natalia Lopez Shan Shan Chung Sheng Chun Wu Kwai Chung Cheung Ming H Wong | 2010 | Environment International2010，，6： | 2 |
| 7 | High corrosion resistance of electroless composite plating coatings on AZ91D magnesium alloys 显示文摘 | SONG Y W SHAN D Y CHEN R S HAN E H | 2008 | Electrochimica Acta2008，53，： | 1 |
| 8 | Quantitative assessment of strain and strain rate by velocity vector imaging during dobutamine stress echocardiography to predict outcome in patients with left bundle branch Block显示文摘 | Shan Y Villarraga H R Pislaru C | 2009 | Journal of the American Society of Echocardiography2009，22，11： | 1 |
| 9 | Genetic analysis of a novel dominant rice dwarf mutant 986083D显示文摘 | Qin R Z Qiu Y Cheng Z J Shan X Y Guo X P Zhai H Q Wan J M | 2008 | Euphytica2008，160，： | 1 |
| 10 | MieroRNA-1 downregulation byprop- ranolol in a rat model of myocardial infarettion : a new mechanism for isehemie cardioprotecfion 显示文摘 | Lu Y Zhang Y Shan H | 2009 | Cardiovasc Res2009，84，3： | 1 |
| 11 | Development of a class selective immunoassay for the type Ⅱ pyrethroid insecticides 显示文摘 | MAK S K SHAN G LEE H | 2005 | Analytica Chimica Acta2005，534，1： | 1 |
| 12 | HSP10 and HSP60 modulate Bcl- 2 family and mitochondria apoptisis signaling induced by doxorubicin in cardiac muscle cells 显示文摘 | SHAN Y X LIU T J SU H F | 2003 | J Mol Cell Cardiol2003，35，9： | 1 |
| 13 | Pharmacological characteristics of the endothelial target for acetylcholine induced vascular relaxation显示文摘 | Shan L M Wang H | 2002 | Life Sci2002，11，： | 1 |
| 14 | Downregulation of miR-133 and miR-590 contributes to nicofine-induced atrial remodelling in ca- nines 显示文摘 | Shan H Zbang Y Lu Y | 2009 | Cardiovasc Res2009，83，3： | 1 |
| 15 | Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis显示文摘 | Xi S Xu H Shan J | 2013 | J Clin Invest2013，123，3： | 1 |
| 16 | Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding proteinlc (SREBP-lc) gene by antagonizing ligand-dependent activation of the LXR显示文摘 | Ou J Tu H Shan B Luk A DeBose-Boyd RA Bashmakov Y Goldstein JL Brown MS | | 0，，11： | 1 |
| 17 | Fat-suppressed 3D T1 -weighted gradient-echo imaging of the cartilage with a volumetric interpolated breath-hold examination 显示文摘 | Zheng ZZ Shan H Li X | 2010 | AJR Am J Roentgenol2010，194，5： | 1 |
| 18 | MicroRNA-1 downregulation by pro- pranolol in a rat model of myocardial infarction : a new mechanism for ischaemic eardioprotection 显示文摘 | Lu Y Zhang Y Shan H | 2009 | Cardiovasc Res2009，84，3： | 1 |
| 19 | Novel Li4SiO4-based sorbents from diatomite for high temperature COs capture 显示文摘 | SHAN S H JIA Q M JIANG L H | 2013 | Ceramics International2013，39，： | 1 |
| 20 | Evaluation of plant availability of rare earth elements in soils by chemical fractionation and multiple regression analysis 显示文摘 | Li F L Shan X Q Zhang T H | 1998 | Environmental Pollution1998，102，： | 1 |
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