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| 1 | Cerebral ischemia and neuroregeneration显示文摘Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke(a form of cerebral ischemia)-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral ischemia/stroke are limited. All therapies except anti-thrombolytics(i.e., tissue plasminogen activator) and hypothermia have failed to reduce neuronal injury, neurological deficits, and mortality rates following cerebral ischemia, which suggests that development of novel therapies again st stroke/cerebral ischemia are urgently needed. Here, we discuss the possible mechanism(s) underlying cerebral ischemia-induced brain injury, as well as current and future novel therapies(i.e., growth factors, nicotinamide adenine dinucleotide, melatonin, resveratrol, protein kinase C isozymes, pifithrin, hypothermia, fatty acids, sympathoplegic drugs, and stem cells) as it relates to cerebral ischemia. | Reggie H.C.Lee Michelle H.H.Lee Celeste Y.C.Wu Alexandre Couto e Silva Harlee E.Possoit Tsung-Han Hsieh Alireza Minagar Hung Wen Lin | 2018 | Neural Regeneration Research2018，13，3： | 30 |
| 2 | 查看详情显示文摘 | J.J.Chen H.H.Lee C.Y.Duh | | 0，，： | 1 |
| 3 | Algorithms for controlling both the DC boost and AC output voltage of Z-source inverter显示文摘 | Q.V.Tran T.W.Chun J.R.Ahn H.H.Lee | | 0，，05： | 1 |
| 4 | 现场快速相关点检测作为沙眼抗生素靶向治疗指导的比较研究显示文摘Background:Trachoma results from repeated episodes of conjunctival infection with Chlamydia trachomatis and is the leading infectious cause of blindness.To eliminate trachoma,control programmes use the SAFE strategy(Surgery,Antibiotics,Face cleanliness,and Environmental improvement).The A component is designed to treat C trachomatis infection,and is initiated on the basis of the prevalence of the clinical sign trachomatous inflammation-follicular(TF).Unfortunately,TF correlates poorly with C trachomatis infection.We sought to assess a newly developed point-of-care(POC)assay compared with presence of TF for guiding the use of antibiotics for trachoma control.Methods:We compared performance outcomes of the POC assay and presence of TF using commercial PCR as a comparator in 664 children aged 1-9 years in remote,trachoma-endemic villages in Tanzania.Signs of trachoma were graded according to the WHO simplified trachoma grading system.Findings:Of 664 participants,128(19%)were positive for ocular C trachomatis infection by PCR.Presence of TF had a sensitivity of 64.1%(95% CI 55.8-72.4),specificity of 80.2%(76.8-83.6),and positive predictive value of 43.6%(36.5-50.7).By contrast,the POC assay had a sensitivity of 83.6%(77.2-90.0),specificity of 99.4%(98.8-100.0),and positive predictive value of 97.3%(94.2-100.3).Interagreements and intra-agreements between four novice operators were 0.988(0.973-1.000)and 0.950(0.894-1.000),respectively.Interpretation:The POC assay is substantially more accurate than TF prevalence in identifying the presence or absence of infection.Additional studies should assess the use of the assay in the planning and monitoring of trachoma control activities. | Michel C.-E.C. Solomon A.W. Magbanua J.P. H.H.Lee 张磊 | 2006 | 世界核心医学期刊文摘(眼科学分册)2006，2，9： | 0 |
| 5 | 输血机构基因技术筛选带病毒血液显示文摘一、介绍 基因筛选传染源,尤其是病毒,随着各种核酸放大技术,诸如PCR、LCR、NASBA、TMA的应用而成为可能。这些不同的基因放大技术(GATs)体现了基于生物体内核酸复制和修补的原理而完成体外核酸放大的不同途径。CATs被成功地应用于放大核酸序列,而这种核酸序列不论对于临床相关的微生物,还是基因疾病,都是特异的。因此基因放大试验仍是传染病诊断的主要方法,因为GATs吸收了比传统的方法,如培养法或酶免检测抗原法(EIA),更为敏感的直接检测生物体的优点。另外,以核酸杂交技术为基础的诊断方法有其天然特异性。 | H.H.Lee J-P.Allain 宋任浩 | 2000 | 国外医学(输血及血液学分册)2000，23，3： | 0 |
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