| 1 | 数字皮肤镜图像可帮助皮肤病理医生诊断可疑的皮肤肿瘤显示文摘Background: A variety of pigmented skin tumours can lead to diagnostic difficulties in dermatopathology. Objectives: To investigate whether the inter observer agreement between histopathological diagnoses of equivocal pigmented tumours made by two referral centres can be improved by additional use of dermoscopic images. Material and methods: Retrospective study using 160 tumours excised in the pigmented skin lesions clinic in Graz and 141 from Tubingen. Tumours were diagnosed in the referring centres using clinical data, histopathology and, if required, immunohistochemistry. The tumours were initially diagnosed as 74 melanomas, 218 melanocytic naevi and nine nonmelanocytic tumours. Haematoxylin and eosin sections, patients’age and sex, tumour localization and digital dermoscopic images were then exchanged between the participating centres. Then, diagnoses were made initially based solely on dermatopathology and clinical information. After a washout phase, the same sections were reevaluated with the additional use of dermoscopic images. The main outcome measures were the Cohen’s κ-coefficients of the initial diagnoses of the center submitting the cases and the diagnoses of the other centre without and with dermoscopy. Results: The κ-coefficient between the initial diagnoses with those made by the second center without dermoscopy was 0.90 in Graz, 0.73 in Tübingen, and 0.81 overall. With the additional use of dermoscopy the κ-value was invariably high with 0.89 in Graz, and improved to 0.87 in Tübingen, and to 0.88 overall. Conclusions: The additional use of digital dermoscopic images further improved the overall very good agreement of histopathological diagnoses between two referral centres. | Bauer J. Leinweber B. Metzler G. H.P.Soyer 党倩丽 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，，12： | 1 |
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