|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A randomized open-label trial of on-demand rabeprazole vs ranitidine for patients with non-erosive reflux disease显示文摘AIM:To compare the efficacy of the proton-pump inhibitor,rabeprazole,with that of the H 2-receptor antagonist,ranitidine,as on-demand therapy for relieving symptoms associated with non-erosive reflux disease(NERD).METHODS:This is a single center,prospective,randomized,open-label trial of on-demand therapy with rabeprazole(group A) vs ranitidine(group B) for 4 wk.Eighty-three patients who presented to the American University of Beirut Medical Center with persistent gastroesophageal reflux disease(GERD) symptoms and a normal upper gastrointestinal endoscopy were eligible for the study.Patients in group A(n = 44) were allowed a maximum rabeprazole dose of 20 mg twice daily,while those in group B(n = 39) were allowed a maximum ranitidine dose of 300 mg twice daily.Efficacy was assessed by patient evaluation of global symptom relief,scores of the SF-36 quality of life(QoL) questionnaires,total number of pills used,and number of medication-free days.RESULTS:Among the 83 patients who were enrolled in the study,76 patients(40 in the rabeprazole group and 36 in the ranitidine group) completed the 4-wk trial.Baseline characteristics were comparable between both groups.After 4 wk,there was no significant difference in the subjective global symptom relief between the rabeprazole and the ranitidine groups(71.4% vs 65.4%,respectively;P = 0.9).There were no statistically significant differences between mean cumulative scores of the SF-36 QoL questionnaire for the two study groups(rabeprazole 22.40 ± 27.53 vs ranitidine 17.28 ± 37.06;P = 0.582).There was no significant difference in the mean number of pills used(rabeprazole 35.70 ± 29.75 vs ranitidine 32.86 ± 26.98;P = 0.66).There was also no statistically significant difference in the mean number of medication-free days between both groups.CONCLUSION:Rabeprazole has a comparable efficacy compared to ranitidine when given on-demand for the treatment of NERD.Both medications were associated with improved quality of life. | Abdallah A Kobeissy Jana G Hashash Faek R Jamali Assaad M Skoury Reham Haddad Sarah El-Samad Rami Ladki Rola Aswad Assaad M Soweid | 2012 | World Journal of Gastroenterology2012，18，19： | 4 |
| 2 | Selected contribution:acute cellular and molecular responses to resistance exorcise显示文摘 | Haddad F Adams G R | 2002 | J Appl Physiol2002，93，1： | 1 |
| 3 | Effect of dietary forage:concentrate ratio on growth performance and carcass characteristics of growing Baladi kids显示文摘 | Haddad S G | 2005 | Small Rumin Res2005，57，： | 1 |
| 4 | The modulato- ry effect of leptin on the overall insulin production in ex-vivo normal rat pancreas 显示文摘 | Haddad N Howland R Baroody G | 2006 | Canadian Journal of Physiology and Pharmacology2006，84，2： | 1 |
| 5 | Miscibility and vis- coelastic properties of acrylic polyhedral oIigomeric siIsesquioxane- poly( methyl methacrylate ) blends 显示文摘 | Kopesky E T Haddad T S McKinley G H | 2005 | Polymer2005，46，3： | 1 |
| 6 | Resonant tunneling diodes: model and properties 显示文摘 | SUN J P HADDAD G I MAZUMDER P | 1998 | Proc IEEE1998，86，4： | 1 |
| 7 | Optimum dietary crude protein level for finishing Awassi lambs显示文摘 | Haddad S G Nasr R E Muwalla M M | 2001 | 39(1): 41-462001，39，1： | 1 |
| 8 | Mechanisms Underlying Hypoxia-induced Neuronal Apoptosis显示文摘 | Banasiak K J Xia Y Haddad G G | 2000 | Prog Neurobiology2000，62，3： | 1 |
| 9 | Predicting the potential distribution of the alien invasive American bullfrog(Lithobates catesbeianus)in Brazil显示文摘 | GIOVANELLI J G R HADDAD C F B Alexandrino J | 2008 | Biological Invasions2008，10，： | 1 |
| 10 | Stercoral perforation of thesigmoid colon显示文摘 | Haddad R Bursle G Piper B | 2005 | ANZ J Surg2005，75，4： | 1 |
| 11 | The prevalence of cardiac risk factors in women 45 years of age or younger undergoing angiography for evaluation of undiagnosed chest pain显示文摘 | De S Searles G Haddad H | 2002 | Can J Cardiol2002，18，9： | 1 |
| 12 | Oil Wastes as Unconventional Substrates for Rhamnolipid Biosurfactant Production by Pseudomonas aeruginosa LBI显示文摘 | Nitschke M Costa S G V A O Haddad R | 2005 | Biotechnol Prog2005，21，： | 1 |
| 13 | Stercoral perforation of the sigmoid colon显示文摘 | Haddad R Bursle G Piper B | 2005 | ANZ J Surg2005，75，4： | 1 |
| 14 | Speciation of arsenic and selenium by capillary electrophoresis显示文摘 | SUN B G MACKA M HADDAD P R | 2004 | Journal of Chromatography A2004，1039，： | 1 |
| 15 | Conservative treat-ment of cervical intra ithelial neoplasia using a cold knife sectiontechnique显示文摘 | MAZOUNI C PORCU G HADDAD O | 2005 | Eur J Obstet Gynecol Reprod Bio12005，121，1： | 1 |
| 16 | Age-related macular degeneration and apoptosis显示文摘 | Haddad WM Coscas G Soubrane G | 2003 | J Fr Ophtalmol2003，26，3： | 1 |
| 17 | A metric for defining the energy efficiency of themlally assisted machining 显示文摘 | PFEFFERKORN F E LEI S JEON Y H HADDAD G | 2009 | International Journal of Machine Tools & Manufacture2009，49，： | 1 |
| 18 | Associative effect of supplementing barley straw diets with alfalfa hay on rumen environment and nutrient intake and digestibility for ewes 显示文摘 | Haddad S G | 2000 | Anim Feed Sei Technol2000，87，： | 1 |
| 19 | Effect of yeast culture supplementation on nutrient intake,digestibility and growth performance of Awassi lambs显示文摘 | Haddad S G Goussous S N | 2005 | Animal Feed Science and Technology2005，118，： | 1 |
| 20 | Quantitation of nitrotyrosine levels in lung section of patients and animals with acute lung injury 显示文摘 | Haddad IY Pataki G Hu P | 1994 | J Clin Invest1994，94，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员