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		题名	作者	年代	出处	被引量
	1	Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells显示文摘AIM: To present an approach for selectively killing retrovirus-infected cells that combines the toxicity of Pseudomonas exotoxin (PE) and the presence of reverse transcriptase (RT) in infected cells. METHODS: PE antisense toxin RNA has palindromic stem loops at its 5' and 3' ends enabling self-primed generation of cDNA in the presence of RT. The RT activity expressed in retrovirus-infected cells converts 'antisense-toxin-RNA' into a lethal toxin gene exclusively in these cells. RESULTS: Using cotransfection studies with PE-expressing RNAs and β-gal expressing reporter plasmids, we show that, in HepG2 and HepG2.2.15 hepatoma cells as well as in duck hepatitis B virus (DHBV) infected cells, HBV or DHBV-polymerase reverse transcribe a lethal cDNA copy of an antisense toxin RNA, which is composed of sequences complementary to a PE gene and eukaryotic transcription and translation signals. CONCLUSION: This finding may have important implications as a novel therapeutic strategy aimed at the elimination of HBV infection.	Peter Hafkemeyer Ulrich Brinkmann Elizabeth Brinkmann Ira Pastan Hubert E Blum Thomas F Baumert	2008	World Journal of Gastroenterology2008，14，18：	2
	2	Reliability analysis of gate dielectrics by apply- ing array test structures and automated test systems 显示文摘	DOMDEY A HAFKEMEYER K M SCHROEDER D	2009	NORCHIP2009，15，：	1
	3	A single amino acid residue contributes to distinct mechanisms of inhibition of the human multidrug transporter by stereoisomers of the dopamine receptor antagonist flupentixol 显示文摘	Dey S Hafkemeyer P Pastan I	1999	Biochemistry1999，38，20：	1
	4	Role of caspases in immunotoxin induced apoptosis of cancer cells 显示文摘	Keppler Hafkemeyer A Brinkmann U Pastan I	1998	Biochemistry1998，37，16：	1
	5	Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoprotein 显示文摘	Perter Hafkemeyer Ira Pastan Michael M Gottesman	1998	Biochemistry1998，37，16：	1
	6	Recombinant immunotoxins for cancer therapy显示文摘	Brinkmann U Keppler-Hafkemeyer A Hafkemeyer P	2001	Exp Opin Biol Ther2001，1，4：	1

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