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| 1 | p53 antibodies,metallothioneins,and oxidative stress markers in chronic ulcerative colitis with dysplasia显示文摘AIM:To investigate the role of p53 antibodies (p53Abs),metallothioneins (MTs) and oxidative stress markers in the early detection of dysplasia in chronic ulcerative colitis (UC).METHODS:The study included 30 UC patients,15 without dysplasia (group Ⅱ) and 15 with dysplasia (group Ⅲ),in addition to 15 healthy volunteers (group Ⅰ,control subjects).The enzyme-linked immunosorbent assay technique was used to measure serum p53Abs and MTs,while advanced oxidation protein products (AOPPs),and reduced glutathione (GSH) levels were measured by spectrophotometric method in all subjects.RESULTS:In group Ⅱ and group Ⅲ compared to group Ⅰ,there were significant increases in serum levels of AOPPs (145.94 ± 29.86 μmol/L and 192.21 ± 46.71 μmol/L vs 128.95 ± 3.06 μmol/L,P < 0.002 and P <0.001,respectively),MTs (8.18 ± 0.35 μg/mL and 9.20 ± 0.58 μg/mL vs 6.12 ± 0.25 μg/mL,P < 0.05 and P < 0.05,respectively),and p53Abs (20.19 ± 3.20 U/mL and 34.66 ± 1.34 U/mL vs 9.42 ± 1.64 U/mL,P < 0.001 and P < 0.001,respectively).There were significantly higher levels of AOPPs (P < 0.05) and p53Abs (P < 0.001) in UC patients with dysplasia compared to those without dysplasia,while MTs showed no significant difference between the 2 groups (P > 0.096).In contrast,GSH levels showed a significant decrease in both patients' groups (1.87 ± 0.02 μmol/mL and 1.37 ± 0.09 μmol/mL vs 2.49 ± 0.10 μmol/mL,P < 0.05 and P < 0.05 in groups Ⅱ and Ⅲ,respectively) compared with group Ⅰ,and the levels were significantly lower in group Ⅲ than group Ⅱ (P < 0.05).There was a positive correlation between AOPPs and both MTs (r=0.678,P < 0.001) and p53Abs (r=0.547,P < 0.001),and also between p53Abs and MTs (r=0.739,P < 0.001).There was a negative correlation between AOPPs and GSH (r =-0.385,P < 0.001),and also between GSH and both MTs (r=-0.662,P < 0.001) and p53Abs (r=-0.923,P < 0.001).CONCLUSION:Oxidative stress and oxidative cellular damage play an important role in the pathogenesis of chronic UC and the associated carcinogenetic process.p53Abs levels could help in early detection of dysplasia in these conditions. | Hala E Hamouda Soha S Zakaria Saber A Ismail Mahmoud A Khedr Wael W Mayah | 2011 | World Journal of Gastroenterology2011，17，19： | 5 |
| 2 | Drainage vs. non-drainage after cholecystectomy for acute cholecystitis:a retrospective study显示文摘Many surgeons practice prophylactic drainage after cholecystectomy without reliable evidence,this study was conducted to answer the question whether to drain or not to drain after cholecystectomy for acute calculous cholecystitis.A retrospective review of all patients who had cholecystectomy for acute cholecystitis in Aseer Central Hospital,Abha,Saudi Arabia,was conducted from April 2010 to April 2012.Data were extracted from hospital case files.Preoperative data included clinical presentation,routine investigations and liver function tests.Operative data included excessive adhesions,bleeding,bile leak,and drain insertion.Complicated cases such as pericholecystic collections,mucocele and empyema were also reported.Patients who needed therapeutic drainage were excluded.Postoperative data included hospital stay,volume of drained fluid,time of drain removal,and drain site problems.The study included 103 patients allocated into two groups;group A(n = 38) for patients with operative drain insertion and group B(n = 65) for patients without drain insertion.The number of patients with preoperative diagnosis of acute non-complicated cholecystitis was significantly greater in group B(80%) than group A(36.8%)(P < 0.001).Operative time was significantly longer in group A.All patients who were converted from laparoscopic to open cholecystectomy were in group A.Multivariate analysis revealed that hospital stay was significantly(P < 0.001) longer in patients with preoperative complications.There was no added benefit for prophylactic drain insertion after cholecystectomy for acute calculous cholecystitis in non-complicated or in complicated cases. | Mohammed A Bawahab Walid M Abd El Maksoud Saeed A Alsareii Fahad S Al Amri Hala F Ali Abdul Rahman Nimeri Abdul Rahman M Al Amri Adel A Assiri Mohammed I Abdul Aziz | 2014 | The Journal of Biomedical Research2014，28，3： | 3 |
| 3 | Isotopic abundances of water of crystallization of gypsum from the Miocene evaporite formation, Carpathian Foredeep, Poland 显示文摘 | HALAS S KROUSE H R | 1982 | Geochimica et Cosmochimica Acta1982，46，2： | 1 |
| 4 | Small-scale deceit:deception as a marker of two-,three-,and four-year-olds' early theories of mind显示文摘 | Fritz A S Hala S | 1989 | Child Development1989，，6： | 1 |
| 5 | Learning and memory disabilities in young adult rats from mildly zinc deficient dams显示文摘 | Halas E S Hunt C D Eberhardt M J | 1986 | Physiol Behav1986，37，3： | 1 |
| 6 | Resistance to glucocorticoid-induced apoptosis in human T-cell acute lymphoblastic leukemia CEM-Cl cells is due to insufficient glucocorticoid receptor expression显示文摘 | Geley S Hartmann BL Hala M | 1996 | Cancer Res1996，56，21： | 1 |
| 7 | Mild zinc deficiency and undemutrition during the prenatal and postnatal periods in rats: effects on weight, food consumption, and brain catecholamine concentrations显示文摘 | HALAS E S WALLWORK J C SANDSTEAD H H | 1982 | Journal of Nutrition1982，112，： | 1 |
| 8 | Isolation of helicobacter pylori from sheep—implications for transmission to humans显示文摘 | Maria P Dore Antonia R Sepulveda Hala El-Zimaity Yoshio Yamaoka Michael S Osato Kato Mototsugu Antonio M Nieddu Giuseppe Realdi David Y Graham | 2001 | The American Journal of Gastroenterology2001，，5： | 1 |
| 9 | Nanoshell-enabled photothermal cancer therapy:impending clinical impact显示文摘 | Lal S Clare SE Halas NJ | 2008 | Acc Chem Res2008，41，12： | 1 |
| 10 | A rapid-curing alginate gel system:utility in periosteum-derived cartilage tissue engineering显示文摘 | Molly M S Hala F Q Robert L | 2004 | Biomaterials2004，25，： | 1 |
| 11 | The automated windows task: the per- formance of preschool children, children with autism, and children with moderate learning difficulties 显示文摘 | Russell J Hala S Hill E | 2003 | Cogn Develop2003，18，： | 1 |
| 12 | Learning and memory impairment in adult rats due to sever zinc deficiency lactation 显示文摘 | Halas E S Eberhardt M J Diers A | 1983 | Physiol Behav1983，30，3： | 1 |
| 13 | Temperature-sensitive polymer-nanoshell composites for photothermally modulated drug delivery 显示文摘 | Sershen S R West C S L Halas N J | 2000 | Journal of Biomedical Materials Rasearch2000，51，3： | 1 |
| 14 | A Cellular Trojan Horse for delivery ofther apeutic nanoparticles into tumors显示文摘 | Choi M R Stanton - Maxey K J Stanley J K Levin C S Bardhan R Akin D Badve S Sturgis J Robinson J P Bashir B Halas H J and Clare S E | 2007 | Nano Letters2007，7，12： | 1 |
| 15 | Fledgling theories of mind:Deception asa marker of three - year - oldsr understanding of false belief 显示文摘 | Hala S Chandler M Fritz A S | 1991 | ChildDevelopment1991，62，： | 1 |
| 16 | Treatment of domestic wastewater using an anaerobic baffled reactor followed by a duckweed pond for agricultural purposes显示文摘 | Fayza A Nasr Hala S Donna Hossaam F Nassar | 2009 | Environmentalist2009，29，： | 1 |
| 17 | Linear Optical Properties of Gold Nanoshells显示文摘 | Westcott S L Halas N J | 1999 | Opt Soc Am B1999，16，10： | 1 |
| 18 | Malondialdehyde and coenzyme Q10 in platelets and serum in type 2 diabetes mellitus: correlation with glycemic control显示文摘 | Eman A El-ghoroury Hala M Raslan Ehsan A Badawy Gamila S El-Saaid Mervat H Agybi Ibrahem Siam Sohair I Salem | 2009 | Blood Coagulation & Fibrinolysis2009，，4： | 1 |
| 19 | Linear optical properties of gold nanoshells显示文摘 | Averitt R D Westtcott S L Halas N J | 1999 | J Opt Soc Am(A)1999，16，10： | 1 |
| 20 | A new weighted rough set framework based classification for Egyptian NeoNatal Jaun- dice 显示文摘 | Hala S OwnAjith Abraham | 2012 | Applied Soft Computing2012，12，3： | 1 |
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