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| 1 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 2 | DNA typing and genetic mapping with trimetric and tetrametric tandem repeats 显示文摘 | Edwards A Civitello A Hammond H A | 1991 | Am J Hum Genet1991，49，4： | 2 |
| 3 | DNA typ- ing and genetic mapping with trimeric and tetrametic tandem repeats显示文摘 | Edwards A Civitello A Hammond H A | 1991 | American Journal of Human Genet- ics1991，49，： | 1 |
| 4 | Infection with Chlamydia pneumoniae accelerates the development of atherosclerosis and treatment with azithromycin prevents it in a rabbit mode 显示文摘 | Muhlestein J B Anderson J L Hammond E H | 1998 | Circulation1998，97，： | 1 |
| 5 | DNA typing and genetic mapping with trimeric and tetrameric tandem repeats显示文摘 | Edwards A Civitello A Hammond H A | 1991 | Animal Journal and Human Genetic1991，49，： | 1 |
| 6 | The effect of dexmedetomidine on agitation during weaning of mechanical ventilation in critically ill patients显示文摘 | SHEHABI Y NAKAE H HAMMOND | | 0，，01： | 1 |
| 7 | Tracking Spore-Forming Bacterial Contaminants in Fluid Milk-Processing Sys- tems 显示文摘 | HUCK J R HAMMOND B H MURPHY S C | 2007 | Journal of Dairy Science2007，90，： | 1 |
| 8 | Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex 显示文摘 | Rees T Hammond P I Soreq H | 2003 | Neurobiol Aging2003，24，： | 1 |
| 9 | Human adult marrow cells support prolonged expansion of human embryonic stem cells in culture 显示文摘 | CHENG L HAMMOND H YE Z | 2003 | Stem Cells2003，21，： | 1 |
| 10 | Vitamin A Degradation and Light-Oxidized Flavor Defects in Milk 显示文摘 | WHITED L J HAMMOND B H CHAPMAN K W | 2002 | J Dairy Sci2002，85，： | 1 |
| 11 | Making supply meet demand in an uncertainty world显示文摘 | Fisher M L Hammond J H Obermeyer W R | 1994 | Harvard Business Review1994，72，3： | 1 |
| 12 | The Effects of Fluid Type and Viscosity on the Steady-state and Advancing Front Permeability Behavior of Textile Performs显示文摘 | Hammond V H Loos A C | 1997 | Journal of Reinforcement Plastics and Composites1997，16，1： | 1 |
| 13 | Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex 显示文摘 | Rees T Hammond P I Soreq H | 2003 | Neurobiol Aging2003，24，： | 1 |
| 14 | Human adult marrow cells support prolonged expansion of human embryonic stem ceils incuhure 显示文摘 | Cheng L Hammond H Ye Z | 2003 | Stem Cells2003，21，13： | 1 |
| 15 | Genes and enviro- ment in refractive error: The twin eye study显示文摘 | HAMMOND CJ SNEIDER H GILBERT CE | 2001 | Invest Ophthalmol Vis Sci2001，42，6： | 1 |
| 16 | DNA typing and genetic mapping with trimeric and tetrameric tandem repeats 显示文摘 | Edwards A Civitello A Hammond H A | 1991 | Am J Hum Oenet1991，49，： | 1 |
| 17 | Genes and environment in refractive error: the twin eye study 显示文摘 | Hammond C J Snieder H Gilbert CE Spector TD | 2001 | Invest Ophthalmol Vis Sei2001，42，6： | 1 |
| 18 | Efficient numerical treatment of periodic systems with application to stability problems显示文摘 | Friedmann P Hammond C E Woo T H | 1977 | International Journal of Numerical Methods in Engineering1977，11，： | 1 |
| 19 | Application of best linear unbiased prediction to genetic evaluation in pigs 显示文摘 | Long T Brandt H Hammond K | 1991 | Pig News and Information1991，12，2： | 1 |
| 20 | Structural relaxation in a bulk metallic glass显示文摘 | Hammond V H Houtz M D O'Reilly J M | 2003 | J Non-Cryst Solids2003，325，： | 1 |
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