|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development显示文摘cytosine 的 Methylation 是与基因压抑联系的 DNA 修正。最近,新奇 cytosine 修正, 5-hydroxymethylcytosine (5-hmC ) 被发现了。这里,我们在哺乳动物的开发期间并且在细胞的系统检验 5-hmC 分发,并且证明 5-hmC 的发展动力学与 5-methylcytosine (5-mC ) 的那些不同;特别地 5-hmC 与成年纸巾相比在胚胎的上下文被充实。一个可检测的 5-hmC 信号在在父亲的染色体受到 5-mC 的染色体宽的 hydroxylation 的地方,在接合子阶段开始的培植前开发出现,它精确在父亲的前核与 5-mC 信号的损失与一致。5-hmC 的层次与在老鼠的表示 nestin 房间人口在在胚囊,和修正 colocalises 的内部房间团的房间高培植以后的胚胎。比作另外的成年哺乳动物的机关, 5-hmC 强烈在骨头髓和大脑被充实, 5-hmC 内容在那里高是 neuronal 祖先和 mitotic 以后神经原的一个特征。我们证明 5-hmC 的那高水平是在老鼠和人的胚胎的干细胞(转换字符) 的不仅现在并且,在区别期间输以前被报导了,而且在导致的 pluripotent 干细胞的产生期间重现;因此, 5-hmC 丰富与一个 pluripotent 房间状态相关。我们的调查结果建议除了 neuronal 系的房间, genomic 5-hmC 的高水平是胚胎的房间人口和细胞的 pluri 系和多系力量的一个 epigenetic 特征。到我们的知识, 5-hmC 那么代表其丰富是的发现的 DNA 的第一 epigenetic 修正房间类型特定。 | Alexey Ruzov Yanina Tsenkina Andrea Serio Tatiana Dudnakova Judy Fletcher Yu Bai Tatiana Chebotareva Steve Pells Zara Hannoun Gareth Sullivan Siddharthan Chandran David C Hay Mark Bradley Ian Wilmut Paul De Sousa | 2011 | Cell Research2011，21，9： | 4 |
| 2 | Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asian hepatitis B virus carriers显示文摘 | Lindh M Hannoun C Dhillon AP | 1999 | J Infect Dis1999，179，4： | 2 |
| 3 | Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asian hepatitis B virus carriers显示文摘 | Lindh M Hannoun C Dhillon AP | 1999 | J Infect Dis1999，179，4： | 1 |
| 4 | Immunogenicity and protective effi cacy of influenza vaccination显示文摘 | Hannoun C Megas F Piercy J | 2004 | Virus Research2004，103，： | 1 |
| 5 | Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asian hepatitis B virus carrier显示文摘 | Lindh M Hannoun C Dhillon AP | 1999 | J Infect Dis1999，179，： | 1 |
| 6 | Genotype mixtures of hepatitis B virus in patients treated with interferon显示文摘 | Hannoun C Krogsgaard K Horal P | 2002 | J Infect Dis2002，186，： | 1 |
| 7 | Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asian hepatitis B virus carriers显示文摘 | Lindh M Hannoun C Dhion AP | 1999 | J Infect Dis1999，179，： | 1 |
| 8 | Long-term mutation rates in the hepatitis B virus genome显示文摘 | Hannoun C Horal P Lindh M | 2000 | J Gen Virol2000，81，1： | 1 |
| 9 | Immunogenicity and protective efficacy of influenza vaccination显示文摘 | Hannoun C Megas F Piercy J | 2004 | Virus Res2004，103，12： | 1 |
| 10 | An aberrant genotype re- vealed in recombinant hepatitis B virus strains from Vietnam显示文摘 | HANNOUN C NORDER H LINDH M | 2000 | J Gen Virol2000，81，9： | 1 |
| 11 | Core promoter mutations and genotype in relation to viral replication and liver damage in East Asian hepatitis B virus carriers显示文摘 | Lindh M Hannoun C Dhillon AP | 1999 | J Infect Dis1999，179，4： | 1 |
| 12 | Genotype mixtures of hepatitis B virus in patients treated with interferon显示文摘 | Hannoun C Krogsgaard K Horal P et al.Lindh M | | 0，，： | 1 |
| 13 | Core promoter mutations and genotypes in relation to viral replication and liver damage in east Asian hepatitis B virus carriers 显示文摘 | Lindh M Hannoun C Dhillon AP | 1999 | J Infect Dis1999，179，4： | 1 |
| 14 | Combined radiotherapy and chemotherapy (cisplatin and 5-FU) as palliative treatment for localised unresectable or adjuvant treatment for resected pancreatic adenocarcinoma: results of a feasibility study显示文摘 | André T Balosso J Louvet C Hannoun L Houry S Hughier M | | 0，，： | 1 |
| 15 | Diffusion tensor- MRI evidence for extra-axonal neuronal degeneration in caudate and thalamic nuclei of patients with multiple sclerosis显示文摘 | Hannoun S Durand-Dubief F Confavreux C | 2012 | AJNR2012，33，： | 1 |
| 16 | Hepatitis B viral DNA decline at loss of HBeAg is mainly explained by reduced cccDNA load-down-regulated transcription of PgRNA has limited impact显示文摘 | MALMSTROM S LARSSON SB HANNOUN C | 2012 | PLoS One2012，7，36： | 1 |
| 17 | Sensitevity, specificity and predictive values of health service based indicators for the surveil- lance of influenza A epidemics显示文摘 | Quenel P Dab W Hannoun C | 1994 | International Journal of Epide- miology1994，23，4： | 1 |
| 18 | Core promoter mutations and genolypes in relation to viral repplieation and liver damage in east asian he patitis B virus carriers 显示文摘 | Lindh M Hannoun C Dhillon AP | 1999 | J Infect1999，179，： | 1 |
| 19 | Long-term mutation rates in the hepatitis B virus genome 显示文摘 | Hannoun C Horal P Lindh M | 2000 | J Gen Virol2000，81，1： | 1 |
| 20 | Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asian hepatitis B virus carrier显示文摘 | Lindh M Hannoun C Dhillon AP | 1999 | J Infect Dis1999，179，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员