|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Probiotics and gut health:A special focus on liver diseases显示文摘Probiotic bacteria have well-established beneficial ef-fects in the management of diarrhoeal diseases.Newer evidence suggests that probiotics have the potential to reduce the risk of developing inflammatory bowel diseases and intestinal bacterial overgrowth after gut surgery.In liver health,the main benefits of probiotics might occur through preventing the production and/or uptake of lipopolysaccharides in the gut,and therefore reducing levels of low-grade inflammation.Specific immune stimulation by probiotics through processes involving dendritic cells might also be beneficial to the host immunological status and help prevent pathogen translocation.Hepatic fat metabolism also seems to be influenced by the presence of commensal bacteria,and potentially by probiotics;although the mechanisms by which probiotic might act on the liver are still unclear.However,this might be of major importance in the fu-ture because low-grade inflammation,hepatic fat infil-tration,and hepatitis might become more prevalent as a result of high fat intake and the increased prevalence of obesity. | Silvia Wilson Gratz Hannu Mykkanen Hani S El-Nezami | 2010 | World Journal of Gastroenterology2010，16，4： | 24 |
| 2 | 中国亚热带地区不同发育阶段杉木林生物量、凋落物及养分流(英文)显示文摘杉木生长快、产量高、材质好,是中国亚热带地区最重要的造林树种之一,在中国南方人工林经营中占有重要地位。对8、14和24年生杉木人工林生物量、凋落物及其养分流进行的研究结果表明:杉木人工林具有很高的生物生产力和50%-70%的树干生物量积累比例。杉木是低养分归还的针叶树种,凋落量少,而且针叶凋落前养分发生一定程度的转移,凋落物养分含量低,短轮伐期连栽收获制度造成的养分损失是导致杉木人工林地力衰退的原因之一。图1表7参22。 | 马祥庆 刘春江 Ilvesniemi Hannu Carl J.Westman 刘爱琴 | 2002 | Journal of Forestry Research2002，13，3： | 17 |
| 3 | Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa显示文摘AIM: To analyze possible relationships between CA ⅠⅩ/CA Ⅻ and pVHL expression in normal and neoplastic colorectal mucosa.METHODS: Immunohistochemical staining of 42 tissue specimens obtained from 17 cancer patients was performed to evaluate the distribution and semi-quantitatively assess the levels of CA ⅠⅩ, CA Ⅻ and pVHL. VHL mRNAs from 14 fresh-frozen tumors was amplified by RT-PCR and subjected to sequencing. CA9 and CA12 mRNA levels were analyzed by semi-quantitative RT-PCR in comparison with VEGFas an indicator of hypoxia that uncouples the pVHL control.RESULTS: Tumor tissues were associated with a borderline increase of CA ⅠⅩ staining signal and slight but significant decrease of CA Ⅻ immunoreactivity, whereas no association was found for pVHL. Sequence analysis of RT-PCR-amplified VHL mRNAs revealed no deletions/mutations, suggesting that they were VHL-competent. We did not observe any correlation between pVHL and CA ⅠⅩ/CA Ⅻ proteins as well as between VEGF and CA9 mRNAs, but the tumor-associated changes in mRNA levels of VEGF and CA12 showed a significant inverse relationship.CONCLUSION: Our results indicate that CA9 and CA12 are regulated by different intratumoral factors and that lack of apparent relationship between the levels of CA ⅠⅩ/CA Ⅻ and pVHL cannot be fully assigned to uncoupling of negative regulatory function of pVHL by tumor hypoxia signified by induced VEGF transcription. The interplay between the functional pVHL and CA ⅠⅩ/CA Ⅻ in colorectal tumors seems rather complex and is not evident merely at the expression levels. | Antti J. Kivela Seppo Parkkila Juha Saarnio Tuomo J. Karttunen Jyrki Kivela Anna-Kaisa Parkkila Maria Bartosova Vojtech Mucha Michal Novak Abdul Waheed William S. Sly Hannu Rajaniemi Silvia Pastorekova Jaromir Pastorek | 2005 | World Journal of Gastroenterology2005，11，17： | 10 |
| 4 | Quality of life following laparoscopic Nissen fundoplication: Assessing short-term and long-term outcomes显示文摘AIM: To investigate the quality of life following lapa-roscopic Nissen fundoplication by assessing short-term and long-term outcomes. METHODS: From 1992 to 2005, 249 patients under-went laparoscopic Nissen fundoplication. Short-term outcome data including symptom response, side effects of surgery, endoscopy, and patient's perception of over-all success were collected prospectively. Long-term out-comes were investigated retrospectively in patients witha median follow-up of 10 years by assessment of reflux symptoms, side effects of surgery, durability of antire-flux surgery, need for additional treatment, patient's perception of success, and quality of life. Antireflux sur-gery was considered a failure based on the following criteria: moderate to severe heartburn or regurgitation; moderate to severe dysphagia reported in combination with heartburn or regurgitation; regular proton pump inhibitor medication use; endoscopic evidence of erosive esophagitis Savary-Miller grade 1-4; pathological 24-h pH monitoring; or necessity to undergo an additional surgery. The main outcome measures were short-and long-term cure rates and quality of life, with patient sat-isfaction as a secondary outcome measure. RESULTS: Conversion from laparoscopy to open sur-gery was necessary in 2.4% of patients. Mortality was zero and the 30-d morbidity was 7.6% (95%CI: 4.7%-11.7%). The median postoperative hospital stay was 2 d [interquartile range (IQR) 2-3 d]. Two hundred and forty-seven patients were interviewed for short-term analysis following endoscopy. Gastro-esophageal reflux disease was cured in 98.4% (95%CI: 95.9%-99.6%) of patients three months after surgery. New-onset dysphagia was encountered postoperatively in 13 patients (6.7%); 95% reported that the outcome was better after antireflux surgery than with preopera-tive medical treatment. One hundred and thirty-nine patients with a median follow-up of 10.2 years (IQR 7.2-11.6 years) were available for a long-term evalu-ation. Cumulative long-term cure rates were 87.7% (81.0%-92.2%) at 5 years and 72.9% (64.0%-79.9%) at 10 years. Gastrointestinal symptom rating scores and RAND-36 quality of life scores of patients with treatment success were similar to those of the general population but significantly lower in those with failed antireflux surgery. Of the patients available for long-term follow-up, 83% rated their operation a success. CONCLUSION: For the long-term, our results indicate decreasing effectiveness of laparoscopic antirefluxsurgery, although most of the patients seem to have an overall quality of life similar to that of the general population. | Ilmo Kellokumpu Markku Voutilainen Caj Haglund Martti Frkkil Peter J Roberts Hannu Kautiainen | 2013 | World Journal of Gastroenterology2013，19，24： | 7 |
| 5 | 生产溶解浆的最新技术显示文摘在过去,溶解浆生产以亚硫酸盐法蒸煮为主。由于环境的原因,亚硫酸盐法蒸煮有所减少,而采用预水解硫酸盐法蒸煮。开始只采用间歇蒸煮技术,但由于溶解浆的需求不断增加,开发了基于预水解硫酸盐法蒸煮的连续蒸煮技术。这一新的解决方案已经通过广泛的试验室试验,随后安装和运行在现有的最初设计生产漂白硫酸盐商品浆的工厂。新的工艺和设备设计,已经解决了先前尝试在溶解浆生产中采用连续蒸煮技术遇到的负面问题。新建和现有浆厂可以从该新工艺解决方案中受益,这也使得溶解浆与造纸用浆可共用同一制浆生产线。 | Hannu Ramark | 2012 | 中华纸业2012，，21： | 7 |
| 6 | Myofibroblastic cell activation and neovascularization predict native liver survival and development of esophageal varices in biliary atresia显示文摘AIM:To study the relation between collagen 1,α-smooth muscle actin(α-SMA)and CD34 expression and the most essential portoenterostomy(PE)outcomes.METHODS:Liver specimens were obtained at PE from33 biliary atresia(BA)patients for immunohistochemical analysis of collagen 1,α-SMA and CD34.Liver biopsies from 35 organ donors were used as controls.Expression patterns were related to clinical data including age at PE,serum total and conjugated bilirubin concentration at the time of PE and during follow-up,incidence of esophageal varices in follow-up upper gastrointestinal endoscopies,and native liver survival as well as to detailed histopathological findings.RESULTS:Collagen 1(16.4%vs 4.5%,P<0.0001),α-SMA(17.9%vs 4.6%,P<0.0001)and CD34(4.9%vs 3.8%,P=0.017)were markedly overexpressed in BA patients compared with controls.Patients who underwent liver transplantation by age of two years had significantly higher expression of collagen 1(18.6%vs 13.7%,P=0.024),α-SMA(20.4%vs 15.4%,P=0.009)and CD34(5.9%vs 4.0%,P=0.029)at PE compared with native liver survivors.CD34-positive microvessels were identified in the centrizonal region close to central vein in every BA patient.In majority of BA cases(56%)neovascularization was frequent as CD34-positive microvessels were observed in over half of the hepatic lobules.In controls,the CD34-positive microvessels were rare as they were completely absent in 40%and were found in less than 5%of the hepatic lobules in the rest.The difference between BA patients and controls was significant(P<0.0001).Patients who developed esophageal varices by two years had significantly higher expression of CD34 at PE compared with patients without varices(5.6%vs 4.0%,P=0.019).Expression ofα-SMA(r=0.758,P<0.0001)and collagen 1(r=0.474,P=0.016),and the amount of CD34-positive microvessels(r=0.356,P=0.047)were related to patient age at PE.CONCLUSION:Hepatic myofibroblastic cell activation,fibrogenesis and neovascularization are enhanced in BA,progress with increasing PE age and relate to native liver survival and development of esophageal varices. | Janne S Suominen Hanna Lampela Pivi Heikkil Jouko Lohi Hannu Jalanko Mikko P Pakarinen | 2014 | World Journal of Gastroenterology2014，20，12： | 6 |
| 7 | Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults显示文摘AIM: To evaluate the effects of three potentially anti- inflammatory probiotic bacteria from three different genera on immune variables in healthy adults in a clinical setting based on previous in vitro characterization of cytokine responses. METHODS: A total of 62 volunteers participated in this randomized, double-blind and placebo-controlled parallel group intervention study. The volunteers were randomized to receive a milk-based drink containing either Lactobacillus rhamnosus GG (LGG), Bifidobacterium animalis ssp. lactis Bb12 (Bb12), or Propionibacterium freudenreichii ssp. shermanii JS (PJS) or a placebo drink for 3 wk. Venous blood and saliva samples were taken at baseline and on d 1, 7 and 21. Fecal samples were collected at baseline and at the end of intervention. RESULTS: The serum hsCRP expressed as the median AUC0-21 (minus baseline) was 0.018 mg/L in the placebo group, -0.240 mg/L in the LGG group, 0.090 mg/L in the Bb12 group and -0.085 mg/L in the PJS group (P = 0.014). In vitro production of TNF-α from in vitro cultured peripheral blood mononuclear cells (PBMC) was significantly lower in subjects receiving LGG vs placebo. IL-2 production from PBMC in the Bb12 group was significantly lower compared with the other groups. CONCLUSION: In conclusion, probiotic bacteria have strain-specific anti-inflammatory effects in healthy adults. | Riina A Kekkonen Netta Lummela Heli Karjalainen Sinikka Latvala Soile Tynkkynen Salme Jrvenp Hannu Kautiainen Ilkka Julkunen Heikki Vapaatalo Riitta Korpela | 2008 | World Journal of Gastroenterology2008，14，13： | 6 |
| 8 | Seasonal variations of acute appendicitis and nonspecific abdominal pain in Finland显示文摘AIM:To investigate whether seasonal changes had an effect on the incidence of acute appendicitis(AA)or nonspecific abdominal pain(NSAP).METHODS:We carried out a national register study of all patients with a hospital discharge diagnosis of AA and acute NSAP in Finland.Data were analyzed for the whole country and correlated to seasonal and weather parameters(temperature,humidity).Moreover,additional sub-analyses were performed for five geographically different area of Finland.RESULTS:The observation period spanned 21 years,with 186558 appendectomies,of which 137528(74%)cases were reported as AA.The incidence of AA declined for 32%over the study period.The average incidence of the NSAP was 34/10000 per year.The mean annual temperature,but not relative humidity,showed clear geographical variations.The incidence of AA decreased significantly during the cold months of the year.No correlation was detected between temperature and incidence of NSAP.Humidity had a statistically significant impact on NSAP.CONCLUSION:The incidence of acute appendicitis is declining in Finland.We detected a clear seasonality in the incidence of AA and NSAP. | Imre Ilves Anne Fagerstrm Karl-Heinz Herzig Petri Juvonen Pekka Miettinen Hannu Paajanen | 2014 | World Journal of Gastroenterology2014，20，14： | 6 |
| 9 | 当前造纸设备研究与发展方向显示文摘论述了造纸设备的研究与开发主体已从原来的以造纸厂为主转向目前的以造纸机械厂为主,且集中在少数实力雄厚的造纸机械厂中。同时介绍了纸机、纸板机及整饰设备的最新技术动向。 | Hannu Oinonen | 2004 | 中华纸业2004，25，5： | 5 |
| 10 | Century-long variability and trends in daily precipitation characteristics at three Finnish stations显示文摘Long-term variations and trends in a wide range of statistics for daily precipitation characteristics in terms of intensity, frequency and duration in Finland were analysed using precipitation records during 1908e2008 from 3 meteorological stations in the south(Kaisaniemi),centre(Kajaani) and north(Sodankyl€a). Although precipitation days in northern part were more frequent than in central and southern parts, daily precipitation intensity in the south was generally higher than those in the centre and north of the country. Annual sum of very light precipitation(0 mm < daily precipitation long-term 50 th percentile of daily precipitation more than 0 mm) significantly( p < 0.05) decreased over time,with the highest rate in northern Finland. These decreasing trends might be the result of significant increases in frequency of days with very light precipitation at all the stations, with the highest and lowest rates in northern and southern Finland, respectively. Ratio of annual total precipitation to number of precipitation days also declined in Finland over 1908e2008, with a decreasing north to south gradient. However, annual duration indices of daily precipitation revealed no statistically significant trends at any station. Daily precipitation characteristics showed significant relationships with various well-known atmospheric circulation patterns(ACPs). In particular, the East Atlantic/West Russia(EA/WR)pattern in summer was the most influential ACP negatively associated with different daily precipitation intensity, frequency and duration indices at all three stations studied. | Masoud IRANNEZHAD Hannu MARTTILA Deliang CHEN Bj?rn KL?VE | 2016 | Advances in Climate Change Research2016，7，1： | 4 |
| 11 | 气候变化和紫外线辐射对北极淡水鱼类及溯河产卵鱼类渔业的影响显示文摘北极淡水鱼类和洄游鱼类渔业为北方经济做出了重大贡献。但是,对于淡水水体,气候变化和增长的紫外线辐射对渔业产生的巨大影响有3个方面:可获鱼的数量、质量和捕捞成功率。因此,在这些影响发生作用之际,可能需要实质有效的适应行为以引导北极未来的渔业走向可持续性。当务之急是为商业渔业选择灵活和快速反应的'适宜管理'方式;改变生计渔业的当地土地和资源利用模式;改变很多休闲渔业的特性、管理方式和地点。总的来说,在气候变化及其对北极淡水水域和生物区影响的复杂性和不确定性情况下,为保证生态系统和主导鱼种有足够的恢复力和应对将来变化的能力,需要对渔业的各个方面实施更保守的管理办法。 | James D.Reist Frederick J.Wrona Terry D.Prowse J.Brian Dempson Michael Power Günter Kck Theresa J.Carmichael Chantelle D.Sawatzky Hannu Lehtonen Ross F.Tallman 曾首英 | 2006 | AMBIO-人类环境杂志2006，35，7： | 4 |
| 12 | 北方沼泽地水位下降对全球气候变暖的影响显示文摘自从最后一次冰川消退以来,北方沼泽地(3.46亿hm^2)积存了300~500Pg碳。这些沼泽地在分离二氧化碳(CO_2)的同时,释放了相当数量的甲烷(CH_4)到大气中。正如对高纬地区预报的那样,如果夏季变得更热、更干,未来沼泽地温室气体的平衡将发生变化,随之而来的CH_4排放将减少,而CO_2和N_2O的排放将增加。北部沼泽地水位下降预计将增强温室效应的影响。我们分别在不同营养水平的未排水和排水的沼泽地测量了碳循环的组分,并把这些结果归纳成一个简单的辐射强迫因子,用以评价水位下降对大气的综合影响。在对存于土壤和树木中的碳以及为经营森林而排水引起的水位下降后CO_2、CH_4和N_2O的通量的变化作出测量的基础上,我们提出一个假设,即由气候变化引发的干旱趋势将减弱北方沼泽地对总辐射强迫的影响,这一影响在100年内约为0.1W/m^2。CH_4排放的减少,沼泽地碳储量的微小变化和树木生物量储存的增加都将导致这一变化。 | Jukka Laine Jouko Silvola Kimmo Tolonen Jukka Alm Hannu Nyknen Harri Vasander Tapani Sallantaus Ilkka Savolainen Jukka Sinisalo Pertti J.Martikainen 钱云 | 1996 | 人类环境杂志1996，25，3： | 4 |
| 13 | Thiol-stabilized atomically precise, superatomic silver nanoparticles for catalysing cycloisomerization of alkynyl amines显示文摘Both the electronic and surface structures of metal nanomaterials play critical roles in determining their chemical properties. However, the non-molecular nature of conventional nanoparticles makes it extremely challenging to understand the molecular mechanism behind many of their unique electronic and surface properties. In this work, we report the synthesis, molecular and electronic structures of an atomically precise nanoparticle, [Ag206 L72]~q(L = thiolate, halide; q = charge). With a four-shell Ag7@Ag32@Ag77@Ag90 Ino-decahedral structure having a nearly perfect D_(5h) symmetry, the metal core of the nanoparticle is co-stabilized by 68 thiolate and 4 halide ligands. Both electrochemistry and plasmonic absorption reveal the metallic nature of the nanoparticles, which is explained by density functional theory calculations.Electronically, the nanoparticle can be considered as a superatom, just short of a major electron shell closing of 138 electrons(q = –4). More importantly, many of ligands capping on the nanoparticle are labile due to their low-coordination modes, leading to high surface reactivity for catalysing the synthesis of indoles from 2-ethynylaniline derivatives. The results exemplify the power of the atomic-precision nanocluster approach to catalysis in probing reaction mechanisms and in revealing the interplay of heterogeneous reactivities,electronic and surface structural dynamics, thereby providing ways for optimization. | Juanzhu Yan Jun Zhang Xumao Chen Sami Malola Bo Zhou Elli Selenius Xiaomin Zhang Peng Yuan Guocheng Deng Kunlong Liu Haifeng Su Boon K.Teo Hannu Hakkinen Lansun Zheng Nanfeng Zheng | 2018 | National Science Review2018，5，5： | 3 |
| 14 | Multi-scale study of ductility-dip cracking in nickel-based alloy dissimilar metal weld显示文摘A ductility-dip-cracking(DDC)-concentrated zone(DCZ) in a width of about 3 mm was observed adjacent to the AISI 316 L/52 Mw fusion boundary(FB) in 52 Mw. The morphology, microstructure, mechanical and thermal properties and corrosion behavior in simulated primary water of DDC/DCZ were investigated by scanning electron microscopy(SEM), transmission electron microscopy(TEM), 3 D X-ray tomography(XRT), 3 D atom probe(3 DAP), slow strain rate tensile(SSRT) testing and thermal dilatometry. The results indicate that DDCs are random-shaped and disc-like cavities with corrugated structure of inner surface and are parallel in groups along straight high-angle boundaries of columnar grains, ranging from micrometers to millimeters in size. Large-size M_(23)C_6 carbides dominate on the grain boundaries rather than MC(M=Nb, Ti), and thus the bonding effect of carbides is absent for the straight grain boundaries.The impurity segregation of O is confirmed for the inner surfaces of DDC. The oxide film formed on the inner surface of DDC(about 50 nm) is approximately twice as thick as that on the matrix(about 25 nm)in simulated primary water. The yield strength, tensile strength and elongation to fracture of 52 MwDCZ(400 MPa, 450 MPa and 20 %, respectively) are lower than those of 52 Mw-MZ(460 MPa, 550 MPa and 28 %, respectively). The intrinsic high-restraint weld structure, the additional stress/strain caused by the thermal expansion difference between AISI 316 L and 52 Mw as well as the detrimental carbide precipitation and the resulting grain boundary structure all add up to cause the occurrence of DCZ in the dissimilar metal weld. | Yifeng Li Jianqiu Wang En-Hou Han Wenbo Wu Hannu Hanninen | 2019 | Journal of Materials Science & Technology2019，35，4： | 3 |
| 15 | Faecal calprotectin and lactoferrin are reliable surrogate markers of endoscopic response during Crohn’s disease treatment显示文摘 | Taina Sipponen Clas-Gö ran AF Bjö rkesten Martti Fä rkkilä Hannu Nuutinen Erkki Savilahti Kaija-Leena Kolho | 2010 | Scandinavian Journal of Gastroenterology2010，，3： | 2 |
| 16 | Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings显示文摘 | Hannu JA Inna EG David NL | 1994 | Radiology1994，191，1： | 2 |
| 17 | 溶解浆的市场趋势和最新技术显示文摘溶解浆的生产过去以亚硫酸盐法蒸煮为主,由于环境的原因,亚硫酸盐法蒸煮已较少采用,而采用预水解硫酸盐法蒸煮。开始只采用间歇蒸煮技术,但由于溶解浆的需求不断增加,开发了基于预水解硫酸盐法蒸煮的连续蒸煮技术。这一新的解决方案已经通过广泛的实验室实验,随后在最初设计生产漂白硫酸盐商品浆的浆厂应用。新设计的工艺和设备已经解决了先前尝试在溶解浆生产中采用连续蒸煮技术遇到的负面问题。新建和现有的浆厂可以从该新工艺解决方案中受益,这也使得溶解浆与造纸用浆可共用同一制浆生产线。 | Hannu Ramark | 2013 | 中国造纸2013，32，1： | 2 |
| 18 | Optimization of biofiltration for odor control: Model development and parameter sensitivity显示文摘 | Li Hebi Crittenden John C Mihelcic James R Hautakangas Hannu | 2002 | Water Environment Research2002，74，1： | 1 |
| 19 | The effect of intravenous ketoprofen on postoperative epidnral snfentanil analgesia in children 显示文摘 | Hannu K Kati T Heikki H | 2000 | Anesth Analg2000，88，5： | 1 |
| 20 | The Economic Value of Urban Forest Amenities:An Application of the Contingent Valuation Method显示文摘 | Tyrv(a)inen Liisa V(a)(a)n(a)nen Hannu | 1998 | Landscape and Urban Planning1998，43，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员