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| 1 | An overview of PCI in the very elderly显示文摘心血管的疾病,和特别地 ischemic 心疾病(IHD ) ,是病态和死亡的一个主要原因在老(>80 年) 世界范围。这些病人代表为经皮的冠的干预(一种总线标准) 介绍的一个很快成长的队,现在在五个病人组成超过一在真实世界的实践与一种总线标准对待。而且,他们经常比他们的更年轻的对应物有更大的 ischemic 负担,建议他们有从冠的 revascularization 治疗的利益的更大的范围。尽管有这,老在那里在临床的 revascularization 试用并且历史上经常是未被充分代表的是在为一种总线标准过程提交他们的医生勉强的度与令人失望的结果的感觉,低成功和高复杂并发症评价。几个问题贡献了这,包括为有晚介绍的 IHD 的更老的病人的趋势,与不正常的症状或关于他们的程序的 risk-to-benefit 比率的非诊断的 ECG,和保留由于更短的预期寿命,从 antiplatelet 和 anticoagulation 药的 comorbidities 和增加的流血风险的存在。然而,在在过去的十年的一种总线标准技术和技术的进展导致了更好的结果和复杂并发症和存在身体的更低的风险证据现在显示那老实际上比更年轻的人口从一种总线标准导出更相对的利益。重要地,这适用于所有一种总线标准背景:选任,迫切并且紧急情况。这评论在与长期的稳定的 IHD 的老介绍讨论一种总线标准的角色,非圣举起急性冠的症候群,和圣举起心肌的梗塞。当认为在为研究和开发的这个队和进行中的需要的一种总线标准进一步在这些挑战性的病人改进结果时,它也探讨遇见的临床的挑战。 | Vimalraj Bogana Shanmugam Richard Harper Ian Meredith Yuvaraj Malaiapan Peter J Psaltis | 2015 | Journal of Geriatric Cardiology2015，12，2： | 22 |
| 2 | Successful surgical management of ruptured umbilical hernias in cirrhotic patients显示文摘Acute umbilical hernia rupture in patients with hepatic cirrhosis and ascites is an unusual,but potentially lifethreatening complication,with postoperative morbidity about 70% and mortality between 60%-80% after supportive care and 6%-20% after urgent surgical repair.Management options include primary surgical repair with or without concomitant portal venous system decompression for the control of the ascites.We present a retrospective analysis of our centre's experience over the last 6 years.Our cohort consisted of 11 consecutive patients(median age:53 years,range:36-63 years) with advanced hepatic cirrhosis and refractory ascites.Appropriate patient resuscitation and optimisation with intravenous fluids,prophylactic antibiotics and local measures was instituted.One failed attempt for conservative management was followed by a successful primary repair.In all cases,with one exception,a primary repair with non-absorbable Nylon,interrupted sutures,without mesh,was performed.The perioperative complication rate was 25% and the recurrence rate 8.3%.No mortality was recorded.Median length of hospital stay was 14 d(range:4-31 d).Based on our experience,the management of ruptured umbilical hernias in patients with advanced hepatic cirrhosis and refractory ascites is feasible without the use of transjugular intrahepatic portosystemic shunt routinely in the preoperative period,provided that meticulous patient optimisation is performed. | Nikolaos A Chatzizacharias J Andrew Bradley Simon Harper Andrew Butler Asif Jah Emmanuel Huguet Raaj K Praseedom Michael Allison Paul Gibbs | 2015 | World Journal of Gastroenterology2015，21，10： | 4 |
| 3 | 过瘤胃蛋氨酸、赖氨酸和组氨酸对泌乳奶牛生产性能的影响显示文摘试验旨在研究饲料中单独添加或综合添加过瘤胃(RP)蛋氨酸、赖氨酸和组氨酸及可代谢蛋白(MP)对泌乳后期奶牛生产性能的影响。试验选取72头荷斯坦奶牛,随机分为6组,试验期9周。奶牛随机分配到6个试验组中,2周作为1个变量周期:MPA组,根据美国国家科学研究委员会(2001)标准,在饲料中添加调节MP到243 g·d-1;MPD组,不添加MP,MP含量低于标准量54 g·d-1;MPDM组,在MPD组的基础上加入RP蛋氨酸;MPDL组,在MPD组的基础上加入RP赖氨酸;MPDH组,在MPD组的基础上加入组氨酸;MPDMLH组,在MPD组的基础上加入RP蛋氨酸、RP赖氨酸和RP组氨酸。试验结果表明,与MPA组对比,MPD组的干物质采食量(DMI)、产奶量、乳成分(乳脂肪、乳蛋白和乳糖)及能量校正的牛乳(ECM)、ECM饲料利用效率、牛奶和血浆中的N均降低。在MPD基础上补充RP赖氨酸可使乳蛋白率、血浆中葡萄糖浓度增加,且牛奶中N元素含量有增加的趋势;补充RP组氨酸可使DMI、牛奶浓缩蛋白增加,且乳脂肪、乳蛋白和ECM显著增加;补充3种RP氨基酸时,增加了乳蛋白率,使DMI和乳脂率有增加趋势,也提高了乳脂肪、乳蛋白含量和ECM及ECM饲料利用效率。与MPA相比,MPD组牛奶中N的含量有降低趋势,且血浆中必需氨基酸(除赖氨酸和蛋氨酸)浓度均降低。补充RP赖氨酸、RP蛋氨酸和RP组氨酸提高了血浆中蛋氨酸(除MPDM组)、赖氨酸和组氨酸浓度。饲喂MPD的奶牛血红蛋白浓度降低,血浆生长素含量高于MPA组。MPD组牛奶中总饱和脂肪酸浓度有高于MPA和MPDMLH组的趋势。MPD组的多元不饱和脂肪、牛奶中奇链与支链脂肪酸含量与MPA组相比,有降低趋势。试验结果表明,对于饲料中缺乏MP的奶牛,在饲料中添加组氨酸和添加3种RP氨基酸(赖氨酸、蛋氨酸和组氨酸)均有提高牛奶产量和牛奶组分含量的可能性。 | Giallongo F Harper M T Oh J Lopes J C Lapierre H Patton R A Parys C Shinzato I Hristov A N | 2016 | 饲料博览2016，0，7： | 4 |
| 4 | The anaphase-promoting complex:It's not just for mitosis any more显示文摘 | Harper J W Burton J L Solomon M J | 2002 | Genes Dev2002，16，： | 2 |
| 5 | Nonulcer dyspepsia associated with psychiatric disorder显示文摘 | Strohlein J Harper RG | 1993 | South Med J1993，86，6： | 1 |
| 6 | Surface disturbance of cryptobiotic soil crusts: Nitrogenase activity,chlorophyll content,and chlorophyll degradation显示文摘 | Belnap J Harper K T Warren S D | 1994 | Arid Soil Research and Rehabilitation1994，8，： | 1 |
| 7 | Developments in broad beam ion source technology and applications显示文摘 | Harper J M E Cuomo J J | 1983 | J Vac Sci Technol A1983，1，2： | 1 |
| 8 | Life-history concepts andthepopulation biology of clonal organisms 显示文摘 | Saekvilh Hamilton N R Schmid B Harper J L | 1987 | Proceeding of Royal Society London B1987，232，： | 1 |
| 9 | Bo-vine citrullinaemia-A clinical,pathological,biochemi-cal and genetic study显示文摘 | HEALY P J HARPER P A W DENNIS J A | 1990 | Aust Vet J1990，67，： | 1 |
| 10 | Effect of capture and season on fecal glucocorticoid levels in dee mice(Peromyscus maniculatus) and red-backed voles (Clethrionomys gapperi)显示文摘 | Harper J M Austad S N | 2001 | General and Comparative Endocrinology2001，123，3： | 1 |
| 11 | Acin: a 1, 3-di- hydroisobenzofuran from Pestalotiopsis microspora possessing an- tioxidant and antimycotic activities显示文摘 | Harper J K Ford E J Strobe1 G A | 2003 | Tetrahedron2003，59，： | 1 |
| 12 | Communication with calcium显示文摘 | Sanders D Brownlee C Harper J F | 1999 | Plant Cell1999，11，： | 1 |
| 13 | Increasing hydroxyapatite incorporation into poly(methylmethacrylate)cement increases osteoblast adhesion and response显示文摘 | DALBY M J SILVIO L D HARPER E J | 2002 | Biomaterials2002，23，2： | 1 |
| 14 | EGFR and cancer prognosis显示文摘 | Nicholson R I Gee J M Harper M E | 2001 | Eur J Cancer2001，37，4： | 1 |
| 15 | Pestacin:a 1,3-dihydro isobenzofuran from Pestalotiopsis microspora possessing antioxidant and antimycotic activities显示文摘 | HARPER J K ARIF A M FORD E J | 2003 | Tetrahedron2003，59，14： | 1 |
| 16 | Determinants of increased regional left atrial coagulation activity in patients with mitral stenosis显示文摘 | Harper RW Gelman J | 1996 | Circulation1996，94，3： | 1 |
| 17 | Technology and applications of broad beam ion sources used in sputtering(Part 2): Application显示文摘 | Harper J M E Cuomo J J | 1982 | J Vac Sci Technol1982，21，3： | 1 |
| 18 | Mustard gas casual ties显示文摘 | REES J HARPER P ELLIS F | 1991 | The Lancet1991，337，： | 1 |
| 19 | Magnetocaloric effect in NiMnGa particles produced by spark erosion显示文摘 | TANG Y J SOLOMON V C SMITH D J HARPER H BERKOWITZ A E | 2005 | J Appl Phys2005，97，309： | 1 |
| 20 | Chronic ulcer of the leg: clinical history 显示文摘 | Callam M J Harper DR Dale JJ | 1987 | Br Med J (Clin Res Ed)1987，294，： | 1 |
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