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| 1 | Hepatitis E virus in patients with acute severe liver injury显示文摘AIM: To examine the incidence of hepatitis E(HepE) in individuals with acute liver injury severe enough to warrant treatment at a transplant unit.METHODS: Hepatitis E virus(HEV) is an emerging pathogen in developed countries causing severe illness, particularly in immunocompromised patients or those with underlying chronic liver disease. HepE infection isoften under diagnosed, as clinicians can be reluctant to test patients who have not travelled to regions traditionally considered hyperendemic for HepE. There are few data regarding the significance of HEV in patients with very severe acute liver injury in developed countries. Eighty patients with acute severe liver injury attending the Scottish Liver Transplant unit were tested for HEV and anti-HEV IgG and IgM. Severe acute liver injury was defined as a sudden deterioration in liver function confirmed by abnormal liver function tests and coagulopathy or presence of hepatic encephalopathy. Eighty percent of these patients were diagnosed with paracetomol overdose. No patients had a history of chronic or decompensated chronic liver disease at time of sampling. IgG positive samples were quantified against the World Health Organization anti-HEV IgG standard. Samples were screened for HEV viral RNA by quantitative reverse transcription polymerase chain reaction.RESULTS: Four cases of hepatitis E were identified. Three of the four cases were only diagnosed on retrospective testing and were initially erroneously ascribed to drug-induced liver injury and decompensated chronic liver disease, with the cause of the decompensation uncertain. One case was caused by HEV genotype 1 in a traveller returning from Asia, the other three were autochthonous and diagnosed on retrospective testing. In two of these cases(where RNA was detected) HEV was found to be genotype 3, the most prevalent genotype in developed countries. Three patients survived, two of whom had been misdiagnosed as having drug induced liver injury. The fourth patient died from sepsis and liver failure precipitated as a result of hepatitis E infection and previously undiagnosed cirrhosis. Histopathology data to date is limited to mainly that seen for endemic HepE. All patients, with the exception of patient 1, demonstrated characteristics of HepE infection, as seen in previously described locally acquired cases.CONCLUSION: In patients with acute severe liver injury, HEV testing should be part of the initial diagnostic investigation algorithm irrespective of suspected initial diagnosis, age or travel history. | Claire Louise Crossan Kenneth J Simpson Darren G Craig Christopher Bellamy Janice Davidson Harry R Dalton Linda Scobie | 2014 | World Journal of Hepatology2014，6，6： | 4 |
| 2 | Stimulation of bone formation in vitro and in rodents by statins 显示文摘 | JMUNDY G GARRETT R HARRIS S | 1999 | Science1999，286，： | 1 |
| 3 | The Effect of Financial Liberalization on the Capital Structure and Invest- ment Decisions of Indonesian Manufacturing Establishments 显示文摘 | Harris J R Schiantarelli F Siregar M G | 1994 | World Bank Economic Review1994，8，1： | 1 |
| 4 | Odour intensities of hop oil components 显示文摘 | Guadagni D G Buttery R G Harris J | 1966 | Journal of the Science of Food and Agriculture1966，17，3： | 1 |
| 5 | Artifacts in MR imaging,description,cause and solutions显示文摘 | Wesbey G Edelman RR Harris R | 1990 | Clin Magn Reson Imaging1990，，5： | 1 |
| 6 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 7 | SLimuluLion of bone formation in vitro and in rodents by statins 显示文摘 | Mundy G Carrett R Harris S | 1999 | Science1999，286，： | 1 |
| 8 | Stimulation of bone formation in vitro and in rodents by statins显示文摘 | Mundy G Garrett R Harris S | | 0，，5446： | 1 |
| 9 | Stimulation of bone forma- tion in vitro and in rodents by statins显示文摘 | Mundy G Garrett R Harris S | 1999 | Science1999，286，5446： | 1 |
| 10 | Screening for asymptomtic deep vein thrombosis in surgical intensive care patients显示文摘 | Harris L M Curl G R Booth F V | 1997 | J Vasc Surg1997，26，6： | 1 |
| 11 | Phosphate-induced metal immobilization in a contaminated site 显示文摘 | CAO R X MA L Q CHEN M SINGH S P HARRIS W G | 2003 | Environmental Pollution2003，122，： | 1 |
| 12 | Chemoprevention of breast cancer in rats by celecoxib,a cyxlooxygenase 2 inhibitor显示文摘 | Alshafie G A Abou Issa H | 2000 | Cancer Res2000，60，8： | 1 |
| 13 | Stimulation of bone formation in vitro and in rodents by stains显示文摘 | Mundy G Garrett R Harris S | 1999 | Science1999，286，5446： | 1 |
| 14 | Odour intensities of hop oil components显示文摘 | Guadagni D G Buttery R G Harris J | 1966 | Journal of Agricultural and Food Chemistry1966，17，3： | 1 |
| 15 | Stimulation of bone formation in vitro and in rodents by statins显示文摘 | Mundy G Garrett R Harris S | 1999 | Science1999，286，5446： | 1 |
| 16 | Effect of prone position on regional shunt,aeration,and perfusion in experimental acute lung injury显示文摘 | Richter T Bellani G Scott Harris R | | 0，，： | 1 |
| 17 | Dynamics of soil aggregation 显示文摘 | Harris R F Chesters G Anllen O N | 1996 | Advance in Agronomy1996，18，： | 1 |
| 18 | Staphylococci and implant surfaces: A review显示文摘 | Harris L G Richards R G | 2006 | Injury2006，37，2： | 1 |
| 19 | A novelmicromachined pump based on thick-film piezoelectric actuation显示文摘 | Michael Koch Nick Harris Alan G R Evans | 1998 | Sens Actuators A1998，70，： | 1 |
| 20 | Psy-chometrically equivalent Russian speech audiometrymaterials by male and female talkers显示文摘 | HARRIS R W NISSEN S L POLA M G | 2007 | Int J Audiol2007，46，： | 1 |
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