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| 1 | Systematic mechanism-orientated approach to chronic pancreatitis pain显示文摘Pain in chronic pancreatitis(CP) shows similarities with other visceral pain syndromes(i.e.,inflammatory bowel disease and esophagitis),which should thus be managed in a similar fashion.Typical causes of CP pain include increased intrapancreatic pressure,pancreatic inflammation and pancreatic/extrapancreatic complications.Unfortunately,CP pain continues to be a major clinical challenge.It is recognized that ongoing pain may induce altered central pain processing,e.g.,central sensitization or pro-nociceptive pain modulation.When this is present conventional pain treatment targeting the nociceptive focus,e.g.,opioid analgesia or surgical/endoscopic intervention,often fails even if technically successful.If central nervous system pain processing is altered,specific treatment targeting these changes should be instituted(e.g.,gabapentinoids,ketamine or tricyclic antidepressants).Suitable tools are now available to make altered central processing visible,including quantitative sensory testing,electroencephalograpy and(functional) magnetic resonance imaging.These techniques are potentially clinically useful diagnostic tools to analyze central pain processing and thus define optimum management approaches for pain in CP and other visceral pain syndromes.The present review proposes a systematic mechanism-orientated approach to pain management in CP based on a holistic view of the mechanisms involved.Future research should address the circumstances under which central nervous system pain processing changes in CP,and how this is influenced by ongoing nociceptive input and therapies.Thus we hope to predict which patients are at risk for developing chronic pain or not responding to therapy,leading to improved treatment of chronic pain in CP and other visceral pain disorders. | Stefan AW Bouwense Marjan de Vries Luuk TW Schreuder Soren S Olesen Jens B Frokjær Asbjorn M Drewes Harry van Goor Oliver HG Wilder-Smith | 2015 | World Journal of Gastroenterology2015，21，1： | 6 |
| 2 | Cost-utility of molecular adsorbent recirculating system treatment in acute liver failure显示文摘AIM:To determine the short-term cost-utility of mo-lecular adsorbent recirculating system(MARS) treatment in acute liver failure(ALF).METHODS:A controlled retrospective study was conducted with 90 ALF patients treated with MARS from 2001 to 2005.Comparisons were made with a historical control group of 17 ALF patients treated from 2000 to 2001 in the same intensive care unit(ICU) specializing in liver diseases.The 3-year outcomes and number of liver transplantations were recorded.All direct liver disease-related medical expenses from 6 mo before to 3 years after ICU treatment were determined for 31 MARS patients and 16 control patients.The health-related quality of life(HRQoL) before MARS treatment was estimated by a panel of ICU doctors and after MARS using a mailed 15D(15-dimensional generic healthrelated quality of life instrument) questionnaire.The HRQoL,cost,and survival data were combined and the incremental cost/quality-adjusted life years(QALYs) was calculated.RESULTS:In surviving ALF patients,the health-related quality of life after treatmeant was generally high and comparable to the age-and gender-matched general Finnish population.Compared to the controls,the average cost per QALY was considerably lower in the MARS group(64 732€ vs 133 858€) within a timeframe of 3.5 years.The incremental cost of standard medical treatment alone compared to MARS was 10 928€,and the incremental number of QALYs gained by MARS was 0.66.CONCLUSION:MARS treatment combined with standard medical treatment for ALF in an ICU setting is more cost-effective than standard medical treatment alone. | Taru Kantola Suvi Mklin Anna-Maria Koivusalo Pirjo Rsnen Anne Rissanen Risto Roine Harri Sintonen Krister Hckerstedt Helena Isoniemi | 2010 | World Journal of Gastroenterology2010，16，18： | 3 |
| 3 | The influence of SiC reinforcement on pitting behavior of aluminum显示文摘 | Trowsdale A J Noble B Harris S J Gibbins I S R | 1996 | Corrosion Science1996，38，： | 2 |
| 4 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 5 | Stimulation of bone formation in vitro and in rodents by statins 显示文摘 | JMUNDY G GARRETT R HARRIS S | 1999 | Science1999，286，： | 1 |
| 6 | Chloroplast DNA and biosystematics: The effects of intraspecific diversity and plastid transmission 显示文摘 | Harris S A Ingram R | 1991 | Taxon1991，40，： | 1 |
| 7 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 8 | SLimuluLion of bone formation in vitro and in rodents by statins 显示文摘 | Mundy G Carrett R Harris S | 1999 | Science1999，286，： | 1 |
| 9 | Bronchial epithelial cells are rendered insensitive to glucocorticoid transactivation by transforming growth factor-β1显示文摘 | Keenan C R Mok J S Harris T | 2014 | Respir Res2014，15，1： | 1 |
| 10 | Stimulation of bone formation in vitro and in rodents by statins显示文摘 | Mundy G Garrett R Harris S | | 0，，5446： | 1 |
| 11 | Stimulation of bone forma- tion in vitro and in rodents by statins显示文摘 | Mundy G Garrett R Harris S | 1999 | Science1999，286，5446： | 1 |
| 12 | Phosphate-induced metal immobilization in a contaminated site 显示文摘 | CAO R X MA L Q CHEN M SINGH S P HARRIS W G | 2003 | Environmental Pollution2003，122，： | 1 |
| 13 | Stimulation of bone formation in vitro and in rodents by stains显示文摘 | Mundy G Garrett R Harris S | 1999 | Science1999，286，5446： | 1 |
| 14 | Prospective study of nonsteriodal anti-inflammatiory drugs and breast cancer显示文摘 | Harris R E Kasbari S Farrar W B | 1999 | Oncol Rep1999，6，1： | 1 |
| 15 | Relationship between dehydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels:evidence for circadian variation of plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion显示文摘 | Harris B Song R Soong S | 1990 | Cancer Res1990，50，： | 1 |
| 16 | Heterologous Metalloprotein Biosynthesis in Escherichia Coll: Conditions for the Overproduction of Functional Copper-Containing Nitrite Reductase and Azurin From Alcaligenes Xylosoxidans显示文摘 | Harris R L PrudeAncio M Hasnain S S | 2005 | J Synchrotron Rad2005，12，： | 1 |
| 17 | Relations between first flowering date and temperature in the flora of a locality in central England显示文摘 | Fitter A H Fitter R S R Harris I T B | 1995 | Function Ecology1995，9，1： | 1 |
| 18 | Directed evolution of ionizing radiation resistance in Escherichia coli 显示文摘 | Harris D R Pollock S V Wood E A Goiffon R J Klingele A J Cabot E L Schackwitz W Martin J Eggington J Durfee T J Middle C M Norton J E Popelars M C Li H Klugman S A Hamilton L L Bane L B Pennacchio L A Albert T J Perna N T Cox M M Battista J R | 2009 | Journal of Bacteriology2009，191，16： | 1 |
| 19 | Stimulation of bone formation in vitro and in rodents by statins显示文摘 | Mundy G Garrett R Harris S | 1999 | Science1999，286，5446： | 1 |
| 20 | Stripes and belly-spots - a review of pigment cell morphogenesis in vertebrates 显示文摘 | KELSH R N HARRIS M L COLANESI S | 2009 | Semin Cell Dev Biol2009，20，1： | 1 |
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