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| 1 | 世界卫生组织(WHO)造血与淋巴组织肿瘤分类方案:临床顾问委员会会议报告显示文摘引言 :从 1995年开始 ,欧洲病理学工作者协会和血液病理学会一直致力于制定一个新的世界卫生组织 (WHO)血液恶性肿瘤分类方案 ,该分类方案包括淋巴系肿瘤、髓系肿瘤、组织细胞肿瘤和肥大细胞肿瘤。 材料与方法 :此项 WHO计划共组成十个病理学工作者委员会 ,负责确定病种和作出定义。另外还成立一个由国际血液学家和肿瘤学家组成的临床顾问委员会 (CAC)以保证该分类的临床实用性。 1997年 11月召开会议讨论了与该分类有关的临床问题。 结果 :WHO采纳了 1994年国际淋巴瘤研究组 (IL SG)报告的修订欧美淋巴系肿瘤分类 (REAL)方案作为淋巴系肿瘤的分类方案。该方案的分类方法遵循以下原则 :分类应是联合应用形态学、免疫表型、遗传特征及临床特征能够清楚界定的“真实存在”(“real”)病种的名录 ,上述各项特征的相对重要性因病种不同而异 ,不存在任何“金标准”。 WHO将 REAL分类原则延用于髓系肿瘤和组织细胞肿瘤 ,髓系肿瘤的分类包括联合应用细胞形态学和细胞遗传学异常能够界定的各个病种。围绕一系列临床问题召集的这次 CAC会议 ,就提交的大多数问题达成共识 ,这些问题及共识将详述于下。对于另外一些问题 ,CAC认为淋巴系肿瘤临床分组既无必要也不必需 ,患者的治疗取决于淋巴瘤的具体类型 ,如有? | N L Harris E S Jaffe J Diebold G Flandrin H K Muller-Hermelink J Vardiman T A Lister C D Bloomfield 张凤奎 郝玉书 | 2001 | 白血病.淋巴瘤2001，10，3： | 20 |
| 2 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 3 | Hepatitis E virus in patients with acute severe liver injury显示文摘AIM: To examine the incidence of hepatitis E(HepE) in individuals with acute liver injury severe enough to warrant treatment at a transplant unit.METHODS: Hepatitis E virus(HEV) is an emerging pathogen in developed countries causing severe illness, particularly in immunocompromised patients or those with underlying chronic liver disease. HepE infection isoften under diagnosed, as clinicians can be reluctant to test patients who have not travelled to regions traditionally considered hyperendemic for HepE. There are few data regarding the significance of HEV in patients with very severe acute liver injury in developed countries. Eighty patients with acute severe liver injury attending the Scottish Liver Transplant unit were tested for HEV and anti-HEV IgG and IgM. Severe acute liver injury was defined as a sudden deterioration in liver function confirmed by abnormal liver function tests and coagulopathy or presence of hepatic encephalopathy. Eighty percent of these patients were diagnosed with paracetomol overdose. No patients had a history of chronic or decompensated chronic liver disease at time of sampling. IgG positive samples were quantified against the World Health Organization anti-HEV IgG standard. Samples were screened for HEV viral RNA by quantitative reverse transcription polymerase chain reaction.RESULTS: Four cases of hepatitis E were identified. Three of the four cases were only diagnosed on retrospective testing and were initially erroneously ascribed to drug-induced liver injury and decompensated chronic liver disease, with the cause of the decompensation uncertain. One case was caused by HEV genotype 1 in a traveller returning from Asia, the other three were autochthonous and diagnosed on retrospective testing. In two of these cases(where RNA was detected) HEV was found to be genotype 3, the most prevalent genotype in developed countries. Three patients survived, two of whom had been misdiagnosed as having drug induced liver injury. The fourth patient died from sepsis and liver failure precipitated as a result of hepatitis E infection and previously undiagnosed cirrhosis. Histopathology data to date is limited to mainly that seen for endemic HepE. All patients, with the exception of patient 1, demonstrated characteristics of HepE infection, as seen in previously described locally acquired cases.CONCLUSION: In patients with acute severe liver injury, HEV testing should be part of the initial diagnostic investigation algorithm irrespective of suspected initial diagnosis, age or travel history. | Claire Louise Crossan Kenneth J Simpson Darren G Craig Christopher Bellamy Janice Davidson Harry R Dalton Linda Scobie | 2014 | World Journal of Hepatology2014，6，6： | 4 |
| 4 | Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention显示文摘 | Debasis Bagchi Manashi Bagchi Sidney J Stohs Dipak K Das Sidhartha D Ray Charles A Kuszynski Shantaram S Joshi Harry G Pruess | 2000 | Toxicology2000，，2： | 3 |
| 5 | 糖尿病患者累积收缩压负荷与心血管病风险的关系显示文摘该研究旨在评估2型糖尿病患者累积收缩压负荷与心血管事件风险的关系。方法:对百普乐和达美康缓释片对糖尿病和血管疾病的对照评估试验的观察性研究(action in diabetes and vascular disease preterax and diamicron MR controlled evaluation post trial observational study, ADVANCE-ON)中的2型糖尿病患者进行事后分析。 | Wang N Harris K Hamet P Harrap S Mancia G Poulter N Williams B Zoungas S Woodward M Chalmers J Rodgers A 刘青(译) 郑武洪(审校) | 2022 | 中华高血压杂志2022，30，12： | 2 |
| 6 | Long-term outcome in patients with apical hypertrophic cardiomyopathy显示文摘 | Maria J Eriksson Brian Sonnenberg Anna Woo Paul Rakowski Thomas G Parker E.Douglas Wigle Harry Rakowski | 2002 | Journal of the American College of Cardiology2002，，4： | 2 |
| 7 | Frictional characteristics of teflon-steel interfaces under dynamic conditions显示文摘 | Constantinou M C Caccese J Harris H G | 1987 | Earthquake Engineering and Structural Dynamics1987，15，6： | 1 |
| 8 | The Effect of Financial Liberalization on the Capital Structure and Invest- ment Decisions of Indonesian Manufacturing Establishments 显示文摘 | Harris J R Schiantarelli F Siregar M G | 1994 | World Bank Economic Review1994，8，1： | 1 |
| 9 | Odour intensities of hop oil components 显示文摘 | Guadagni D G Buttery R G Harris J | 1966 | Journal of the Science of Food and Agriculture1966，17，3： | 1 |
| 10 | Plasmas as antennas: Theory, experiment and applications显示文摘 | Borg G G Harris J H Martin N M etal | 2000 | Phys Plasmas2000，7，7： | 1 |
| 11 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 12 | Selective sulphidation and flotation of nickel from a nickeliferrous laterite ore 显示文摘 | Harris C T Peacey J G Pickles C A | 2013 | Minerals Engineering2013，54，： | 1 |
| 13 | Selective sulphidation and flotation of nickel from a nickeliferous laterite ore显示文摘 | HARRIS C T PEACEY J G PICKLES C A | 2013 | Minerals Engineering2013，54，： | 1 |
| 14 | Factors affecting local recurrence of colonic adenocarcinoma 显示文摘 | Harris G J Church J M Senagore A J | 2002 | Dis Colon Rectum2002，45，8： | 1 |
| 15 | The SOS response regulates adaptive mutation显示文摘 | McKenzie G J Harris B S Lee P L | 2000 | Proc Natl Acad Sci USA2000，97，： | 1 |
| 16 | Trace element discrimination diagrams for the tectonic interpretation of granitic rocks 显示文摘 | Pearce J A Harris N B W Tindle A G | 1984 | J Petrol1984，25，4： | 1 |
| 17 | Trace element discrimination diagrams for the tecotonic interpretation of granitic rocks显示文摘 | Pearce J A Harris N B W and Tindle A G | 1984 | Journal of Petrology1984，25，： | 1 |
| 18 | Expression of bone morphogenetic protein-7 mRNA in normal and is chemic adult rat kidney 显示文摘 | Simon M Maresh J G Harris S E | 1999 | Am J Physiol1999，276，： | 1 |
| 19 | Odour intensities of hop oil components显示文摘 | Guadagni D G Buttery R G Harris J | 1966 | Journal of Agricultural and Food Chemistry1966，17，3： | 1 |
| 20 | Personality and Team Performance : A Meta - Analysis 显示文摘 | Miranda A G Peeters Harrie F J M Vantuijl Christel G Rutte Isabelle M M J Reymen | 2006 | European Journal of Personality2006，，20： | 1 |
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