|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Low-cost all-polymer integrated circuits 显示文摘 | Drury C J Mutsaers C M J Hart C M | 1998 | Applied Physics Letters1998，73，： | 2 |
| 3 | High rates of nitrification and nitrate turnover in undisturbed coniferous forests显示文摘 | Stark J M Hart S C | 1997 | Nature1997，385，： | 1 |
| 4 | Creating wealth in organizations: The role of strategic leadership 显示文摘 | Brush C Greene P Hart M | 2001 | Academy of Management Executive2001，15，1： | 1 |
| 5 | Apramycin-resistant Escheriehia coli isolated from pigs and a stockman显示文摘 | Hunter J E B Bennett M Hart C A | 1994 | Epidemiol infect1994，112，： | 1 |
| 6 | Childhood mental ability and blood pressure at midlife: linking the Scottish mental survey 1932 and the midspan studies显示文摘 | Starr J M Taylor M D Hart C L | 2004 | J Hypertens2004，22，5： | 1 |
| 7 | Expression of nitric oxide synthase and effect of substrate manipulation of the nitric oxide pathway in mouse ovarian follicles 显示文摘 | LEILA M RICHARD C HART G M | 2004 | Human Reprod2004，19，： | 1 |
| 8 | The great leap: driving innovation from the base of the pyramid 显示文摘 | Hart S L Christensen C M | 2002 | MIT Sloan Management Review2002，44，1： | 1 |
| 9 | Evaluation of analytical methods for determining pesticides in baby foods and adult duplicate-diet samples 显示文摘 | Chuang J C Hart K Chang J S Boman L E Van Emon J M Reed A W | 2001 | Analytica Chimica Acta2001，444，1： | 1 |
| 10 | Settlements of HSL immersed tunnels 显示文摘 | Mortier H Hakkaart C J A Hart W M T | 2006 | Geotechnical Aspects of Underground Construction in Soft Ground2006，，： | 1 |
| 11 | Ion microprobe analysis of oxygen,carbon and hydrogen isotope ratios显示文摘 | Graham C M Harte B | 1998 | SEG Reviews in Economic Geology1998，7，： | 1 |
| 12 | Apramycin-resistant Escheriehia coli isolated from pigs and a stockman显示文摘 | Hunter J E B Bennett M Hart C A | 1994 | Epidemiol infect1994，112，： | 1 |
| 13 | Low-cost all- polymer integrated circuits显示文摘 | Drury C J Mutsaers C M J Hart C M | 1998 | Appl Phys Lett1998，73，1： | 1 |
| 14 | From initial idea to unique advantage:the entrepreneurial challenge of constructing a resource base显示文摘 | BRUSH C G GREENE P G HART M M | 2001 | Academy of Management Executive2001，15，1： | 1 |
| 15 | Neuropeptide Y attenuates satiety:evidence from a detailed analysis of patterns of ingestion显示文摘 | Lynch W C Hart P Babcock A M | | 0，，： | 1 |
| 16 | Mechanisms of action of probiotics:recent advances显示文摘 | NG S C HART A L KAMM M A | 2009 | Inflamm Bowel Dis2009，15，2： | 1 |
| 17 | Middle Cambrian to Permian subduction-related accretionary orogenesis of North Xinjiang, NV~ China: implications for the tectonic evolution of Central Asia显示文摘 | Xiao W J Hart C M Yuan C | 2008 | Journal of Asian Earth Sciences2008，32，： | 1 |
| 18 | The great disruption 显示文摘 | Christensen C M Craig T Hart S L | 2001 | Foreign Policy2001，80，2： | 1 |
| 19 | IL-8 in sepsis: relation to shock and inflammatory mediators 显示文摘 | Hack C E Hart M Strack van Schijadel K J M | 2002 | Infection and Immunity2002，60，： | 1 |
| 20 | Hypoxia-inducible factor-lalpha-dependent protection from intestinal ischemia/reperfusion injury involves ecto-5' -nucleotidase (CD73) and the A2B adenosine receptor 显示文摘 | HART M L GRENZ A GORZOLLA I C | 2011 | J Immtmol2011，186，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员