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657篇 您的检索式：作者名="HART M J"

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	题名	作者	年代	出处	被引量
1	Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides.	John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin	2015	World Journal of Gastroenterology2015，21，35：	3
2	Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘	Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington	2001	Human Pathology2001，，4：	3
3	Low-cost all-polymer integrated circuits 显示文摘	Drury C J Mutsaers C M J Hart C M	1998	Applied Physics Letters1998，73，：	2
4	High rates of nitrification and nitrate turnover in undisturbed coniferous forests显示文摘	Stark J M Hart S C	1997	Nature1997，385，：	1
5	Indirect enzyme-linked immunosorbent assay for the mycotoxin zearalenone显示文摘	Liu M T Ram B P Hart L P and Pestka J J	1985	Appl Environ Microbiol1985，50，2：	1
6	Apramycin-resistant Escheriehia coli isolated from pigs and a stockman显示文摘	Hunter J E B Bennett M Hart C A	1994	Epidemiol infect1994，112，：	1
7	Vibration analysis of circtdar Mindlin plates using the differential quadrature method显示文摘	Liew K M Hart J B Xiao Z M	1997	Journal of Sound and Vibration1997，205，5：	1
8	External skeletal fixation of canine tibial osteotomies: Compression compared with no compression显示文摘	Hart M B Wu J J Chao EYS	1985	J Bone Joint Surg(Am)1985，67，4：	1
9	Childhood mental ability and blood pressure at midlife: linking the Scottish mental survey 1932 and the midspan studies显示文摘	Starr J M Taylor M D Hart C L	2004	J Hypertens2004，22，5：	1
10	Controlling release from the lipidic cubic phase by selective alkylation显示文摘	Clogston J Craciun G Hart D J Caffrey M	2005	J Contr Rel2005，102，：	1
11	Plant extracts to manipulate rumen fermentation显示文摘	HART K J YáEZ-RUIZ D R DUVALET S M	2007	Animal Feed Science and Technology2007，147，123：	1
12	Histone Methyltransferase Activity of a Drosophila Polycomb Group Repressor Complex显示文摘	Jürg Müller Craig M. Hart Nicole J. Francis Marcus L. Vargas Aditya Sengupta Brigitte Wild Ellen L. Miller Michael B. O’Connor Robert E. Kingston Jeffrey A. Simon	2002	Cell2002，，2：	1
13	Plant extracts to manipulate rumen fermentation 显示文摘	Hart K J Y'ancz-Ruiz D R Duvalet S M	2007	Animal Feed Science and Technology2007，147，13：	1
14	Evaluation of analytical methods for determining pesticides in baby foods and adult duplicate-diet samples 显示文摘	Chuang J C Hart K Chang J S Boman L E Van Emon J M Reed A W	2001	Analytica Chimica Acta2001，444，1：	1
15	Determination ofsugars in yogurt and microbiological media by high performance liquidchromatography during processing and subsequent storage显示文摘	RICHMOND M L HARTE B R GRAY J I	1987	Journal ofDairy Science1987，70，6：	1
16	Modern approachesto pediatric brain injury therapy显示文摘	Walker P A Harting M T Baumgartner J E	2009	J Trauma2009，67，2：	1
17	Thin layer high - voltage devices ( resurf devices) 显示文摘	Appels J A Collet M G Hart P A H	1979	Philips Jour- nal of Research1979，35，1：	1
18	Regulation of c-SRC activity and function by the adapter pro- tein CAS显示文摘	BURNBAM M R BRUCE-STASKAL P J HARTE M T et al	2000	Mol Cell Biol2000，20，16：	1
19	Settlements of HSL immersed tunnels 显示文摘	Mortier H Hakkaart C J A Hart W M T	2006	Geotechnical Aspects of Underground Construction in Soft Ground2006，，：	1
20	The mantle sources of ocean ridges, islands and arc basalts: the Hf isotope connec- tion 显示文摘	Salters V J M Hart S R	1991	Earth and Planetary Science Letters1991，104，：	1

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