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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Design of an optofluidic biosensor using the slow - light effect in photonic crystal structures显示文摘 | Hosseinibalam F Hassanzadeh S Ebnali tteidari A | 2012 | Appl Opt2012，51，5： | 1 |
| 3 | Statistical methods and regression analysis of stratospheric ozone and meteoro- logical variables in Isfahan 显示文摘 | HASSANZADEH S HOSSEINIBALAM F | 2008 | Physica A2008，387，： | 1 |
| 4 | Framework for evaluating clustering algorithms in duplicate detection 显示文摘 | Hassanzadeh O Chiang F Lee H C | 2009 | Proceedings of the VLDB Endowment2009，2，1： | 1 |
| 5 | Time series analysis of ozone data in Isfahan显示文摘 | M Omidvari S Hassanzadeh F Hosseinibalam | 2008 | Physica A:Statistical Mechanics and Its Applications2008，387，1617： | 1 |
| 6 | Synthesis of Pluronic F127-poly (methyl vinyl ether-alt- maleie acid) cpo显示文摘 | VARSHOSAZ J HASSANZADEH F SADEGHI-ALIABADI H | 2014 | Chem Eagin J2014，240，： | 1 |
| 7 | Visual tracking system for dense traffic intersections显示文摘 | Rostamianfar O Janabi-Sharifi F Hassanzadeh I | 2006 | Electrical and Computer Engineering2006，，4： | 1 |
| 8 | Surface Modieation of Fe3O4-SiO2 Mierosphere by Silane Coupling Agent Int 显示文摘 | Ahangaran F Hassanzadeh A Nouri S | 2013 | Nano Letters2013，3，24： | 1 |
| 9 | Web site accessibility evaluation methods in action a comparative approach for ministerial web sites in Iran 显示文摘 | Hassanzadeh M Navidi F | 2010 | The Electronic Library2010，28，6： | 1 |
| 10 | Galactosylat-ed nanostructured lipid carriers for delivery of 5-FU to hepato- cellular carcinoma 显示文摘 | Varshosaz J Hassanzadeh F Sadeghi H | 2012 | J Liposome Res2012，22，3： | 1 |
| 11 | Preparation of cofuroxime axetil nanoparticles by rapid expansion of supereritical fluid technology显示文摘 | J Varshosaz F Hassanzadeh | 2009 | Powder Technology2009，189，： | 1 |
| 12 | Framework for evaluating clustering algorithms in duplicate detec- tion显示文摘 | Hassanzadeh O Chiang F Miller R J | 2009 | PVLDB2009，2，1： | 1 |
| 13 | Statistical methods and regression analysis of stratospheric ozone and meteorological variables in Isfahan显示文摘 | Hassanzadeh S Hosseinibalam F | 2008 | Physica A2008，387，： | 1 |
| 14 | The ameliorative effects of sesamol against seizures, cognitive impairment and oxidative stress in the experimental model of epilepsy显示文摘 | Hassanzadeh P Arbabi E Rostami F | 2014 | Iran J Basic Med Sci2014，17，2： | 1 |
| 15 | Web site accessibility evaluation methods in action a comparative apprmch for ministerial web sites in lran显示文摘 | Hassanzadeh M Navidi F | 2010 | Electrmic Library2010，28，6： | 1 |
| 16 | Preparation of cefuroxime axetil nanoparticles by rapid expansion of supercritical fluid technology显示文摘 | Varshosaz J Hassanzadeh F Mahmoudzadeh M | 2009 | Powder Technology2009，189，： | 1 |
| 17 | Statistical methods and regression analysis of stratospheric ozone and meteorological variables in Isfahan显示文摘 | Hassanzadeh S Hosseinibalam F Omidvari M | 2008 | Physica A-statistical Mechanics And Its Applications2008，387，10： | 1 |
| 18 | Framework for evaluating clustering algorithms in duplicate detection 显示文摘 | Hassanzadeh O Chiang F Lee H C | 2009 | Proceedings of the VLDB Endowment2009，2，1： | 1 |
| 19 | Preparation of cefuroxime axetil nanoparticles by rapid expansion of supercritical fluid technology显示文摘 | Varshosaz J Hassanzadeh F Mahmoudzadeh M | 2009 | Powder Technology2009，189，： | 1 |
| 20 | A Practical R&D Selection Model Using Fuzzy Pay-Off Method 显示文摘 | Hassanzadeh F Collan M | 2012 | The International Journal of Advanced Manufacturing Technology2012，58，： | 1 |
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