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| 1 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 2 | Microbial structure of an anaerobic bioreactor population that continuously dechlorinates 1, 2-dichloropropane 显示文摘 | SCHLOTELBURG C WINTZINGERODE C HAUCK R | 2002 | FEMS Microbiology Ecology2002，39，3： | 1 |
| 3 | Can anatomical left ventricular mass be estimated reliably by M-mode echocardiography? A clinic pathological study of 93 patients显示文摘 | Bachenberg TC Shub C Hauck AJ Edwards WD | 1991 | Echocardiography1991，8，： | 1 |
| 4 | How social context impacts on women's fears of childbirth:a western Australian example显示文摘 | Fisher C Hauck Y Fenwick J | 2006 | Social Science & Medicine2006，63，： | 1 |
| 5 | FAK integrates growth factor and integrin signals to promote cell migration显示文摘 | Sieg D J Hauck C R Ilic D | 2000 | Nat Cell Biol2000，2，5： | 1 |
| 6 | Rehabilitation nursing-an important additional qualification:the rehabilitation process requires qualified nurses显示文摘 | Egert S Hauck C Zippel T | 2010 | Pflege Z2010，63，2： | 1 |
| 7 | Does an interspinous device (Coflex)improve the outcome of decompressive surgery in lumbar spinal stenosis One-year follow up of a prospective care control studv of 60 patients显示文摘 | Richter A Schütz C Hauck M | | 0，，： | 1 |
| 8 | Upregulation ofmRNA expression of MCP-1 by TGF-(5etalin fibroblast cells fromPeyronie's disease显示文摘 | Szardening-Kirchner C Konrad L Hauck EW | 2009 | World J Urol2009，27，： | 1 |
| 9 | Soybean protein composition and tofu quality显示文摘 | MURPHY P A CHEN H P HAUCK C C | 1997 | Food Technology1997，51，88： | 1 |
| 10 | Exercise adherence or maintenance among older adults1 - year follow - up study 显示文摘 | Emery C F Hauck E R Blumenthal J A | 1992 | Psychol Aging1992，7，3： | 1 |
| 11 | Placement and routing tools for the triptych FPGA显示文摘 | Ebeling C McMurchie L Hauck S A | 1995 | IEEE Transactions on Very Large Scale Integration (VLSI) Systems1995，3，4： | 1 |
| 12 | Soybean protein composition and tofu quality显示文摘 | MURPHY P A CHEN H P HAUCK C C | 1997 | Food Technology1997，51，3： | 1 |
| 13 | Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration显示文摘 | Sieg D J Hauck C R Schlaepfer D D | 1999 | J Cell Sc1999，112，： | 1 |
| 14 | Sticky connections:extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus显示文摘 | Hauck C R Ohlsen K | 2006 | Current opinion in microbiology2006，9，1： | 1 |
| 15 | How social context impacts on women's fears of childbirth:a Western Australian example显示文摘 | Fisher C Hauck Y Fenwick J | 2006 | Soc Sci Med2006，63，1： | 1 |
| 16 | Does an interspinous device(Coflex)improve the outcome of decompressive surgery in lumbar spinal stenosis?One-year follow up of a prospective case control study of 60 patients显示文摘 | Richter A Schütz C Hauck M | 2010 | Eur Spine J2010，19，2： | 1 |
| 17 | The neuroprotec- five potential of retinal MUller glial cells 显示文摘 | Hauck S M von Toerne C Ueffing M | 2014 | Adv Exp Med Biol2014，801，： | 1 |
| 18 | Can anatomical left ventricular mass be estimated reliably by Mmode echocardiography? A clinic pathological study of 93 patients显示文摘 | BACHENBERG T C SHUB C HAUCK A J | 1991 | Echocardiography1991，8，1： | 1 |
| 19 | Complete preoperative embolization of hemangioblastoma vessels with Onyx 18 显示文摘 | Horvathy D B Hauck E F Ogilvy C S | 2011 | J Clin Neurosci2011，18，3： | 1 |
| 20 | Meltwater infiltration into the frozen active layer at an alpine permafrost site显示文摘 | Scherler M Hauck C Hoelzle M Stalali M Volksch I | 2010 | Permafrost and Perglacial Process2010，21，4： | 1 |
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