|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure. | Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz | 2021 | Bioactive Materials2021，6，12： | 7 |
| 2 | Translocation of two glucose transporters in heart: effects of rotenone, uncouplers,workload, palmitate, insulin and anoxia显示文摘 | WHEELER T J FELL R D HAUCK M A | 1994 | Biochim Biophys Acta1994，1196，2： | 1 |
| 3 | Microbial structure of an anaerobic bioreactor population that continuously dechlorinates 1, 2-dichloropropane 显示文摘 | SCHLOTELBURG C WINTZINGERODE C HAUCK R | 2002 | FEMS Microbiology Ecology2002，39，3： | 1 |
| 4 | FAK integrates growth factor and integrin signals to promote cell migration显示文摘 | Sieg D J Hauck C R Ilic D | 2000 | Nat Cell Biol2000，2，5： | 1 |
| 5 | Comparison of the speci? city and sensitivity of PCR, nested PCR and real-time PCR for the diagnosis of histomoniasis显示文摘 | Ha{ez HM Hauck R Luschow D | 2005 | Avian Disease2005，493，： | 1 |
| 6 | Exercise adherence or maintenance among older adults1 - year follow - up study 显示文摘 | Emery C F Hauck E R Blumenthal J A | 1992 | Psychol Aging1992，7，3： | 1 |
| 7 | Ultrastrnctural changes in soredia of the epiphytic lichen Hypogymnia physodes cultivated with manganese显示文摘 | Paul A Hauck M Langenfeld-Heyser R | 2004 | Environmental and Experimental Botany2004，52，： | 1 |
| 8 | Global transcriptional profiling of Shewanella oneidensis MR-1 during Cr(VI) and U(VI) reduction显示文摘 | Bencheikh-Latmani R Williams SM Haucke L | 2005 | Applied and Environmental Microbiology2005，71，11： | 1 |
| 9 | Primary structural features of the S haplotype-specific F-box protein, SFB, in Prunus显示文摘 | IKEDA K IGIC B USHIJIMA K YAMANE H HAUCK N R NAKANO R SASSA H IEZZONI A F KOHN J R TAO R | 2004 | Sexual Plant Reproduction2004，16，5： | 1 |
| 10 | Methods for detecting errors in numerically controlled machining of sculptured surfaces显示文摘 | Jerard R B Drysdale R L Hauck K | 1989 | IEEE Computer Graphics and Applications1989，9，1： | 1 |
| 11 | The basic pacing rate in CRT patiens the higher the better显示文摘 | Voss F Becker R Hauck M | 2009 | Clin Res Cardiol2009，98，4： | 1 |
| 12 | Primary structural features of the S haplotype -specific F -box protein, SFB, in Prunus显示文摘 | IKEDA K IGIC B USHIJIMA K YAMANE H HAUCK N R NAKANO R SASSA H IEZZONI A F KOHN J R TAO R | 2004 | Sex Plant Reprod2004，16，： | 1 |
| 13 | Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration显示文摘 | Sieg D J Hauck C R Schlaepfer D D | 1999 | J Cell Sc1999，112，： | 1 |
| 14 | Misalignment sensitivity of optical resonators显示文摘 | Hauck R Kortz H P Weber H | 1980 | Applied Optics1980，19，4： | 1 |
| 15 | Cellular composition of stent penetrating tissue显示文摘 | Hauck RW Barbur M Lembeck R | 2002 | Chest2002，122，5： | 1 |
| 16 | Methods for Detecting Errors in Numerically Controlled Machining of Sculptured Surfaces显示文摘 | Jerard R B Drysdale R L Hauck K | 1989 | IEEE Computer Graphics & Applications1989，9，1： | 1 |
| 17 | Pri- mary structural features of the S hyplotype-specifie F-box protein, SFB, in Prunus显示文摘 | IKEDA K IGIC B USHIIJIMA K YANANE H HAUCK N R NAKANO R SASSA H IEZZONI A F KOHN J R TAO R | 2004 | Sex Plant Repord2004，16，： | 1 |
| 18 | Sticky connections:extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus显示文摘 | Hauck C R Ohlsen K | 2006 | Current opinion in microbiology2006，9，1： | 1 |
| 19 | Primary structural features of the S haplotype -specific F -box protein, SFB, in Prunus显示文摘 | IKEDA K IGIC B USHIJIMA K YAMANE H HAUCK N R NAKANO R SASSA H IEZZONI A F KOHN J R TAO R | 2004 | Sex Plant Reprod2004，16，： | 1 |
| 20 | Comparison of the specificity and sensitivity of PCR, nested PCR, and real-time PCR for the diagnosis of histomoniasis 显示文摘 | Hafez HM Hauck R Luschow D | 2005 | Avian Dis2005，49，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员