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| 1 | Lithium beyond psychiatric indications:the reincarnation of a new old drug显示文摘Lithium has been used in the treatment of bipolar disorders for decades,but the exact mechanisms of action remain elusive to this day.Recent evidence suggests that lithium is critically involved in a variety of signaling pathways affecting apoptosis,inflammation,and neurogenesis,all of which contributing to the complex pathophysiology of various neurological diseases.As a matter of fact,preclinical work reports both acute and longterm neuroprotection in distinct neurological disease models such as Parkinson’s disease,traumatic brain injury,Alzheimer’s disease,and ischemic stroke.Lithium treatment reduces cell injury,decreasesα‑synuclein aggregation and Tau protein phosphorylation,modulates inflammation and even stimulates neuroregeneration under experimental conditions of Parkinson’s disease,traumatic brain injury,and Alzheimer’s disease.The therapeutic impact of lithium under conditions of ischemic stroke was also studied in numerous preclinical in vitro and in vivo studies,giving rise to a randomized double-blind clinical stroke trial.The preclinic data revealed a lithium-induced upregulation of anti-apoptotic proteins such as B-cell lymphoma 2,heat shock protein 70,and activated protein 1,resulting in decreased neuronal cell loss.Lithium,however,does not only yield postischemic neuroprotection but also enhances endogenous neuroregeneration by stimulating neural stem cell proliferation and by regulating distinct signaling pathways such as the RE1-silencing transcription factor.In line with this,lithium treatment has been shown to modulate postischemic cytokine secretion patterns,diminishing microglial activation and stabilizing blood-brain barrier integrity yielding reduced levels of neuroinflammation.The aforementioned observations culminated in a first clinical trial,which revealed an improved motor recovery in patients with cortical stroke after lithium treatment.Beside its well-known psychiatric indications,lithium is thus a promising neuroprotective candidate for the aforementioned neurological diseases.A detailed understanding of the lithium-induced mechanisms,however,is important for prospective clinical trials which may pave the way for a successful benchto-bedside translation in the future.In this review,we will give an overview of lithiuminduced neuroprotective mechanisms under various pathological conditions,with special emphasis on ischemic stroke. | Matteo Haupt Mathias Bähr Thorsten R.Doeppner | 2021 | Neural Regeneration Research2021，16，12： | 2 |
| 2 | Role of the apolipoprotein E and catechol - 0 - methyltransferase genes in prospective and ret- rospective memory traits 显示文摘 | Donges B Haupt LM Lea RA | 2012 | Gene2012，506，1： | 1 |
| 3 | Activity of enzymes immobilized in colloidal spherical polyelectrolyte brushes 显示文摘 | Haupt B Neumann T Wittemann A | 2005 | Biomacromolecules2005，6，： | 1 |
| 4 | Synthesis of a mo lecularly imprinted polymer for the solid-phase extraction of betulin and betulinic acid from plane bark显示文摘 | Claude B Viron-Lamy C Haupt K | 2010 | Phytochem A- nal2010，21，2： | 1 |
| 5 | Adsorptionof proteins on spherical polyelectrolyte brushes in aqueous so-lution显示文摘 | WITTEMANN A HAUPT B BALLAUFF M | 2003 | Phys Chem Chem Phys2003，5，： | 1 |
| 6 | A novel photoreactor for the production ofelectrosterically stabilised colloidal particles at larger scales 显示文摘 | Schrinner M Haupt B Wittemann A | 2008 | ChemicalEngineering Journal(S1385-8947)2008，144，1： | 1 |
| 7 | Interaction ofdissolved proteins with spherical polyelectrolyte brushes显示文摘 | WITTEMANN A HAUPT B MERKLE R | 2003 | Macromol Symp2003，191，1： | 1 |
| 8 | Depth-sensing indentation measurements with vickers and berkovich indenters 显示文摘 | Rother B Steiner A Dietrich D A Jehn H A Haupt J Gissler W | 1998 | Journal of Materials Research1998，13，： | 1 |
| 9 | Therapeutic efficacy of magnesium in acoustic trauma in the guinea pig显示文摘 | Haupt H Scheibe F Mazurek B | 2003 | ORL J Otorhinolaryngol Relat Spec2003，65，3： | 1 |
| 10 | A modified version of tinnitus retraining therapy: observing long-term out-come and predictors 显示文摘 | Azurek B Fischer F Haupt H | 2006 | Audiol Neurotol2006，11，5： | 1 |
| 11 | Metastatic prostatic car cinoma to testis: histological features mimicking lymphoma 显示文摘 | Haupt B Ro JY Ayala A G | 2009 | Int J Clin Exp Pathol2009，2，10： | 1 |
| 12 | Rescol-Versuche zur prtifung der dynamischen langzeitstabilltat yon TA/TM-Boden unter eisenbahnverkehr 显示文摘 | Hu Y Haupt W Milliner B | 2004 | Bautechnik2004，81，4： | 1 |
| 13 | A model of peripherally developing hearing loss and tinnitus based on the role of hypoxia and ischemia 显示文摘 | Mazurek B Haupt H Georgiewa P | 2006 | Med hypotheses2006，67，4： | 1 |
| 14 | 查看详情显示文摘 | Haupt K Linares A V Bompart M Tse Sum Bui B | | 0，，： | 1 |
| 15 | Neuroblasto- ma with symptomatic epidural compression in the infant: the AIEOP experience 显示文摘 | De Bernardi B Quaglietta L Haupt R | 2014 | Pediatr Blood Cancer2014，61，8： | 1 |
| 16 | Drug-induced scleroderma and scle-rodermiform conditions显示文摘 | Haustein UF Haupt B | | 0，，： | 1 |
| 17 | High potassium concentrations protect inner and outer hair cells in the newborn rat culture from ischemia-induced damage显示文摘 | Mazurek B Nyamaa A Haupt H | 2006 | Hear Res2006，15，12： | 1 |
| 18 | Pharmacotherapy in acute tinnitis,the special role of hypoxia and ischemia in the pathogenesis of tinnitis显示文摘 | Mazurek B Haupt H Gross J | 2006 | HNO2006，54，1： | 1 |
| 19 | Immobilization of molecularly imprinted polymer nanoparticles in electrospun poly (vinyl alcohol) nanofibers显示文摘 | Piperno S Tse Sum Bui B Haupt K | 2011 | Langmuir2011，27，5： | 1 |
| 20 | Molecular biological aspects of neuroplasticity:approaches for treating tinnitus and hearing disorders显示文摘 | Mazurek B Olze H Haupt H | 2010 | HNO2010，58，10： | 1 |
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