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	题名	作者	年代	出处	被引量
1	Angiogenic markers endoglin and vascular endothelial growth factor in gastroenteropancreatic neuroendocrine tumors显示文摘AIM:To investigate the expression and potential prognostic role of vascular endothelial growth factor(VEGF) and endoglin in gastroenteropancreatic neuroendocrine tumors(GEP-NETs) . METHODS:Microvessel density(MVD) in GEP-NETs was evaluated using endoglin and CD31 immunohistochemistry.In addition,tissue levels of endoglin and VEGF were determined in homogenates by ELISA. RESULTS:Endoglin was highly expressed on tumor endothelial cells.CD31 MVD in GEP-NETs was significantly higher compared to endoglin MVD(P<0.01) .Two-tofour-fold higher tissue levels of endoglin and VEGF were seen in tumors compared to associated normal tissue. This increased endoglin tissue expression in tumors was significantly related to tumor size(P<0.01) ,presence of metastases(P=0.04) ,and a more advanced tumor stage(P=0.02) ,whereas expression of VEGF was not. CONCLUSION:We suggest that endoglin is a potential marker to indicate and predict metastases,which might be useful in the post-resection therapeutic approach of patients with GEP-NETs.	Patricia Kuiper Lukas JAC Hawinkels Eveline SM de Jonge-Muller Izk Biemond Cornelis BHW Lamers Hein W Verspaget	2011	World Journal of Gastroenterology2011，17，2：	4
2	Matrix metalloprotei- nase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis 显示文摘	Hawinkels LI Kuiper P Wiercinska E	2010	Cancer Res2010，70，10：	1
3	Clinical evidence for a protective role of lipocalin-2 against mmp-9 autodegradation and the impact for gastric cancer显示文摘	Kubben F J Sier C F Hawinkels L J	2007	Eur J Cancer2007，43，12：	1
4	Matrix me-talloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis显示文摘	Hawinkels LJ Kuiper P Wiercinska E	2010	Cancer Res2010，70，10：	1
5	Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis显示文摘	Hawinkels LJ Kuiper P Wiercinska E	2010	Cancer Res2010，70，10：	1
6	Clinical evidence for a protective role of lipoealin-2 against MMP-9 autodegradation and the impact for gastric cancer 显示文摘	Kubben FJ Sier CF Hawinkels LJ et 01	2007	Eur J Cancer2007，43，12：	1
7	VEGF release byMMP-9 mediated heparan sulphate cleavage induces colorectal cancerangiogenesis显示文摘	Hawinkels L J Zuidwijk K Verspaget H W	2008	Eur J Cancer2008，44，13：	1
8	Exploring anti-TGF-t3 therapies in cancer and fibrosis 显示文摘	Hawinkels LA Ten Dijke P	2011	Growth factors2011，29，4：	1
9	Interaction with colon cancer cells hyperactivates TGF-13 signaling in cancer- associated fibroblasts显示文摘	Hawinkels LJ Paauwe M Verspaget HW	2014	Oncogene2014，33，1：	1
10	Clinical evidence for a protective rele of lipocalin-2 against MMP- 9 autodegradation and the impact for gastric cancer 显示文摘	Kubben FJ Sior CF Hawinkels LJ	2007	Eur J Cancer2007，43，12：	1
11	Clinical evidence for a pro- tective role of lipocalin-2 against MMP-9 autodegradation and the im- pact for gastric cancer显示文摘	Kubben FJ Sier CF Hawinkels LJ	2007	Eur J Cancer2007，43，12：	1
12	MMP -2 and MMP- 9 in normal mucosa are independently associ- ated with outcome of colorectal cancer patients 显示文摘	Langers AMJ Verspaget HW Hawinkels L	2012	British Journal of Cancer2012，106，9：	1
13	Tissue level, activation and cellular localisation of TGF-betal and association with survival in gastric cancer patients 显示文摘	Hawinkels LJ Verspaget HW	2007	Br J Cancer2007，97，3：	1
14	VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis显示文摘	Hawinkels LJ Zuidwijk K Verspaget HW		0，，13：	1
15	Matrix metal-loproteinase-14-mediated endoglin shedding inhibits tumorangiogenesis显示文摘	Hawinkels LJ Kuiper P Wiercinska E	2010	Cancer Res2010，70，：	1
16	Clinical evi- dence for a protective role of lipocalin-2 against MMP-9 autodegradation and the impact for gastric cancer显示文摘	Kubben FJ Sier CF Hawinkels LJ	2007	Eur J Cancer2007，43，12：	1
17	Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis显示文摘	Hawinkels LJ Kuiper P Wiercinska E	2010	Cancer Res2010，70，10：	1
18	Clinical evidence for aprotective role of lipocalin-2 against MMP-9 autodegradation and the impact for gastric cancer 显示文摘	Kubben FJ Sier CF Hawinkels LJ	2007	Eur J Cancer2007，43，12：	1
19	MMP- 2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients 显示文摘	Langers AM Verspaget HW Hawinkels LJ	2012	Br J Cancer2012，106，9：	1
20	Clinical evidence for a protective role of lipocalin-2 against MMP-9 autodegradation and the impact for gastric cancer 显示文摘	Kubben FJ Sier CF Hawinkels LJ	2007	Eur J Cancer2007，43，12：	1

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