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| 1 | Role of matrix metalloproteinase,tissue inhibitor of metalloproteinase and tumor necrosis factor-α single nucleotide gene polymorphisms in inflammatory bowel disease显示文摘AIM:To study the (functional) relevance of single nucleotide polymorphisms (SNPs) in genes encoding matrix metalloproteinases (MMP)-1,-2,-3,-9,tissue inhibitors of metalloproteinases (TIMP)-1,-2 and tumor necrosis factor (TNF)-α in the etiopathogenesis of inflammatory bowel diseases (IBD),that may enhance susceptibility and/or disease severity. METHODS:Genomic DNA from 134 Crohn's disease (CD),111 ulcerative colitis (UC) patients and 248 control subjects was isolated from resected intestinal tissue or blood. Allelic composition at SNP loci was determined by PCR-RFLP or tetra primer ARMS PCR. RESULTS:The TIMP-1 genotype TT in women and T in men at SNP +372 T/C was found to increase CD susceptibility (39% vs 23.8%,P=0.018 and 67.9% vs 51.6%,P=0.055,respectively),while women with this genotype were less prone to development of fistulae during follow-up (41.4% vs 68.3%,P=0.025). Male IBD or CD patients carrying the TIMP-1 +372 T-allele expressed lower levels of TIMP-1 in surgically resected macroscopically inflamed tissue (0.065 < P < 0.01). The 5T5T genotype at MMP-3 SNP -1613 5T/6T increased the chance of stenotic complications in CD during follow-up (91.2% vs 71.8%,P = 0.022) but seemed to protect against colonic involvement of this disease at first endoscopic/radiologic examination (35.3% vs 59.5%,P=0.017). CONCLUSION:Allelic composition at the examinedSNPs in genes coding for TIMP-1 and MMP-3 affect CD susceptibility and/or phenotype,i.e.,fistulizing disease,stricture pathogenesis and first disease localisation. These findings reinforce the important role of these proteins in IBD. | Martin JW Meijer Marij AC Mieremet-Ooms Ruud A van Hogezand Cornelis BHW Lamers Daniel W Hommes Hein W Verspaget | 2007 | World Journal of Gastroenterology2007，13，21： | 15 |
| 2 | Angiogenic markers endoglin and vascular endothelial growth factor in gastroenteropancreatic neuroendocrine tumors显示文摘AIM:To investigate the expression and potential prognostic role of vascular endothelial growth factor(VEGF) and endoglin in gastroenteropancreatic neuroendocrine tumors(GEP-NETs) . METHODS:Microvessel density(MVD) in GEP-NETs was evaluated using endoglin and CD31 immunohistochemistry.In addition,tissue levels of endoglin and VEGF were determined in homogenates by ELISA. RESULTS:Endoglin was highly expressed on tumor endothelial cells.CD31 MVD in GEP-NETs was significantly higher compared to endoglin MVD(P<0.01) .Two-tofour-fold higher tissue levels of endoglin and VEGF were seen in tumors compared to associated normal tissue. This increased endoglin tissue expression in tumors was significantly related to tumor size(P<0.01) ,presence of metastases(P=0.04) ,and a more advanced tumor stage(P=0.02) ,whereas expression of VEGF was not. CONCLUSION:We suggest that endoglin is a potential marker to indicate and predict metastases,which might be useful in the post-resection therapeutic approach of patients with GEP-NETs. | Patricia Kuiper Lukas JAC Hawinkels Eveline SM de Jonge-Muller Izk Biemond Cornelis BHW Lamers Hein W Verspaget | 2011 | World Journal of Gastroenterology2011，17，2： | 4 |
| 3 | Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer显示文摘Matrix metalloproteinases(MMPs) are implicated in cancer development and progression and are associated with prognosis.Single-nucleotide polymorphisms(SNPs) of MMPs,most frequently located in the promoter region of the genes,have been shown to influence cancer susceptibility and/or progression.SNPs of MMP-1,-2,-3,-7,-8,-9,-12,-13 and-21 and of the tissue inhibitor of metalloproteinases(TIMPs) TIMP-1 and TIMP-2 have been studied in digestive tract tumors.The contribution of these polymorphisms to the cancer risk and prognosis of gastrointestinal tumors are reviewed in this paper. | Alexandra MJ Langers Hein W Verspaget Daniel W Hommes Cornelis FM Sier | 2011 | World Journal of Gastrointestinal Oncology2011，3，6： | 4 |
| 4 | Risk factors for infection after liver transplantation显示文摘 | Bart van Hoek Bert-Jan de Rooij Hein W. Verspaget | 2012 | Best Practice & Research Clinical Gastroenterology2012，，1： | 2 |
| 5 | Crohn’s Disease in the Elderly: A Comparison With Young Adults显示文摘 | M. J. Wagtmans H. W. Verspaget C. B.H.W. Lamers R. A. van Hogezand | 1998 | Journal of Clinical Gastroenterology1998，，： | 2 |
| 6 | Development of a Radioimmunoassay for Human Metallothionein 显示文摘 | Mulder TP Janssens AR Verspaget HW etal | 1990 | lmmtmol Methods1990，3130，2： | 1 |
| 7 | Plasminogen activators and tumor development in the human colon:activity levels in normal mucosa,adenomatous polyps, and adenocarcinomas显示文摘 | de Bruin PA Griffioen G Verspaget HW | 1987 | Cancer Res1987，47，17： | 1 |
| 8 | Glutathione S-transferase π in colorectal tumors is predictive for overall survival显示文摘 | Mulder TP Verspaget HW Sier CF | 1995 | Cancer Res1995，55，12： | 1 |
| 9 | Crohn's disease in the elderly:a comparison with young adults显示文摘 | Verspaget HW Lamers CB | 1998 | J Clin Gastroenterol1998，27，2： | 1 |
| 10 | Clinical aspects of Crohn' s disease of the upper gastrointestinal tract: a comparison with distal Crohn' s disease 显示文摘 | Wagtmans M J Verspaget HW Lamers C | 1997 | Am J Gastroenterol1997，92，9： | 1 |
| 11 | Symptoms in patients with ulcerative colitis in remission are associated with visceral hypersensitivity and mast cell activity显示文摘 | Eduard A. van Hoboken Annemieke Y. Thijssen Rob Verhaaren Patrick P.J. van der Veek Frans. A. Prins Hein. W. Verspaget Ad A.M. Masclee | 2011 | Scandinavian Journal of Gastroenterology . 2011 (7-8)2011，，： | 1 |
| 12 | Assessment of serum matrix metalloproteinases MMP-2 and MMP-9 after human liver transplantation:increased serum MMP-9 level in acute rejection显示文摘 | KUYVENHOVEN JP VERSPAGET HW GAO Q | 2004 | Transplantation2004，77，： | 1 |
| 13 | Vadiation of the Dutch version of the Walking Impairment Questionnaire显示文摘 | Verspaget M Nicola? SP Kruidenier LM | 2009 | Eur J Endovasc surg2009，37，1： | 1 |
| 14 | Review article:Oxidative stress as apathogenic factor in inflammatory bowel disease-radicals or ridiculous 显示文摘 | KRUIDINIER L VERSPAGET H W | 2002 | Aliment Hiarmacol Ther2002，16，： | 1 |
| 15 | VEGF release byMMP-9 mediated heparan sulphate cleavage induces colorectal cancerangiogenesis显示文摘 | Hawinkels L J Zuidwijk K Verspaget H W | 2008 | Eur J Cancer2008，44，13： | 1 |
| 16 | Interaction with colon cancer cells hyperactivates TGF-13 signaling in cancer- associated fibroblasts显示文摘 | Hawinkels LJ Paauwe M Verspaget HW | 2014 | Oncogene2014，33，1： | 1 |
| 17 | Expression of somatostatin receptors in human pancreatic tumor显示文摘 | Tang C Biemond I Verspaget HW | 1998 | Pancreas1998，17，1： | 1 |
| 18 | MMP -2 and MMP- 9 in normal mucosa are independently associ- ated with outcome of colorectal cancer patients 显示文摘 | Langers AMJ Verspaget HW Hawinkels L | 2012 | British Journal of Cancer2012，106，9： | 1 |
| 19 | Tissue level, activation and cellular localisation of TGF-betal and association with survival in gastric cancer patients 显示文摘 | Hawinkels LJ Verspaget HW | 2007 | Br J Cancer2007，97，3： | 1 |
| 20 | Vadiation of the Dutch version of the walking impairment questionnaire显示文摘 | Verspaget M Nicolas SP Kruidenier LM | 2009 | Eur J Endovasc surg2009，37，1： | 1 |
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