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| 1 | Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis.显示文摘 | Zhang J Liu Q Chen Q Liu NQ Li FL Lu ZB Qin C Zhu H Huang YY He W Zhao BL | 2006 | 中国生物学文摘2006，20，9： | 17 |
| 2 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 3 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 4 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 5 | 血清netrin-1增加与缺血性脑卒中预后改善相关显示文摘先前的实验研究表明,血清netrin-1与缺血性脑卒中进展相关。进一步了解缺血性脑卒中患者中netrin-1的变化可能为缺血性脑卒中的预后评估提供新的思路。该研究旨在探讨血清netrin-1与缺血性脑卒中预后的关系。研究人员测定3346例中国急性缺血性脑卒中抗高血压试验(China antihypertensive trial in acute ischemic stroke,CATIS)中缺血性脑卒中患者基线血清netrin-1水平,所有患者均在脑卒中发病后3个月进行随访。主要观察指标是脑卒中发病后3个月内死亡和严重残疾(改良Rankin 量表评分≥3)。 | 刘莉 叶鹏 Guo D Zhu Z Zhong C Peng H Wang A Xu T Peng Y Xu T Chen CS Li Q Ju Z Geng D Chen J Zhang Y He J | 2019 | 中华高血压杂志2019，27，5： | 6 |
| 6 | CABYR binds to AKAP3 and Ropporin in the human sperm fibrous sheath显示文摘钙绑定酷氨酸调整 phosphorylation 的蛋白质(CABYR ) 是高度多态的钙绑定 tyrosine-/threonine-phosphorylated 和 serine-/threonine-phosphorylated 涉及 capacitation 的含纤维的鞘(FS ) 蛋白质。一个通常认为的领域(氨基酸 12 鈥 ? 8 ) 对类型 II 营地依赖者蛋白质 kinase A (RII ) dimerisation 和抛锚 kinase 蛋白质(AKAP ) 的规章的子单元相应在 N 终点的蛋白质 kinase A 的有约束力的领域建议那 CABYR 可以自我装配并且绑在 AKAP。而且,有证据, CABYR 与 AKAP 限制了相互作用。然而,推进在 CABYR 之间的证据和新关系,包括 AKAP,另外的 FS 蛋白质将在理解 FS 的基本生理学是有用的。在这研究,为不可溶解的蛋白质的 co-immunoprecipitation 的新策略,以及在有集体 spectrometry 和西方的污点的联合的标准 co-immunoprecipitation 方法,被采用探索在 CABYR, AKAP3 和 Ropporin 之间的关系。结果证明 AKAP3 是有由 anti-CABYR-A polyclonal 抗体的 CABYR 的 co-immunoprecipitated,并且,相反地, CABYR 也是有由 anti-AKAP3 polyclonal 抗体的 AKAP3 的 co-immunoprecipitated。包含蛋白质的另一象 RII 一样域, Ropporin,也是有 CABYR 的 co-immunoprecipitated,显示 Ropporin 是 CABYR 的绑定之一合伙。在 CABYR, AKAP3 和 Ropporin 之间的相互作用被酵母证实二混血儿的试金。进一步的分析显示出那 CABYR 不仅由它的 RII 领域绑在 AKAP3 而且除象 RII 一样领域以外通过另外的区域绑在 Ropporin。这是 CABYR 变体形成的第一示范不仅有 scaffolding 蛋白质 AKAP3 而且与在人的精子 FS 的另一象 RII 一样包含域的蛋白质的建筑群。 | Yan-Feng Li Wei He Arabinda Mandal Young-Hwan Kim Laura Digilio Ken Klotz Charles J Flickinger John C Herr | 2011 | Asian Journal of Andrology2011，13，2： | 5 |
| 7 | Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries显示文摘冠的动脉把血流动带到心肌肉。理解冠的动脉的发展程序提供卓见进冠的动脉疾病的治疗。多重来源被描述了为包括 proepicardium,湾穴 venosus (SV ) ,和心内膜贡献冠的动脉。然而,冠的容器的发展起源仍然在强烈学习下面。我们为学习冠的开发生产了一个新基因工具,一只 AplnCreER 老鼠在开发冠的容器明确地衬里 recombinase,它表示可诱导的 Cre。冠的开发和 AplnCreER 命运跟踪的预定正式就职的定量分析证明 subepicardial endothelial 房间(EC ) 的子孙两个都入侵紧缩的心肌层形成冠的动脉并且在表面上留下生产静脉。我们发现这些 subepicardial EC 是 intramyocardial 的主要来源在发展中的心的冠的容器。在 vitro 将生物的活组织移植于培养基中培养,试金显示这些 subepicardial EC 的多数从 SV 和中庭的心内膜,然而并非从室的心内膜产生。Apln 积极的房间的同种细胞的分析显示单个 subepicardial EC 同等地作出贡献到冠的动脉和静脉。一起,这些数据建议 subepicardial EC 是 intramyocardial 的主要来源在室的冠的动脉墙,和那冠的动脉和静脉在发展中的心有普通起源。 | Xueying Tian Tianyuan Hu Hui Zhang Lingjuan He Xiuzhen Huang Qiaozhen Liu Wei Yu Liang He Zhongzhou Yang Zhen Zhang Tao P Zhong Xiao Yang Zhen Yang Yan Yan Antonio Baldini Yunfu Sun Jie Lu Robert J Schwartz Sylvia M Evans Adriana C Gittenberger-de Groot Kristy Red-Horse Bin Zhou | 2013 | Cell Research2013，23，9： | 3 |
| 8 | Reduction and restoration of mitochondrial DNA content after focal cerebral ischemia/ reperfusion 显示文摘 | Chen H Hu C J He Y Y | 2001 | Stroke2001，32，10： | 1 |
| 9 | A conformationally sensitive GHR antibody : impact on GH signaling and GHR proteolysis显示文摘 | Jiang J Wang X He K Li X Chen C M Sayeski P P Waters M J Frank S J | 2004 | Mol Endocrinol2004，18，12： | 1 |
| 10 | Interfacial microstructure and mechanical properties of aluminium-zinc-coated steel joints made by a modified metal inert gas welding-brazing process显示文摘 | ZHANG H T FENG J C HE P HACKL H | 2007 | Materials Characterization2007，58，7： | 1 |
| 11 | Speciation of heavy metals in marine sediments from the East China Sea by ICP-MS with sequential extraction显示文摘 | Yuan C G Shi J B He B | 2004 | Environment International2004，30，： | 1 |
| 12 | Preparation and a structure-function analysis of human ciliary neurotrophic factor显示文摘 | He C Chen J Ao S | 1995 | Neurosci Res1995，23，4： | 1 |
| 13 | Maps preserving numerical radius of products of self-adjoint operators显示文摘 | He K Hou J C Zhang X L | 2010 | Acta Math Sinca-Eng-lish Series2010，6，： | 1 |
| 14 | Energetics of charged point defects in rutile TiO2 by density functional theory显示文摘 | LI X FINNIS M W HE J BEHERA R K PHILLPOT S R SINNOTT S B DICKEY E C | 2009 | Acta Materialia2009，57，： | 1 |
| 15 | Newly synthesized dyes and their polymer/Glass composites for one-and two-photon pumped solid-state cavity lasing显示文摘 | Zhao C F He G S Bhawalkar J D | 1995 | Chem Mater1995，，7： | 1 |
| 16 | Sea surface temperature variability in the north side of the South China Sea over the last 55 years revealed by coral δ^18O records显示文摘 | Peng Z C He J F Chen T G | 2003 | Geochimica et Cosmochimica Acta2003，67，18： | 1 |
| 17 | Parametric optimum analysis of an irreversible regenerative magnetic Brayton refrigeration cycle 显示文摘 | Y L Yang J C Chen J Z He | 2005 | Physica B2005，364，： | 1 |
| 18 | Aqueous-phasehydrodeoxygenation of bio-derived phenols to cycloalkanes 显示文摘 | Zhao C He J Lemonidou A A | 2011 | Journal of Catalysis2011，280，1： | 1 |
| 19 | Modeling Rotor Wake Dynamics with Vis- cous Vortex Particle Method 显示文摘 | He C J Zhao J G | 2009 | AIAA Journal2009，47，4： | 1 |
| 20 | Mechanical properties of single crystal tungsten microwhiskers characterized by nanoindentation 显示文摘 | HUANG H WU Y Q WANG S L HE Y H ZOU J HUANG B Y LIU C T | 2009 | Materials Science and Engeering A2009，53，12： | 1 |
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