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| 1 | Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis显示文摘精子发生在双 spermatogonial 干细胞(SSC ) 哪个生产 haploid 精子期间是一个区别过程。这个高度专业化的过程精确在 transcriptional, posttranscriptional,和翻译层次被控制。这里,我们报导那 N 6-methyladenosine (m 6 一) ,调整基因表示的一个 epitranscriptomic 标记,在精子发生期间起必要作用。我们现在的全面 m 6 从五个发展阶段的老鼠 spermatogenic 房间的 mRNA methylomes:无差别的 spermatogonia,类型 A 1 spermatogonia, preleptotene spermatocytes, pachytene/diplotene spermatocytes,和圆 spermatids。m 6 有 Vasa-Cre 的 RNA methyltransferase Mettl3 或 Mettl14 引起 m 6 SSC 的 A 和弄空。m 6 为 SSC 增长 / 区别被要求的抄本的一个弄空 dysregulates 翻译。在有 Stra8-GFPCre 的先进细菌房间的 Mettl3 和 Mettl14 的联合删除破坏精子形式,而有在先进细菌房间的 Mettl3 或 Mettl14 的单个删除的老鼠显示出正常精子发生。从双异种老鼠展览的 spermatids 损害了为精子形式是必要的 haploid 特定的基因的翻译。这研究加亮 mRNA m 6 在 germline 开发的修正,潜在地保证在精子发生的不同阶段协调了翻译。 | Zhen Lin Phillip J Hsu Xudong Xing Jianhuo Fang Zhike Lu Qin Zou Ke-Jia Zhang Xiao Zhang Yuchuan Zhou Teng Zhang Youcheng Zhang Wanlu Song Guifang Jia Xuerui Yang Chuan He Ming-Han Tong | 2017 | Cell Research2017，27，10： | 61 |
| 2 | 虹鳟肿瘤坏死因子(TNFα)基因体外表达与纯化的研究显示文摘将虹鳟两种肿瘤坏死因子TNFα1和TNFα2基因的成熟肽编码区域 ,用带有BamHI和HindIII酶切位点的基因特异性引物进行PCR扩增。扩增片段用限制性内切酶消化并连接到pQE30表达载体上 ,连接产物转化到大肠杆菌JM10 9感受态细菌中。转化子经PCR筛选 ,质粒测序 ,完成了虹鳟两种TNFα基因重组子的构建。重组子经体外培养和诱导后 ,获得了高效表达的TNFα重组蛋白。高效表达的重组TNFα不受诱导剂IPTG的影响 ,并且由于重组子高效表达而形成了包涵体 ;重组蛋白产量约占菌体蛋白总量的 2 5 %— 30 %。应用Ni NTA和固定金属亲和层析 (IM PC)技术 ,在变性条件下获得了高度纯化的重组蛋白 ,纯化重组蛋白的产量约为 0 5— 1mg L。 | 蔡中华 宋林生 ZOU Jun C J SECOMBES 董双林 | 2003 | 水生生物学报2003，27，6： | 7 |
| 3 | A NEW CYCLOPEPTIDE FROM VACCARIA SEGETALIS显示文摘ANEWCYCLOPEPTIDEFROMVACCARIASEGETALIS￥RongPingZHANG;ChengZOU;YuKunCHAI;JunZHOU(LaboratoryofPhytochemistry,KunmingInstituteoFb... | Zhang, RP Zou, C Chai, YK Zhou, J | 1995 | Chinese Chemical Letters1995，6，8： | 6 |
| 4 | 母亲妊娠期焦虑抑郁对孩子应激性心率及血压的影响显示文摘心理障碍,包括焦虑和抑郁在妊娠期间十分常见。该研究目的在于确定母亲的这些心理障碍是否会对后代的心血管反应产生影响。方法:对231名孕妇的心理状态进行评定,在其后代(n=216)7~9岁时进行视频压力反应测试。测定静息时、观看压力视频时和恢复期的心率及血压水平。 | 刘莉 叶鹏 Fan F Zou Y Tian H Zhang Y Zhang J Ma X Meng Y Yue Y Liu K Dart AM | 2015 | 中华高血压杂志2015，23，6： | 5 |
| 5 | Isolation and characterization of neural stem cells from human fetal striatum显示文摘 | Li X Xu J Bai Y Wang X Dai X Liu Y Zhang J Zou J Shen L Li L | 2006 | 中国生物学文摘2006，20，5： | 3 |
| 6 | Prospective, naturalistic study of open-label OROS methylphenidate treatment in Chinese school-aged children with attention-deficit/hyperactivity disorder显示文摘背景注意赤字活动过度混乱( ADHD )在童年期间是最普通的心理混乱之一,由活动过度, impulsivity 和疏忽的核心症状描绘了并且自己把大负担放在孩子上,他们的家庭和 society.Osmotic 释放口头的系统 methylphenidate (OROS哩/时)开发克服一些限制的一次每日的控制版本明确的表达与立即版本的 methylphenidate (红外哩/时)被联系 .It | ZHENG Yi WANG Yu-feng QIN Jiong WANG Li-wen ZOU Li-ping J IN Xing-ming XU Tong WANG Yi OI Yuan-li GONG Mei-en YIN Qing-yun MAI Jian-ning JING Jin LUO Xiang-yang MA Hong-wei LI Hai-bo XIE Ling LIYan Kuang Gui-fang YI Ming-ji WANG Feng ZHU Xiao-hua YAO Yan-bin | 2011 | Chinese Medical Journal2011，，20： | 2 |
| 7 | Hypoxia-associated induction of early growth response-1 gene expression 显示文摘 | Yan S F Lu J Zou Y S | 1999 | J Biol Chem1999，274，15： | 2 |
| 8 | Degradation of methylene blue with H2O2 activated by peroxidase-like Fe3O4 magnetic nanoparticles显示文摘 | Jiang J Zou J Zhu L | | 0，，06： | 2 |
| 9 | A New Triterpenoid Saponin from the Seeds of Deccaria segetalis显示文摘A new triterpenoid saponin, named segetoside k, has been isolated from the seeds of Vaccaria segetalis. On the basis of chemical reaction and spectral analysis, the structure of segetoside K was established as:olean-12-ene-23a, 286-dioic acid 36, 16a-dihydroxy-28-O- [βD-glucopyranosyl-(1 →3)]-β-D-glucopyra-nosyl-(l →2)-β-D-glucopyranosyl-(l→6)-β-D- glucopyranoside(1). | Sheng Min SANG Min Liang ZOU Ai Na LAO Zhong Liang CHEN Jun UZAWA and Yasuo FUJIMOTO (Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 20003 1 The Institute of Physical and Chemical Research (RIKEN), Wako, Saitama 351-01, J | 2000 | Chinese Chemical Letters2000，11，1： | 2 |
| 10 | E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas显示文摘 | Tamura G Yin J Wang S Fleisher AS Zou T Abraham JM Kong D Smolinski KN Wilson KT James SP Silverberg SG Nishizuka S Terashima M Motoyama T Meltzer SJ | | 0，，： | 2 |
| 11 | Traveling wavefronts in diffusive and cooperative Lotka-Volterra system with delays显示文摘 | Huang J Zou X | 2002 | J Math Anal Appl2002，271，： | 2 |
| 12 | Effect of cervical spine motion on neuroforamina dismensions显示文摘 | Yoo Yu Bayley J Zou D | 1992 | Spine1992，17，： | 2 |
| 13 | QUADRILATERAL FINITE ELEMENTS FOR PLANAR LINEAR ELASTICITY PROBLEM WITH LARGE LAME CONSTANT显示文摘In this paper, we discuss the quadrilateral finite element approximation to the two-dimensional linear elasticity problem associated with a homogeneous isotropic elastic material. The optimal convergence of the finite element method is proved for both the L2-norm and energy-norm, and in particular, the convergence is uniform with respect to the Lain6 constant A. Also the performance of the scheme does not deteriorate as the material becomes nearly incompressible. Numerical experiments are given which are consistent with our theory. | Cheng, XL Huang, HC Zou, J | 1998 | Journal of Computational Mathematics1998，16，4： | 2 |
| 14 | Effect of organic modifiers on the capacity factor in micellar electrokinetic chromatography显示文摘Organic modifiers were effective both to extend the migration time window and to improve the separation of very hydrophobic compounds in MEKC.An iteration method was used to determine the migration time of micelles.The quantitative relationship between the capacity factor k’ and the concentration of organic modifiers was derived,which was investigated experimentally.The linear solvation energy relationships (LSER) methodology was applied to MEKC,and good linear relationships between Ink’ and solvatochromic parameters of 15 solutes were obtained in the presence of organic modifier in different concentrations,which indicated a new access in MEKC to predict k’ from the structural parameters of solutes.The effect of column temperature T on k’ was also investigated. | Shi, W Zhang, J Wang, L Zou, HF Zhang, YK | 1997 | Chinese Journal of Chemistry1997，15，2： | 2 |
| 15 | High-fat emulsion-induced rat model of nonalcoholic steatohepatitis显示文摘 | Zou Y Li J Lu C | 2006 | Life Sci2006，79，： | 1 |
| 16 | Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy显示文摘 | Schessl J Zou Y McGrath MJ | 2008 | J Clin Invest2008，118，3： | 1 |
| 17 | Seed-mediated synthesis of branched gold nanoparticles with the assistance of citrate and their surface-enhanced Raman scattering properties显示文摘 | Zou X Q Ying E B Dong S J | 2006 | Nanotechnol2006，17，： | 1 |
| 18 | Effect of β-mannanase (Hemicell) on growth performance and immunity of broilers显示文摘 | Zou X T Qiao X J Xu Z R | 2006 | Poult Sci2006，85，12： | 1 |
| 19 | Molecular cloning,expression profiling and functional analysis of a DXR gane encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Camptotheca acuminata 显示文摘 | YAO H Y GONG Y F ZOU K J | 2008 | J Plant Physiology2008，165，： | 1 |
| 20 | Photocatalytic decomposition of organic contaminants by Bi2WO6 under visible light irradiation显示文摘 | TANG J W ZOU Z G YIE J H | 2004 | Catal Lett2004，92，12： | 1 |
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