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| 1 | In vivo flow cytometry reveals a circadian rhythm of circulating tumor cells显示文摘Circulating tumor cells(CTCs)is an established biomarker of cancer metastasis.The circulation dynamics of CTCs are important for understanding the mechanisms underlying tumor cell dissemination.Although studies have revealed that the circadian rhythm may disrupt the growth of tumors,it is generally unclear whether the circadian rhythm controls the release of CTCs.In clinical examinations,the current in vitro methods for detecting CTCs in blood samples are based on a fundamental assumption that CTC counts in the peripheral blood do not change significantly over time,which is being challenged by recent studies.Since it is not practical to draw blood from patients repeatedly,a feasible strategy to investigate the circadian rhythm of CTCs is to monitor them by in vivo detection methods.Fluoresce nee in vivo flow cytometry(IVFC)is a powerful optical technique that is able to detect fluoresce nt circulating cells directly in living animals in a noninvasive manner over a long period of time.In this study,we applied fluorescence IVFC to monitor CTCs noninvasively in an orthotopic mouse model of human prostate cancer.We observed that CTCs exhibited stochastic bursts over cancer progression.The probability of the bursting activity was higher at early stages than at late stages.We longitudinally monitored CTCs over a 24-h period,and our results revealed striking daily oscillations in CTC counts that peaked at the onset of the night(active phase for rodents),suggesting that the release of CTCs might be regulated by the circadian rhythm. | Xi Zhu Yuanzhen Suo Yuting Fu Fuli Zhang Nan Ding Kai Pang Chengying Xie Xiaofu Weng Meilu Tian Hao He Xunbin Wei | 2021 | Light(Science & Applications)2021，10，6： | 6 |
| 2 | Ferrocenyl-isoxazole Derivative: a Novel Electrochemical, Colorimetric and Fluorescent Multiple Signal Probe for Highly Selective Recognition of Cu2+ Ions显示文摘 | ZHANG Zhiqin HE Xinwei SHANG Yongjia YU Zhiyu WANG Sufan WU Fuli | 2017 | Chemical Research in Chinese Universities2017，33，1： | 3 |
| 3 | Reply to Comment on “In vivo flow cytometry reveals a circadian rhythm of circulating tumor cells”显示文摘Dear Editor,We thank Niedre et al.for their correspondence regarding our recent paper1.They proposed a point that the temporal distribution of circulating tumor cells(CTCs)monitored by diffuse in vivo flow cytometry in a multiple myeloma mouse model in their previous work2 might be different from our results.Niedre et al.claimed that CTC detection statistics deviated from Poisson but did not found circadian variations in CTC numbers in a multiple myeloma mouse model.They also cite another literature by Juratli.et al.3,in which the authors reported that CTC numbers did not always correlate with tumor size during cancer progression.However,by establishing an orthotopic mouse model of prostate cancer and utilizing the technology in vivo flow cytometry(IVFC),we found CTCs exhibited bursting activity and daily oscillation in an orthotopic model of prostate cancer. | Xi Zhu Yuanzhen Suo Yuting Fu Fuli Zhang Nan Ding Kai Pang Chengying Xie Xiaofu Weng Meilu Tian Hao He Xunbin Wei | 2021 | Light(Science & Applications)2021，10，10： | 2 |
| 4 | Comparison of the effects of two typesof multileaf collimators on tumor control probabilityin radiotherapy for breast cancer after conservativesurgery based on the EUD model显示文摘Objective To compute and compare the tumor control probability(TCP) of volumetric modulated arc therapy(VMAT) for breast cancer after conservative surgery based on two types of multileaf collimator(MLC) through a retrospective planning study.Methods For a group of 9 patients diagnosed with left breast cancer,VMAT plan based on Agility MLC and beam modulator(BM) MLC were designed.The prescription dose was 50 Gy covering at least 95% of the planning target volume,2 Gy per fraction.TCPs were calculated according to dose-volume histogram(DVH) analysis.Results The TCP of the BM VMAT plan was slightly higher than that of the Agility VMAT plan(94.61% vs 94.23%) but was inferior with respect to delivery efficiency;the delivery time was reduced for Agility VMAT plan by 35% compared to BM VMAT plan.Conclusion For breast cancer radiation therapy after conservative surgery,BM VMAT plans provide slightly higher TCP while the delivery of Agility VMAT plans is significantly faster than the BM VMAT plans. | Fuli Zhang Yadi Wang Weidong Xu Huayong Jiang Junmao Gao Qingzhi Liu Na Lu Diandian Chen Bo Yao Jun Hou Heliang He Jianping Chen | 2017 | Oncology and Translational Medicine2017，3，2： | 2 |
| 5 | Perinatal c~- linolenic acid availability alters the expression of genes related to memory and to epigenetic machinery, and the Mecp2 DNA methylation in the whole brain of mouse off- spring显示文摘 | He Fuli Daniel S Lupu Mihai D Niculescu | 2014 | International Journal of Developmental Neuro- science2014，36，： | 1 |
| 6 | Hybrid genetic algorithm for economic dispatch with valve-point effect 显示文摘 | He Dakuo Wang Fuli Mao Zhizhong | 2008 | Electric Power Systems Research2008，78，4： | 1 |
| 7 | Linear and nonlinear photophysical properties of ZnSe/CdS/ZnS core/shell/shell typeⅡnanocrystals显示文摘In this work,one kind of typeⅡZnSe/CdS/ZnS core/shell/shell nanocrystals(NCs)is synthesized,and their linear and nonlinear photophysical properties are investigated.Through measurements of the temperaturedependent photoluminescence spectra of NCs,their excitonic properties,including the coefficient of the bandgap change,coupling strength of the exciton acoustic phonons,exciton longitudinal optical(LO)phonons,and LO–phonon energy are revealed.Femtosecond transient absorption spectroscopy was employed to obtain insight into ultrafast processes occurring at the interface of ZnSe and CdS,such as those involving the injection of photoinduced electrons into the CdS shell,interfacial state bleaching,and charge separation time.At the end,their multiphoton absorption spectra were determined by using the z-scan technique,which yielded a maximum twophoton absorption cross section of 3717 GM at 820 nm and three-photon absorption cross section up to 3.9×10^-77cm^6·s^2·photon^-2at 1220 nm,respectively.The photophysical properties presented here may be important for exploiting their relevant applications in optoelectronic devices and deep-tissue bioimaging. | YANG GAO XIN QIU FULI ZHAO SHUYU XIAO JUNZI LI XIAODONG LIN RUI CHEN AND TINGCHAO HE | 2020 | Photonics Research2020，8，9： | 1 |
| 8 | Optimization of dynamic economic dispatch with valve-point effect using chaotic sequence based differential evolution algorithms 显示文摘 | HE Dakuo DONG Gang WANG Fuli | 2011 | Energy Conversion and Management2011，52，2： | 1 |
| 9 | Dominant changes in the breast muscle lipid profiles of broiler chickens with wooden breast syndrome revealed by lipidomics analyses显示文摘Background: Chicken is the most consumed meat worldwide and the industry has been facing challenging myopathies. Wooden breast(WB), which is often accompanied by white striping(WS), is a serious myopathy adversely affecting meat quality of breast muscles. The underlying lipid metabolic mechanism of WB affected broilers is not fully understood.Results: A total of 150 chickens of a white-feathered, fast-growing pure line were raised and used for the selection of WB, WB + WS and control chickens. The lipids of the breast muscle, liver, and serum from different chickens were extracted and measured using ultra performance liquid chromatography(UPLC) plus Q-Exactive Orbitrap tandem mass spectrometry. In the breast, 560 lipid molecules were identified. Compared to controls, 225/225 of 560 lipid molecules(40.2%) were identified with differential abundance(DA), including 92/100 significantly increased neutral lipids and 107/98 decreased phospholipids in the WB/WB + WS groups, respectively. The content of monounsaturated fatty acids(MUFA) was significantly higher, and the polyunsaturated fatty acids(PUFA) and saturated fatty acids(SFA) were significantly lower in the affected breasts. In the liver, 434 lipid molecules were identified, and 39/61 DA lipid molecules(6.7%/14.1%) were detected in the WB and WB + WS groups, respectively. In the serum, a total of 529 lipid molecules were identified and 4/44 DA lipid molecules(0.8%/8.3%) were detected in WB and WB + WS group, respectively. Compared to controls, the content of MUFAs in the serum and breast of the WB + WS group were both significantly increased, and the content of SFAs in two tissues were both significantly decreased. Only five lipid molecules were consistently increased in both liver and serum in WB + WS group.Conclusions: We have found for the first time that the dominant lipid profile alterations occurred in the affected breast muscle. The relative abundance of 40.2% of lipid molecules were changed and is characteristic of increased neutral lipids and decreased phospholipids in the affected breasts. Minor changes of lipid profiles in the liver and serum of the affected groups were founded. Comprehensive analysis of body lipid metabolism indicated that the abnormal lipid profile of WB breast may be independent of the liver metabolism. | Ranran Liu Fuli Kong Siyuan Xing Zhengxiao He Lu Bai Jiahong Sun Xiaodong Tan Di Zhao Guiping Zhao Jie Wen | 2022 | Journal of Animal Science and Biotechnology2022，13，6： | 1 |
| 10 | Time-Modulated Transmissive Programmable Metasurface for Low Sidelobe Beam Scanning显示文摘Programmable metasurfaces have great potential for the implementation of low-complexity and low-cost phased arrays.Due to the difficulty of multiple-bit phase control,conventional programmable metasurfaces suffer a relatively high sidelobe level(SLL).In this manuscript,a time modulation strategy is introduced in the 1-bit transmissive programmable metasurface for reducing the SLLs of the generated patterns.After the periodic time modulation,harmonics are generated in each reconfigurable unit and the phase of the first-order harmonic can be dynamically controlled by applying different modulation sequences onto the corresponding unit.Through the high-speed modulation of the real-time periodic coding sequences on the metasurface by the programmable bias circuit,the equivalent phase shift accuracy to each metasurface unit can be improved to 6-bit and thus the SLLs of the metasurface could be reduced remarkably.The proposed time-modulated strategy is verified both numerically and experimentally with a transmissive programmable metasurface,which obtains an aperture efficiency over 34%and reduced SLLs of about-2o dB.The proposed design could offer a novel approach of a programmable metasurface framework for radar detection and secure communication applications. | Xudong Baio Fuli Zhang Li Sun Anjie Cao Jin Zhang Chong He Longhai Liu Jianquan Yao Weiren Zhu | 2022 | Research2022，，4： | 1 |
| 11 | A Representation of sl(2;C) on Clifford Algebra of Even Dimension显示文摘Under the foundation of Hermitean Clifford setting,we define the fundamental operators for complex Clifford algebra valued functions,obtain some properties of these operators,and discuss a representation of sl(2;C) on Clifford algebra of even dimension. | HE Fuli DU Jinyuan WANG Ying | 2011 | Wuhan University Journal of Natural Sciences2011，16，6： | 1 |
| 12 | Online quality prediction for cobalt oxalate synthesis process using least squares support vector regression approach with dual updating 显示文摘 | ZHANG Shuning WANG Fuli HE Dakuo | 2013 | Control Engineering Practice2013，21，10： | 1 |
| 13 | A dosimetric evaluation of flattening filter-free volumetric modulated arc therapy for postoperative treatment of cervical cancer显示文摘Objective The aim of the study was to compare flattening filter-free(FFF) beams and conventional flattening filter(FF) beams in volumetric modulated arc therapy(VMAT) for cervical cancer after surgery, through a retrospective planning study.Methods VMAT plans of FFF beams and normal FF beams were designed for a cohort of 15 patients. The prescribed dose was 45 Gy to 1.8 Gy per fraction, and at least 95% of the planning target volume received this dose. Doses were computed with a commercially available treatment planning system using a Monte Carlo(MC) algorithm. Plans were compared according to dose-volume histogram analysis in terms of planning target volume homogeneity and conformity indices(HI and CI), as well as organs at risk(OAR) dose and volume parameters. Results FFF-VMAT was similar to FF-VMAT in terms of CI, but inferior to FF-VMAT considering HI. No statistically differences were observed between FFF-VMAT and FF-VMAT in following organ at risks including pelvic bone marrow, small bowel, bladder, rectum, and normal tissue(NT)..Conclusion For patients with cervical cancer after hysterectomy, the FFF beam achieved target and OAR dose distribution similar to that of the FF beam. Reduction of beam-on time in cervical cancer is beneficial. | Fuli Zhang Huayong Jiang Weidong Xu Yadi Wang Junmao Gao Qingzhi Liu Ping Wang Na Lu Diandian Chen Bo Yao Jun Hou Heliang He Jianping Chen | 2016 | Oncology and Translational Medicine2016，2，4： | 1 |
| 14 | Real-time product quality control for batch processes based on stacked least-squares support vector regression models显示文摘 | Shuning Zhang Fuli Wang Dakuo He Runda Jia | 2011 | Computers and Chemical Engineering2011，，： | 1 |
| 15 | 鸦胆子、丝裂霉素和卡介苗膀胱灌注预防浅表性膀胱癌术后复发的前瞻性临床研究(英文)显示文摘Objective:The aim of this study was to evaluate the effects and safety of brucea javanica oil,mitomycin and BCG for preventing postoperative relapse of superficial bladder cancer through perfusion.Methods:From July 2000 to May 2006,178 patients with primary superficial bladder cancer(Ta-1,G1-2) were divided into three groups after operation in random:57 patients in group A received perfusion of 60 mL 10% brucea javanica oil,and 66 patients in group B received perfusion of 20 mg mitomycin while 55 patients in group C received perfusion of 120 mg BCG.Eighteen perfusions per patient were carried out regularly a week after operation.Patients were followed up for clinical,analytical and cystoscopic evaluations every 3 months for 2 years.The tumor relapse rates and side effects after treatment were evaluated.Results:The relapse rate was 14.04%(8/57),34.85%(23/66) and 18.18%(10/55) in group A,B and C respectively.The relapse rate in group A was obviously lower than that in group B(χ2 = 6.17,P < 0.05).Disease free interval in group A was significantly different from that in group B(F = 7.03,P < 0.05).Side effect in group A(12.28%) was observably lower than that in group B(43.94%) and group C(83.64%)(χ2AB = 15.72,P < 0.01;χ2AC = 55.34,P < 0.01).Conclusion:Perfusion of 10% brucea javanica oil after operation is safer and more effective in preventing superficial bladder tumour relapse and worth for popularizing. | Fuli Wang Weijun Qin Geng Zhang Yuntao Zhang Heliang Liu Lijun Yang He Wang Jianlin Yuan | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，4： | 1 |
| 16 | Effects of Coal Metakaolin on the Mechanical Properties and Microstructure of High-belite Sulphoaluminate Cement显示文摘The effects of coal metakaolin on the mechanical properties of high-belite sulphoaluminate cement under compressive loading were investigated.The composition and microstructure of hydration products at different hydration times were analyzed by X-ray diffraction and scanning electronic microscopy.The hydration process of blended cement was studied via electrochemical impedance spectroscopy.In particular,replacing a part of cement with CMK(10%,20%,and 30%)was found to promote the hydration process,to refine the pore size,and to improve the compressive strength of the composite.The best compressive strength of the cement was achieved at a CMK content of 30%after 28 days hydration,being improved by 20.13 MPa,or1.44 times relative to that of undoped specimens.Furthermore,the compressive strength is shown to correlate with the impedance parameter R_(CCP),which allows the latter to be used for nondestructive assessment of the compressive strength of blended cement materials. | WANG Xingyi HAN Pengju NIU Shiwei HE Bin MA Fuli GUO Tiantian XU Jinchuan | 2023 | Journal of Wuhan University of Technology(Materials Science)2023，38，2： | 0 |
| 17 | Polyharmonic Boundary Value Problem in a Sector显示文摘In this article, a polyharmonic Neumann function in a sector with angle π n (n N) is studied by convolution. Especially, the outward normal derivatives at three corner points are defined properly. We give the recursive expressions for the polyharmonic Neumann function, obtaining the solution and the condition of solvability for the related polyharmonic Neumann problem. | WANG Ying HE Qi HE Fuli | 2013 | Wuhan University Journal of Natural Sciences2013，18，4： | 0 |
| 18 | Fano-Resonant Hybrid Metamaterial for Enhanced Nonlinear Tunability and Hysteresis Behavior显示文摘Artificial resonant metamaterial with subwavelength localized filed is promising for advanced nonlinear photonic applications.In this article,we demonstrate enhanced nonlinear frequency-agile response and hysteresis tunability in a Fano-resonant hybrid metamaterial.A ceramic cuboid is electromagnetically coupled with metal cut-wire structure to excite the high-Q Fano-resonant mode in the dielectric/metal hybrid metamaterial.It is found that the significant nonlinear response of the ceramic cuboid can be employed for realization of tunable metamaterials by exciting its magnetic mode,and the trapped mode with an asymmetric Fano-like resonance is beneficial to achieve notable nonlinear modulation on the scattering spectrum.The nonlinear tunability of both the ceramic structure and the ceramic/metal hybrid metamaterial is promising to extend the operation band of metamaterials,providing possibility in practical applications with enhanced light-matter interactions. | Yuancheng Fan Xuan He Fuli Zhang Weiqi Cai Chang Li Quanhong Fu Nataliia V.Sydorchuk Sergey L.Prosvirnin | 2021 | Research2021，，1： | 0 |
| 19 | A Review on Reasons of Increasing Perennial Weeds and Control Technology of Perennial Weeds in Heilongjiang Province显示文摘The main reasons that perennial weeds has becoming the dominant weeds in Heilongjiang Province were summarized. The biological mechanism that explained why it was difficult to control perennial weeds was analyzed. During dormancy course, variation regularity of some inner matters in perennial weeds was researched and new tentative for controlling the perennial weeds was pointed out. | ZHAO Changshan HE Fuli SHI Na YAN Chunxiu | 2009 | Journal of Northeast Agricultural University(English Edition)2009，16，1： | 0 |
| 20 | Dosimetric analysis of tomotherapy-based intensity-modulated radiotherapy with and without bone marrow sparing for the treatment of cervical cancer显示文摘Objective The aim of the study was to compare tomotherapy-based bone marrow-sparing intensity-modulated radiotherapy(BMS-IMRT) with intensity-modulated radiotherapy(IMRT) without entering the pelvic bone marrow as a planning constraint in the treatment of cervical cancer after hysterectomy. Methods BMS-IMRT and IMRT plans were designed for a cohort of nine patients. The prescribed dose was 45 Gy in 1.8 Gy daily fractions, and 95% of the planned target volume received this dose. The doses were computed using a commercially available treatment planning system with the convolution/superposition algorithm. Plans were compared according to dose-volume histogram analysis in terms of planning target volume homogeneity and conformity indices(HI and CI) as well as organ at risk dose and volume parameters. Results BMS-IMRT had advantages over IMRT in terms of CI, but was equivalent to the latter in HI. V5, V10, V20, V30, and V40 of pelvic bone marrow in BMS-IMRT decreased by 0.06%, 17.33%, 22.19%, 13.85%, and 16.46%, respectively, compared with IMRT. Except for V30 of the small bowel and V30 and V40 of the bladder, no statistically significant differences were found between BMS-IMRT and IMRT in the small bowel, bladder, and rectum. Conclusion For cervical cancer patients receiving tomotherapy-based radiotherapy after hysterectomy, BMS-IMRT reduced pelvic bone marrow volume receiving low-dose radiation, and it may be conducive to preventing acute hematologic toxicity. | Fuli Zhang Weidong Xu Huayong Jiang Yadi Wang Junmao Gao Qingzhi Liu Na Lu Diandian Chen Bo Yao Jianping Chen Heliang He | 2015 | Oncology and Translational Medicine2015，1，3： | 0 |
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