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| 1 | Characterization of the receptor-binding domain(RBD)of 2019 novel coronavirus:implication for development of RBD protein as a viral attachment inhibitor and vaccine显示文摘The outbreak of Coronavirus Disease 2019(COVID-19)has posed a serious threat to global public health,calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),also known as 2019 novel coronavirus(2019-nCoV).The CoV spike(S)protein plays the most important roles in viral attachment,fusion and entry,and serves as a target for development of antibodies,entry inhibitors and vaccines.Here,we identified the receptor-binding domain(RBD)in SARS-CoV-2 S protein and found that the RBD protein bound strongly to human and bat angiotensin-converting enzyme 2(ACE2)receptors.SARS-CoV-2 RBD exhibited significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD and could block the binding and,hence,attachment of SARS-CoV-2 RBD and SARS-CoV RBD to ACE2-expressing cells,thus inhibiting their infection to host cells.SARS-CoV RBD-specific antibodies could crossreact with SARS-CoV-2 RBD protein,and SARS-CoV RBD-induced antisera could cross-neutralize SARS-CoV-2,suggesting the potential to develop SARS-CoV RBD-based vaccines for prevention of SARS-CoV-2 and SARS-CoV infection. | Wanbo Tai Lei He Xiujuan Zhang Jing Pu Denis Voronin Shibo Jiang Yusen Zhou Lanying Du | 2020 | Cellular & Molecular Immunology2020，17，6： | 35 |
| 2 | Clinical prognostic sig- nificance of heart abnormality and heart rate variability in patients with stroke显示文摘 | HE Lanying LI Changqing LUO Yong etal | 2010 | Neurological Research2010，32，5： | 1 |
| 3 | Research of processing techniques used in fabrication of solid oxide fuel cells and study of their selected properties显示文摘 | Jiang Liu Zhe Lü Wei Liu Li Pei Xin Zhao Li Jia Yanbin Song Xiaomei Liu Lanying He Wenhui Su | 1998 | Science in China Series A: Mathematics1998，，5： | 1 |
| 4 | The Effects of Different Fixation Methods on Quality of Lycium ruthenicum Murr Bud-tea显示文摘The effects of three fixation methods( steaming,blanching and microwave fixation) on chemical composition and sensory quality of Lycium ruthenicum bud-tea were investigated.The results showed the fixation technique( the leaf weight 3 g/cm^2,the time 1.5 min,and the temperature 100 ℃) was the best,which was beneficial to the conservation of free amino acid and soluble sugar in L.ruthenicum bud-tea.The loss of chlorophyll was limited,and the score of sensory quality review was higher. | Xiaoying LI Heying AI Xiyan ZHANG Yamei YAN Lanying LIU Jia MI Lu LU Jun HE | 2018 | Agricultural Biotechnology2018，7，6： | 1 |
| 5 | Structure, morphology and properties of Fe-doped ZnO films prepared by facing-target magnetron sputtering system显示文摘 | Changzheng Wang Zhong Chen Ying He Lanying Li Dong Zhang | 2009 | Applied Surface Science2009，，15： | 1 |
| 6 | Application of finite element analysis in properties test of finger-jointed lumber显示文摘Finger-jointed lumber production has now become the most extensively used method for spliced lumbers jointing together endwise.The properties of finger-jointed lumber are affected by many different factors such as the end-pressure.The main mechanical properties to be tested for struc-tural use finger-jointed lumber include the modulus of elasticity in static bending and the bending strength.The most commonly used method for testing these properties at present is the experi-mental test.In this study,we used finite element method to investigate the end-pressure range,the modulus of elasticity in static bending and the bending strength for Pinus sylvistriv var.finger-jointed lumber under three different fitness ratios(0 mm,0.1 mm,0.3 mm).With finite element analysis(FEA)modelling results compared with the experimental test results,it is possible to find the relationship between these two kinds of results and use the FEA to predict the properties of finger-jointed lumber.The FEA applied in the end pressure tests showed a narrower range com-pared with the modelling results.It indicated that the FEA could be used in the prediction of the end pressure for finger-jointed lumber.The modelling results for modulus of elasticity(MOE)test and bending strength(MOR)test showed about 20%discrepancies compared with the experimen-tal results.Moreover,the MOE modelling results showed the same trend as experimental results under three different fitness levels while the MOR modelling results showed the different trend.It can be concluded that the FEA is a feasible way in analysing the properties of finger-jointed lumber if the errors could be eliminated properly.Some modifications should be made in order to realize the prediction of the properties of finger-jointed lumber more accurately. | Sheng He Lanying Lin Zaixing Wu Zhangmin Chen | 2020 | Journal of Bioresources and Bioproducts2020，5，2： | 0 |
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