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| 1 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 2 | Expression and release of IL-29 by mast cells and modulation of mast cell behavior by IL-29显示文摘 | He, S Zhang, H Chen, H Yang, H Huang, T Chen, Y Lin, J Wang, F Chen, X Li, TL Yang, P | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 6 |
| 3 | Development of an educational cartoon to prevent worm infections in Chinese schoolchildren显示文摘Background:With more than two billion people infected worldwide,soil-transmitted helminths(STH)are the most widespread infections.To date,STH control efforts rely predominantly on recurrent mass drug administration(MDA),which does not prevent reinfection.Additional public health measures including novel health educational tools are required for more sustained integrated control of STH.We describe the development of an educational cartoon video(The Magic Glasses)targeting STH infections in Chinese schoolchildren and its pilot testing in China.We applied an extensive community-based mixed methods approach involving input from the target group of 9–10 year old schoolchildren and key informants,such as teachers,doctors and parents,in order to identify potential STH infection risks in the study area and to formulate key messages for the cartoon.The development of the educational cartoon included three major steps:formative research,production,and pilot testing and revision.Results:We found that most adults and approximately 50%of the schoolchildren were aware of roundworm(Ascaris)infection,but knowledge of transmission,prevention and treatment of STH was poor.Observations in the study area showed that unhygienic food practices,such as eating raw and unwashed fruit or playing in vegetable gardens previously fertilised with human faeces,posed major STH infection risks.Conclusions:It was crucial to assess the intellectual,emotional,social and cultural background of the target population prior to video production in order to integrate the key messages of the cartoon into everyday situations.Overall,our strategy for the development of the cartoon and its incorporation into a health education package proved successful,and we provide a summary of recommendations for the development of future educational videos based on our experiences in China. | Franziska A Bieri Li-Ping Yuan Yue-Sheng Li Yong-Kang He Andrew Bedford Robert S Li Feng-Ying Guo Sheng-Ming Li Gail M Williams Donald P McManus Giovanna Raso Darren J Gray | 2013 | Infectious Diseases of Poverty2013，2，1： | 2 |
| 4 | A conformationally sensitive GHR antibody : impact on GH signaling and GHR proteolysis显示文摘 | Jiang J Wang X He K Li X Chen C M Sayeski P P Waters M J Frank S J | 2004 | Mol Endocrinol2004，18，12： | 1 |
| 5 | MMP-2 and MMP-9 secretion by rpe is stimulated by angiogenic molecules found in choroidal neovascular membranes 显示文摘 | Hoffmann S He S Ehren M Ryan S J Wiedemann P Hinton DR | 2006 | Retina2006，26，4： | 1 |
| 6 | Thermal stability of recorded information at high densities显示文摘 | Charap S H Lu P L He Y J | 1997 | IEEE Trans Magn1997，33，1： | 1 |
| 7 | Cooperative advertising and pricing in a dynamic stochastic supply chain: Feedback Stackelberg strategies显示文摘 | He X Prasad A Sethi S P | 2009 | Production and Operations Management2009，18，1： | 1 |
| 8 | Sol-Gel Synthesis and char- acterization of ytterbium silicate powders显示文摘 | Wen H Dong S He P | 2007 | Journal of the American Ceramic Society2007，90，： | 1 |
| 9 | Single-crystal- line sodium-doped p-type ZnO and ZnMgO nanowires via eombination of thin-film and nano techniques 显示文摘 | HE H P LIN S S YUAN G D | 2011 | Jour- nal of Physical Chemistry: C2011，115，39： | 1 |
| 10 | Percutaneous ethanol injection therapy in the treatment ofthyroid and parathyroid diseases显示文摘 | B E N N E D B A E K F N K A R S T R U P S HE G E D U S L | 1997 | Eur J Endocrinol1997，136，3： | 1 |
| 11 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 12 | Thiazole-containing Tripodal Ligand:Synthesis,Characterization,and Interaction with Metal Ions and Matrix Metalloproteinases显示文摘 | He H S Linder D P Rodgers K R | 2004 | Inorg Chem2004，，： | 1 |
| 13 | An epoxy resin copolymer with zero shrinkage显示文摘 | He P S Zhou Z Q Pan C Y | 1989 | J Mater Sci1989，，24： | 1 |
| 14 | Condensation of DNA by multivalent cations:experimental studies of condensation kinetics显示文摘 | HE S ARSCOTT P G BLOOMFIELD V A | 2000 | Biopolymers2000，53，： | 1 |
| 15 | Taxonomic, phylogenetie, and environmental trade-offs between leaf productivity and persistence 显示文摘 | HE J S WANG X P FLYNN D F B | 2009 | Ecology2009，90，10： | 1 |
| 16 | Surgical treatment for hypopharynx carcinoma:feasibility,mortality,and results显示文摘 | Eckel HE Staar S Volling P | 2001 | Otolaryngol Head Neck Surg2001，124，5： | 1 |
| 17 | Nanocelluloses as innovative polymers in research and application显示文摘 | Klemm D Schumann D Kramer F He(B)ler N Hornung M Schmauder H P Marsch S | | 0，，09： | 1 |
| 18 | Enhanced root-to-shoot translocation of cadmium in the hyperaccumulating ecotype of Sedum alfredii 显示文摘 | Lu L L Tian S K Yang X E Wang X C Brown P Li T Q He Z L | 2008 | Journal of Experimental Botany2008，59，11： | 1 |
| 19 | A comprehensive review on biosorption of heavy metals by algal biomass:Materials,performances,chemistry,and modeling simulation tools显示文摘 | HE J S CHEN J P | 2014 | Bioresource Technology2014，160，： | 1 |
| 20 | Stability analysis of slopes rein forced with piles using limit analysis method 显示文摘 | Li X P He S M Wang C H | 2014 | Journal of NeuralEngineering2014，9，151： | 1 |
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