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| 1 | Time range of Mesozoic tectonic regime inversion in eastern North China Block显示文摘An important tectonic inversion took place in eastern North China Block(NCB) during Mesozoic, which caused a great lithosphere thinning, reconstruction of basin-range series, powerful interaction between mantle and crust, a vast granitic intrusion and volcanism, and large-scale metallogenic explosion. The time range of the Mesozoic tectonic regime inversion in the eastern North China Block is one of the key issues to understand mechanism of tectonic regime inversion. Our updated results for recognizing the time range are mainly obtained from the following aspects: structural analyses along northern and southern margins of the NCB and within the NCB for revealing tectonic inversion from compression to extension and structural striking from ~EW to NNE; geothermic analyses of the eastern sedimental basins for a great change of thermal history and regime; basin analysis for basin inversion from compression to extension and basin migration from ~EW to NNE; petrological and geochemical studies of volcanic rocks and lowermost crust xenoliths for recognizing peak period of mantle upwelling and intense interaction between mantle and crust, and main metallogenic epoch. All the studies of the above give the same time range from~150-140 Ma to ~110-100Ma, peaking at ~120 Ma. | ZHAI Mingguo ZHU Rixiang LIU Jianming MENG Qingren HOU Quanlin HU Shengbiao LIU Wei LI Zhong ZHANG Hongfu ZHANG Huafeng | 2004 | Science China Earth Sciences2004，47，2： | 89 |
| 2 | Dysfunction of peripheral blood dendritic cells from patients with chronic hepatitis B virus infection显示文摘AIM To identify the property of dendritic cella (DCs) of peripheral blood monocytes (PBMC) in patlents with chronic HBV infection.METHODS Twenty patients with persistent HBV infectlon were included in this study, 10 healthy subjects being used as a control group. The peripheral blood mononuclear cells (PBMC) of T cell-depleted populations were incubated and induced into mature dendritic cells in the RPMI-1640 medium in the presence of cytokines GMCSF, IL-4, FLt-3, TNF-α and 100 mL@ L-1 of fetal calf serum for a total of 10 - 12 days. The expressions of surface markers on DCs were evaluated using flow cytometric analysis. ELISA method was used to determine the cytokine levels of interleukin-12 (IL-12) and IL-10 in the supernatant produced by DCs. For detection of the stimulatory capacity of DCs to T cell proliferation,mytomycin C-treated DC were incubated with allogenic T cells.RESULTS A typical morphology of mature DCs from healthy subjects and HBV-infected patients was induced in in vitro incubation, but the proliferation ability and cellular number of DCs from HBV-infected patients significantly decreased compared with healthy individuals. In particular, the expression levels of HLADR, CD80 (B7-1) and CD86 (B7-2) on DC surface from patients were also lower than that from healthy individuals (0.46 vs 0.92 for HLA-DR, 0.44 vs 0.88 for CD80 and 0.44 vs 0. 84 for CD86, P< 0.05). The stimulatory capacity and production of IL-12 of DCs from patients in allogenic mixed lymphocyte reaction (AMLR) significantly decreased, but the production level of nitric oxide (NO) by DCa simultaneously increased compared with healthy subjects (86± 15 vs 170±22 μmoI@L 1, P<0.05).CONCLUSION The patients with chronic HBV infection have the defective function and immature phenotype of dendritic cells, which may be associated with the inability of efficient presentation of HBV antigens to host immune system for the clearance of HBV. | Fu-Sheng Wang Li-He Xing Ming-Xu Liu Chuan-Lin Zhu Hui-Gang Liu Hui-Fen Wang Zhou-Yun Lei Division of Biological Engineering,~2 Fourth Department of Liver Diseases,Beijing Institute of Infectious Diseases,Beijing Hospital of Infectious Diseases,Beijing 100039,China | 2001 | World Journal of Gastroenterology2001，7，4： | 131 |
| 3 | Quantitative analysis of vascular endothelial growth factor, microvascular density and their clinicopathologic features in human hepatocellular carcinoma显示文摘BACKGROUND: Angiogenesis is known to be essential to the survival, growth, invasion, and metastasis of tumor cells. Vascular endothelial growth factor (VEGF) are an important angiogenic factor regulating tumor angiogenesis, but its significance and tumor pathologic features are un- clear in hepatocellular carcinoma (HCC). In the present study, we analyzed expression of tissue VEGF, alteration of microvascular density (MVD) in microvessel angiogenesis, development and metastasis of HCC, and level of serum VEGF in differential diagnosis of benign and malignant liv- er diseases. METHODS: Tumor specimens were prospectively collected from HCC patients undergoing resection. Total RNAs were extracted and the expression levels were detected from different parts of HCC tissues. The cellular distributions of VEGF and MVD of liver tumors and their paracancerous and distal cancerous tissues were investigated by streptavi- din peroxidase (S-P) immunohistochemistry, respectively. The VEGF levels of circulating blood and hepatoma tissues were measured by enzyme-linked immunosorbent assay. RESULTS: The incidence of VEGF expression was 63.9% in HCCs (23/36 cases), 78.3% in non-encapsulated HCCs (18/23), and 90.9% in HCCs with extrahepatic metastasis (10/11), respectively. The VEGF expression was tightly correlated with MVD (P <0.01). The MVD in HCC with metastasis, low differentiation or non-encapsulation was significantly higher than that in HCC with intact capsule, high differentiation, or no metastasis. No significant diffe- rence was found between VEGF, MVD, tumor size, and hepatitis virus infection. The level of total RNA in HCC tis- sues was significantly lower but the VEGF level significantly higher than those in paracancerous or distal cancerous ones (P<0.01). The abnormal expression levels of VEGF in sera of HCC patients were directly correlated with the me- tastasis and recurrence of tumors. CONCLUSION: The high expression of VEGF and abnor- mality of tissue MVD are useful predictors for vascular inva- sion and metastasis of liver tumors. | Deng-Fu Yao, Xin-Hua Wu, Yong Zhu, Gong-Sheng Shi, Zhi-Zhen Dong, Deng-Bing Yao, Wei Wu, Li-Wei Qiu and Xian-Yong Meng Nantong, China Research Center of Clinical Molecular Biology , Department of Pathology and Department of Gastroenterology , Affiliated Hos- pital of Nantong University Department of Diagnostics , and Institute of Neurosciences , Nantong University Nantong 226001, China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，2： | 81 |
| 4 | Petrogenesis of highly fractionated I-type granites in the Zayu area of eastern Gangdese, Tibet: Constraints from zircon U-Pb geochronology, geochemistry and Sr-Nd-Hf isotopes显示文摘The Cretaceous granitoids in the middle and northern Gangdese, Tibet are generally interpreted as the products of anatexis of thickened deep crust genetically associated with the Lhasa-Qiangtang collision. This paper reports bulk-rock major element, trace element and Sr-Nd isotopic data, zircon U-Pb age data, and zircon Hf isotopic data on the Zayu pluton in eastern Gangdese, Tibet. These data shed new light on the petrogenesis of the pluton. Our SHRIMP zircon U-Pb age dates, along with LA-ICPMS zircon U-Pb age dates recently reported in the literature, indicate that the Zayu pluton was emplaced at about 130 Ma, coeval with Early Cretaceous magmatic rocks in other areas of eastern Gangdese (e.g., Rawu, Baxoi areas) and the Middle Gangdese. The Zayu pluton samples lack amphibole and muscovite, and are compositionally characterized by high SiO2 (69.9%―76.8%), K2O (4.4%―5.7%), and low P2O5 (0.05%―0.12%). These samples also have A/CNK values of 1.00-1.05, and are enriched in Rb, Th, U, and Pb, and depleted in Ba, Nb, Ta, Sr, P, Ti, and Eu. These geochemical features suggest that the Zayu pluton samples are metaluminous to slightly peraluminous and are of highly fractionated I-type granite. The Zayu pluton samples have high εNd(t) values (-10.9--7.6) and low initial 87Sr/86Sr ratios (0.7120- 0.7179) relative to melts derived from mature continental crust in the Gangdese (e.g., Ningzhong Early Jurassic strongly peraluminous granite). The Zayu pluton samples are heterogeneous in zircon εHf(t) values (-12.8--2.9), yielding ancient zircon Hf crustal model ages of 1.4―2.0 Ga. The data obtained in this study together with the data in the recent literature suggest that the Early Cretaceous granitoids in eastern Gangdese represent the eastward extension of the Early Cretaceous magmatism in the middle Gangdese, and that the Lhasa micro-continent block with ancient basement may extend for ~2000 km from east to west. Zircon Hf isotopic data and bulk-rock zircon saturation temperature (789-821℃) indicate that mantle-derived materials likely played a role in the generation of the Zayu pluton. We propose that the Zayu pluton was most likely generated in a setting associated with southward sub- duction of the Bangong-Nujiang ocean floor, where mantle wedge-derived magmas may have providedthe heat and material for the anatexis of ancient crust of the Lhasa micro-continent, resulted in hybrid melts (i.e., mantle-derived basaltic magmas + crust-derived felsic magmas). Such hybrid melts with subsequent fractional crystallization are responsible for the highly evolved Zayu pluton (crust thick- ening is not a prerequisite). | ZHU DiCheng MO XuanXue WANG LiQuan ZHAO ZhiDan NIU Yaoling ZHOU ChangYong YANG YueHeng | 2009 | Science China Earth Sciences2009，52，9： | 107 |
| 5 | Increasing the frequency of CIK cells adoptive immunotherapy may decrease risk of death in gastric cancer patients显示文摘AIM: To analyze the correlation between cytokineinduced killer (CIK) cells adoptive immunotherapy and cancer-related death in gastric cancer patients. METHODS: One hundred and fifty-six gastric cancer patients after operation at the Third Affiliated Hospital of Soochow University were enrolled in this study. Their clinical data including demographic characteristics, operation time, tumor size, pathological type and staging, tumor metastasis, outcome of chemotherapy or CIK cells adoptive immunotherapy, survival time or time of death were collected with a standard structured questionnaire. Kaplan-Meier method was used to estimate the median survival time, and the 2- and 5- year survival rates. Hazard risk (HR) and 95% confidence interval (95% CI) of CIK cells adoptive immunotherapy for gastric cancer were calculated using the two-stage time-dependent covariates Cox model. RESULTS: The survival time of gastric cancer patients was longer after CIK cells adoptive immunotherapy than after chemotherapy (χ 2 = 10.907, P = 0.001). The median survival time of gastric cancer patients was also longer after CIK cells adoptive immunotherapy than after chemotherapy (49 mo vs 27 mo, P < 0.05). The 2- and 5-year survival rates of gastric cancer patients were significantly higher after CIK cells adoptive immunotherapy than after chemotherapy (73.5% vs 52.6%, 40.4% vs 23.9%, P < 0.05). A significant difference was observed in the survival curve for patients who received CIK cells adoptive immunotherapy (0, 1-10, 11-25, and over 25 frequencies) (χ 2 = 14.534, P = 0.002). The frequencies of CIK cells adoptive immunotherapy were significantly related with the decreasing risk of death in gastric cancer patients after adjustment for sex and age of the patients, tumor stage and relapse (HR = 0.54, 95% CI: 0.36-0.80) when the first stage Cox model was used to define the subjects who remained alive beyond 36 mo as survivors. However, no correlation was observed between the frequencies of death in CIK cells adoptive immunotherapy and the risk of gastric cancer patients (HR = 1.09, 95% CI: 0.63-0.89) when the second stage Cox model was used to define the subjects who survived for more than 36 mo as survivors. CONCLUSION: The survival time of the gastric cancer patients treated with chemotherapy combined with CIK cells adoptive immunotherapy is significantly longer than that of the patients treated with chemotherapy alone and increasing the frequency of CIK cells adoptive immunotherapy seems to benefit patients more. | Jing-Ting Jiang, Chang-Ping Wu, Lu-Jun Chen, Xiao Zheng, Department of Tumor Biological Treatment, Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China Yi-Bei Zhu, Jing Sun, Xue-Guang Zhang, Key Laboratory of Stem Cell of Jiangsu Province, Institute of Biotechnology, Key Laboratory of Clinical Immunology of Jiangsu Province, Soochow University, Suzhou 215123, Jiangsu Province, China Yue-Ping Shen, Wen-Xiang Wei, Department of Medicine, Soochow University, Suzhou 215123, Jiangsu Province, China Bin-Feng Lu, Department of Immunology, University of Pitts- burgh School of Medicine, Pittsburgh, PA 15261, United States | 2010 | World Journal of Gastroenterology2010，16，48： | 82 |
| 6 | 我国胆石病十年来的变迁显示文摘作者报道了由全国胆道外科学组组织的来自7个省市、33所医院3911例胆结石手术病例的第二次全国临床调查资料并与十年前首次调查的结果(中华外科杂志1987,25:321~329)比较。调查证实:胆石病仍是我国普外临床的多发病,约占同时期住院患者的11.5%;多见于50岁以上的女性;女:男约2.57:1。约80%的单一部位结石分布于胆囊,以胆固醇类结石为主;而以胆色素类为主的胆管结石仅占10%。与十年前相比,胆囊:胆管结石从1.5:1上升至7.36:1;胆固醇:胆色素结石从1.4:1升至3.4:1。调查还发现:上述关于结石类型及结石部位上的变化与近十年来胆道蛔虫及胆道感染率的显著下降及饮食结构的变化有关。 | Zhu Xueguang Zhang Shengduo HuangZhiqiang et al. People′s Hospital,Beijing Medical U-niversity,Beijing100044. | 1995 | 中华外科杂志1995，33，11： | 155 |
| 7 | The zircon SHRIMP chronology and trace elementgeochemistry of the Carboniferous volcanic rocksin western Tianshan Mountains显示文摘The genesis of the Carboniferous volcanic rocks in the Dahalajunshan group, mainly consisting of trachytes and trachy-andesites and distributing widely in western Tianshan Mountains, remains to be controversial. It has been proposed to be relevant to “rift” or “plume”. Detailed pe-trology and geochemical data presented in this paper show that these volcanic rocks represent typical continental arc magmatism. The volcanic rocks are mainly trachy-andesitic, and the magma source is enriched in LILE, Th and Pb, and depleted in HFSE and Ce. Trace element geochemical study suggests that the basalts could be modeled by 7%-11% partial melt of garnet lherzolite. The volcanic rocks in the Dahala-junshan group are neither the products of “rift” nor so-called “plume” but represent the continental island arc of the Pa-leo-Southern Tianshan Ocean. The mantle wedge had been modified by the melt generating in subduction zone during a long evolution history of this island arc. The continental crust materials (i.e. mainly sediment on ocean floor) had been added into island arc through melt in subduction zone. Volcanic rocks occurring in different regions might represent magma eruption in different time. The zircon SHRIMP dat-ing indicates that the ages of the basalt varies between 334.0 Ma and 394.9 Ma. The 13 analyses give an average age of 353.7 ±4.5 Ma (MSWD = 1.7). The apparent ages of zircons in trachy-andesite vary between 293.0 Ma and 465.4 Ma. All analyses fall on the U-Pb concordant line and are divided into two groups. 8 analyses produce an average age of 312.8±4.2 Ma (MSWD = 1.7), which represents the crystal-lizing age of zircon rims in trachy-andesite. The acquired two ages (i.e. 354 and 313 Ma) belong to the Early Carboniferous and Late Carboniferous epochs, respectively. Thus, the Da-halajunshan group would be separated into several groups with the accumulation of high-quality age dating and data of trace element and isotopic geochemistry, in our opinion. | ZHU Yongfeng ZHANG Lifei GU Libing GUO Xuan ZHOU Jing | 2005 | Chinese Science Bulletin2005，50，19： | 188 |
| 8 | Source profiles of particulate organic matters emitted from cereal straw burnings显示文摘谷物稻草足够地是在中国烧的最丰富的生物资源之一,但是到好微粒的 itscontribution 不是 understood.In 这研究,三根主要类型 ofcereal 稻草从从使遭到控制烧的谷物稻草在 China.Fine 微粒事( PM2.5 )生产区域的五谷物被收集,两个在闷烧和 flamingstatus 下面,被在 thelaboratory.Element 碳( EC )使用一个特定的做的冲淡房间和采样系统取样,器官的碳( OC )是 analyzed. | ZHANG Yuan-xun SHAO Min ZHANG Yuan-hang ZENG Li-min HE Ling-yan ZHU Bin WEI Yong-jie ZHU Xian-lei | 2007 | Journal of Environmental Sciences2007，19，2： | 88 |
| 9 | MicroRNA-21 targets tumor suppressor genes in invasion and metastasis显示文摘MicroRNAs (miRNAs ) 是在 post-transcriptional 指向编码蛋白质的 mRNAs 的小非编码的 RNA 铺平的自然地发生的一个班。我们的以前的研究建议 mir-21 作为 oncogene 工作并且在 tumorigenesis 有一个角色,部分地通过肿瘤的规定压制或基因对流肌浆球蛋白 1 (TPM1 ) 。给那 TPM1 在房间移植被含有,在我们进一步调查了的这研究在房间侵略和肿瘤转移的 mir-21 的角色。我们发现在变形乳癌 MDA-MB-231 房间的 mir-21 的抑制显著地减少了侵略和肺转移。与这一致, TPM1 的宫外的表示显著地减少了房间侵略。而且,我们识别了二个另外的直接 mir-21 目标,规划房间死亡 4 (PDCD4 ) 并且妈大头针,哪个在侵略和转移被含有。象 TPM1 一样, PDCD4 和妈大头针也减少了 MDA-MB-231 房间的侵略海角。最后, PDCD4 的表示和妈大头针相反地在人的胸肿瘤标本与 mir-21 表示相关,显示由在这些肿瘤的 mir-21 的 PDCD4 和妈大头针的潜在的规定。总起来说,结果建议作为 oncogenic miRNA, mir-21 由指向多重肿瘤 / 转移不仅在肿瘤生长而且在侵略和肿瘤转移有一个角色压制或基因。因此, mir-21 的抑制可以为先进癌症的治疗提供一条新奇途径。 | Shuomin Zhu Hailong Wu Fangting Wu Daotai Nie Shijie Sheng Yin-Yuan Mo | 2008 | Cell Research2008，18，3： | 205 |
| 10 | Clinical application of a new device for minimally invasive circumcision显示文摘瞄准:与 phimosis 或过量包皮在不同年龄的男病人的治疗学习一台可处理的割礼设备的临床的效果。方法:在 5 和 95 年的年龄之间的 1200 个病人在在 2005 年 10 月和 2007 年 9 月之间的 2 年的时期用这个过程经历了割礼。这些盒子, 904 有过量包皮, 296 是 phimosis 的盒子。结果:在 96.33% 盒子中,切口愈合了,离开没有使好化妆结果留下疤痕并且生产的内部包皮的最小的数量。没有到系带的设备脱臼或损坏的事件。平均起作用的时间为 phimosis 是为过量包皮,和 3.5 min 的 2.5 min。在穿设备的 7 天期间,对中等浮肿温和与 phimosis 与过量包皮并且在那些的 2.58 % 发生在盒子的 10.08 % 。在系带的浮肿在 1.67% 病人被看见,并且仅仅, 0.67% 有切口的感染。86.25% 病人的一个总数由于阴茎勃起报导了疼痛。在设备的移动以后, 0.58% 案例有在切口附近的最小的流血,并且 2.42% 弯屈裂开。结论:新设备能与 phimosis 和过量包皮被用于病人的一个压到优势的多数。这种技术相对简单表现,并且经历了这个手术的病人有很少的复杂并发症。抗菌素没比用常规方法被割除的那些被要求,病人们报导了更少的疼痛。有这台设备的割礼要求最小的组织操作,并且比用常规技术的割礼更快、安全。 | Yi-Feng Peng Yue Cheng Guo-Yao Wang Suo-Qun Wang Chao Jia Ben-Hai Yang Ru Zhu Shu-Chuan Jian Qing-Wen Li Da-Wei Geng | 2008 | Asian Journal of Andrology2008，10，3： | 105 |
| 11 | Image Fusion Algorithm Based on Spatial Frequency-Motivated Pulse Coupled Neural Networks in Nonsubsampled Contourlet Transform Domain显示文摘Nonsubsampled contourlet 变换(NSCT ) 为图象提供灵活 multiresolution, anisotropy,和方向性的扩大。与原来的 contourlet 变换相比,它是移动不变的并且能在奇特附近克服 pseudo-Gibbs 现象。脉搏联合了神经网络(PCNN ) 是一个视觉启发外皮的神经网络并且由全球联合和神经原的脉搏同步描绘。它为图象处理被证明合适并且成功地在图象熔化采用。在这份报纸, NSCT 与 PCNN 被联系并且在图象熔化使用了充分利用他们的特征。在 NSCT 领域的空间频率是输入与大开火的时间在 NSCT 领域激发 PCNN 和系数作为熔化图象的系数被选择。试验性的结果证明建议算法超过典型基于小浪,基于 contourlet,基于 PCNN,并且 contourlet-PCNN-based 熔化算法以客观标准和视觉外观。 | QU Xiao-Bo YAN Jing-Wen XIAO Hong-Zhi ZHU Zi-Qian | 2008 | 自动化学报2008，34，12： | 119 |
| 12 | Destruction geodynamics of the North China Craton and its Paleoproterozoic plate tectonics显示文摘Much attention has been paid in the last two decades to the physical and chemical processes as well as temporal-spatial variations of the lithospheric mantle beneath the North China Craton. In order to provide insights into the geodynamics of this variation, it is necessary to thoroughly study the state and structure of the lithospheric crust and mantle of the North China Craton and its adjacent regions as an integrated unit. Based on the velocity structure of the crust and upper mantle constrained from seismological studies, this paper presents various available geophysical results regarding the lithosphere thickness, the nature of crust-mantle boundary, the upper mantle structure and deformation characteristics as well as their tectonic features and evolution systematics. Combined with the obtained data from petrology and geochemistry, a mantle flow model is proposed for the tectonic evolution of the North China Craton during the Mesozoic-Cenozoic. We suggest that subduction of the Pacific plate made the mantle underneath the eastern Asian continent unstable and able to flow faster. Such a regional mantle flow system would cause an elevation of melt/fluid content in the upper mantle of the North China Craton and the lithospheric softening, which, subsequently resulted in destruction of the North China Craton in different ways of delamination and thermal erosion in Yanshan, Taihang Mountains and the Tan-Lu Fault zone. Multiple lines of evidence recorded in the crust of the North China Craton, such as the amalgamation of the Archean eastern and western blocks, the subduction of Paleo-oceanic crust and Paleo-continental residue, indicate that the Earth in the Paleoproterozoic had already evolved into the plate tectonic system similar to the present plate tectonics. | ZHU RiXiang ZHENG TianYu | 2009 | Chinese Science Bulletin2009，54，19： | 89 |
| 13 | Timing,scale and mechanism of the destruction of the North China Craton显示文摘The North China Craton (NCC) is a classical example of ancient destroyed cratons.Since the initiation of the North China Craton Destruction Project by the National Natural Science Foundation of China,numerous studies have been conducted on the timing,scale,and mechanism of this destruction through combined interdisciplinary research.Available data suggest that the destruction occurred mainly in the eastern NCC,whereas the western NCC was only locally modified.The sedimentation,magmatic activities and structural deformation after cratonization at ~1.8 Ga indicate that the NCC destruction took place in the Mesozoic with a peak age of ca 125 Ma.A global comparison suggests that most cratons on Earth are not destroyed,although they have commonly experienced lithospheric thinning;destruction is likely to occur only when the craton has been disturbed by oceanic subduction.The destruction of the NCC was coincident with globally active plate tectonics and high mantle temperatures during the Cretaceous.The subducted Pacific slab destabilized mantle convection beneath the eastern NCC,which resulted in cratonic destruction in the eastern NCC.Delamination and/or thermal-mechanical-chemical erosion resulted from the destabilization of mantle convection. | ZHU RiXiang CHEN Ling WU FuYuan LIU JunLai | 2011 | Science China Earth Sciences2011，54，6： | 178 |
| 14 | Nitrogen Balance and Loss in a Greenhouse Vegetable System in Southeastern China显示文摘High rates of fertilizer nitrogen (N) are applied in greenhouse vegetable fields in southeastern China to maximize production;however,the N budgets of such intensive vegetable production remain to be explored.The goal of this study was to determine the annual N balance and loss in a greenhouse vegetable system of annual rotation of tomato,cucumber,and celery at five N (urea) application rates (0,348,522,696,and 870 kg N ha-1 year-1).Total N input to the 0-50 cm soil layer ranged from 531 to 1 053 kg ha-1,and N fertilizer was the main N source,accounting for 66%-83% of the total annual N input.In comparison,irrigation water,wet deposition,and seeds in total accounted for less than 1% of the total N input.The fertilizer N use efficiency was only 18% under the conventional application rate of 870 kg N ha-1 and decreased as the application rate increased from 522 to 870 kg N ha-1.Apparent N losses were 196-201 kg N ha-1,of which 71%-86% was lost by leaching at the application rates of 522-870 kg N ha-1.Thus,leaching was the primary N loss pathway at high N application rates and the amount of N leached was proportional to the N applied during the cucumber season.Moreover,dissolved organic N accounted for 10% of the leached N,whereas NH3 volatilization only contributed 0.1%-0.6% of the apparent N losses under the five N application rates in this greenhouse vegetable system. | MIN Ju ZHAO Xu SHI Wei-Ming XING Guang-Xi ZHU Zhao-Liang | 2011 | Pedosphere2011，21，4： | 91 |
| 15 | Coexistence of Th1/Th2 and Thl7/Treg imbalances in patients with allergic asthma显示文摘背景高度敏化的病人的数字正在升起,并且促进感受性能导致肾移植失败。现在的学习试图在高度敏化的肾与 rituximab 调查肾的移植追随者正式就职治疗的安全和功效移植 recipients.Methods 七个高度敏化的肾移植接受者从 2008 年 12 月经历了 rituximab 治疗到 2009 年 12 月的人,回顾地被分析。有 3 个男人和 4 个女人,与 38.5 年的吝啬的年龄(范围, 21-47 年) 。hemodialysis 的持续时间是 3-12 月,与 11 个月的吝啬的持续时间。为 4 个病人,这是第二移植;以前的接枝幸存时间是 2-11 年,与 5.8 年的一吝啬的幸存时间。所有女接受者有多重怀孕的历史,并且所有病人以前收到了输血。所有施主是男人,与 32.5 年的吝啬的年龄(范围, 25-37 年) 。在 7 个病人中的 2 个,面板的一级和类 II 反应抗体高;留下 5 个病人在一级或在面板的班 II 高显示出任何一个反应抗体。吝啬的面板反应抗体价值为一级是 31% 并且 51% 为类 II 分别地。施主和接受者让同宗打字,与从 2% ~ 5%的低淋巴细胞 cytotoxicity。人的白血球抗原(HLA ) 失配数字从 2 ~ 4。所有病人收到了 tacrolimus (0.1 mg ???????湡楧杯慲桰 吗? | SHI Yu-heng SHI Guo-chao WAN Huan-ying JIANG Li-hua AI Xiang-yan ZHU Hai-xing TANG Wei MA Jia-yun JIN Xiao-yan ZHANG Bo-ying | 2011 | Chinese Medical Journal2011，，13： | 120 |
| 16 | Preoperative administration of intramuscular dezocine reduces postoperative pain for laparoscopic cholecystectomy显示文摘Postoperative pain is the most common complaint after laparoscopic cholecystectomy.This study was carried out to evaluate whether preoperative administration of intramuscular dezocine can provide postoperative analgesia and reduce postoperative opioid consumption in patients undergoing laparoscopic cholecystectomy.Patients (ASA Ⅰ or Ⅱ) scheduled for laparoscopic cholecystectomy were randomly assigned into intramuscular dezocine group (group 1) or intramuscular normal saline group (group 2).Dezocine and equal volume normal saline were administered intramuscularly 10 min before the induction of anesthesia.After operation,the severity of postoperative pain,postoperative fentanyl requirement,incidence and severity of side-effects were assessed.Postoperative pain and postoperative patient-controlled fentanyl consumption were reduced significantly in group 1 compared with group 2.The incidence and severity of side effects were similar between the two groups.Preoperative single-dose administration of intramuscular dezocine 0.1 mg/kg was effective in reducing postoperative pain and postoperative patient-controlled fentanyl requirement in patients undergoing laparoscopic cholecystectomy. | Yaomin Zhu Guixia Jing Wei Yuan | 2011 | The Journal of Biomedical Research2011，25，5： | 138 |
| 17 | Exogenous plant MIR168a specifically targets mammalian LDLRAPI: evidence of cross-kingdom regulation by microRNA显示文摘 | Lin Zhang Dongxia Hou Xi Chen Donghai Li Lingyun Zhu Yuj ing Zhang Jing Li Zhen Bian Xiangying Liang Xing Cai Yuan Yin Cheng Wang Tianfu Zhang Dihan Zhu Dianmu Zhang Jie Xu Qun Chen Yi Ba Jing Liu Qiang Wang Jianqun Chen Jin Wang Meng Wang Qipeng Zhang Junfeng Zhang Ke Zen Chen-Yu Zhang | 2012 | Cell Research2012，22，1： | 155 |
| 18 | Photoperiod- and thermo-sensitive genic male sterility in rice are caused by a point mutation in a novel noncoding RNA that produces a small RNA显示文摘光周期敏感、 thermo 敏感的遗传因子的男绝育(PGMS 和 TGMS ) 是为在庄稼的混合繁殖的核心部件。基于使用的较普通活字大一倍的系统, PGMS 和 TGMS 衬里的混合大米是成功地在农业广泛地发展了并且适用。然而,位于 PGMS 和 TGMS 的控制下面的分子的机制仍然保持阴暗。在这研究,我们印射并且克隆一个主要地点, p/tms12-1 (染色体 12 上的感光性或 thermo 敏感的遗传因子的男绝育地点) 它在装饰用的梨树米饭线 Nongken 58S (NK58S ) 授与 PGMS 和在 indica 米饭的 TGMS 衬里 Peiai 64S (PA64S,源于 NK58S ) 。包含野类型的等位基因 P/TMS12-1 的 A 2.4-kb DNA 碎片能在基因互补恢复 NK58S 和 PA64S 植物的花粉富饶。P/TMS12-1 编码唯一的 noncoding RNA,它生产 21 核苷酸我们说出 osa-smR5864w 的小 RNA。在 p/tms12-1 的 C-to-G 的替换,相对 P/TMS12-1 的唯一的多型性,在变异的小 RNA 是在场的,也就是 osa-smR5864m。而且,在转基因的 NK58S 和 PA64S 植物的 P/TMS12-1 的一个 375-bp 序列的 overexpression 也生产了 osa-smR5864w 并且恢复了花粉富饶。小 RNA 在年轻圆锥花序优先地被表示,但是它的表示没被不同的天长度或温度显著地影响。我们的结果表明在 p/tms12-1 的点变化,可能为 osa-smR5864m 导致 loss-of-function,分别地在装饰用的梨树和 indica 线为 PGMS 和 TGMS 组成一个普通原因。我们的调查结果因此建议那小 RNA 基因是的这 noncoding 男开发的一个重要管理者由在基因网络和环境条件之间的串音控制了。 | Hai Zhou Qinjian Liu Jing Li Dagang Jiang Lingyan Zhou Ping Wu Sen Lu Feng Li Liya Zhu Zhenlan Liu Letian Chen Yao-Guang Liu Chuxiong Zhuang | 2012 | Cell Research2012，22，4： | 99 |
| 19 | Outline of the Report on Cardiovascular Disease in China,2010显示文摘Major and profound changes have taken place in China over the past 30 years.Rapid socioeconomic progress has exerted a great impact on lifestyle,ranging from food,clothing,working and living conditions,and means of transportation to leisure activities and entertainment.At the same time,new health problems have emerged,and health services are facing new challenges.Presently,cardiovascular diseases (CVD) are among the top health problems of the Chinese people,and pose a serious challenge to all engaged in the prevention and control of these diseases.An epidemic of CVD in China is emerging as a result of lifestyle changes,urbanization and longevity.Both national policy decision-making and medical practice urgently need an authoritative report which comprehensively reflects the trends in the epidemic of CVD and current preventive measures.Since 2005,guided by the Bureau of Disease Prevention of the Ministry of Health of the People's Republic of China and the National Center for Cardiovascular Diseases of China,nationwide experts in the fields of epidemiology,clinical medicine and health economics in the realms of CVD,cerebrovascular disease,diabetes and chronic kidney disease,completed the Report on Cardiovascular Diseases in China every year.The report aims to provide a timely review of the trend of the epidemic and to assess the progress of prevention and control of CVD.In addition,as the report is authoritative,representative and readable,it will become an information platform in the CVD field and an important reference book for government,academic institutes,medical organizations and clinical physicians.This publication is expected to play a positive role in the prevention and control of CVD in China.We present an abstract from the Report on Cardiovascular Diseases in China (2010),including trends in CVD,morbidity and mortality of major CVDs,up-to-date assessment of risk factors,as well as health resources for CVD,and a profile of medical expenditure,with the aim of providing evidence for decision-making in CVD prevention and control programs in China,and of delivering the most authoritative information on CVD prevention and control for all citizens. | HUSheng Shou KONG Ling Zhi GAO Run Lin ZHU Man Lu WANG Wen WANG Yong Jun WU Zhao Su CHEN Wei Wei LIU Ming Bo For the editorial board | 2012 | Biomedical and Environmental Sciences2012，25，3： | 93 |
| 20 | Destruction of the North China Craton显示文摘A National Science Foundation of China(NSFC) major research project,Destruction of the North China Craton(NCC),has been carried out in the past few years by Chinese scientists through an in-depth and systematic observations,experiments and theoretical analyses,with an emphasis on the spatio-temporal distribution of the NCC destruction,the structure of deep earth and shallow geological records of the craton evolution,the mechanism and dynamics of the craton destruction.From this work the following conclusions can be drawn:(1) Significant spatial heterogeneity exists in the NCC lithospheric thickness and crustal structure,which constrains the scope of the NCC destruction.(2) The nature of the Paleozoic,Mesozoic and Cenozoic sub-continental lithospheric mantle(CLM) underneath the NCC is characterized in detail.In terms of water content,the late Mesozoic CLM was rich in water,but Cenozoic CLM was highly water deficient.(3) The correlation between magmatism and surface geological response confirms that the geological and tectonic evolution is governed by cratonic destruction processes.(4) Pacific subduction is the main dynamic factor that triggered the destruction of the NCC,which highlights the role of cratonic destruction in plate tectonics. | ZHU RiXiang XU YiGang ZHU Guang ZHANG HongFu XIA QunKe ZHENG TianYu | 2012 | Science China Earth Sciences2012，55，10： | 119 |
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