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| 1 | Novel Cascaded Z-Source Neutral Point Clamped Inverter显示文摘Z-source Neutral point clamped(NPC) inverter inherits the advantages of Z-source inverter, which can buck-boost energy and allow the shoot-through states.At the same time, Z-source NPC inverter has high running efficiency and less harmonic content. Hence, it can be widely used in motor drives and fuel cell applications.When increasing the modulation index, one can only get smaller shoot through value in Z-source NPC inverter,therefore the output voltage of the inverter can not be boosted very high. In this paper, a novel cascaded Z-source neutral point clamped inverter is proposed by cascading two Z-source networks in series. An Alternative phase opposition disposition(APOD) carrier-based modulator is applied to control the proposed Z-source inverter. To confirm the operating principle of the new Z-source NPC inverter, a generic APOD carrier-based modulator for the cascaded Z-source NPC Inverter under Matlab/Sinmulink is built. The simulation results show that the boost factor has been increased from 1/(1- 2D) for the traditional Z source NPC inverter to 1/(1- 4D) for the proposed cascaded Z-source NPC inverter. A prototype of the cascaded Z-source NPC inverter has been set up. The experimental results verify that the new topology can increase the boost factor and expand the voltage regulation range of the inverter. | HE Yuyao LIU Hailong FENG Wei LI Jie | 2016 | Chinese Journal of Electronics2016，25，5： | 2 |
| 2 | Chaotic simulated annealing with decaying chaotic noise显示文摘 | | 2002 | IEEE Trans On Neural Networks2002，13，6： | 1 |
| 3 | Optimization of agitation, aeration, and temperature condition for maximum β-mannanse production显示文摘 | FENG Yuyao HE Zhimin ONG S L | 2003 | Enzyme and Microbial Technology2003，32，： | 1 |
| 4 | Chaotic simulated annealing with decaying chaotic noise 显示文摘 | Yuyao He | 2002 | IEEE Trans on NN2002，13，6： | 1 |
| 5 | Phase-Shifted Suboptimal Pulse-Width Modulation Strategy for Multilevel Inverter 显示文摘 | Jing Ning Yuyao He | 2006 | I ST IEEE Conference on2006，，： | 1 |
| 6 | HDAC I/IIb selective inhibitor Purinostat Mesylate combined with GLS1 inhibition effectively eliminates CML stem cells显示文摘Purinostat Mesylate(PM)is a novel highly selective and active HDAC I/IIb inhibitor,and the injectable formulation of PM(PMF)based on the compound prescription containing cyclodextrin completely can overcome PM’s poor solubility and improves its stability and pharmacokinetic properties.Here,we showed that PM effectively repressed the survival of Ph+leukemia cells and CD34+leukemia cells from CML patients in vitro.In vivo studies demonstrated that PMF significantly prevented BCR-ABL(T315I)induced CML progression by restraining leukemia stem cells(LSCs),which are insensitive to chemotherapy and responsible for CML relapse.Mechanism studies revealed that targeting HDAC I/IIb repressed several important factors for LSCs survival including c-Myc,β-Catenin,E2f,Ezh2,Alox5,and mTOR,as well as interrupted some critical biologic processes.Additionally,PMF increased glutamate metabolism in LSCs by increasing GLS1.The combination of PMF and glutaminase inhibitor BPTES synergistically eradicated LSCs by altering multiple key proteins and signaling pathways which are critical for LSC survival and self-renewal.Overall,our findings represent a new therapeutic strategy for eliminating LSCs by targeting HDAC I/IIb and glutaminolysis,which potentially provides a guidance for PMF clinical trials in the future for TKI resistance CML patients. | Qiang Qiu Linyu yang Yunyu Feng Zejiang Zhu Ning Li Li Zheng Yuanyuan Sun Cong Pan Huandi Qiu Xue Cui Wei He Fang Wang Yuyao Yi Minghai Tang Zhuang Yang Yunfan Yang Zhihui Li Lijuan Chen Yiguo Hu | 2023 | Bioactive Materials2023，，3： | 1 |
| 7 | Solid-Phase Enzymatic Peptide Synthesis to Produce an Antioxidant Dipeptide显示文摘Peptide bond synthesis is favorable to the production of bioactive small peptides. However, the abuse of toxic reagents remains an issue for chemical synthesis method, whereas the low product yield and purity limit the widespread use of enzymatic method. In this study, a new solid-phase enzymatic peptide synthesis(SPEPS) strategy was developed to produce an antioxidant tyrosine-alanine dipeptide(Tyr-Ala) by using recombinant carboxypeptidase Y(CPY) as the catalyst. The general SPEPS procedure involves three steps. First, the N-protected acyl donor was covalently attached to solid resin. Second,the peptide bond was condensed between the acyl donor and the nucleophile under the catalysis of CPY. Finally, one-step cleavage was performed to remove the protecting group and cleave the peptides from solid resin. Upon the optimization of reaction conditions, 77.92%(±2.723%) yield of Tyr-Ala with high product purity of 90.971%(±2.695%) was obtained.In addition, the antioxidant activity of Tyr-Ala was determined by ABTS method, indicating that the synthesized Tyr-Ala obtained by SPEPS showed a superior antioxidant capability compared with commercial glutathione. | Yuyao Shan Mengfan Wang Wei Qi Rongxin Su Zhimin He | 2019 | Transactions of Tianjin University2019，25，3： | 0 |
| 8 | From macro to microarchitecture:reviews and trends of SRAM-based compute-in-memory circuits显示文摘The rapid growth of CMOS logic circuits has surpassed the advancements in memory access,leading to significant“memory wall”bottlenecks,particularly in artificial intelligence applications.To address this challenge,compute-in-memory(CIM)has emerged as a promising approach to enhance the performance,area efficiency,and energy efficiency of computing systems.By enabling memory cells to perform parallel computations,CIM improves data reuse and minimizes data movement between the memory and the processor.This study conducts a comprehensive review of various domains of SRAM-based CIM macros and their associated computing paradigms.Additionally,it presents a survey of recent SRAM-CIM macros,with a specific focus on the key challenges and design tradeoffs involved.Furthermore,this research identifies potential future trends in SRAM-CIM macro-level design,including hybrid computing,precision enhancement,and operator reconfiguration.These trends aim to resolve the tradeoff between computational accuracy,energy efficiency,and support for diverse operators within the SRAM-CIM framework.At the microarchitecture level,two possible solutions for tradeoffs are proposed:chiplet integration and sparsity optimization.Finally,research perspectives are proposed for future development. | Zhaoyang ZHANG Jinwu CHEN Xi CHEN An GUO Bo WANG Tianzhu XIONG Yuyao KONG Xingyu PU Shengnan HE Xin SI Jun YANG | 2023 | Science China(Information Sciences)2023，66，10： | 0 |
| 9 | Kinetically Controlled Carboxypeptidase-Catalyzed Synthesis of Novel Antioxidant Dipeptide Precursor BOC-Tyr-Ala显示文摘Recently, enzymatic peptide synthesis has drawn increasing attention due to its eco-friendly reagents and mild conditions, as compared to traditional chemical peptide synthesis. In this study, we successfully produced an important antioxidant dipeptide precursor, BOC-Tyr-Ala, via a kinetically controlled enzymatic peptide synthesis reaction, catalyzed by the recombinant carboxypeptidase Y(CPY) expressed in P. pastoris GS115. In this reaction, the enzyme activity was 95.043 U/mL, and we used t-butyloxycarbonyl-L-tyrosine-methyl ester(BOC-Tyr-OMe) as the acyl donor and L-alanine( L-Ala) was the amino donor. We optimized the reaction conditions to be: 30 °C, pH 9.5, organic phase(methanol)/aqueous phase = 1:20, BOC-Tyr-OMe 0.05 mol/L, Ala 0.5 mol/L, and a reaction time of 12 h. Under these conditions, the dipeptide yield reached 49.84%. Then, we established the kinetic model of the synthesis reaction in the form of Michaelis–Menten equation according to the concentration–time curve during the process and the transpeptidation mechanism. We calculated the apparent Michaelis constant K_m^(app) and the apparent maximum reaction rate r_(max)^(app) to be 2.9946 × 10^(-2)mol/L and 2.0406 × 10^(-2)mmol/(mL h), respectively. | Yuyao Shan Wei Qi Mengfan Wang Rongxin Su Zhimin He | 2018 | Transactions of Tianjin University2018，24，6： | 0 |
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