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| 1 | An Investigation on the Molecular Characteristics and Intracellular Growth Ability among Environmental and Clinical Isolates of Legionella pneumophila in Sichuan Province, China显示文摘Objective To investigate the molecular characteristics and intracellular growth ability of Legionella pneumophila(L. pneumophila) strains from 1989 to 2016 in Sichuan Province, China. Methods Seventy-nine isolates of L. pneumophila were collected from environmental and clinical sources, including cooling towers, hot springs, bath water, fountains, and patients, and identified with 16 S rRNA gene analysis and serum agglutination assay. The isolates were then typed by Sequence-Based Typing(SBT), and Genotyping of forty-two LP1 strains were analyzed by means of multiple-locus VNTR analysis with 8 loci(MLVA-8). All strains were further analyzed for two virulence genes: Legionella vir homologue(lvh) and repeats in structural toxin(rtx A). The intracellular growth ability of 33 selected isolates was determined by examining their interaction with J774 cells. Results All isolates were identified to L. pneumophila including 11 serogroups, among which the main serogroup were LP1, accounting for 54.43%. Thirty-three different sequence types(STs) from five main clonal groups and five singletons were identified, along with 8 different MLVA patterns. Both the lvh and rtx A loci were found in all 79 strains. Thirty isolates showed high intracellular growth ability in J774 cells. Conclusion L. pneumophila is a potential threat to public health, and effective control and prevention strategies are urgently needed. | ZENG Lin Zi LIAO Hong Yu LUO Long Ze HE Shu Sen QIN Tian ZHOU Hai Jian LI Hong Xia CHEN Da Li CHEN Jian Ping | 2019 | Biomedical and Environmental Sciences2019，32，7： | 1 |
| 2 | A modified realGA for the sparse linear array synthesis with multipleconstraints 显示文摘 | Song Chen Ke shu He Zi lin Han Chun | 2006 | IEEE Transactions on Antennas andPropagation2006，54，7： | 1 |
| 3 | A modified real GA for the sparse linear array synthesis with multiple constraints 显示文摘 | CHEN Ke Song HE Zi Shu HAN Chun Lin | 2006 | IEEE Trans Antennas Propag2006，54，7： | 1 |
| 4 | Synthesis of sparse planar arrays using modified real genetic algorithm显示文摘 | CHEN Ke Song YUN Xiao Hua HE Zi Shu | 2007 | IEEE Trans Antennas Propag2007，55，4： | 1 |
| 5 | A Modified Real GA for the Sparse Linear Array Synthesis with Multiple Constraints显示文摘 | Chen Ke- song He Zi - shu Han Chun- lin | 2006 | IEEE Transactions on Antennas and Propaga- tion2006，54，7： | 1 |
| 6 | Multiple-target Localization and Estimation of MIMO Radars With Unknown Transmitted Signals 显示文摘 | XIA Wei HE Zi shu | 2008 | IEEE International Symposium on Signal Processing and Information Technology2008，，： | 1 |
| 7 | Identification of Dual Receptor-binding Specific Strains of Human H5N1 Viruses in China显示文摘Objective Both the 2,6 linkage and its topology on target cells are critical for the recognition by human influenza virus.The binding preference of avian flu virus H5N1 HA to the 2,3-linked sialylated glycans is considered the major factor limiting its efficient infection and transmission in humans.To monitor potential adaptation of H5N1 virus in human population,the surveillance of receptor-binding specificity was undertaken in China.Methods The binding specificity of 32 human H5N1 virus strains isolated from 2003 to 2009 was tested by 2,3-specific sialidase-treated chicken red blood cell (CRBC) agglutination assay and a solid-phase direct binding assay with synthetic sialylglycopolymers.Results Dual binding preference to 2,3 and 2,6-glycans were found in two strains:A/Guangdong/1/06 (A/GD/1/06) and A/Guangxi/1/08 (A/GX/1/08).Thoughminor effect of short-2,6-binding was detected in A/GX/1/08 at a low virus titer,both showed high affinity to the oligosaccharide at a high load.Notably both are of the long-2,6-recognition,with the same topology as that of human H1N1 and H3N2 viruses.Conclusion The findings suggest that human H5N1 virus in China likely acquired the potential human-adaptation ability.Further research and surveillance on receptor-binding specificity of H5N1 viruses are required. | ZHOU Jian Fang ZOU Shu Mei LI Zi WANG Min DONG Jie GUO Jun Feng WEI He Jiang WEN Le Ying XU Hong SHU Yue Long | 2012 | Biomedical and Environmental Sciences2012，25，1： | 0 |
| 8 | A Web-based Condition Monitoring and Diagnostic System of Rolling Mill显示文摘A web based condition monitoring and fault diagnosis system (CMAFDS) for the F2 finishing mill of the 2050 Hot Strip Mill was developed at a steel works. The features of the condition monitoring and fault diagnosis system based on the Web are analyzed in this paper. This paper also describes the main frame of the hardware and the software in the system and emphatically points out the function of the database management system(DBMS) based on the Web. It is proved that the web based CMAFDS is practical in technology and much superior to the CMAFDS based on other network technology in functions. | XIONG Liang cai, HE Lin song, SHI Tie lin, YANG Shu zi Huazhong University of Science and Technology, Wuhan 430074, P.R.China | 2002 | International Journal of Plant Engineering and Management2002，7，1： | 0 |
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