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| 1 | Mechanical thrombectomy in patients with M1 occlusion and NIHSS score≤5:a single-centre experience显示文摘Background:The recent success of several mechanical thrombectomy trials has resulted in a significant change in management for patients presenting with stroke.However,it is still unclear how to manage patients that present with stroke and low National Institutes of Health Stroke Scale(NIHSS)≤5.We sought to review our experience of mechanical thrombectomy in patients with low NIHSS and confirmed M1 occlusion.Methods:We retrospectively analysed our prospectively maintained database of all patients undergoing mechanical thrombectomy between January 2008 and August 2016.We identified 41 patients with confirmed M1 occlusion and low NIHSS(≤5)on admission to our hospital.We collected demographic,radiological,procedural and outcome data.Results:The mean age of patients was 72±14,with 20 male patients.Associated medical conditions were common with hypertension seen in∼80%.Just over 50%presented with NIHSS 4 or 5.The average ASPECTS score on admission was 8.8(range 6–10),and the average clot length 10 mm.Angiographically Thrombolysis in Cerebral Infarction(TICI)≥2b was obtained in 87.8%of patients.7 patients had haemorrhage on follow-up,2 of which were symptomatic.Of 40 patients with 90-day follow-up,75%had modified Rankin Scale(mRS)score 0–2.There were 3 deaths at 90 days.Conclusions:Mechanical thrombectomy in patients with low NIHSS and proximal large vessel occlusion is technically possible and carries a high degree of success with good safety profile.Patients with low NIHSS and confirmed occlusion should be considered for mechanical thrombectomy. | P Bhogal P Bucke O Ganslandt H Bazner H Henkes M Aguilar Perez | 2016 | Stroke & Vascular Neurology2016，1，4： | 9 |
| 2 | Anemia and long-term outcome in adjuvant and neoadjuvant radiochemotherapy of stage Ⅱ and Ⅲ rectal adenocarcinoma:The Freiburg experience(1989-2002)显示文摘AIM:To evaluate the long-term outcome of standard5-FU based adjuvant or neoadjuvant radiochemotherapyand to identify the predictive factors,especially anemiabefore and after radiotherapy as well as hemoglobinincrease or decrease during radiotherapy.METHODS:Two hundred and eighty-six patientswith Union International Contre Cancer(UICC)stageⅡ and Ⅲ rectal adenocarcinomas,who underwentresection by conventional surgical techniques(lowanterior or abdominoperineal resection),receivedeither postoperative(n=233)or preoperative(n=53)radiochemotherapy from January 1989 until July 2002.Overall survival(OAS),cancer-specific survival(CSS),disease-free survival(DFS),local-relapse-free(LRS)and distant-relapse-free survival(DRS)were evaluatedusing Kaplan-Meier,Log-rank test and Cox's proportionalhazards as statistical methods.Multivariate analysis wasused to identify prognostic factors.Median follow-uptime was 8 years.RESULTS:Anemia before radiochemotherapy was anindependent prognostic factor for improved DFS(riskratio 0.76,P=0.04)as well as stage,grading,R status(free radial margins),type of surgery,carcinoembryonicantigen(CEA)levels,and gender.The univariate analysisrevealed that anemia was associated with impaired LRS (better local control)but with improved DFS.In contrast,hemoglobin decrease during radiotherapy was anindependent risk factor for DFS(risk ratio 1.97,P=0.04).During radiotherapy,only 30.8% of RO-resected patientssuffered from hemoglobin decrease compared to 55.6%if R1/2 resection was performed(P=0.04).The 5-yearOAS,CSS,DFS,LRS and DRS were 47.0%,60.0%,41.4%,67.2%,and 84.3%,respectively.Significantdifferences between preoperative and postoperativeradiochemotherapy were not found.CONCLUSION:Anemia before radiochemotherapyand hemoglobin decrease during radiotherapy have nopredictive value for the outcome of rectal cancer.Stage,grading,R status(free radial margins),type of surgery,CEA levels,and gender have predictive value for theoutcome of rectal cancer. | Christian Weissenberger Geissler Michael Otto Florian Barke Annette Henne Karl von Plehn Georg Rein Alex Müller Christine Bartelt Susanne Henke Michael | 2006 | World Journal of Gastroenterology2006，12，12： | 4 |
| 3 | ABT-450, Ritonavir, Ombitasvir, and Dasabuvir Achieves 97% and 100% Sustained Virologic Response With or Without Ribavirin in Treatment-experienced Patients with HCV Genotype 1b Infection显示文摘 | Pietro Andreone Massimo G. Colombo Jeffrey V. Enejosa Iftihar Koksal Peter Ferenci Andreas Maieron Beat Müllhaupt Yves Horsmans Ola Weiland Henk W. Reesink Lino Rodrigues Yiran B. Hu Thomas Podsadecki Barry Bernstein | 2014 | Gastroenterology2014，，： | 2 |
| 4 | X-ray interactions: photabsorption, scattering, transmission, and reflection at E-50-30000 eV, Z=1-92显示文摘 | HENKE B L GULLIKSON E M DAVIS J C | 1993 | Atomic Data and Nuclear Tables1993，54，： | 2 |
| 5 | Blood hemoglobin level may affect radiosensitivity-preliminary results on acutely reacting normal tissues显示文摘 | Henke M Bechtold C Momm F | 2000 | Int J Radiat Oncol Bid Phys2000，48，2： | 1 |
| 6 | X-ray interactions: photoabsorption scattering, transmission and reflection at E=50-30000 eV, Z=1-92显示文摘 | HENKE B L GULLIKSON E M DAVIS J C | 1993 | Atomic Data and Nuclear Data Tables1993，54，： | 1 |
| 7 | Macrolide antibiotics as immu-nomodulatory medications: proposed mechanisms of action 显示文摘 | Shinkai M Henke MO Rubin BK | 2008 | Pharmacol Ther2008，117，： | 1 |
| 8 | A novel, self- expanding, nitinol stent in medically refractory intracranial atherosclerotic stenoses: the Wingspan study显示文摘 | Bose A Hartmann M Henkes H | 2007 | Stroke2007，38，5： | 1 |
| 9 | X-ray interaction:photoabsorption,scattering,transmission and reflection at E=50-30000eV,Z=1-92显示文摘 | HENKE B L GULLIKSEN E M DAVIS J C | 1993 | Atomic Data and Nuclear Data Tables1993，54，2： | 1 |
| 10 | X-ray interactions: photoabsorption, scattering, transmission, and reflection at E=50-30 000 eV, Z= 1-92显示文摘 | HENKE B L GULLIKSON E M DAVIS J C | 1993 | Atomic Data and Nuclear Data Tables1993，54，2： | 1 |
| 11 | Chromosomal changes characterize head and neck cancer with poor prognosis显示文摘 | Bauer VL Braselmann H Henke M | 2008 | J Mol Med(Berl)2008，86，12： | 1 |
| 12 | Ex situ conservation of vegetatively propagated species: Development of a seed-based core collection for Ma!us sieversii 显示文摘 | VOLK M G RICHARDS M C REILLEY A A HENK D A | 2005 | Journal of the American Society for Horticultural Science2005，130，： | 1 |
| 13 | Blood hemoglobin level may affect radiosensitivity, preliminary results on acutely rearing normal tissue显示文摘 | Henke M Bechtold C Momm F | 2000 | Int Radiat Oncol Biol Phys2000，48，： | 1 |
| 14 | Endovascular management of dural carotid-cavernous sinus fistulas in 141 patients显示文摘 | Henkes H Liebig T | 2006 | Neuroradiology2006，48，： | 1 |
| 15 | Quantification of crack-healing in novel bacteria-based self-healing concrete显示文摘 | Virginie Wiktor Henk M Jonkers | 2011 | Cement&Concrete Composites2011，，33： | 1 |
| 16 | Emerging fungal threats to animal,plant and ecosystem health显示文摘 | FISHER M C HENK D A BRIGGS C J | 2012 | Nature2012，484，7396： | 1 |
| 17 | Effectiveness of commercial reagents for heavy metal removal from water with new insights for future chelate designs显示文摘 | MATLOCK M M HENKE K R ATWOOD D A | 2002 | Journal of Hazardous Materials B2002，92，2： | 1 |
| 18 | Reduced growth of the cyan bacterium microcystis in an artificially mixed lake and reservoir 显示文摘 | Visser Petra M Ketelaars Henk A M | 1995 | Water Science Technology1995，32，4： | 1 |
| 19 | Effects of activated charcoal on callus growth and shoot organo genesis in tobacco显示文摘 | CONSTANTIN M J HENKE R R MANSUR M A | 1977 | In Vitro1977，13，5： | 1 |
| 20 | A novel self-expanding nitinol stent in medically refractory intracranial atherosclerotic stenoses the Wingspan study 显示文摘 | Boose A Hartmann M Henkes H | 2007 | Stroke2007，38，4： | 1 |
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